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The map label for this gene is mdmC [H]

Identifier: 78224171

GI number: 78224171

Start: 3365457

End: 3366086

Strand: Direct

Name: mdmC [H]

Synonym: Gmet_2978

Alternate gene names: 78224171

Gene position: 3365457-3366086 (Clockwise)

Preceding gene: 78224164

Following gene: 78224172

Centisome position: 84.19

GC content: 61.59

Gene sequence:

>630_bases
ATGATCCCCATAACCGATTCCCGCATCGAGGAGTACCTCATGGGGCTGGCGCCCGAGGATAACCCCAGCCTCCTCGCAAT
GGAAAGCCGGGCCAAGGCTTTGGGCTTCCCCATCGTTGACCGCCTGGTTGGGCGGTTCCTCTATATCCTCACACGCATCA
AGCAGCCTCGGCTCGTGGTGGAACTGGGCTCGGGGTTCGGCTACTCGGCCTGGTGGTTCGCCCGGGCCATCAGCATCACG
GGGAAGGTGGTCATGACCGACTACTCCCCCACCAATATTGCTTATGCCCGGGAAATGTTCCAGGAAAGCGGCCTCAGCGA
CCGGGTGGAGTTCCGGGTCGGCGACGCCCTGAATATCGGCCGCGATTACCGCGACATCGACATCCTCTTCATCGACCTGG
ACAAGCACCAGTACCGGGAAGCCATGGAGGCCATGATCCCGCACCTCGCCCCCCATGCCCTGGTCATCGCCGACAACGTC
CTCTGGTACGGCAAGGTGGTGGAGGGAGAGGACGACCCCGAAACCCGCGGCATCCGGGACTTCAACGATTTCATGACCGG
TAGGAAGGACTTTTTCACCTCCATCCTTCCGCTGCGCGACGGGGTGATGGTCGCCTATCGCCTGTCATAA

Upstream 100 bases:

>100_bases
CAGTTTTTACCCTTTTTCCCGGCTCGAATTGCGCATCCCGGCGAAAGTGTTAGACTTAACAGACTGTATGGGTAACGGAT
ACCTGGAAGGAAAACGAACG

Downstream 100 bases:

>100_bases
CGCCAGAACGGCATCACAAGGGGGAACCATGAAACGAATCGTCACTGCGGCAGTCATCCCGTTCCTCGCCCTCACGGCGG
GGTGCGCCACCAAAACATTC

Product: O-methyltransferase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MIPITDSRIEEYLMGLAPEDNPSLLAMESRAKALGFPIVDRLVGRFLYILTRIKQPRLVVELGSGFGYSAWWFARAISIT
GKVVMTDYSPTNIAYAREMFQESGLSDRVEFRVGDALNIGRDYRDIDILFIDLDKHQYREAMEAMIPHLAPHALVIADNV
LWYGKVVEGEDDPETRGIRDFNDFMTGRKDFFTSILPLRDGVMVAYRLS

Sequences:

>Translated_209_residues
MIPITDSRIEEYLMGLAPEDNPSLLAMESRAKALGFPIVDRLVGRFLYILTRIKQPRLVVELGSGFGYSAWWFARAISIT
GKVVMTDYSPTNIAYAREMFQESGLSDRVEFRVGDALNIGRDYRDIDILFIDLDKHQYREAMEAMIPHLAPHALVIADNV
LWYGKVVEGEDDPETRGIRDFNDFMTGRKDFFTSILPLRDGVMVAYRLS
>Mature_209_residues
MIPITDSRIEEYLMGLAPEDNPSLLAMESRAKALGFPIVDRLVGRFLYILTRIKQPRLVVELGSGFGYSAWWFARAISIT
GKVVMTDYSPTNIAYAREMFQESGLSDRVEFRVGDALNIGRDYRDIDILFIDLDKHQYREAMEAMIPHLAPHALVIADNV
LWYGKVVEGEDDPETRGIRDFNDFMTGRKDFFTSILPLRDGVMVAYRLS

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Homo sapiens, GI31542747, Length=219, Percent_Identity=24.6575342465753, Blast_Score=68, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 23848; Mature: 23848

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPITDSRIEEYLMGLAPEDNPSLLAMESRAKALGFPIVDRLVGRFLYILTRIKQPRLVV
CCCCCHHHHHHHHHHCCCCCCCCEEEECHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEE
ELGSGFGYSAWWFARAISITGKVVMTDYSPTNIAYAREMFQESGLSDRVEFRVGDALNIG
EECCCCCCHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCC
RDYRDIDILFIDLDKHQYREAMEAMIPHLAPHALVIADNVLWYGKVVEGEDDPETRGIRD
CCCCEEEEEEEECCHHHHHHHHHHHHHHCCCCEEEEECCEEEEEEEECCCCCCCCCCCCH
FNDFMTGRKDFFTSILPLRDGVMVAYRLS
HHHHHCCHHHHHHHHHHCCCCEEEEEEEC
>Mature Secondary Structure
MIPITDSRIEEYLMGLAPEDNPSLLAMESRAKALGFPIVDRLVGRFLYILTRIKQPRLVV
CCCCCHHHHHHHHHHCCCCCCCCEEEECHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEE
ELGSGFGYSAWWFARAISITGKVVMTDYSPTNIAYAREMFQESGLSDRVEFRVGDALNIG
EECCCCCCHHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCC
RDYRDIDILFIDLDKHQYREAMEAMIPHLAPHALVIADNVLWYGKVVEGEDDPETRGIRD
CCCCEEEEEEEECCHHHHHHHHHHHHHHCCCCEEEEECCEEEEEEEECCCCCCCCCCCCH
FNDFMTGRKDFFTSILPLRDGVMVAYRLS
HHHHHCCHHHHHHHHHHCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]