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The map label for this gene is mutS2 [H]

Identifier: 78224167

GI number: 78224167

Start: 3360327

End: 3362684

Strand: Reverse

Name: mutS2 [H]

Synonym: Gmet_2974

Alternate gene names: 78224167

Gene position: 3362684-3360327 (Counterclockwise)

Preceding gene: 78224168

Following gene: 78224166

Centisome position: 84.12

GC content: 68.11

Gene sequence:

>2358_bases
ATGATACGACACGAAACCCTCCGCACCCTCGAATTCGACAAGGTCCTCGCGGCCGTCGGCGGCTACGGCCACAGCACCGC
CACCCAGGATGAGATCGCCCTGATCCGTCCCCTGGACGATTGGTCGGCCATCACCCGGCGCTTCGGCCAGGTGGACGAGA
TCCGGCGCATGACCCAGCAGGGGATCGCCATCCCCCTCTCCACGTTCGACGACATCTCGGCCCTTCTGGACGCGGTGCGC
CCCGAGGGTGCGGTCCTCGACCCCACGGAATTGGTGATACTCTTTCCGGTGCTCCGGACCATGACCGCCATCGCCAAACA
GTTCGCCTACCGGTCCGACATCCCGCTCCTGAAGGAGTTGGCTGGCCACGTGACCGGCTTCCCCGACATCCTGGACGAGC
TGGAGGTGTCCATCGACAGCGAGGGGGAGATCCTCGACTCCGCCTCGCCGCTCCTCTTCGACCTGCGCAAGAAAAAGCGC
GCCCTCACCGAGCGGATCCGGCGGCGGCTGGCCGAGATCGTCCGGGAGACCGGCGTCACCACCTTCCTCCAGGACGACTT
CATCACCCAGCGGGGTGGCCGGTGGGTGATCCCGGTCCGGATGGACTCCAAGGGGATGGTCCCCGGCGTGGTCCACGACG
TCTCCAACTCCGGCGAGACCGCCTTCATGGAACCATTGGAAATCATCGGCCTCGCCAACGAGTTGGAAAACCTGGTGGCC
GAGGAGAAGGCCGAGATGATCCGCATCGTCCGGGCCATCTGCCGGATGCTTCGCCGCGAGGCCGATCCCCTGGCGGAACA
GTTCCGGACCCTGGTCCACCTGGACCTCCTGAACGCCGTGGCCACCTTCGCCGATTCCCTCTCCGCCGAAAACCCCGAGA
TCAACGACGCCCGCTTCATCCGGGTAAACGAAGGGCGGCATCCCCTCCTGGCCCTCATGGCCCGGGAGCGGGGTGCCGGC
AGGGTCGTGCCCCTGGACCTTTCCCTCGGGGAGACTGAGCAGGTCATGGTCATCACCGGCCCCAACGCCGGCGGCAAAAC
CATCTCCCTCAAGACCACCGGCCTCCTCCACCTCATGGCCCTGGCCGGGCTTCCGGTACCGGCCGCATCCACCTCGTCGT
TCCCCCTCATCTCCGACCTCCTGGTGGACATCGGCGATGAGCAGTCCATCGAGCAGAGCCTCTCCACCTTCTCGGCCCAC
GTCTCCAACATCGCGGGGATCCTGGAACGGGCCGACGACCGGACCGTGGTGCTTCTGGACGAGCTGGGGACCGGTACCGA
GCCGGTCCAGGGGGCGGCCATCTCCTGCGCCGTCCTGGCCGATCTCCAGGAGAAGGGGGCACGGGTCATCGCCACGACCC
ACCTCACCGACATCGTCGGCTTCGTCCACAAGCGGGACGGGATGGTGAACGCCTCCATGGAGTTCGACCGGGCGACCCTC
ACCCCCCTCTACCGCCTCAAGAAGGGGGAGCCGGGGCAGTCCCACGCCCTGGAGATCGCCCGCCGTTACGGCCTCCCGGA
CCGGGTGGTGGAGTTCGCCACCGGCATGCTCTCCCGCATGGAGACCGAGTTCCACGAGCTTCTGGCCGAGCTGAAGGACC
AGCGCCGGCGCCACGAGGAGGCCCTGGCCGAGGCGGAGCGACTGCGGCGGGATGCCGAGGAAAAGGCCCGCATCGTCCGT
GAGCGGCTGGCCGAGGCCGAGGCGAAGCGGCGGGAGGCGGTGGAAAAGGCGTTTCAGGAGGCGAAGGAGATTGTCCGAAG
TGCCCGGCGGGAGGTGAACGCCATCATCGAGGAGGCCCGGAAAGAGAAGAGCCGCGAGGCCCGGAAAAAGATCGACGAGG
CCGAGGCGCGGGTGGAGGAGCAGCTCCAGGAGTTCCACCCCGAGGAGCGCGTTCCCCTGGAGGCCATCAGCGAGGGGGAC
ACGGTCCATGTGAAGCGTCTCGGCCACGACGTGACCGTCCTCGCCGTGGACCGGAAGGGGGAGACCCTCAAGGTCCGGGC
CGGCACCTTCGAGCTGGTGGTGGAGGCGGCCGACGTGGCCCCGCCGAGGGAAAAGGGGGGGAAGAAACCCAAGGCCAGGG
CCGCCGCCAAGATCGCCGCCCCTTCCCGGGAGTCCACACCCCACGAACTGAACCTCATCGGCCTGCGGGTGGACGATGCC
CTGGGGCGGCTGGAGCCGTTCCTGAACCATGCATCCCTGGAAGGGTACGGCGAGGTGCGGATCGTTCACGGCAAGGGGAC
CGGCGCCCTCATGCGGGGGGTGCGGGAGTACCTGGACGGCCATCCCCTGGTGCGGGAGTTCCGCCCCGGCGAGCCCTTCG
AGGGGGGCGAGGGGGCCACGGTGGTGCTGCTAAGGTAG

Upstream 100 bases:

>100_bases
AGTGGGATCACTCGAAATTCACTCCACTTCTGCACTAATTTGTTGACTGAGAACACGGTTGCTCTGTGTTTCAATAAGCC
TTTTACTAAGGATTTTTCTG

Downstream 100 bases:

>100_bases
GGGGTAAATCTGCTTGACGTTTAACGTGGAGCGTTATATCTTTTTGCCATGATCAAGTCATTCCGCTGCAAGGACACCCA
GGCTTTGTTCGAGGGGAAAT

Product: MutS 2 protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 785; Mature: 785

Protein sequence:

>785_residues
MIRHETLRTLEFDKVLAAVGGYGHSTATQDEIALIRPLDDWSAITRRFGQVDEIRRMTQQGIAIPLSTFDDISALLDAVR
PEGAVLDPTELVILFPVLRTMTAIAKQFAYRSDIPLLKELAGHVTGFPDILDELEVSIDSEGEILDSASPLLFDLRKKKR
ALTERIRRRLAEIVRETGVTTFLQDDFITQRGGRWVIPVRMDSKGMVPGVVHDVSNSGETAFMEPLEIIGLANELENLVA
EEKAEMIRIVRAICRMLRREADPLAEQFRTLVHLDLLNAVATFADSLSAENPEINDARFIRVNEGRHPLLALMARERGAG
RVVPLDLSLGETEQVMVITGPNAGGKTISLKTTGLLHLMALAGLPVPAASTSSFPLISDLLVDIGDEQSIEQSLSTFSAH
VSNIAGILERADDRTVVLLDELGTGTEPVQGAAISCAVLADLQEKGARVIATTHLTDIVGFVHKRDGMVNASMEFDRATL
TPLYRLKKGEPGQSHALEIARRYGLPDRVVEFATGMLSRMETEFHELLAELKDQRRRHEEALAEAERLRRDAEEKARIVR
ERLAEAEAKRREAVEKAFQEAKEIVRSARREVNAIIEEARKEKSREARKKIDEAEARVEEQLQEFHPEERVPLEAISEGD
TVHVKRLGHDVTVLAVDRKGETLKVRAGTFELVVEAADVAPPREKGGKKPKARAAAKIAAPSRESTPHELNLIGLRVDDA
LGRLEPFLNHASLEGYGEVRIVHGKGTGALMRGVREYLDGHPLVREFRPGEPFEGGEGATVVLLR

Sequences:

>Translated_785_residues
MIRHETLRTLEFDKVLAAVGGYGHSTATQDEIALIRPLDDWSAITRRFGQVDEIRRMTQQGIAIPLSTFDDISALLDAVR
PEGAVLDPTELVILFPVLRTMTAIAKQFAYRSDIPLLKELAGHVTGFPDILDELEVSIDSEGEILDSASPLLFDLRKKKR
ALTERIRRRLAEIVRETGVTTFLQDDFITQRGGRWVIPVRMDSKGMVPGVVHDVSNSGETAFMEPLEIIGLANELENLVA
EEKAEMIRIVRAICRMLRREADPLAEQFRTLVHLDLLNAVATFADSLSAENPEINDARFIRVNEGRHPLLALMARERGAG
RVVPLDLSLGETEQVMVITGPNAGGKTISLKTTGLLHLMALAGLPVPAASTSSFPLISDLLVDIGDEQSIEQSLSTFSAH
VSNIAGILERADDRTVVLLDELGTGTEPVQGAAISCAVLADLQEKGARVIATTHLTDIVGFVHKRDGMVNASMEFDRATL
TPLYRLKKGEPGQSHALEIARRYGLPDRVVEFATGMLSRMETEFHELLAELKDQRRRHEEALAEAERLRRDAEEKARIVR
ERLAEAEAKRREAVEKAFQEAKEIVRSARREVNAIIEEARKEKSREARKKIDEAEARVEEQLQEFHPEERVPLEAISEGD
TVHVKRLGHDVTVLAVDRKGETLKVRAGTFELVVEAADVAPPREKGGKKPKARAAAKIAAPSRESTPHELNLIGLRVDDA
LGRLEPFLNHASLEGYGEVRIVHGKGTGALMRGVREYLDGHPLVREFRPGEPFEGGEGATVVLLR
>Mature_785_residues
MIRHETLRTLEFDKVLAAVGGYGHSTATQDEIALIRPLDDWSAITRRFGQVDEIRRMTQQGIAIPLSTFDDISALLDAVR
PEGAVLDPTELVILFPVLRTMTAIAKQFAYRSDIPLLKELAGHVTGFPDILDELEVSIDSEGEILDSASPLLFDLRKKKR
ALTERIRRRLAEIVRETGVTTFLQDDFITQRGGRWVIPVRMDSKGMVPGVVHDVSNSGETAFMEPLEIIGLANELENLVA
EEKAEMIRIVRAICRMLRREADPLAEQFRTLVHLDLLNAVATFADSLSAENPEINDARFIRVNEGRHPLLALMARERGAG
RVVPLDLSLGETEQVMVITGPNAGGKTISLKTTGLLHLMALAGLPVPAASTSSFPLISDLLVDIGDEQSIEQSLSTFSAH
VSNIAGILERADDRTVVLLDELGTGTEPVQGAAISCAVLADLQEKGARVIATTHLTDIVGFVHKRDGMVNASMEFDRATL
TPLYRLKKGEPGQSHALEIARRYGLPDRVVEFATGMLSRMETEFHELLAELKDQRRRHEEALAEAERLRRDAEEKARIVR
ERLAEAEAKRREAVEKAFQEAKEIVRSARREVNAIIEEARKEKSREARKKIDEAEARVEEQLQEFHPEERVPLEAISEGD
TVHVKRLGHDVTVLAVDRKGETLKVRAGTFELVVEAADVAPPREKGGKKPKARAAAKIAAPSRESTPHELNLIGLRVDDA
LGRLEPFLNHASLEGYGEVRIVHGKGTGALMRGVREYLDGHPLVREFRPGEPFEGGEGATVVLLR

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI284813531, Length=428, Percent_Identity=25, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI26638666, Length=275, Percent_Identity=32, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI4505253, Length=275, Percent_Identity=32, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI36949366, Length=486, Percent_Identity=22.0164609053498, Blast_Score=100, Evalue=8e-21,
Organism=Homo sapiens, GI26638664, Length=276, Percent_Identity=31.8840579710145, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI4504191, Length=273, Percent_Identity=30.03663003663, Blast_Score=92, Evalue=2e-18,
Organism=Homo sapiens, GI4557761, Length=195, Percent_Identity=29.7435897435897, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI262231786, Length=219, Percent_Identity=32.8767123287671, Blast_Score=84, Evalue=4e-16,
Organism=Escherichia coli, GI1789089, Length=262, Percent_Identity=29.3893129770992, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17534743, Length=360, Percent_Identity=25, Blast_Score=112, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI17508445, Length=277, Percent_Identity=25.9927797833935, Blast_Score=88, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17508447, Length=267, Percent_Identity=29.2134831460674, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17539736, Length=339, Percent_Identity=21.8289085545723, Blast_Score=70, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6321912, Length=311, Percent_Identity=25.08038585209, Blast_Score=92, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6324482, Length=313, Percent_Identity=25.5591054313099, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319935, Length=231, Percent_Identity=31.1688311688312, Blast_Score=87, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6321109, Length=264, Percent_Identity=26.8939393939394, Blast_Score=84, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6320302, Length=234, Percent_Identity=29.4871794871795, Blast_Score=78, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6320047, Length=210, Percent_Identity=27.6190476190476, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24664545, Length=300, Percent_Identity=27.6666666666667, Blast_Score=107, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24584320, Length=324, Percent_Identity=27.1604938271605, Blast_Score=104, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 86818; Mature: 86818

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS50828 SMR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRHETLRTLEFDKVLAAVGGYGHSTATQDEIALIRPLDDWSAITRRFGQVDEIRRMTQQ
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCHHHHHHHHHHCCHHHHHHHHHC
GIAIPLSTFDDISALLDAVRPEGAVLDPTELVILFPVLRTMTAIAKQFAYRSDIPLLKEL
CCEEECCCHHHHHHHHHHHCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
AGHVTGFPDILDELEVSIDSEGEILDSASPLLFDLRKKKRALTERIRRRLAEIVRETGVT
HHHCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
TFLQDDFITQRGGRWVIPVRMDSKGMVPGVVHDVSNSGETAFMEPLEIIGLANELENLVA
HHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
EEKAEMIRIVRAICRMLRREADPLAEQFRTLVHLDLLNAVATFADSLSAENPEINDARFI
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEE
RVNEGRHPLLALMARERGAGRVVPLDLSLGETEQVMVITGPNAGGKTISLKTTGLLHLMA
EECCCCCHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEECCCCCCCEEEEEHHHHHHHHH
LAGLPVPAASTSSFPLISDLLVDIGDEQSIEQSLSTFSAHVSNIAGILERADDRTVVLLD
HHCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
ELGTGTEPVQGAAISCAVLADLQEKGARVIATTHLTDIVGFVHKRDGMVNASMEFDRATL
CCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHCCCCEECCCCCCCHHH
TPLYRLKKGEPGQSHALEIARRYGLPDRVVEFATGMLSRMETEFHELLAELKDQRRRHEE
HHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALAEAERLRRDAEEKARIVRERLAEAEAKRREAVEKAFQEAKEIVRSARREVNAIIEEAR
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEKSREARKKIDEAEARVEEQLQEFHPEERVPLEAISEGDTVHVKRLGHDVTVLAVDRKG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCEEEEEECCCCEEEEEEECCC
ETLKVRAGTFELVVEAADVAPPREKGGKKPKARAAAKIAAPSRESTPHELNLIGLRVDDA
CEEEEECCCEEHHEEHHCCCCCHHHCCCCCHHHHHHHHCCCCCCCCCCEEEEEEEEHHHH
LGRLEPFLNHASLEGYGEVRIVHGKGTGALMRGVREYLDGHPLVREFRPGEPFEGGEGAT
HHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCE
VVLLR
EEEEC
>Mature Secondary Structure
MIRHETLRTLEFDKVLAAVGGYGHSTATQDEIALIRPLDDWSAITRRFGQVDEIRRMTQQ
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCHHHHHHHHHHCCHHHHHHHHHC
GIAIPLSTFDDISALLDAVRPEGAVLDPTELVILFPVLRTMTAIAKQFAYRSDIPLLKEL
CCEEECCCHHHHHHHHHHHCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
AGHVTGFPDILDELEVSIDSEGEILDSASPLLFDLRKKKRALTERIRRRLAEIVRETGVT
HHHCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
TFLQDDFITQRGGRWVIPVRMDSKGMVPGVVHDVSNSGETAFMEPLEIIGLANELENLVA
HHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
EEKAEMIRIVRAICRMLRREADPLAEQFRTLVHLDLLNAVATFADSLSAENPEINDARFI
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEE
RVNEGRHPLLALMARERGAGRVVPLDLSLGETEQVMVITGPNAGGKTISLKTTGLLHLMA
EECCCCCHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEECCCCCCCEEEEEHHHHHHHHH
LAGLPVPAASTSSFPLISDLLVDIGDEQSIEQSLSTFSAHVSNIAGILERADDRTVVLLD
HHCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
ELGTGTEPVQGAAISCAVLADLQEKGARVIATTHLTDIVGFVHKRDGMVNASMEFDRATL
CCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHCCCCEECCCCCCCHHH
TPLYRLKKGEPGQSHALEIARRYGLPDRVVEFATGMLSRMETEFHELLAELKDQRRRHEE
HHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALAEAERLRRDAEEKARIVRERLAEAEAKRREAVEKAFQEAKEIVRSARREVNAIIEEAR
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEKSREARKKIDEAEARVEEQLQEFHPEERVPLEAISEGDTVHVKRLGHDVTVLAVDRKG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCEEEEEECCCCEEEEEEECCC
ETLKVRAGTFELVVEAADVAPPREKGGKKPKARAAAKIAAPSRESTPHELNLIGLRVDDA
CEEEEECCCEEHHEEHHCCCCCHHHCCCCCHHHHHHHHCCCCCCCCCCEEEEEEEEHHHH
LGRLEPFLNHASLEGYGEVRIVHGKGTGALMRGVREYLDGHPLVREFRPGEPFEGGEGAT
HHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCE
VVLLR
EEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA