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The map label for this gene is moeB [H]

Identifier: 78224051

GI number: 78224051

Start: 3234034

End: 3234780

Strand: Direct

Name: moeB [H]

Synonym: Gmet_2855

Alternate gene names: 78224051

Gene position: 3234034-3234780 (Clockwise)

Preceding gene: 78224050

Following gene: 78224052

Centisome position: 80.9

GC content: 62.12

Gene sequence:

>747_bases
ATGTTAACCGCTGAACAATCTGAGCGATACGCCCGGCACCTCATTCTGGAAAACGTTGGCGAGGTGGGGCAGGAACGGCT
CCTGGCAGGACGGGTCATGGTGATCGGTGCCGGTGGCCTCGGCTCCCCCGTTGCCCTCTACCTGGCGGCCGCGGGTGTCG
GCACCATCGGCATTGCCGATTCAGACAGGGTGGAGCTCTCGAACCTCCAGCGACAGATAGCCCATCACACCGCCGACCTG
GGGCGTCCCAAGGTCGTTTCGGCAAGGGAAAAAATGGCCGCCATGAACCCCGACGTAACCGTCATCCCCTTCGAAACGAG
GGTCGAGGCATCGAACATCGCAGAAATCATCGCCGACTTCGATTTCGTCATCGACGCCACCGACAATTTCGCCGCAAAGT
TCCTCATCAACGACGCCTGCGTCGCCGCCGGCAAGCCTTTCTCCCACGGCGGCATTCTCCGCTTCAACGGGCAGACCATG
ACCGTCCTGCCGGGGGAATCCCCCTGCTACCGCTGCATCTTTCCCGAACCTCCGGAAAGCGACGAGGTGGCCACCGCCTG
TTCACGGGCCGGCGTCATCGGGGTCCTTCCCGGCGTCATCGGCACCATCCAGGCCACCGAAGCGATCAAGTATCTCATGG
GCATCGGCGAACTCCTTACGGGGCGCCTTCTCACCTACAGCGCCCTGGCGCTGAAATTCCGCGAAGTTCCCATCAAGAAG
AAACTAACGTGCCCCGCCTGCGGTTAG

Upstream 100 bases:

>100_bases
CCATTTTCTCATTGATACATCCAGACCCCGCCTTGACGAGACGGGGTTTTTTTATTATTACTGTCAAGAAATACTCATCA
CCAACGGGGAGAATACCCAC

Downstream 100 bases:

>100_bases
GCCGCAGGCGAAAATACCCCACCGCCCCTCAAAACCTCCGAGCCTGTGGCAAACTGGTACCTACACGGCTTGCTCACCCA
TCTCGCGGGCATATTTCTAG

Product: UBA/THIF-type NAD/FAD binding fold:MoeZ/MoeB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MLTAEQSERYARHLILENVGEVGQERLLAGRVMVIGAGGLGSPVALYLAAAGVGTIGIADSDRVELSNLQRQIAHHTADL
GRPKVVSAREKMAAMNPDVTVIPFETRVEASNIAEIIADFDFVIDATDNFAAKFLINDACVAAGKPFSHGGILRFNGQTM
TVLPGESPCYRCIFPEPPESDEVATACSRAGVIGVLPGVIGTIQATEAIKYLMGIGELLTGRLLTYSALALKFREVPIKK
KLTCPACG

Sequences:

>Translated_248_residues
MLTAEQSERYARHLILENVGEVGQERLLAGRVMVIGAGGLGSPVALYLAAAGVGTIGIADSDRVELSNLQRQIAHHTADL
GRPKVVSAREKMAAMNPDVTVIPFETRVEASNIAEIIADFDFVIDATDNFAAKFLINDACVAAGKPFSHGGILRFNGQTM
TVLPGESPCYRCIFPEPPESDEVATACSRAGVIGVLPGVIGTIQATEAIKYLMGIGELLTGRLLTYSALALKFREVPIKK
KLTCPACG
>Mature_248_residues
MLTAEQSERYARHLILENVGEVGQERLLAGRVMVIGAGGLGSPVALYLAAAGVGTIGIADSDRVELSNLQRQIAHHTADL
GRPKVVSAREKMAAMNPDVTVIPFETRVEASNIAEIIADFDFVIDATDNFAAKFLINDACVAAGKPFSHGGILRFNGQTM
TVLPGESPCYRCIFPEPPESDEVATACSRAGVIGVLPGVIGTIQATEAIKYLMGIGELLTGRLLTYSALALKFREVPIKK
KLTCPACG

Specific function: Involved In The Biosynthesis Of A Demolybdo Cofactor (Molybdopterin), Necessary For Molybdoenzymes. Plays A Role In The Activation Of The Small Subunit Of The Molybdopterin Converting Factor (Moad). [C]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=248, Percent_Identity=41.1290322580645, Blast_Score=172, Evalue=2e-43,
Organism=Homo sapiens, GI4885649, Length=156, Percent_Identity=31.4102564102564, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI38045942, Length=180, Percent_Identity=29.4444444444444, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI38045944, Length=180, Percent_Identity=29.4444444444444, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI13376212, Length=261, Percent_Identity=28.735632183908, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI38327032, Length=219, Percent_Identity=27.8538812785388, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI23510338, Length=167, Percent_Identity=30.5389221556886, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI23510340, Length=167, Percent_Identity=30.5389221556886, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1787048, Length=249, Percent_Identity=40.9638554216867, Blast_Score=188, Evalue=3e-49,
Organism=Escherichia coli, GI87082356, Length=241, Percent_Identity=41.49377593361, Blast_Score=182, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17540406, Length=249, Percent_Identity=38.5542168674699, Blast_Score=194, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI193203301, Length=151, Percent_Identity=27.8145695364238, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17508819, Length=265, Percent_Identity=29.0566037735849, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI86565433, Length=167, Percent_Identity=31.7365269461078, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI86565431, Length=167, Percent_Identity=31.7365269461078, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321903, Length=254, Percent_Identity=37.7952755905512, Blast_Score=169, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6320598, Length=169, Percent_Identity=28.9940828402367, Blast_Score=86, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6322639, Length=167, Percent_Identity=30.5389221556886, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6325323, Length=170, Percent_Identity=27.0588235294118, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24582879, Length=248, Percent_Identity=41.5322580645161, Blast_Score=193, Evalue=7e-50,
Organism=Drosophila melanogaster, GI24660640, Length=150, Percent_Identity=34.6666666666667, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28573937, Length=179, Percent_Identity=29.608938547486, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI20129973, Length=161, Percent_Identity=29.1925465838509, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24641311, Length=258, Percent_Identity=29.0697674418605, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 26311; Mature: 26311

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTAEQSERYARHLILENVGEVGQERLLAGRVMVIGAGGLGSPVALYLAAAGVGTIGIAD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHHHCCCEEECCC
SDRVELSNLQRQIAHHTADLGRPKVVSAREKMAAMNPDVTVIPFETRVEASNIAEIIADF
CCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCC
DFVIDATDNFAAKFLINDACVAAGKPFSHGGILRFNGQTMTVLPGESPCYRCIFPEPPES
CEEEECCCCCEEHEEECHHHHHCCCCCCCCCEEEECCCEEEEECCCCCCEEEECCCCCCC
DEVATACSRAGVIGVLPGVIGTIQATEAIKYLMGIGELLTGRLLTYSALALKFREVPIKK
CHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KLTCPACG
CCCCCCCC
>Mature Secondary Structure
MLTAEQSERYARHLILENVGEVGQERLLAGRVMVIGAGGLGSPVALYLAAAGVGTIGIAD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHHHCCCEEECCC
SDRVELSNLQRQIAHHTADLGRPKVVSAREKMAAMNPDVTVIPFETRVEASNIAEIIADF
CCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCC
DFVIDATDNFAAKFLINDACVAAGKPFSHGGILRFNGQTMTVLPGESPCYRCIFPEPPES
CEEEECCCCCEEHEEECHHHHHCCCCCCCCCEEEECCCEEEEECCCCCCEEEECCCCCCC
DEVATACSRAGVIGVLPGVIGTIQATEAIKYLMGIGELLTGRLLTYSALALKFREVPIKK
CHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KLTCPACG
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA