Click here to switch to the map view.

The map label for this gene is dxs2

Identifier: 78224018

GI number: 78224018

Start: 3195019

End: 3196926

Strand: Direct

Name: dxs2

Synonym: Gmet_2822

Alternate gene names: 78224018

Gene position: 3195019-3196926 (Clockwise)

Preceding gene: 78224017

Following gene: 78224019

Centisome position: 79.93

GC content: 66.14

Gene sequence:

>1908_bases
ATGTACAAGCTGCTCGACACCATAACCGGCCCGGCCGATCTCAAGAATATTCCCCGGGAGGAGCTCCCGGGGCTGGCAGA
TGAAATCCGCCGGTTTCTCATCGAGACAGTGTCGCAAACGGGCGGCCATCTGGCCTCGAACCTGGGGGCAGTGGAGCTCT
CCGTCGCCCTCCACTACTGCTTCGACTCCCCGGCCGACAAGCTCATCTGGGACGTGGGGCACCAGGCCTACACCCACAAG
ATCCTCACGGGTCGGCGCGAAAGCTTCCACACCCAGCGCCAGTACAAGGGGATCAGCGGCTTCCCCAAGCGGAGCGAGTC
ACCCCACGACGCCTTCGGGGCCGGCCACTCCTCCACCTCCATCTCGGCGGGGCTCGGCATGGCCGCGGCACAGGATCTGA
AGGGGAGCGGCAGCCGGGCCATCGCGGTGATCGGCGACGGCTCCCTCACCGGCGGCATGGCCTATGAGGCCCTCAACCAG
GCGGGGCACCTGAAGAAAAACCTGATCGTGGTCCTGAACGACAACGAGATGTCCATCTCCCAAAACGTGGGGGCCTTCTC
CTCGTTCGTCTCCCGCAAGATGACCGGCAGCGACTTCCGCAAGCTGAAGAAGGAGATGCAGGGCCTTCTGGAGAACATCC
CGGCCATCGGGAAGGACATCCTCCACTTCGCCCGCCGGGCCGAAAACTCCCTCAAGGGGTTCCTCACCCCGGGGATGCTC
TTCGAGGCCCTGGGCTTCGACTACATCGGCCCGATTCCTGGACACGACCTGCCGCAGCTCCTGGAGGTCTTCGAGAACGT
GAAGGGGCTCGAAGGGCCGGTGCTCGTCCACGTCATGACCACCAAGGGGAAGGGGTACCAGCCGGCCGAGGAGAACCCGG
CCGCCTTCCACGGGGTCGGCCCCTTCGACGTGGCCACGGGCAAGACCACCGGCGGCAAGCCGGGGGCGGCATCCTACACC
GGGGTCTTCGGCGCGACCCTCGTGAAGCTGGCCGAGGAGGACGAGAAGATCATCGCCATCACTGCGGCCATGCCCGACGG
CACCGGCCTCACCCCCTTCGCGAAACGGTTCCCGGAACGCTTCTTCGACGTGGGAATTGCCGAGCAGCACGCCCTCACCT
TTGCGGCGGGCCTCGCCGCCGACGGGTTTCGGCCCGTGACGGCCATCTACTCCACCTTCCTCCAGCGGGCCTACGACCAG
GTATTCCATGATGTCTGCCTCCAGAAACTGCCGGTGACCATGGCCCTGGACCGGGGGGGGCTCGTGGGTGACGACGGCCC
CACCCACCACGGCACCTTCGACCTCTCGTACCTGCGGCACCTGCCGGAGATGACCCTCATGGCCCCCAAGGACGAGAACG
AGCTCCAGCACATGCTGAAGACCGCCATCTACGCCGGCCGCCCCGTGGCGCTCCGCTACCCCCGTGGTGCCGGGTATGGA
CTTCCCCTTGACCAGACTATCCAGTCCCTGGAGATCGGCCGGGGCGAGCTTCTGACTGAAGGGGACGATGTCGCCATCGT
GGCCATCGGTTCCACGGTCTATCCGGCCCAGGAGGCAGCGAAGCTCCTGGAAGCTAGGGGGATCCGGGCAACGGTGGTCA
ACGCCCGCTTCGTGAAACCCCTTGACCGGGAGCTCATCCTCGGCGCGGCACGGCGGACCGGGTGCATCGTCACCGTGGAG
GAGAACGCCCTCCAGGGAGGCTTCGGGAGCGCCGTCCTGGAGTTGCTGGCGGACGAAGGGATGACCGATGTGCGGGCCAA
GCGGATCGGTATCCCCGACCGCTTCATCGAGCAGGGGCCCCAACCCCAGCTTCGCAAGGATCTGGGCCTGGACGGCGCCG
GCATCGCCGCCACCGTCGAGGCATTTCTGACTGCAAAAGGACAAGCGGCGCTGTCGCTGGTGAAATAA

Upstream 100 bases:

>100_bases
CCGCGCCAACGGATATGTACGGTAAATATGGAGGGGCGCAATTCATTGCTCCCCGGGCGTGGTGAATCACGCCCCTACGC
AACCGATGAAGGAGAGCGTC

Downstream 100 bases:

>100_bases
CCATTCGAAGGGGCGGACACGCGCCCCCACACAAGCATCAATGAAAGGAAGTACCGTTTAATGCGTTTTCCCCTGAAATT
GAACGCTGACCTCACGAAGT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase 2; DXP synthase 2; DXPS 2

Number of amino acids: Translated: 635; Mature: 635

Protein sequence:

>635_residues
MYKLLDTITGPADLKNIPREELPGLADEIRRFLIETVSQTGGHLASNLGAVELSVALHYCFDSPADKLIWDVGHQAYTHK
ILTGRRESFHTQRQYKGISGFPKRSESPHDAFGAGHSSTSISAGLGMAAAQDLKGSGSRAIAVIGDGSLTGGMAYEALNQ
AGHLKKNLIVVLNDNEMSISQNVGAFSSFVSRKMTGSDFRKLKKEMQGLLENIPAIGKDILHFARRAENSLKGFLTPGML
FEALGFDYIGPIPGHDLPQLLEVFENVKGLEGPVLVHVMTTKGKGYQPAEENPAAFHGVGPFDVATGKTTGGKPGAASYT
GVFGATLVKLAEEDEKIIAITAAMPDGTGLTPFAKRFPERFFDVGIAEQHALTFAAGLAADGFRPVTAIYSTFLQRAYDQ
VFHDVCLQKLPVTMALDRGGLVGDDGPTHHGTFDLSYLRHLPEMTLMAPKDENELQHMLKTAIYAGRPVALRYPRGAGYG
LPLDQTIQSLEIGRGELLTEGDDVAIVAIGSTVYPAQEAAKLLEARGIRATVVNARFVKPLDRELILGAARRTGCIVTVE
ENALQGGFGSAVLELLADEGMTDVRAKRIGIPDRFIEQGPQPQLRKDLGLDGAGIAATVEAFLTAKGQAALSLVK

Sequences:

>Translated_635_residues
MYKLLDTITGPADLKNIPREELPGLADEIRRFLIETVSQTGGHLASNLGAVELSVALHYCFDSPADKLIWDVGHQAYTHK
ILTGRRESFHTQRQYKGISGFPKRSESPHDAFGAGHSSTSISAGLGMAAAQDLKGSGSRAIAVIGDGSLTGGMAYEALNQ
AGHLKKNLIVVLNDNEMSISQNVGAFSSFVSRKMTGSDFRKLKKEMQGLLENIPAIGKDILHFARRAENSLKGFLTPGML
FEALGFDYIGPIPGHDLPQLLEVFENVKGLEGPVLVHVMTTKGKGYQPAEENPAAFHGVGPFDVATGKTTGGKPGAASYT
GVFGATLVKLAEEDEKIIAITAAMPDGTGLTPFAKRFPERFFDVGIAEQHALTFAAGLAADGFRPVTAIYSTFLQRAYDQ
VFHDVCLQKLPVTMALDRGGLVGDDGPTHHGTFDLSYLRHLPEMTLMAPKDENELQHMLKTAIYAGRPVALRYPRGAGYG
LPLDQTIQSLEIGRGELLTEGDDVAIVAIGSTVYPAQEAAKLLEARGIRATVVNARFVKPLDRELILGAARRTGCIVTVE
ENALQGGFGSAVLELLADEGMTDVRAKRIGIPDRFIEQGPQPQLRKDLGLDGAGIAATVEAFLTAKGQAALSLVK
>Mature_635_residues
MYKLLDTITGPADLKNIPREELPGLADEIRRFLIETVSQTGGHLASNLGAVELSVALHYCFDSPADKLIWDVGHQAYTHK
ILTGRRESFHTQRQYKGISGFPKRSESPHDAFGAGHSSTSISAGLGMAAAQDLKGSGSRAIAVIGDGSLTGGMAYEALNQ
AGHLKKNLIVVLNDNEMSISQNVGAFSSFVSRKMTGSDFRKLKKEMQGLLENIPAIGKDILHFARRAENSLKGFLTPGML
FEALGFDYIGPIPGHDLPQLLEVFENVKGLEGPVLVHVMTTKGKGYQPAEENPAAFHGVGPFDVATGKTTGGKPGAASYT
GVFGATLVKLAEEDEKIIAITAAMPDGTGLTPFAKRFPERFFDVGIAEQHALTFAAGLAADGFRPVTAIYSTFLQRAYDQ
VFHDVCLQKLPVTMALDRGGLVGDDGPTHHGTFDLSYLRHLPEMTLMAPKDENELQHMLKTAIYAGRPVALRYPRGAGYG
LPLDQTIQSLEIGRGELLTEGDDVAIVAIGSTVYPAQEAAKLLEARGIRATVVNARFVKPLDRELILGAARRTGCIVTVE
ENALQGGFGSAVLELLADEGMTDVRAKRIGIPDRFIEQGPQPQLRKDLGLDGAGIAATVEAFLTAKGQAALSLVK

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=681, Percent_Identity=23.6417033773862, Blast_Score=122, Evalue=9e-28,
Organism=Homo sapiens, GI4507521, Length=681, Percent_Identity=23.6417033773862, Blast_Score=122, Evalue=9e-28,
Organism=Homo sapiens, GI225637463, Length=526, Percent_Identity=23.574144486692, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI225637459, Length=526, Percent_Identity=23.574144486692, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI225637461, Length=526, Percent_Identity=23.574144486692, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI133778974, Length=530, Percent_Identity=24.5283018867925, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI156564403, Length=264, Percent_Identity=25.3787878787879, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI4557353, Length=242, Percent_Identity=22.7272727272727, Blast_Score=75, Evalue=3e-13,
Organism=Homo sapiens, GI34101272, Length=242, Percent_Identity=22.7272727272727, Blast_Score=75, Evalue=3e-13,
Organism=Homo sapiens, GI291084858, Length=256, Percent_Identity=24.609375, Blast_Score=70, Evalue=7e-12,
Organism=Escherichia coli, GI1786622, Length=626, Percent_Identity=50.3194888178914, Blast_Score=620, Evalue=1e-179,
Organism=Caenorhabditis elegans, GI17539652, Length=668, Percent_Identity=24.4011976047904, Blast_Score=124, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17538422, Length=245, Percent_Identity=27.7551020408163, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319698, Length=233, Percent_Identity=27.4678111587983, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24645119, Length=487, Percent_Identity=26.2833675564682, Blast_Score=116, Evalue=5e-26,
Organism=Drosophila melanogaster, GI45551847, Length=487, Percent_Identity=26.2833675564682, Blast_Score=116, Evalue=6e-26,
Organism=Drosophila melanogaster, GI45550715, Length=487, Percent_Identity=26.2833675564682, Blast_Score=116, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24666278, Length=581, Percent_Identity=24.9569707401033, Blast_Score=113, Evalue=5e-25,
Organism=Drosophila melanogaster, GI21358145, Length=235, Percent_Identity=25.531914893617, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24650940, Length=235, Percent_Identity=25.531914893617, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS2_GEOMG (Q39RT4)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_385765.1
- ProteinModelPortal:   Q39RT4
- SMR:   Q39RT4
- STRING:   Q39RT4
- GeneID:   3741088
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_2822
- NMPDR:   fig|269799.3.peg.2800
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- PhylomeDB:   Q39RT4
- ProtClustDB:   PRK05444
- BioCyc:   GMET269799:GMET_2822-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 67996; Mature: 67996

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKLLDTITGPADLKNIPREELPGLADEIRRFLIETVSQTGGHLASNLGAVELSVALHYC
CCCHHHHCCCCHHHHCCCHHHCCCHHHHHHHHHHHHHHHCCCHHHHCCCCEEHHHHHHHH
FDSPADKLIWDVGHQAYTHKILTGRRESFHTQRQYKGISGFPKRSESPHDAFGAGHSSTS
HCCCHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCC
ISAGLGMAAAQDLKGSGSRAIAVIGDGSLTGGMAYEALNQAGHLKKNLIVVLNDNEMSIS
HHHCCCHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCEEEEECCCCEEHH
QNVGAFSSFVSRKMTGSDFRKLKKEMQGLLENIPAIGKDILHFARRAENSLKGFLTPGML
HCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHH
FEALGFDYIGPIPGHDLPQLLEVFENVKGLEGPVLVHVMTTKGKGYQPAEENPAAFHGVG
HHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCEEECCC
PFDVATGKTTGGKPGAASYTGVFGATLVKLAEEDEKIIAITAAMPDGTGLTPFAKRFPER
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHH
FFDVGIAEQHALTFAAGLAADGFRPVTAIYSTFLQRAYDQVFHDVCLQKLPVTMALDRGG
HHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCC
LVGDDGPTHHGTFDLSYLRHLPEMTLMAPKDENELQHMLKTAIYAGRPVALRYPRGAGYG
CCCCCCCCCCCCEEHHHHHHCCCCEEECCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCC
LPLDQTIQSLEIGRGELLTEGDDVAIVAIGSTVYPAQEAAKLLEARGIRATVVNARFVKP
CCHHHHHHHHHCCCCCEEECCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEEECHHHHCC
LDRELILGAARRTGCIVTVEENALQGGFGSAVLELLADEGMTDVRAKRIGIPDRFIEQGP
CCHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHCCC
QPQLRKDLGLDGAGIAATVEAFLTAKGQAALSLVK
CCHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHCCC
>Mature Secondary Structure
MYKLLDTITGPADLKNIPREELPGLADEIRRFLIETVSQTGGHLASNLGAVELSVALHYC
CCCHHHHCCCCHHHHCCCHHHCCCHHHHHHHHHHHHHHHCCCHHHHCCCCEEHHHHHHHH
FDSPADKLIWDVGHQAYTHKILTGRRESFHTQRQYKGISGFPKRSESPHDAFGAGHSSTS
HCCCHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCC
ISAGLGMAAAQDLKGSGSRAIAVIGDGSLTGGMAYEALNQAGHLKKNLIVVLNDNEMSIS
HHHCCCHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCEEEEECCCCEEHH
QNVGAFSSFVSRKMTGSDFRKLKKEMQGLLENIPAIGKDILHFARRAENSLKGFLTPGML
HCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHH
FEALGFDYIGPIPGHDLPQLLEVFENVKGLEGPVLVHVMTTKGKGYQPAEENPAAFHGVG
HHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCEEECCC
PFDVATGKTTGGKPGAASYTGVFGATLVKLAEEDEKIIAITAAMPDGTGLTPFAKRFPER
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCHHHHHHHHH
FFDVGIAEQHALTFAAGLAADGFRPVTAIYSTFLQRAYDQVFHDVCLQKLPVTMALDRGG
HHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCC
LVGDDGPTHHGTFDLSYLRHLPEMTLMAPKDENELQHMLKTAIYAGRPVALRYPRGAGYG
CCCCCCCCCCCCEEHHHHHHCCCCEEECCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCC
LPLDQTIQSLEIGRGELLTEGDDVAIVAIGSTVYPAQEAAKLLEARGIRATVVNARFVKP
CCHHHHHHHHHCCCCCEEECCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEEECHHHHCC
LDRELILGAARRTGCIVTVEENALQGGFGSAVLELLADEGMTDVRAKRIGIPDRFIEQGP
CCHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHCCC
QPQLRKDLGLDGAGIAATVEAFLTAKGQAALSLVK
CCHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA