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The map label for this gene is pdhA [H]

Identifier: 78223956

GI number: 78223956

Start: 3117338

End: 3118315

Strand: Reverse

Name: pdhA [H]

Synonym: Gmet_2760

Alternate gene names: 78223956

Gene position: 3118315-3117338 (Counterclockwise)

Preceding gene: 78223957

Following gene: 78223955

Centisome position: 78.01

GC content: 65.03

Gene sequence:

>978_bases
ATGGAATCGAAACTCCGCGCCCTTCTCCCCGACGCCGAACTTATCAGGATGTACGAACAGATGGTCCTTTCCCGCGAGTT
CGAGGAGTCGTGCGCCGAACAGTACACCAAGGGGCACATCACCGGCTTCCTCCACCTCTACAGCGGCCAGGAGGCCGTGG
CCGTGGGGGCCACCGCCGGCCTCCACCGGGACGACTACATCCTCTCCGCCTACCGGGAACACGCCCAGGCCATCGTCCGG
GGGGCCGAGCCGCGGCGGGTCATGGCCGAGCTCTTCGGCAAGCGGACCGGCATCTGCAAGGGGAAGGGGGGCTCCATGCA
CCTCTTCGACCCGAATCTCTCCTTCATGGGGGGATACGCCATTGTCGGCGGCCAGTTCCCCATCGCCGTGGGGCTCGCCT
TTGCCGCCAAATTCCGGAAGGAGGGACGGATCGTCGCCTGTTTCTTCGGCGACGGCGCCGCGAACCAGGGAACGTTCCAC
GAATCACTCAACTGGGCCCGGCTCTGGGAACTGCCGGTCCTCTTCATCTGCGAGAACAACAGTTACGGCATCGGCACCTC
CGTGGAGAGGGCATCGGCACTCCCTGACATCCACCGGCGGACCTGCGGCTACGACATCCCGTCGGAGCGGGTTCACGGCA
TGGACGTGATCGCGGTGTACGAGGCGGTCAAATGGGCGGCCGAGTGGGTGCGGGAGCAGAACCGCCCCTTCCTCATCGAG
GCGATCACCTACCGGTTCCGGGGGCACTCCATGTCCGATCCGGGCAAATACCGCAGCCTTGCCGAGGTGGAGCTGTGGAA
GAGCCGCGACCCCATCCCGGCCTTCGCGAACCGGCTGGTGGAGGAAGAGATAGCCACCGAGGCCCAGCTGGAGGGGATCA
AACAGCAGGCCCTGGTGACGGTGGCCGATGCGGTGAAGTTTGCCGAGGATTCGCCGTGGCCCGAGGATAGTGAGGTGTGG
GAAGATGTTTATGCCTGA

Upstream 100 bases:

>100_bases
TCGACAGCCTGCTGGAGCAGGCCCAGGTTGAAAGAATACGCTGAACTCACCGAGTTTGCCCCCAAGGGCGGGCACTACCC
GCCCGGATAGCGAGGTCCCC

Downstream 100 bases:

>100_bases
GGCGGTCAACTGGAACAGACCGATAAAGGTTGGCGTCAGTTCCTGCCTCCTGGGAGAGAAGGTGCGCTATGACGGCGGCC
ACAAGCACGATCACTACATA

Product: dehydrogenase, E1 component

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MESKLRALLPDAELIRMYEQMVLSREFEESCAEQYTKGHITGFLHLYSGQEAVAVGATAGLHRDDYILSAYREHAQAIVR
GAEPRRVMAELFGKRTGICKGKGGSMHLFDPNLSFMGGYAIVGGQFPIAVGLAFAAKFRKEGRIVACFFGDGAANQGTFH
ESLNWARLWELPVLFICENNSYGIGTSVERASALPDIHRRTCGYDIPSERVHGMDVIAVYEAVKWAAEWVREQNRPFLIE
AITYRFRGHSMSDPGKYRSLAEVELWKSRDPIPAFANRLVEEEIATEAQLEGIKQQALVTVADAVKFAEDSPWPEDSEVW
EDVYA

Sequences:

>Translated_325_residues
MESKLRALLPDAELIRMYEQMVLSREFEESCAEQYTKGHITGFLHLYSGQEAVAVGATAGLHRDDYILSAYREHAQAIVR
GAEPRRVMAELFGKRTGICKGKGGSMHLFDPNLSFMGGYAIVGGQFPIAVGLAFAAKFRKEGRIVACFFGDGAANQGTFH
ESLNWARLWELPVLFICENNSYGIGTSVERASALPDIHRRTCGYDIPSERVHGMDVIAVYEAVKWAAEWVREQNRPFLIE
AITYRFRGHSMSDPGKYRSLAEVELWKSRDPIPAFANRLVEEEIATEAQLEGIKQQALVTVADAVKFAEDSPWPEDSEVW
EDVYA
>Mature_325_residues
MESKLRALLPDAELIRMYEQMVLSREFEESCAEQYTKGHITGFLHLYSGQEAVAVGATAGLHRDDYILSAYREHAQAIVR
GAEPRRVMAELFGKRTGICKGKGGSMHLFDPNLSFMGGYAIVGGQFPIAVGLAFAAKFRKEGRIVACFFGDGAANQGTFH
ESLNWARLWELPVLFICENNSYGIGTSVERASALPDIHRRTCGYDIPSERVHGMDVIAVYEAVKWAAEWVREQNRPFLIE
AITYRFRGHSMSDPGKYRSLAEVELWKSRDPIPAFANRLVEEEIATEAQLEGIKQQALVTVADAVKFAEDSPWPEDSEVW
EDVYA

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=321, Percent_Identity=43.613707165109, Blast_Score=271, Evalue=5e-73,
Organism=Homo sapiens, GI291084742, Length=313, Percent_Identity=42.4920127795527, Blast_Score=236, Evalue=3e-62,
Organism=Homo sapiens, GI4505685, Length=313, Percent_Identity=42.4920127795527, Blast_Score=235, Evalue=3e-62,
Organism=Homo sapiens, GI291084744, Length=320, Percent_Identity=41.5625, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI291084757, Length=313, Percent_Identity=38.6581469648562, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI11386135, Length=318, Percent_Identity=34.5911949685535, Blast_Score=169, Evalue=2e-42,
Organism=Homo sapiens, GI258645172, Length=318, Percent_Identity=34.5911949685535, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI17536047, Length=315, Percent_Identity=42.8571428571429, Blast_Score=260, Evalue=5e-70,
Organism=Caenorhabditis elegans, GI32564172, Length=315, Percent_Identity=42.8571428571429, Blast_Score=260, Evalue=6e-70,
Organism=Caenorhabditis elegans, GI86563357, Length=318, Percent_Identity=33.3333333333333, Blast_Score=147, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI86563355, Length=318, Percent_Identity=33.3333333333333, Blast_Score=147, Evalue=9e-36,
Organism=Saccharomyces cerevisiae, GI6321026, Length=317, Percent_Identity=44.4794952681388, Blast_Score=271, Evalue=1e-73,
Organism=Drosophila melanogaster, GI24639744, Length=319, Percent_Identity=42.6332288401254, Blast_Score=251, Evalue=5e-67,
Organism=Drosophila melanogaster, GI28571106, Length=319, Percent_Identity=42.6332288401254, Blast_Score=251, Evalue=5e-67,
Organism=Drosophila melanogaster, GI24639740, Length=319, Percent_Identity=42.6332288401254, Blast_Score=251, Evalue=5e-67,
Organism=Drosophila melanogaster, GI24639746, Length=307, Percent_Identity=43.3224755700326, Blast_Score=244, Evalue=7e-65,
Organism=Drosophila melanogaster, GI24639748, Length=322, Percent_Identity=42.5465838509317, Blast_Score=241, Evalue=7e-64,
Organism=Drosophila melanogaster, GI21355903, Length=318, Percent_Identity=31.7610062893082, Blast_Score=148, Evalue=5e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 36404; Mature: 36404

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESKLRALLPDAELIRMYEQMVLSREFEESCAEQYTKGHITGFLHLYSGQEAVAVGATAG
CCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEECCCCC
LHRDDYILSAYREHAQAIVRGAEPRRVMAELFGKRTGICKGKGGSMHLFDPNLSFMGGYA
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEECCCCEEEEECCCCCCCCCEE
IVGGQFPIAVGLAFAAKFRKEGRIVACFFGDGAANQGTFHESLNWARLWELPVLFICENN
EECCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHCCCHHEEECCCEEEEECCC
SYGIGTSVERASALPDIHRRTCGYDIPSERVHGMDVIAVYEAVKWAAEWVREQNRPFLIE
CCCCCCCHHHHHCCCHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEE
AITYRFRGHSMSDPGKYRSLAEVELWKSRDPIPAFANRLVEEEIATEAQLEGIKQQALVT
EEEHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VADAVKFAEDSPWPEDSEVWEDVYA
HHHHHHHHCCCCCCCHHHHHHHHCC
>Mature Secondary Structure
MESKLRALLPDAELIRMYEQMVLSREFEESCAEQYTKGHITGFLHLYSGQEAVAVGATAG
CCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEECCCCC
LHRDDYILSAYREHAQAIVRGAEPRRVMAELFGKRTGICKGKGGSMHLFDPNLSFMGGYA
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEECCCCEEEEECCCCCCCCCEE
IVGGQFPIAVGLAFAAKFRKEGRIVACFFGDGAANQGTFHESLNWARLWELPVLFICENN
EECCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHCCCHHEEECCCEEEEECCC
SYGIGTSVERASALPDIHRRTCGYDIPSERVHGMDVIAVYEAVKWAAEWVREQNRPFLIE
CCCCCCCHHHHHCCCHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEE
AITYRFRGHSMSDPGKYRSLAEVELWKSRDPIPAFANRLVEEEIATEAQLEGIKQQALVT
EEEHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VADAVKFAEDSPWPEDSEVWEDVYA
HHHHHHHHCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA