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The map label for this gene is ppiA [H]

Identifier: 78223918

GI number: 78223918

Start: 3075735

End: 3076250

Strand: Reverse

Name: ppiA [H]

Synonym: Gmet_2722

Alternate gene names: 78223918

Gene position: 3076250-3075735 (Counterclockwise)

Preceding gene: 78223920

Following gene: 78223914

Centisome position: 76.96

GC content: 56.78

Gene sequence:

>516_bases
ATGGGCGAAGAAACCAATCCCCGCGTCGTCATCGAGACATCCCAGGGGAACATCACCGTCGAACTGTTCAAGGACAAGGC
CCCCATCACCGTCCGCAACTTCATCTCCTACGTGAAGGAAGGGTTCTATGACGGCCTCATCTTCCACCGGGTCATCAAGA
ATTTCATGGTCCAGGGGGGCGGACTCGACGAGAATATGCAGCAGAAAAAATACAAATTTGCCATCAAGAACGAGGCCGCC
AACGGTCTCAAGAACAACAGGGGAACCCTGGCCATGGCCCGGACCGCCGTGGTGGACAGCGCCACCTGCCAGTTTTTCAT
CAACCTGGTGGATAACGCCTTCCTCGATCACAAGGGGAAAACCCCTGATATGTTCGGCTATGCCGTGTTCGGCCAGGTTG
TGGAGGGGATGGATGCGGTGGATGCCATTGCCCAGGTGAAGACCGGCAATAAGGCCGGCCACTCCGATGTGCCGGTGGAG
CCGGTATTCATCACCAAGGCTTCCGTGGTGGAGTAG

Upstream 100 bases:

>100_bases
AAAGGAAGTTGCAAGTGGGCAGGGTGATTCAGAAAACGGTTCTCCTGCCACGGCTTTTGTGGTACAAGAGAGCGATTTTT
CATCGAGAAAGGAGCACACC

Downstream 100 bases:

>100_bases
GCTCCCTGCCCCTCTCCCTTGGGGAGAGGGTGGCCGAAGGTCGGGTGAGGGGAAATAGCGCAGGTTGAGGGTAGATAAAA
AGGCCGTCCGAGTCATCGGG

Product: peptidyl-prolyl cis-trans isomerase, cyclophilin type

Products: NA

Alternate protein names: PPIase A; Cyclophilin A; Rotamase A [H]

Number of amino acids: Translated: 171; Mature: 170

Protein sequence:

>171_residues
MGEETNPRVVIETSQGNITVELFKDKAPITVRNFISYVKEGFYDGLIFHRVIKNFMVQGGGLDENMQQKKYKFAIKNEAA
NGLKNNRGTLAMARTAVVDSATCQFFINLVDNAFLDHKGKTPDMFGYAVFGQVVEGMDAVDAIAQVKTGNKAGHSDVPVE
PVFITKASVVE

Sequences:

>Translated_171_residues
MGEETNPRVVIETSQGNITVELFKDKAPITVRNFISYVKEGFYDGLIFHRVIKNFMVQGGGLDENMQQKKYKFAIKNEAA
NGLKNNRGTLAMARTAVVDSATCQFFINLVDNAFLDHKGKTPDMFGYAVFGQVVEGMDAVDAIAQVKTGNKAGHSDVPVE
PVFITKASVVE
>Mature_170_residues
GEETNPRVVIETSQGNITVELFKDKAPITVRNFISYVKEGFYDGLIFHRVIKNFMVQGGGLDENMQQKKYKFAIKNEAAN
GLKNNRGTLAMARTAVVDSATCQFFINLVDNAFLDHKGKTPDMFGYAVFGQVVEGMDAVDAIAQVKTGNKAGHSDVPVEP
VFITKASVVE

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=164, Percent_Identity=35.9756097560976, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI24308049, Length=163, Percent_Identity=34.9693251533742, Blast_Score=84, Evalue=7e-17,
Organism=Homo sapiens, GI22547212, Length=164, Percent_Identity=34.1463414634146, Blast_Score=81, Evalue=6e-16,
Organism=Homo sapiens, GI7657473, Length=164, Percent_Identity=34.1463414634146, Blast_Score=81, Evalue=6e-16,
Organism=Homo sapiens, GI22547215, Length=164, Percent_Identity=34.1463414634146, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI19557636, Length=151, Percent_Identity=31.7880794701987, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI64276486, Length=133, Percent_Identity=35.3383458646617, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI310110104, Length=156, Percent_Identity=34.6153846153846, Blast_Score=67, Evalue=6e-12,
Organism=Homo sapiens, GI4758950, Length=162, Percent_Identity=33.3333333333333, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1789763, Length=170, Percent_Identity=57.0588235294118, Blast_Score=195, Evalue=2e-51,
Organism=Escherichia coli, GI1786736, Length=163, Percent_Identity=55.8282208588957, Blast_Score=182, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI71980594, Length=146, Percent_Identity=34.9315068493151, Blast_Score=87, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71980590, Length=146, Percent_Identity=34.9315068493151, Blast_Score=87, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17506311, Length=167, Percent_Identity=32.9341317365269, Blast_Score=83, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17539496, Length=168, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17532641, Length=171, Percent_Identity=32.1637426900585, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71997782, Length=135, Percent_Identity=34.8148148148148, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17532643, Length=160, Percent_Identity=36.25, Blast_Score=73, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17552780, Length=159, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6321848, Length=165, Percent_Identity=34.5454545454545, Blast_Score=65, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6320510, Length=163, Percent_Identity=33.1288343558282, Blast_Score=65, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6323562, Length=154, Percent_Identity=33.7662337662338, Blast_Score=64, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17986117, Length=164, Percent_Identity=36.5853658536585, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI19922912, Length=159, Percent_Identity=36.4779874213836, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI19922376, Length=167, Percent_Identity=31.1377245508982, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI17136360, Length=161, Percent_Identity=37.888198757764, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45549139, Length=151, Percent_Identity=39.0728476821192, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24652460, Length=146, Percent_Identity=30.1369863013699, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18783; Mature: 18651

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEETNPRVVIETSQGNITVELFKDKAPITVRNFISYVKEGFYDGLIFHRVIKNFMVQGG
CCCCCCCEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GLDENMQQKKYKFAIKNEAANGLKNNRGTLAMARTAVVDSATCQFFINLVDNAFLDHKGK
CCCHHHHHHHHHHHHHCHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TPDMFGYAVFGQVVEGMDAVDAIAQVKTGNKAGHSDVPVEPVFITKASVVE
CCCHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCC
>Mature Secondary Structure 
GEETNPRVVIETSQGNITVELFKDKAPITVRNFISYVKEGFYDGLIFHRVIKNFMVQGG
CCCCCCEEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GLDENMQQKKYKFAIKNEAANGLKNNRGTLAMARTAVVDSATCQFFINLVDNAFLDHKGK
CCCHHHHHHHHHHHHHCHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TPDMFGYAVFGQVVEGMDAVDAIAQVKTGNKAGHSDVPVEPVFITKASVVE
CCCHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]