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The map label for this gene is mtnP [H]

Identifier: 78223880

GI number: 78223880

Start: 3031508

End: 3032371

Strand: Reverse

Name: mtnP [H]

Synonym: Gmet_2684

Alternate gene names: 78223880

Gene position: 3032371-3031508 (Counterclockwise)

Preceding gene: 78223881

Following gene: 78223879

Centisome position: 75.86

GC content: 63.54

Gene sequence:

>864_bases
ATGAGTGAGCAGGTTATCGGCGTCATTGGAGGAAGCGGTCTCTACGAGATGGAAGGGCTGAGCGATGTCCGGAGCGTGGT
TGTGGAAACCCCCTTCGGGGCCCCGTCGGACGAGTTCATGACCGGTGTTCTTGACGGGGTGCAGATGGTGTTCCTTCCCC
GCCACGGTAAGGGACACCGCCTCCTGCCGTCGGAGGTGAACTACCGGGCTAACATCTACGGGATGAAGAAGCTTGGTGTA
ACGCGGATCATCTCCGTCTCTGCCGTCGGGAGCATGAAGGAGGAGATCGCGCCGGGGCACATCGTTATCCCCGACCAGTT
CATCGACCGCACCAACGCAACCCGGGCCAACACGTTCTTCGGCAACGGCGTGGTGGCCCACGTGCAGTTCGCCGACCCGG
TCTGCGCCGATCTCTCCGGCTGGCTGTACGAGGCGGCCTTGGCCGCCGGAGCAACCGTTCACCGGGGAGGGACCTATATC
TGCATGGAGGGGCCGGCATTCTCAACCCGGGCCGAGTCGAACCTCTACCGCTCCTTCGGCGTCTCGGTCATCGGCATGAC
GAACATCCCCGAGGCGAAACTGGCCCGGGAGGCCGAGATCTGCTACGGGGTCATCGCCCTCTCCACCGATTACGACTGCT
GGCACGAGTCCCACGACGATGTCTCGGTGGATGCTATCCTGGCAATCATTCGGCAGAACGTCGCCATGTCAAAGTCCATC
ATCGGCCACGCCGTGAAGCGGATCTCCGCCGAGCGGGCGTGCCCCTGCGCCTCGGCCCTCACCTACGCCATCATCACCGA
CCGCAGCGCCATTCCCGCCGAGGCCAGGGAGCGGCTCGACCTGATCATCGGCAAGTACCTCTAA

Upstream 100 bases:

>100_bases
GCCGCGGCTCCGATATTTCCGCGGCGTGCGGCCAGCTCAAGGGTAAGCTGGACAAGAACGTTTCGGGCATCTAATTTCTG
CAGCCTGGGAGGACTATGGC

Downstream 100 bases:

>100_bases
CAAGAGACTCTAGAGAGCAAGGAGATTCCCGTGGGCATACTCGTCGTCGGTTCCGTGGCATTTGATTCAGTGGAGACCCC
CTTTGGCAGAGTGGAGAACG

Product: methylthioadenosine phosphorylase

Products: NA

Alternate protein names: 5'-methylthioadenosine phosphorylase; MTA phosphorylase [H]

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MSEQVIGVIGGSGLYEMEGLSDVRSVVVETPFGAPSDEFMTGVLDGVQMVFLPRHGKGHRLLPSEVNYRANIYGMKKLGV
TRIISVSAVGSMKEEIAPGHIVIPDQFIDRTNATRANTFFGNGVVAHVQFADPVCADLSGWLYEAALAAGATVHRGGTYI
CMEGPAFSTRAESNLYRSFGVSVIGMTNIPEAKLAREAEICYGVIALSTDYDCWHESHDDVSVDAILAIIRQNVAMSKSI
IGHAVKRISAERACPCASALTYAIITDRSAIPAEARERLDLIIGKYL

Sequences:

>Translated_287_residues
MSEQVIGVIGGSGLYEMEGLSDVRSVVVETPFGAPSDEFMTGVLDGVQMVFLPRHGKGHRLLPSEVNYRANIYGMKKLGV
TRIISVSAVGSMKEEIAPGHIVIPDQFIDRTNATRANTFFGNGVVAHVQFADPVCADLSGWLYEAALAAGATVHRGGTYI
CMEGPAFSTRAESNLYRSFGVSVIGMTNIPEAKLAREAEICYGVIALSTDYDCWHESHDDVSVDAILAIIRQNVAMSKSI
IGHAVKRISAERACPCASALTYAIITDRSAIPAEARERLDLIIGKYL
>Mature_286_residues
SEQVIGVIGGSGLYEMEGLSDVRSVVVETPFGAPSDEFMTGVLDGVQMVFLPRHGKGHRLLPSEVNYRANIYGMKKLGVT
RIISVSAVGSMKEEIAPGHIVIPDQFIDRTNATRANTFFGNGVVAHVQFADPVCADLSGWLYEAALAAGATVHRGGTYIC
MEGPAFSTRAESNLYRSFGVSVIGMTNIPEAKLAREAEICYGVIALSTDYDCWHESHDDVSVDAILAIIRQNVAMSKSII
GHAVKRISAERACPCASALTYAIITDRSAIPAEARERLDLIIGKYL

Specific function: Catalyzes the formation of methylthio-D-ribose 1- phosphate (MTR-1-P) from methylthioadenosine (MTA) [H]

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=250, Percent_Identity=44.4, Blast_Score=224, Evalue=5e-59,
Organism=Caenorhabditis elegans, GI71980569, Length=248, Percent_Identity=40.3225806451613, Blast_Score=193, Evalue=9e-50,
Organism=Saccharomyces cerevisiae, GI6323045, Length=303, Percent_Identity=34.6534653465347, Blast_Score=173, Evalue=3e-44,
Organism=Drosophila melanogaster, GI20130079, Length=273, Percent_Identity=39.5604395604396, Blast_Score=205, Evalue=3e-53,
Organism=Drosophila melanogaster, GI221459247, Length=251, Percent_Identity=34.6613545816733, Blast_Score=170, Evalue=1e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =2.4.2.28 [H]

Molecular weight: Translated: 30913; Mature: 30782

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEQVIGVIGGSGLYEMEGLSDVRSVVVETPFGAPSDEFMTGVLDGVQMVFLPRHGKGHR
CCCCEEEEECCCCCEECCCHHHHHHHHEECCCCCCHHHHHHHHHCCEEEEEEECCCCCCC
LLPSEVNYRANIYGMKKLGVTRIISVSAVGSMKEEIAPGHIVIPDQFIDRTNATRANTFF
CCCCCCCCEEEEEEEHHHCHHHEEEHHHHHHHHHHCCCCEEECCHHHHCCCCCCCCCEEE
GNGVVAHVQFADPVCADLSGWLYEAALAAGATVHRGGTYICMEGPAFSTRAESNLYRSFG
CCCEEEEEEECCCHHHHHHHHHHHHHHHCCCEEECCCEEEEECCCCCCCHHHHHHHHHHC
VSVIGMTNIPEAKLAREAEICYGVIALSTDYDCWHESHDDVSVDAILAIIRQNVAMSKSI
CEEEEECCCCHHHHHHHHHHEEEEEEEECCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
IGHAVKRISAERACPCASALTYAIITDRSAIPAEARERLDLIIGKYL
HHHHHHHHHHHHCCCHHHHHEEEEEECCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SEQVIGVIGGSGLYEMEGLSDVRSVVVETPFGAPSDEFMTGVLDGVQMVFLPRHGKGHR
CCCEEEEECCCCCEECCCHHHHHHHHEECCCCCCHHHHHHHHHCCEEEEEEECCCCCCC
LLPSEVNYRANIYGMKKLGVTRIISVSAVGSMKEEIAPGHIVIPDQFIDRTNATRANTFF
CCCCCCCCEEEEEEEHHHCHHHEEEHHHHHHHHHHCCCCEEECCHHHHCCCCCCCCCEEE
GNGVVAHVQFADPVCADLSGWLYEAALAAGATVHRGGTYICMEGPAFSTRAESNLYRSFG
CCCEEEEEEECCCHHHHHHHHHHHHHHHCCCEEECCCEEEEECCCCCCCHHHHHHHHHHC
VSVIGMTNIPEAKLAREAEICYGVIALSTDYDCWHESHDDVSVDAILAIIRQNVAMSKSI
CEEEEECCCCHHHHHHHHHHEEEEEEEECCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHH
IGHAVKRISAERACPCASALTYAIITDRSAIPAEARERLDLIIGKYL
HHHHHHHHHHHHCCCHHHHHEEEEEECCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA