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The map label for this gene is lpxC

Identifier: 78223804

GI number: 78223804

Start: 2955707

End: 2956534

Strand: Reverse

Name: lpxC

Synonym: Gmet_2607

Alternate gene names: 78223804

Gene position: 2956534-2955707 (Counterclockwise)

Preceding gene: 78223805

Following gene: 78223802

Centisome position: 73.96

GC content: 61.59

Gene sequence:

>828_bases
ATGATCAAACGACAGACGACCATCAATAGAATCTTCAAGCTGAGCGGCATAGGCCTCCACACGGGGCGGACCGTGACCCT
CGAATTTCTTCCCCGGCGGGAGTTCGGGATAGCCTTTGTCTTCGGCGGCAGCCTTATCCCGGCCCGCTACGACATGGTGG
CGGACACGCGGCTCTCTACCCAGATTGCCGCCGAGGGGGCGTCGGTGGCCACCATCGAGCACCTGATGGCCGCCTTCTAT
TACTCGGGCATCACCAACTGTCTCGTCTACATCGACGGTCCCGAGGTGCCGATCATGGACGGCTCGGCCTGGGAGTTCTA
CCATGAGATGTGGCGGGCCGGGGTCTACGAGTTTCCCGAGGCAGGGGTCTACCTGAAGGTCCTCCGTCCCGTGGAAGCCA
CCCTCAAGGATGCCTGGGTGCGGGTGAAGCCCCTCAACACCCTCGACATCACCATGACCATCGAGTTCCGCCCCCCGGTG
GGGAAGCAGCGCAAGCGGGTCATGGACGTGGAGAATGCCGTTTCCATCATCAATTCCCGCACCTTTGTCCTCCACGAGGA
GATCGAGGCGATCCGCAAGGCGGGGCTGGCCAAGGGGGGATCCCTGGACAACGCCGTGGTGATCGGCGGCGAGAGCATCG
TCAATCCCCATGGCCTGCGCTACAAGCAGGAGCTCGTGAACCACAAGATCCTGGACCTTATCGGAGACCTCTACACCTGC
GGCTACCGGATGCTCGGCAAGGTCGAGGCGCACAAGACCGGCCACCACCTGAACAACCTGCTGTTGCGGGAGATTTTTTC
CGACCCCGAGAACTACGCCATCTATTGA

Upstream 100 bases:

>100_bases
CCGGCCGGGCTTTCGTGTATCCGGCACCCGTAACCGATGCCGGTTTTCTGCGGTTTTTTCTTCCCACCATTGTCCCTTTT
GTGGTACCCATGGGCAAATC

Downstream 100 bases:

>100_bases
GTGACCAGGATTGTTGCATAAGAAAAGCCCGCGTAGAGCGGGCTTTTTTGTGGGCCGATTCCGTCAGATCCCTATAAATG
GAAATCCCCCGCCGCTTCCG

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 275; Mature: 275

Protein sequence:

>275_residues
MIKRQTTINRIFKLSGIGLHTGRTVTLEFLPRREFGIAFVFGGSLIPARYDMVADTRLSTQIAAEGASVATIEHLMAAFY
YSGITNCLVYIDGPEVPIMDGSAWEFYHEMWRAGVYEFPEAGVYLKVLRPVEATLKDAWVRVKPLNTLDITMTIEFRPPV
GKQRKRVMDVENAVSIINSRTFVLHEEIEAIRKAGLAKGGSLDNAVVIGGESIVNPHGLRYKQELVNHKILDLIGDLYTC
GYRMLGKVEAHKTGHHLNNLLLREIFSDPENYAIY

Sequences:

>Translated_275_residues
MIKRQTTINRIFKLSGIGLHTGRTVTLEFLPRREFGIAFVFGGSLIPARYDMVADTRLSTQIAAEGASVATIEHLMAAFY
YSGITNCLVYIDGPEVPIMDGSAWEFYHEMWRAGVYEFPEAGVYLKVLRPVEATLKDAWVRVKPLNTLDITMTIEFRPPV
GKQRKRVMDVENAVSIINSRTFVLHEEIEAIRKAGLAKGGSLDNAVVIGGESIVNPHGLRYKQELVNHKILDLIGDLYTC
GYRMLGKVEAHKTGHHLNNLLLREIFSDPENYAIY
>Mature_275_residues
MIKRQTTINRIFKLSGIGLHTGRTVTLEFLPRREFGIAFVFGGSLIPARYDMVADTRLSTQIAAEGASVATIEHLMAAFY
YSGITNCLVYIDGPEVPIMDGSAWEFYHEMWRAGVYEFPEAGVYLKVLRPVEATLKDAWVRVKPLNTLDITMTIEFRPPV
GKQRKRVMDVENAVSIINSRTFVLHEEIEAIRKAGLAKGGSLDNAVVIGGESIVNPHGLRYKQELVNHKILDLIGDLYTC
GYRMLGKVEAHKTGHHLNNLLLREIFSDPENYAIY

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=288, Percent_Identity=36.1111111111111, Blast_Score=172, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.-

Molecular weight: Translated: 30912; Mature: 30912

Theoretical pI: Translated: 7.75; Mature: 7.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKRQTTINRIFKLSGIGLHTGRTVTLEFLPRREFGIAFVFGGSLIPARYDMVADTRLST
CCCCHHHHHHHHHHCCCEEECCCEEEEEEECCCCCCEEEEECCCCCCCHHHHHHCCHHHH
QIAAEGASVATIEHLMAAFYYSGITNCLVYIDGPEVPIMDGSAWEFYHEMWRAGVYEFPE
HHHHCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEECCCHHHHHHHHHHCCCCCCCC
AGVYLKVLRPVEATLKDAWVRVKPLNTLDITMTIEFRPPVGKQRKRVMDVENAVSIINSR
CCEEEEEHHHHHHHHHHCEEEEECCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCC
TFVLHEEIEAIRKAGLAKGGSLDNAVVIGGESIVNPHGLRYKQELVNHKILDLIGDLYTC
EEEEHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
GYRMLGKVEAHKTGHHLNNLLLREIFSDPENYAIY
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECC
>Mature Secondary Structure
MIKRQTTINRIFKLSGIGLHTGRTVTLEFLPRREFGIAFVFGGSLIPARYDMVADTRLST
CCCCHHHHHHHHHHCCCEEECCCEEEEEEECCCCCCEEEEECCCCCCCHHHHHHCCHHHH
QIAAEGASVATIEHLMAAFYYSGITNCLVYIDGPEVPIMDGSAWEFYHEMWRAGVYEFPE
HHHHCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEECCCHHHHHHHHHHCCCCCCCC
AGVYLKVLRPVEATLKDAWVRVKPLNTLDITMTIEFRPPVGKQRKRVMDVENAVSIINSR
CCEEEEEHHHHHHHHHHCEEEEECCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCC
TFVLHEEIEAIRKAGLAKGGSLDNAVVIGGESIVNPHGLRYKQELVNHKILDLIGDLYTC
EEEEHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
GYRMLGKVEAHKTGHHLNNLLLREIFSDPENYAIY
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA