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The map label for this gene is lon [H]

Identifier: 78223741

GI number: 78223741

Start: 2885715

End: 2888039

Strand: Reverse

Name: lon [H]

Synonym: Gmet_2544

Alternate gene names: 78223741

Gene position: 2888039-2885715 (Counterclockwise)

Preceding gene: 78223742

Following gene: 78223740

Centisome position: 72.25

GC content: 64.13

Gene sequence:

>2325_bases
ATGTCCGAAACCGTGTCGATAACGATACCTGCCGTCGTGCCGCTTTATCCCGTCCGGGAGATCGTGGCCTTTCCCTACAT
GATTTTTCCCCTGTTCCTGAAGGACGAGGAGCTTGCCCGTTTCGAGGAGATGCTGGAAGATGACCAGCTCGTGACCCTCG
TCCGCCCCCGAGATGAGGCCGCTCCCGGCGGTATCCCCCCTTTTTTCGAGGTCGGGACCCTCTGCAAGGTCAACCAGATT
CAGCATCTCTCCGAAGGGGGGGCGAAGATTGTCCTGGAGGGGGTTGCCCGGGTCCGGGTGACGGAGGTGGTAGAGTTCAA
CCATCACCTTCAGGGCCACTGCGAGCCGATCCACGAGTTCGTGGAGCGCTCCATGGTTTCCGAGGCCTTGGTCCAGAGCC
TCAATGCCCTCCTCAAGATTGCCCTTTCCTACGGCCGCCCCCTCCCCGAGGATGTCATGAAGATGATCGATCTCATCGAC
AACCCTGCGCGGCTGGCGGATCTCGTGGCCCTCTACGTGAATCTTCCCCTGGATGAGCAGCAACAACTTCTGGAGACCAT
CGACCCCCTGGAGCGGCTCAAGAAGGTCTACATGCACCTGACGAGCGAGGTGCAGCGGCTCCAGGTGAAGGGGGAGGTCC
AGGCCGAGGTGACCAAGCGGGTCGGCAAGAGCCAGAAGGAGTACCTGCTGCGGGAGCAGATGAAGCAGATCCAGGAGGAA
CTGGGGGAGGAGGATACCCGCGCCGCCGAGATGACCGACCTTCGGAAGAAGATCGATGCGGCCGGCATGCCCTCGGAGGT
GCGCAAGGTCGCTGACAAGGAACTGAAGCGGGTCGAGCGGATCAATCCCGCTTCCCCCGAGTACACGGTCGCCCGCACTT
ACCTGGACTATCTGGCCGGCATGCCCTGGAAGAACGCCACCAGGGACAATAACGACATCAACAAGGCCGAGGCGGTGCTG
GACGAGGACCACTACAACCTCAAGAAGGTGAAGGAGCGGATCCTTGAATACCTGGCGGTCCGGACCCTGCGGGAGAAAAT
GAAGGGGCCGATCCTCTGCTTCGTGGGGCCGCCGGGGGTGGGGAAGACAAGCCTCGGCAAGTCCATCGCCCGGGCACTGG
GGCGGAAATTCATCCGGATGTCCCTGGGGGGGATGCGGGACGAGGCGGAGATCCGCGGCCACCGCCGCACCTACATCGGC
GCCCTCCCGGGCCGGATCATCCAGGAGCTCTACCGCTGCGGCACCAACAATCCGGTCTTCATGCTGGACGAGGTGGACAA
GATCGGCCTCGACTTTCGGGGGGATCCGGCCAGCGCACTCCTGGAGGTGCTGGACCCGGAGCAAAACAACACCTTTACCG
ACCACTACCTGGATGTCCCCTTCGATCTCTCCAACGTCATGTTCATCACCACGGCGAACCAGCTTGACCCGGTCCCCGCT
GCCCTTAAGGACCGGATGGAGGTGATCCGGCTTTCGGGCTACACCGACGAGGAGAAGGAGAAGATCGCGGTCCGCTATCT
GGTTCCCCGGGAGGTCGAGGAGAACGGTCTGGCGAAAAATCCGCCGGCCTTTGCCGACGAGGCGCTCTTCAAGATCATCC
GGGACTACACCCGGGAGGCGGGGGTGCGGAACCTCCAGCGGAACATCGCCTCGGTCTGCCGCAAGGTGGCCAAGGAGATC
ACCCAGGGGAAGCCACTGCGGGAAACCATCACCCCGGCGGTGGTGGAGGAGTTTCTTGGCCCCCGGACCTTCTTCAACGA
GGTGGCCTCGGAGAAGGACCGGGTGGGGGTCGTCACGGGGCTTGCCTGGACCGAGACCGGCGGCGACATCATCTTCGTGG
AGGCAACCCGGATGAAGGGGAAGGGGGAGCTGATCCTCACCGGTTCCCTGGGGGATGTCATGAAGGAATCGGCCCGGGCG
GCCCTCTCCTTCGTGCGGGCCAATGGCGCCGAGTGGGGGGTGGGCGAGACCGCCTTCGCCGACACCGATATCCACATCCA
CGTGCCGGCCGGCGCCATCCCCAAGGATGGGCCGTCGGCGGGGATCACCATGGTGATCGCCATCGTGTCGCTCCTGTCGG
TGCGGCCGGCCCGCCGCGACGTGGCCATGACCGGCGAGATCAGCCTCACGGGGCGGGTCCTGGCCATCGGCGGGCTCAAG
GAGAAGGTGCTGGCGGCCCGGCGCGCCGGGGTGAAGACTGTGGTGGCCCCTGCCCGTAACCGGGAGAACCTGGAGGACAT
CCCCGACGACGTGAAGGGGGAGATCGCCTTCGTCTTTGTGGATGACGTGCGCGAGGCGGTTCAGGTGGTGCTGCAACCGG
TATGA

Upstream 100 bases:

>100_bases
TTTCCCGCGTCGTTCCTTGACAGGAGCGGCCTCAGCGGCTAGTCTGATTATGTAGCCGCCAGCCACCCCGAGCCCCGTTC
GACCCGAGGATCCGATAACT

Downstream 100 bases:

>100_bases
ACCCAGAGCGCACGGTCAAATGGTTTCTCCAGGAATTGCAGGCGTTCTTCGTCCTTTCGGCCAGGGCCGTCGTACGGATT
TTCCGCAGGCCCTGGTACTA

Product: peptidase S16, ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 774; Mature: 773

Protein sequence:

>774_residues
MSETVSITIPAVVPLYPVREIVAFPYMIFPLFLKDEELARFEEMLEDDQLVTLVRPRDEAAPGGIPPFFEVGTLCKVNQI
QHLSEGGAKIVLEGVARVRVTEVVEFNHHLQGHCEPIHEFVERSMVSEALVQSLNALLKIALSYGRPLPEDVMKMIDLID
NPARLADLVALYVNLPLDEQQQLLETIDPLERLKKVYMHLTSEVQRLQVKGEVQAEVTKRVGKSQKEYLLREQMKQIQEE
LGEEDTRAAEMTDLRKKIDAAGMPSEVRKVADKELKRVERINPASPEYTVARTYLDYLAGMPWKNATRDNNDINKAEAVL
DEDHYNLKKVKERILEYLAVRTLREKMKGPILCFVGPPGVGKTSLGKSIARALGRKFIRMSLGGMRDEAEIRGHRRTYIG
ALPGRIIQELYRCGTNNPVFMLDEVDKIGLDFRGDPASALLEVLDPEQNNTFTDHYLDVPFDLSNVMFITTANQLDPVPA
ALKDRMEVIRLSGYTDEEKEKIAVRYLVPREVEENGLAKNPPAFADEALFKIIRDYTREAGVRNLQRNIASVCRKVAKEI
TQGKPLRETITPAVVEEFLGPRTFFNEVASEKDRVGVVTGLAWTETGGDIIFVEATRMKGKGELILTGSLGDVMKESARA
ALSFVRANGAEWGVGETAFADTDIHIHVPAGAIPKDGPSAGITMVIAIVSLLSVRPARRDVAMTGEISLTGRVLAIGGLK
EKVLAARRAGVKTVVAPARNRENLEDIPDDVKGEIAFVFVDDVREAVQVVLQPV

Sequences:

>Translated_774_residues
MSETVSITIPAVVPLYPVREIVAFPYMIFPLFLKDEELARFEEMLEDDQLVTLVRPRDEAAPGGIPPFFEVGTLCKVNQI
QHLSEGGAKIVLEGVARVRVTEVVEFNHHLQGHCEPIHEFVERSMVSEALVQSLNALLKIALSYGRPLPEDVMKMIDLID
NPARLADLVALYVNLPLDEQQQLLETIDPLERLKKVYMHLTSEVQRLQVKGEVQAEVTKRVGKSQKEYLLREQMKQIQEE
LGEEDTRAAEMTDLRKKIDAAGMPSEVRKVADKELKRVERINPASPEYTVARTYLDYLAGMPWKNATRDNNDINKAEAVL
DEDHYNLKKVKERILEYLAVRTLREKMKGPILCFVGPPGVGKTSLGKSIARALGRKFIRMSLGGMRDEAEIRGHRRTYIG
ALPGRIIQELYRCGTNNPVFMLDEVDKIGLDFRGDPASALLEVLDPEQNNTFTDHYLDVPFDLSNVMFITTANQLDPVPA
ALKDRMEVIRLSGYTDEEKEKIAVRYLVPREVEENGLAKNPPAFADEALFKIIRDYTREAGVRNLQRNIASVCRKVAKEI
TQGKPLRETITPAVVEEFLGPRTFFNEVASEKDRVGVVTGLAWTETGGDIIFVEATRMKGKGELILTGSLGDVMKESARA
ALSFVRANGAEWGVGETAFADTDIHIHVPAGAIPKDGPSAGITMVIAIVSLLSVRPARRDVAMTGEISLTGRVLAIGGLK
EKVLAARRAGVKTVVAPARNRENLEDIPDDVKGEIAFVFVDDVREAVQVVLQPV
>Mature_773_residues
SETVSITIPAVVPLYPVREIVAFPYMIFPLFLKDEELARFEEMLEDDQLVTLVRPRDEAAPGGIPPFFEVGTLCKVNQIQ
HLSEGGAKIVLEGVARVRVTEVVEFNHHLQGHCEPIHEFVERSMVSEALVQSLNALLKIALSYGRPLPEDVMKMIDLIDN
PARLADLVALYVNLPLDEQQQLLETIDPLERLKKVYMHLTSEVQRLQVKGEVQAEVTKRVGKSQKEYLLREQMKQIQEEL
GEEDTRAAEMTDLRKKIDAAGMPSEVRKVADKELKRVERINPASPEYTVARTYLDYLAGMPWKNATRDNNDINKAEAVLD
EDHYNLKKVKERILEYLAVRTLREKMKGPILCFVGPPGVGKTSLGKSIARALGRKFIRMSLGGMRDEAEIRGHRRTYIGA
LPGRIIQELYRCGTNNPVFMLDEVDKIGLDFRGDPASALLEVLDPEQNNTFTDHYLDVPFDLSNVMFITTANQLDPVPAA
LKDRMEVIRLSGYTDEEKEKIAVRYLVPREVEENGLAKNPPAFADEALFKIIRDYTREAGVRNLQRNIASVCRKVAKEIT
QGKPLRETITPAVVEEFLGPRTFFNEVASEKDRVGVVTGLAWTETGGDIIFVEATRMKGKGELILTGSLGDVMKESARAA
LSFVRANGAEWGVGETAFADTDIHIHVPAGAIPKDGPSAGITMVIAIVSLLSVRPARRDVAMTGEISLTGRVLAIGGLKE
KVLAARRAGVKTVVAPARNRENLEDIPDDVKGEIAFVFVDDVREAVQVVLQPV

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=828, Percent_Identity=39.3719806763285, Blast_Score=551, Evalue=1e-157,
Organism=Homo sapiens, GI21396489, Length=636, Percent_Identity=44.496855345912, Blast_Score=543, Evalue=1e-154,
Organism=Escherichia coli, GI1786643, Length=763, Percent_Identity=47.1821756225426, Blast_Score=707, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=725, Percent_Identity=39.8620689655172, Blast_Score=512, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17556486, Length=537, Percent_Identity=43.389199255121, Blast_Score=465, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6319449, Length=656, Percent_Identity=41.1585365853659, Blast_Score=504, Evalue=1e-143,
Organism=Drosophila melanogaster, GI221513036, Length=673, Percent_Identity=41.3075780089153, Blast_Score=525, Evalue=1e-149,
Organism=Drosophila melanogaster, GI24666867, Length=647, Percent_Identity=42.6584234930448, Blast_Score=525, Evalue=1e-149,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 86181; Mature: 86049

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETVSITIPAVVPLYPVREIVAFPYMIFPLFLKDEELARFEEMLEDDQLVTLVRPRDEA
CCCEEEEEECCHHCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCCCCC
APGGIPPFFEVGTLCKVNQIQHLSEGGAKIVLEGVARVRVTEVVEFNHHLQGHCEPIHEF
CCCCCCCHHHHCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
VERSMVSEALVQSLNALLKIALSYGRPLPEDVMKMIDLIDNPARLADLVALYVNLPLDEQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHH
QQLLETIDPLERLKKVYMHLTSEVQRLQVKGEVQAEVTKRVGKSQKEYLLREQMKQIQEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LGEEDTRAAEMTDLRKKIDAAGMPSEVRKVADKELKRVERINPASPEYTVARTYLDYLAG
HCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCC
MPWKNATRDNNDINKAEAVLDEDHYNLKKVKERILEYLAVRTLREKMKGPILCFVGPPGV
CCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
GKTSLGKSIARALGRKFIRMSLGGMRDEAEIRGHRRTYIGALPGRIIQELYRCGTNNPVF
CHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHCCCHHHHHHHHHCCCCCCEE
MLDEVDKIGLDFRGDPASALLEVLDPEQNNTFTDHYLDVPFDLSNVMFITTANQLDPVPA
EEECHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCEECCCCCCCCEEEEEECCCCCCCCH
ALKDRMEVIRLSGYTDEEKEKIAVRYLVPREVEENGLAKNPPAFADEALFKIIRDYTREA
HHHHHHHHHHHCCCCCCHHHHEEEEEECCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
GVRNLQRNIASVCRKVAKEITQGKPLRETITPAVVEEFLGPRTFFNEVASEKDRVGVVTG
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHCCHHHHHHHHHCCCCCCEEEEE
LAWTETGGDIIFVEATRMKGKGELILTGSLGDVMKESARAALSFVRANGAEWGVGETAFA
EEEECCCCCEEEEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEC
DTDIHIHVPAGAIPKDGPSAGITMVIAIVSLLSVRPARRDVAMTGEISLTGRVLAIGGLK
CCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCEEECCEEEEECCHH
EKVLAARRAGVKTVVAPARNRENLEDIPDDVKGEIAFVFVDDVREAVQVVLQPV
HHHHHHHHCCCCEEECCCCCCCCHHCCCCCCCCCEEEEEHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SETVSITIPAVVPLYPVREIVAFPYMIFPLFLKDEELARFEEMLEDDQLVTLVRPRDEA
CCEEEEEECCHHCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCCCCC
APGGIPPFFEVGTLCKVNQIQHLSEGGAKIVLEGVARVRVTEVVEFNHHLQGHCEPIHEF
CCCCCCCHHHHCCHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
VERSMVSEALVQSLNALLKIALSYGRPLPEDVMKMIDLIDNPARLADLVALYVNLPLDEQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHH
QQLLETIDPLERLKKVYMHLTSEVQRLQVKGEVQAEVTKRVGKSQKEYLLREQMKQIQEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LGEEDTRAAEMTDLRKKIDAAGMPSEVRKVADKELKRVERINPASPEYTVARTYLDYLAG
HCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCC
MPWKNATRDNNDINKAEAVLDEDHYNLKKVKERILEYLAVRTLREKMKGPILCFVGPPGV
CCCCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCC
GKTSLGKSIARALGRKFIRMSLGGMRDEAEIRGHRRTYIGALPGRIIQELYRCGTNNPVF
CHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHCCCHHHHHHHHHCCCCCCEE
MLDEVDKIGLDFRGDPASALLEVLDPEQNNTFTDHYLDVPFDLSNVMFITTANQLDPVPA
EEECHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCEECCCCCCCCEEEEEECCCCCCCCH
ALKDRMEVIRLSGYTDEEKEKIAVRYLVPREVEENGLAKNPPAFADEALFKIIRDYTREA
HHHHHHHHHHHCCCCCCHHHHEEEEEECCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
GVRNLQRNIASVCRKVAKEITQGKPLRETITPAVVEEFLGPRTFFNEVASEKDRVGVVTG
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHCCHHHHHHHHHCCCCCCEEEEE
LAWTETGGDIIFVEATRMKGKGELILTGSLGDVMKESARAALSFVRANGAEWGVGETAFA
EEEECCCCCEEEEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEC
DTDIHIHVPAGAIPKDGPSAGITMVIAIVSLLSVRPARRDVAMTGEISLTGRVLAIGGLK
CCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCEEECCEEEEECCHH
EKVLAARRAGVKTVVAPARNRENLEDIPDDVKGEIAFVFVDDVREAVQVVLQPV
HHHHHHHHCCCCEEECCCCCCCCHHCCCCCCCCCEEEEEHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA