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The map label for this gene is cmoA

Identifier: 78223731

GI number: 78223731

Start: 2874723

End: 2875526

Strand: Reverse

Name: cmoA

Synonym: Gmet_2532

Alternate gene names: 78223731

Gene position: 2875526-2874723 (Counterclockwise)

Preceding gene: 78223734

Following gene: 78223730

Centisome position: 71.93

GC content: 58.71

Gene sequence:

>804_bases
ATGTCCGGCAGCAAACCCGATATCTTCACCTTATTTACGAATAACCAGATTGAAAAGGACCAGGAGACCGTGACCCACAA
GACTGATGCCATCTATGCGGCACCCCTTCAGAAAATGATCGATTTTCAATTCGATGAACGGGTTGTCGCGGTCTTTCCCG
ACATGATACAGCGCTCGGTCCCCGGCTACGGCATGATAATCTCCAATATCGGCATCGTTGCCGCGAAATATGCCCAGGCC
GGGAGTCACTGCTATGATCTCGGCTGTTCCCTGGGGGCGGTCAGCCTTGCCATGCGCCAGCGGATCACTCAGCCGGACTG
TGACATTATTGCGGTGGATAACTCCCCGGCGATGATCGCGCGGGGCCGTGAGCTGCTGGCCCTCGATACGGCACCGACGG
TGCCGGTGACCATGATCTGTGCCGATCTGCAGGAGGTCGCCATTGAGAACGCCTCGGTCGTGGTCCTCAACTTCACCCTG
CAGTTCATCCCCCCGGCAGAGCGCCTGGCGCTGCTTGAGCGGATCCATGCCGGGCTCAGGCCTGGCGGCGTGCTCATCCT
CTCCGAGAAGATCGCTTTCGGCGAGCCGGGGCGGCAGCAGTTCCATGAAGAGCTGCATCACGATTTCAAACGGGCCAACG
GCTACAGCGATCTGGAAATCAGCCAGAAACGGTCGGCGCTGGAAAAGGTGCTGATCCCCGAGACCCTTGCCTGCCATCAT
GAGCGCCTGCAGGCGGCGGGCTTTTCGTTCTCCGAGCTCTGGTTCCAGTGTTTCAACTTTGCCTCTCTGGTGGCGATGAA
ATGA

Upstream 100 bases:

>100_bases
TTGTGTCAAATGGAAAGTCGAGAAGAATGCAGCTCAACCATCGTACAGCTTGCTGCGCCCTGCTCCGGCCGGTATGTGCT
GTGTCAGCTAACAAGGGTTG

Downstream 100 bases:

>100_bases
GCTGGTACGACGCTCTCTTTCCGCACCTTGCCGCCATGGGGCAGGAGCGCTGGGCCGAGCAGTTGCAGGTGACCCTGTCC
GAGAGCCAGCTCCTCCAACG

Product: methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MSGSKPDIFTLFTNNQIEKDQETVTHKTDAIYAAPLQKMIDFQFDERVVAVFPDMIQRSVPGYGMIISNIGIVAAKYAQA
GSHCYDLGCSLGAVSLAMRQRITQPDCDIIAVDNSPAMIARGRELLALDTAPTVPVTMICADLQEVAIENASVVVLNFTL
QFIPPAERLALLERIHAGLRPGGVLILSEKIAFGEPGRQQFHEELHHDFKRANGYSDLEISQKRSALEKVLIPETLACHH
ERLQAAGFSFSELWFQCFNFASLVAMK

Sequences:

>Translated_267_residues
MSGSKPDIFTLFTNNQIEKDQETVTHKTDAIYAAPLQKMIDFQFDERVVAVFPDMIQRSVPGYGMIISNIGIVAAKYAQA
GSHCYDLGCSLGAVSLAMRQRITQPDCDIIAVDNSPAMIARGRELLALDTAPTVPVTMICADLQEVAIENASVVVLNFTL
QFIPPAERLALLERIHAGLRPGGVLILSEKIAFGEPGRQQFHEELHHDFKRANGYSDLEISQKRSALEKVLIPETLACHH
ERLQAAGFSFSELWFQCFNFASLVAMK
>Mature_266_residues
SGSKPDIFTLFTNNQIEKDQETVTHKTDAIYAAPLQKMIDFQFDERVVAVFPDMIQRSVPGYGMIISNIGIVAAKYAQAG
SHCYDLGCSLGAVSLAMRQRITQPDCDIIAVDNSPAMIARGRELLALDTAPTVPVTMICADLQEVAIENASVVVLNFTLQ
FIPPAERLALLERIHAGLRPGGVLILSEKIAFGEPGRQQFHEELHHDFKRANGYSDLEISQKRSALEKVLIPETLACHHE
RLQAAGFSFSELWFQCFNFASLVAMK

Specific function: Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U)

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. CmoA family

Homologues:

Organism=Escherichia coli, GI1788177, Length=244, Percent_Identity=56.9672131147541, Blast_Score=292, Evalue=2e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CMOA_GEOMG (Q39SM1)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_385478.1
- ProteinModelPortal:   Q39SM1
- SMR:   Q39SM1
- STRING:   Q39SM1
- GeneID:   3738583
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_2532
- NMPDR:   fig|269799.3.peg.2696
- eggNOG:   COG0500
- HOGENOM:   HBG296860
- OMA:   YSELEVS
- PhylomeDB:   Q39SM1
- ProtClustDB:   CLSK2310817
- BioCyc:   GMET269799:GMET_2532-MONOMER
- HAMAP:   MF_01589
- InterPro:   IPR013216
- InterPro:   IPR005271
- PIRSF:   PIRSF006325
- TIGRFAMs:   TIGR00740

Pfam domain/function: PF08241 Methyltransf_11

EC number: NA

Molecular weight: Translated: 29522; Mature: 29391

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: NA

Important sites: BINDING 63-63 BINDING 113-113 BINDING 157-157 BINDING 224-224

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGSKPDIFTLFTNNQIEKDQETVTHKTDAIYAAPLQKMIDFQFDERVVAVFPDMIQRSV
CCCCCCCEEEEEECCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
PGYGMIISNIGIVAAKYAQAGSHCYDLGCSLGAVSLAMRQRITQPDCDIIAVDNSPAMIA
CCCEEHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHCCCCCCCEEEECCCCHHHH
RGRELLALDTAPTVPVTMICADLQEVAIENASVVVLNFTLQFIPPAERLALLERIHAGLR
CCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCHHHHHHHHHHHCCCC
PGGVLILSEKIAFGEPGRQQFHEELHHDFKRANGYSDLEISQKRSALEKVLIPETLACHH
CCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHH
ERLQAAGFSFSELWFQCFNFASLVAMK
HHHHHCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SGSKPDIFTLFTNNQIEKDQETVTHKTDAIYAAPLQKMIDFQFDERVVAVFPDMIQRSV
CCCCCCEEEEEECCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCC
PGYGMIISNIGIVAAKYAQAGSHCYDLGCSLGAVSLAMRQRITQPDCDIIAVDNSPAMIA
CCCEEHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHCCCCCCCEEEECCCCHHHH
RGRELLALDTAPTVPVTMICADLQEVAIENASVVVLNFTLQFIPPAERLALLERIHAGLR
CCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCHHHHHHHHHHHCCCC
PGGVLILSEKIAFGEPGRQQFHEELHHDFKRANGYSDLEISQKRSALEKVLIPETLACHH
CCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHH
ERLQAAGFSFSELWFQCFNFASLVAMK
HHHHHCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA