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The map label for this gene is pdhB [H]

Identifier: 78223710

GI number: 78223710

Start: 2850522

End: 2851484

Strand: Direct

Name: pdhB [H]

Synonym: Gmet_2510

Alternate gene names: 78223710

Gene position: 2850522-2851484 (Clockwise)

Preceding gene: 78223709

Following gene: 78223711

Centisome position: 71.31

GC content: 68.33

Gene sequence:

>963_bases
ATGCCTCAACTGAACATGGTTCAAGCCATAAACCTCGCCCTCCGGGAGGAGATGGCCCGGGACGACCGGGTGGTGCTCCT
CGGAGAGGACGTGGGGAGGGACGGCGGGGTCTTCCGGATTACGGAGGGGCTCTTCGAAGAGTTCGGCCCGAAGCGGGTCA
TCGACACCCCCCTGTCGGAATCGGCCATTGTGGGCGCGGCGGTGGGTATGGCGGCCTACGGCCTTCGCCCCGTGGCGGAG
ATCCAGTTCATGGGGTTCATCTACGCCGCCTTCGACCAGCTCTTCGCCCATGCCGTCCGCATCCGCACGCGGTCCCGGGG
ACGCTTCACGGCACCGCTGGTGGTCCGAACCCCCTACGGGGCCGGCATCAAGGCGCCGGAACTCCACGAGGAGAGCACCG
AGGCCTTTTTCTGCCACATGCCGGGGGTGAAGGTGGTGGTCCCCTCGGGACCGTACAACGCCAAGGGGCTCCTCATGGCC
GCCATCCGCGACCCCGACCCGGTCCTCTTCCTGGAGCCGACCCGCCTCTACCGGATGGTGAAGGAGGAGGTCCCCGAGGG
TGAGTACACCATTCCCCTGGGAAAGGCCCGCATCGCCCGTCCGGGAAACGCCGTCACCGTCGTCGCCTGGGGGAGCATGC
TCCAGCGGGTCATGAAGGCCGTCGAGGGGTACGACGCCGAGGTGATCGACCCCATGACCCTCTCTCCTTTCGACTGGGAG
GCGCTCCTGGCTTCGGTGGAAAAGACGGGGCGACTGGTGGTGGCCCACGAGGCCCCCCTCACCTGCGGCCTCGGCGCCGA
GATCGCCGCCACGGTGGCCCAGGAGGCGATTCTCCACCTCCGGGGGCCGGTCATCCGGGTGGCCGGACCCGACACGCCGG
TGCCCCTGGCGAAGCTGATCGACCACTACCTTCCGTCGCCGGAGCGGATTCGGGCGGCGCTCGATGACGTGCTGCAGTAC
TGA

Upstream 100 bases:

>100_bases
ACTCCTTCTTGGCTCAAAATAAATAAATGGTTCAAGGGGTTGCCTTCTCCGTGCCCTCCGTCTCTCCGTGTTATTACAAA
TTGAAAGGTTTCTATTCACA

Downstream 100 bases:

>100_bases
GGAGCGACCCATGCCCTTTGACTTCAAACTCCCCGATCTCGGTGAAGGGATCACCGAAGCCGAGCTGAGAAAGTGGCTCG
TGAAGGAAGGCGACACCGTT

Product: transketolase-like

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MPQLNMVQAINLALREEMARDDRVVLLGEDVGRDGGVFRITEGLFEEFGPKRVIDTPLSESAIVGAAVGMAAYGLRPVAE
IQFMGFIYAAFDQLFAHAVRIRTRSRGRFTAPLVVRTPYGAGIKAPELHEESTEAFFCHMPGVKVVVPSGPYNAKGLLMA
AIRDPDPVLFLEPTRLYRMVKEEVPEGEYTIPLGKARIARPGNAVTVVAWGSMLQRVMKAVEGYDAEVIDPMTLSPFDWE
ALLASVEKTGRLVVAHEAPLTCGLGAEIAATVAQEAILHLRGPVIRVAGPDTPVPLAKLIDHYLPSPERIRAALDDVLQY

Sequences:

>Translated_320_residues
MPQLNMVQAINLALREEMARDDRVVLLGEDVGRDGGVFRITEGLFEEFGPKRVIDTPLSESAIVGAAVGMAAYGLRPVAE
IQFMGFIYAAFDQLFAHAVRIRTRSRGRFTAPLVVRTPYGAGIKAPELHEESTEAFFCHMPGVKVVVPSGPYNAKGLLMA
AIRDPDPVLFLEPTRLYRMVKEEVPEGEYTIPLGKARIARPGNAVTVVAWGSMLQRVMKAVEGYDAEVIDPMTLSPFDWE
ALLASVEKTGRLVVAHEAPLTCGLGAEIAATVAQEAILHLRGPVIRVAGPDTPVPLAKLIDHYLPSPERIRAALDDVLQY
>Mature_319_residues
PQLNMVQAINLALREEMARDDRVVLLGEDVGRDGGVFRITEGLFEEFGPKRVIDTPLSESAIVGAAVGMAAYGLRPVAEI
QFMGFIYAAFDQLFAHAVRIRTRSRGRFTAPLVVRTPYGAGIKAPELHEESTEAFFCHMPGVKVVVPSGPYNAKGLLMAA
IRDPDPVLFLEPTRLYRMVKEEVPEGEYTIPLGKARIARPGNAVTVVAWGSMLQRVMKAVEGYDAEVIDPMTLSPFDWEA
LLASVEKTGRLVVAHEAPLTCGLGAEIAATVAQEAILHLRGPVIRVAGPDTPVPLAKLIDHYLPSPERIRAALDDVLQY

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=325, Percent_Identity=42.1538461538462, Blast_Score=263, Evalue=2e-70,
Organism=Homo sapiens, GI34101272, Length=325, Percent_Identity=42.1538461538462, Blast_Score=263, Evalue=2e-70,
Organism=Homo sapiens, GI156564403, Length=327, Percent_Identity=37.9204892966361, Blast_Score=208, Evalue=6e-54,
Organism=Homo sapiens, GI291084858, Length=327, Percent_Identity=36.697247706422, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17506935, Length=325, Percent_Identity=45.8461538461538, Blast_Score=266, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI17538422, Length=326, Percent_Identity=38.6503067484663, Blast_Score=223, Evalue=8e-59,
Organism=Saccharomyces cerevisiae, GI6319698, Length=327, Percent_Identity=37.0030581039755, Blast_Score=207, Evalue=2e-54,
Organism=Drosophila melanogaster, GI160714828, Length=325, Percent_Identity=42.7692307692308, Blast_Score=267, Evalue=6e-72,
Organism=Drosophila melanogaster, GI160714832, Length=325, Percent_Identity=42.7692307692308, Blast_Score=267, Evalue=6e-72,
Organism=Drosophila melanogaster, GI21358145, Length=326, Percent_Identity=38.9570552147239, Blast_Score=221, Evalue=5e-58,
Organism=Drosophila melanogaster, GI24650940, Length=326, Percent_Identity=38.9570552147239, Blast_Score=221, Evalue=5e-58,
Organism=Drosophila melanogaster, GI24650943, Length=91, Percent_Identity=46.1538461538462, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24650945, Length=91, Percent_Identity=46.1538461538462, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 34893; Mature: 34762

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQLNMVQAINLALREEMARDDRVVLLGEDVGRDGGVFRITEGLFEEFGPKRVIDTPLSE
CCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEHHHHHHHCCCCCEECCCCCC
SAIVGAAVGMAAYGLRPVAEIQFMGFIYAAFDQLFAHAVRIRTRSRGRFTAPLVVRTPYG
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCEEEECCCC
AGIKAPELHEESTEAFFCHMPGVKVVVPSGPYNAKGLLMAAIRDPDPVLFLEPTRLYRMV
CCCCCCCCCCCCCCEEEEECCCEEEEECCCCCCCCEEEEEEECCCCCEEEECHHHHHHHH
KEEVPEGEYTIPLGKARIARPGNAVTVVAWGSMLQRVMKAVEGYDAEVIDPMTLSPFDWE
HHHCCCCCEEEECCCCEECCCCCEEEEEEHHHHHHHHHHHHCCCCCCEECCCCCCCCCHH
ALLASVEKTGRLVVAHEAPLTCGLGAEIAATVAQEAILHLRGPVIRVAGPDTPVPLAKLI
HHHHHHHHCCCEEEEECCCCEECCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHH
DHYLPSPERIRAALDDVLQY
HHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
PQLNMVQAINLALREEMARDDRVVLLGEDVGRDGGVFRITEGLFEEFGPKRVIDTPLSE
CCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEHHHHHHHCCCCCEECCCCCC
SAIVGAAVGMAAYGLRPVAEIQFMGFIYAAFDQLFAHAVRIRTRSRGRFTAPLVVRTPYG
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCEEEECCCC
AGIKAPELHEESTEAFFCHMPGVKVVVPSGPYNAKGLLMAAIRDPDPVLFLEPTRLYRMV
CCCCCCCCCCCCCCEEEEECCCEEEEECCCCCCCCEEEEEEECCCCCEEEECHHHHHHHH
KEEVPEGEYTIPLGKARIARPGNAVTVVAWGSMLQRVMKAVEGYDAEVIDPMTLSPFDWE
HHHCCCCCEEEECCCCEECCCCCEEEEEEHHHHHHHHHHHHCCCCCCEECCCCCCCCCHH
ALLASVEKTGRLVVAHEAPLTCGLGAEIAATVAQEAILHLRGPVIRVAGPDTPVPLAKLI
HHHHHHHHCCCEEEEECCCCEECCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHH
DHYLPSPERIRAALDDVLQY
HHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2200674; 2253629 [H]