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The map label for this gene is guaB [H]

Identifier: 78223496

GI number: 78223496

Start: 2599311

End: 2600786

Strand: Reverse

Name: guaB [H]

Synonym: Gmet_2293

Alternate gene names: 78223496

Gene position: 2600786-2599311 (Counterclockwise)

Preceding gene: 78223497

Following gene: 78223495

Centisome position: 65.06

GC content: 62.47

Gene sequence:

>1476_bases
ATGTTAGACGAAACGATTCAGGAAGGCCTGACCTTCGACGACGTTCTGCTCGTCCCTGCCCATTCTCAAGTTCTCCCCCG
CGATGTCTCCCTCAATACCCGCCTGACCCGAAATATCCACCTCAATATTCCGCTCGTTTCCGCTGCCATGGATACGGTCA
CCGAGGCCCGGACCGCCATCTGCATGGCCCGCGAGGGGGGAATCGGCATCATCCACAAGAACCTCACCATCGAGGAACAG
GCCATGGAGGTGGACAAGGTCAAGAAAAGCGAATCGGGCATGATCGTGGACCCCATCACCATGCGCCCCAACCAGAAGAT
CCACGAGGCCCTGGCCATCATGGAGAAGTACCGGATCTCCGGGGTTCCGGTTACCAACGCCAAGGGGAAGCTGGTCGGCA
TCCTCACCAACCGCGACCTCCGTTTCGAGACGGATCTGAACCTTCCCATATCCGCCCGCATGACCAAGAAGCGGCTCGTG
ACCGTGGCGGTGGGCACCACCCTCGAAGAGGCCAAGGAGCATCTGAAGCAGACCCGGGTGGAGAAACTCCTGGTTGTGGA
CGACGATAAGAACCTCAAGGGGCTCATCACCATCAAGGATATCGAGAAGGTCAGGAAATACCCCAATGCCTGCAAGGACG
GCCTGGGGCGCCTGCGGGTCGGCGCTGCCGTCGGTCCGACCGCTGACATGCTGGTCCGTGCCGATGCCCTCGTGAAGGCC
GGTGTTGATGTGATTGCCATCGACACGGCCCACGGTCATTCCCAGGGGGTTCTGGACGCAATACGCTCCTTGAAGTCAGC
GTTTCCGGGGGTTGAACTCATCGCCGGCAACATCGCCACTGCCGAGGCCGCCGAGGCTCTCATCAAGGCAGGGGTCGACG
CCATCAAGGTGGGGATCGGTCCCGGCTCCATCTGCACCACCCGCGTGGTGGCCGGGGTCGGCGTGCCCCAGATCAGCGCC
ATCGCCCAATGCGCAAAAGTCGCCCGCAAATACGACATCCCCCTCATCGCCGATGGCGGGGTCAAATACTCCGGCGACGT
CACCAAGGCAGTGGCCGCCGGCGCCGACGTCATCATGATCGGGTCGCTCTTCGCCGGCACCGAGGAGTCCCCCGGCGACA
CCATCCTCTATCAGGGCCGCGCCTACAAGAGCTACCGCGGCATGGGCTCCATCGGCGCCATGAAGGAGGGGAGTAAGGAC
CGCTACTTCCAGAGCGACGTGGAGAGCGAGGTGAAGCTGGTTCCCGAAGGGATTGAGGGGATGGTTCCCCTGCGTGGACC
GCTGGGTGCCAACGTCCACCAGCTCATGGGGGGGCTCAGGGCCGGCATGGGCTACACCGGCTGCCACACCGTCAGCGAAC
TCCAGCAGAAGGGGCGCTTCATCCGGATCACCGGCGCCGGGCTCAAGGAGTCCCACGTCCACGACGTCATGATTACCAAG
GAAGCTCCCAACTACCGGGTTGAGAACGTACGATGA

Upstream 100 bases:

>100_bases
ATTTTCTCTTTGATTTTAACCCCTTTTAACTTGACTCACCTTTTTGCCTCGACTATCTTTTTCGGTTAATACTTTGAGAC
CCACCACAAAGGAGTCCGCG

Downstream 100 bases:

>100_bases
GCAGTGATATCCACAGCGAGAAAATCCTGATCCTGGACTTCGGTTCACAGTACACCCAACTCATCGCCCGGCGAGTGCGG
GAGGCCCACGTCTACTGCGA

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MLDETIQEGLTFDDVLLVPAHSQVLPRDVSLNTRLTRNIHLNIPLVSAAMDTVTEARTAICMAREGGIGIIHKNLTIEEQ
AMEVDKVKKSESGMIVDPITMRPNQKIHEALAIMEKYRISGVPVTNAKGKLVGILTNRDLRFETDLNLPISARMTKKRLV
TVAVGTTLEEAKEHLKQTRVEKLLVVDDDKNLKGLITIKDIEKVRKYPNACKDGLGRLRVGAAVGPTADMLVRADALVKA
GVDVIAIDTAHGHSQGVLDAIRSLKSAFPGVELIAGNIATAEAAEALIKAGVDAIKVGIGPGSICTTRVVAGVGVPQISA
IAQCAKVARKYDIPLIADGGVKYSGDVTKAVAAGADVIMIGSLFAGTEESPGDTILYQGRAYKSYRGMGSIGAMKEGSKD
RYFQSDVESEVKLVPEGIEGMVPLRGPLGANVHQLMGGLRAGMGYTGCHTVSELQQKGRFIRITGAGLKESHVHDVMITK
EAPNYRVENVR

Sequences:

>Translated_491_residues
MLDETIQEGLTFDDVLLVPAHSQVLPRDVSLNTRLTRNIHLNIPLVSAAMDTVTEARTAICMAREGGIGIIHKNLTIEEQ
AMEVDKVKKSESGMIVDPITMRPNQKIHEALAIMEKYRISGVPVTNAKGKLVGILTNRDLRFETDLNLPISARMTKKRLV
TVAVGTTLEEAKEHLKQTRVEKLLVVDDDKNLKGLITIKDIEKVRKYPNACKDGLGRLRVGAAVGPTADMLVRADALVKA
GVDVIAIDTAHGHSQGVLDAIRSLKSAFPGVELIAGNIATAEAAEALIKAGVDAIKVGIGPGSICTTRVVAGVGVPQISA
IAQCAKVARKYDIPLIADGGVKYSGDVTKAVAAGADVIMIGSLFAGTEESPGDTILYQGRAYKSYRGMGSIGAMKEGSKD
RYFQSDVESEVKLVPEGIEGMVPLRGPLGANVHQLMGGLRAGMGYTGCHTVSELQQKGRFIRITGAGLKESHVHDVMITK
EAPNYRVENVR
>Mature_491_residues
MLDETIQEGLTFDDVLLVPAHSQVLPRDVSLNTRLTRNIHLNIPLVSAAMDTVTEARTAICMAREGGIGIIHKNLTIEEQ
AMEVDKVKKSESGMIVDPITMRPNQKIHEALAIMEKYRISGVPVTNAKGKLVGILTNRDLRFETDLNLPISARMTKKRLV
TVAVGTTLEEAKEHLKQTRVEKLLVVDDDKNLKGLITIKDIEKVRKYPNACKDGLGRLRVGAAVGPTADMLVRADALVKA
GVDVIAIDTAHGHSQGVLDAIRSLKSAFPGVELIAGNIATAEAAEALIKAGVDAIKVGIGPGSICTTRVVAGVGVPQISA
IAQCAKVARKYDIPLIADGGVKYSGDVTKAVAAGADVIMIGSLFAGTEESPGDTILYQGRAYKSYRGMGSIGAMKEGSKD
RYFQSDVESEVKLVPEGIEGMVPLRGPLGANVHQLMGGLRAGMGYTGCHTVSELQQKGRFIRITGAGLKESHVHDVMITK
EAPNYRVENVR

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=456, Percent_Identity=41.2280701754386, Blast_Score=326, Evalue=3e-89,
Organism=Homo sapiens, GI66933016, Length=456, Percent_Identity=39.4736842105263, Blast_Score=326, Evalue=4e-89,
Organism=Homo sapiens, GI34328928, Length=456, Percent_Identity=41.2280701754386, Blast_Score=325, Evalue=5e-89,
Organism=Homo sapiens, GI34328930, Length=456, Percent_Identity=41.2280701754386, Blast_Score=325, Evalue=6e-89,
Organism=Homo sapiens, GI156616279, Length=456, Percent_Identity=41.2280701754386, Blast_Score=325, Evalue=7e-89,
Organism=Homo sapiens, GI217035152, Length=450, Percent_Identity=41.1111111111111, Blast_Score=316, Evalue=2e-86,
Organism=Homo sapiens, GI217035148, Length=456, Percent_Identity=40.3508771929825, Blast_Score=314, Evalue=1e-85,
Organism=Homo sapiens, GI217035150, Length=456, Percent_Identity=37.719298245614, Blast_Score=286, Evalue=3e-77,
Organism=Homo sapiens, GI50541956, Length=225, Percent_Identity=40, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI50541954, Length=225, Percent_Identity=40, Blast_Score=162, Evalue=8e-40,
Organism=Homo sapiens, GI50541952, Length=225, Percent_Identity=40, Blast_Score=162, Evalue=8e-40,
Organism=Homo sapiens, GI50541948, Length=225, Percent_Identity=40, Blast_Score=162, Evalue=8e-40,
Organism=Homo sapiens, GI156104880, Length=225, Percent_Identity=38.6666666666667, Blast_Score=159, Evalue=7e-39,
Organism=Escherichia coli, GI1788855, Length=482, Percent_Identity=59.5435684647303, Blast_Score=537, Evalue=1e-154,
Organism=Escherichia coli, GI1786293, Length=222, Percent_Identity=38.7387387387387, Blast_Score=159, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI71994385, Length=485, Percent_Identity=36.2886597938144, Blast_Score=272, Evalue=2e-73,
Organism=Caenorhabditis elegans, GI71994389, Length=435, Percent_Identity=37.9310344827586, Blast_Score=262, Evalue=3e-70,
Organism=Caenorhabditis elegans, GI17560440, Length=241, Percent_Identity=40.6639004149378, Blast_Score=181, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6322012, Length=491, Percent_Identity=41.1405295315682, Blast_Score=343, Evalue=2e-95,
Organism=Saccharomyces cerevisiae, GI6323585, Length=491, Percent_Identity=41.5478615071283, Blast_Score=343, Evalue=4e-95,
Organism=Saccharomyces cerevisiae, GI6323464, Length=491, Percent_Identity=41.3441955193483, Blast_Score=329, Evalue=5e-91,
Organism=Saccharomyces cerevisiae, GI6319352, Length=346, Percent_Identity=43.0635838150289, Blast_Score=263, Evalue=5e-71,
Organism=Saccharomyces cerevisiae, GI6319353, Length=116, Percent_Identity=37.0689655172414, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24641071, Length=483, Percent_Identity=38.3022774327122, Blast_Score=317, Evalue=1e-86,
Organism=Drosophila melanogaster, GI24641073, Length=483, Percent_Identity=38.3022774327122, Blast_Score=317, Evalue=1e-86,
Organism=Drosophila melanogaster, GI28571163, Length=441, Percent_Identity=38.0952380952381, Blast_Score=281, Evalue=5e-76,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52534; Mature: 52534

Theoretical pI: Translated: 8.66; Mature: 8.66

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDETIQEGLTFDDVLLVPAHSQVLPRDVSLNTRLTRNIHLNIPLVSAAMDTVTEARTAI
CCCHHHHHCCCCCCEEEECCCCCCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHE
CMAREGGIGIIHKNLTIEEQAMEVDKVKKSESGMIVDPITMRPNQKIHEALAIMEKYRIS
EEEECCCEEEEECCCEEHHHHHHHHHHHCCCCCEEEECEECCCCHHHHHHHHHHHHHHCC
GVPVTNAKGKLVGILTNRDLRFETDLNLPISARMTKKRLVTVAVGTTLEEAKEHLKQTRV
CCEEECCCCCEEEEEECCCEEEEECCCCCCHHCCCCCEEEEEEECCCHHHHHHHHHHHHH
EKLLVVDDDKNLKGLITIKDIEKVRKYPNACKDGLGRLRVGAAVGPTADMLVRADALVKA
HEEEEEECCCCCEEEEEHHHHHHHHHCCCHHHHCCCCEEECCCCCCCHHHHHHHHHHHHC
GVDVIAIDTAHGHSQGVLDAIRSLKSAFPGVELIAGNIATAEAAEALIKAGVDAIKVGIG
CCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCEEEEECC
PGSICTTRVVAGVGVPQISAIAQCAKVARKYDIPLIADGGVKYSGDVTKAVAAGADVIMI
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEECCCEEECCCHHHHHHCCCCEEEE
GSLFAGTEESPGDTILYQGRAYKSYRGMGSIGAMKEGSKDRYFQSDVESEVKLVPEGIEG
EEECCCCCCCCCCEEEECCCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHEECCCCCCC
MVPLRGPLGANVHQLMGGLRAGMGYTGCHTVSELQQKGRFIRITGAGLKESHVHDVMITK
CEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEEE
EAPNYRVENVR
CCCCCCCCCCC
>Mature Secondary Structure
MLDETIQEGLTFDDVLLVPAHSQVLPRDVSLNTRLTRNIHLNIPLVSAAMDTVTEARTAI
CCCHHHHHCCCCCCEEEECCCCCCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHE
CMAREGGIGIIHKNLTIEEQAMEVDKVKKSESGMIVDPITMRPNQKIHEALAIMEKYRIS
EEEECCCEEEEECCCEEHHHHHHHHHHHCCCCCEEEECEECCCCHHHHHHHHHHHHHHCC
GVPVTNAKGKLVGILTNRDLRFETDLNLPISARMTKKRLVTVAVGTTLEEAKEHLKQTRV
CCEEECCCCCEEEEEECCCEEEEECCCCCCHHCCCCCEEEEEEECCCHHHHHHHHHHHHH
EKLLVVDDDKNLKGLITIKDIEKVRKYPNACKDGLGRLRVGAAVGPTADMLVRADALVKA
HEEEEEECCCCCEEEEEHHHHHHHHHCCCHHHHCCCCEEECCCCCCCHHHHHHHHHHHHC
GVDVIAIDTAHGHSQGVLDAIRSLKSAFPGVELIAGNIATAEAAEALIKAGVDAIKVGIG
CCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCEEEEECC
PGSICTTRVVAGVGVPQISAIAQCAKVARKYDIPLIADGGVKYSGDVTKAVAAGADVIMI
CCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEECCCEEECCCHHHHHHCCCCEEEE
GSLFAGTEESPGDTILYQGRAYKSYRGMGSIGAMKEGSKDRYFQSDVESEVKLVPEGIEG
EEECCCCCCCCCCEEEECCCCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHEECCCCCCC
MVPLRGPLGANVHQLMGGLRAGMGYTGCHTVSELQQKGRFIRITGAGLKESHVHDVMITK
CEECCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEEE
EAPNYRVENVR
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]