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The map label for this gene is etfA [H]

Identifier: 78223466

GI number: 78223466

Start: 2562440

End: 2563345

Strand: Reverse

Name: etfA [H]

Synonym: Gmet_2262

Alternate gene names: 78223466

Gene position: 2563345-2562440 (Counterclockwise)

Preceding gene: 78223467

Following gene: 78223465

Centisome position: 64.12

GC content: 62.25

Gene sequence:

>906_bases
ATGAAAACATTACTGATTGGCGAATACCGGGAGGGAAAACTCCTCGATAGTACCTATGAACTCCTCGGCTTTGCGCAGCA
ACTGGAAGCCCAGAGCGCCATGCTGGTGGTGGGGAGCGAGAGCCAGCTTCCCGCCTATGGTGGCACCCTCTACCTGGCCG
ACGCGGCAAGCTGCGGGGAATACAACCCCGACCTGCACAAACAGCTGATCCTCGACGCCATAGAAAAAGAAAACCCCGAC
TACGTCGTCTTCATCCACTCCTCCTACGGCTGGGACCTGGCGCCGCGTGTGGCGGCCCGACTGAAAGTCGCCCAGGTATC
GGAAGTCATCGGCCTTACCGACGGCGGCTTCGAAGTGGGGTGTTGCAACGCCAAGATGCGGCGGACCGTCAAGCCTGCCA
CTGGCAAAGCGGTCATCACCATCCAGGCTGGTGCCTTTGCCGCCATCCAGCCGGGTGGGACCCCCAGCGTGCAGAAGATA
ACCGCAAGCGTAACGAGCAACGTCAGCTTTGCCGGTTACGAGCCGGCGGAGGCCAAAGACGTGGATCTCACCCGGGCGGA
AGTCATCGTCACCGCGGGACGGGGGATCGGCAAGAAAGAAAACGTCGAGGTCATCGCCGCCCTGGCCAAGGCGCTGGGAG
GGGAGCTGGGAGCGAGCCGGCCGGTGGTCGACGCGGGGTGGGTAGAGCACAGCCACCAGGTGGGTACCACGGGACAGACG
GTAAGCCCGAAACTGTACATCGCCTGCGGGGTCTCCGGTGCCATCCAGCACCTGGCAGGGATGAAGAAATCCGACTTCAT
CGTCGCCATCAACAAGGACAAGGACGCCCCCATCGGCGAGGTGGCCGATGTCCTCGTGGTCGCCGATATCCTCCAGTTCG
TTCCCGCCCTGACGGCGAAACTGTAA

Upstream 100 bases:

>100_bases
AAAAACACAAAACGTAAGGCTCGTGCTTTTCTCCGTGTACCTCCGTGAAAACCCTCTGTGTCCTCTGTGGTAATGCTTTT
AAAAGATTTTTGGAGGTCAT

Downstream 100 bases:

>100_bases
TTCTAAAAAACAAGTTTTTTGAGTGTGATAGTTGGTAAACGGAGCAGTTACTATTTTATTGATTGGAGCTAACGATGAAC
ATTCACGAGTATCAGGCAAA

Product: electron transfer flavoprotein subunit alpha

Products: NA

Alternate protein names: Alpha-ETF; Electron transfer flavoprotein large subunit; ETFLS [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MKTLLIGEYREGKLLDSTYELLGFAQQLEAQSAMLVVGSESQLPAYGGTLYLADAASCGEYNPDLHKQLILDAIEKENPD
YVVFIHSSYGWDLAPRVAARLKVAQVSEVIGLTDGGFEVGCCNAKMRRTVKPATGKAVITIQAGAFAAIQPGGTPSVQKI
TASVTSNVSFAGYEPAEAKDVDLTRAEVIVTAGRGIGKKENVEVIAALAKALGGELGASRPVVDAGWVEHSHQVGTTGQT
VSPKLYIACGVSGAIQHLAGMKKSDFIVAINKDKDAPIGEVADVLVVADILQFVPALTAKL

Sequences:

>Translated_301_residues
MKTLLIGEYREGKLLDSTYELLGFAQQLEAQSAMLVVGSESQLPAYGGTLYLADAASCGEYNPDLHKQLILDAIEKENPD
YVVFIHSSYGWDLAPRVAARLKVAQVSEVIGLTDGGFEVGCCNAKMRRTVKPATGKAVITIQAGAFAAIQPGGTPSVQKI
TASVTSNVSFAGYEPAEAKDVDLTRAEVIVTAGRGIGKKENVEVIAALAKALGGELGASRPVVDAGWVEHSHQVGTTGQT
VSPKLYIACGVSGAIQHLAGMKKSDFIVAINKDKDAPIGEVADVLVVADILQFVPALTAKL
>Mature_301_residues
MKTLLIGEYREGKLLDSTYELLGFAQQLEAQSAMLVVGSESQLPAYGGTLYLADAASCGEYNPDLHKQLILDAIEKENPD
YVVFIHSSYGWDLAPRVAARLKVAQVSEVIGLTDGGFEVGCCNAKMRRTVKPATGKAVITIQAGAFAAIQPGGTPSVQKI
TASVTSNVSFAGYEPAEAKDVDLTRAEVIVTAGRGIGKKENVEVIAALAKALGGELGASRPVVDAGWVEHSHQVGTTGQT
VSPKLYIACGVSGAIQHLAGMKKSDFIVAINKDKDAPIGEVADVLVVADILQFVPALTAKL

Specific function: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) [H]

COG id: COG2025

COG function: function code C; Electron transfer flavoprotein, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ETF alpha-subunit/fixB family [H]

Homologues:

Organism=Homo sapiens, GI4503607, Length=315, Percent_Identity=37.1428571428571, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI189181759, Length=247, Percent_Identity=41.2955465587045, Blast_Score=152, Evalue=3e-37,
Organism=Escherichia coli, GI1786226, Length=251, Percent_Identity=35.8565737051793, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1787990, Length=308, Percent_Identity=28.8961038961039, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI87082157, Length=257, Percent_Identity=29.9610894941634, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17506929, Length=309, Percent_Identity=36.2459546925566, Blast_Score=166, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6325261, Length=230, Percent_Identity=40.8695652173913, Blast_Score=136, Evalue=4e-33,
Organism=Drosophila melanogaster, GI17136898, Length=310, Percent_Identity=36.1290322580645, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24652801, Length=310, Percent_Identity=36.1290322580645, Blast_Score=159, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001308
- InterPro:   IPR014730
- InterPro:   IPR014731
- InterPro:   IPR018206
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01012 ETF; PF00766 ETF_alpha [H]

EC number: NA

Molecular weight: Translated: 31582; Mature: 31582

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00696 ETF_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLLIGEYREGKLLDSTYELLGFAQQLEAQSAMLVVGSESQLPAYGGTLYLADAASCGE
CCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEECCCCCC
YNPDLHKQLILDAIEKENPDYVVFIHSSYGWDLAPRVAARLKVAQVSEVIGLTDGGFEVG
CCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEE
CCNAKMRRTVKPATGKAVITIQAGAFAAIQPGGTPSVQKITASVTSNVSFAGYEPAEAKD
ECCHHHHHCCCCCCCCEEEEEECCCEEEECCCCCCHHHHHHHHHHCCCEECCCCCCCCCC
VDLTRAEVIVTAGRGIGKKENVEVIAALAKALGGELGASRPVVDAGWVEHSHQVGTTGQT
CCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCCCCCCCC
VSPKLYIACGVSGAIQHLAGMKKSDFIVAINKDKDAPIGEVADVLVVADILQFVPALTAK
CCCEEEEEECCHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHC
L
C
>Mature Secondary Structure
MKTLLIGEYREGKLLDSTYELLGFAQQLEAQSAMLVVGSESQLPAYGGTLYLADAASCGE
CCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCEEEEEECCCCCC
YNPDLHKQLILDAIEKENPDYVVFIHSSYGWDLAPRVAARLKVAQVSEVIGLTDGGFEVG
CCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEE
CCNAKMRRTVKPATGKAVITIQAGAFAAIQPGGTPSVQKITASVTSNVSFAGYEPAEAKD
ECCHHHHHCCCCCCCCEEEEEECCCEEEECCCCCCHHHHHHHHHHCCCEECCCCCCCCCC
VDLTRAEVIVTAGRGIGKKENVEVIAALAKALGGELGASRPVVDAGWVEHSHQVGTTGQT
CCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCCCCCCCC
VSPKLYIACGVSGAIQHLAGMKKSDFIVAINKDKDAPIGEVADVLVVADILQFVPALTAK
CCCEEEEEECCHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHC
L
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]