Click here to switch to the map view.

The map label for this gene is gatD [C]

Identifier: 78223358

GI number: 78223358

Start: 2421276

End: 2422349

Strand: Reverse

Name: gatD [C]

Synonym: Gmet_2151

Alternate gene names: 78223358

Gene position: 2422349-2421276 (Counterclockwise)

Preceding gene: 78223359

Following gene: 78223357

Centisome position: 60.6

GC content: 62.1

Gene sequence:

>1074_bases
ATGAGCACTGCACCGCATCGCTGGACAATGACTGCCGTGGGCGAGCCCATGGTGAAGGCGGATTTCGACGCGGCTCCGCC
GTCTGACAATGAAGTGGTGGTTGAGGTTGCCGGATGCGGGGTATGCCATACCGACCTGGGCTTCTATTACGATGGCGTGC
GCGTCAACCATGGCCTGCCGTTGACCCTCGGCCACGAAATCAGCGGCCGGGTGGTTGCCACGGGCAAGGGGGCGGAGGCC
TGGCAAGGGAAGGCGGTGCTGATTCCCGCGGTCATTCCCTGCGGAGTCTGTGACCTCTGCCTTTCGGGCCACGGCACCAT
TTGCCGCACGCAGCAGATGCCGGGCAACGACATCCAGGGGGGCTTTGCCACCCATATCAAGGTGCCCGCCCGGGGACTCT
GTCCCGTCGATGAAAAGAAACTCGCTGCGGCAGGCTTTGAACTGGCGGACATCTCCGTGGTCGCCGACGCCGTCACCACT
CCCTACCAGGCCGTTGTCCAGGCAGAAGTTCAGAAAGGGGACTTGGCCATCGTCATCGGCATCGGCGGGGTAGGGAGCTA
TGCCGTGCAGATCGCCAACGCCATGGGCGCCACGGTCGTCGCCATCGATGTGGACCAGGCCAAGCTGGACAACATGGCCA
AGTATGGCGCGGGCCTTACCATCAATTCGCGGCAGGTGCAGGGGAAAGATCTGAAGAAAGCGATCCAGACCTTCGTGAAG
GAAAAAGGGCTGCCGCAAACCTGCTGGAAGATCTTTGAATGCTCCGGGACTGTCCCGGGCCAGGATACCGCCTTCGGTCT
CCTGACCTTCGGCGCCACCCTGTCGGTAGTAGGCTTCACCATGGACAAGATCGAACTGCGCCTCTCCAACCTCATGGCCT
TCCATGCCCGGGCTCTGGGCAACTGGGGCTGCCTGACCGAGCTGTATCCGGCAGCGCTGGACCTGGTTCTGGAGAAGAAG
ATCGCGCTGGCGCCGTTCATCGAGAAGCACCCCCTGGAGAAGATCAACGAGATCTTTGAAGCAGCCCATGCCCACAAGCT
GACCCGGCGGGCCATTCTGGTTCCCGGCAAGTAA

Upstream 100 bases:

>100_bases
GAAATAGGTAAAAAAGTACCAAGTTGCAAAAATGGTTATGTTGCAACCTGTCGATTAACATGCACTTTTTAAGAACAAAC
GGAATAGGGAGGAAGGATCA

Downstream 100 bases:

>100_bases
TTTGTTGCCGAAAATGACCGGCGGGGCAGCAATGCCCCGCTGAACAATAATCAGCCTGATTTTAGGAGGAAAGAGAATCA
TGAGCGAGAGCCCTCTCAAG

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: ADH-HT [H]

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MSTAPHRWTMTAVGEPMVKADFDAAPPSDNEVVVEVAGCGVCHTDLGFYYDGVRVNHGLPLTLGHEISGRVVATGKGAEA
WQGKAVLIPAVIPCGVCDLCLSGHGTICRTQQMPGNDIQGGFATHIKVPARGLCPVDEKKLAAAGFELADISVVADAVTT
PYQAVVQAEVQKGDLAIVIGIGGVGSYAVQIANAMGATVVAIDVDQAKLDNMAKYGAGLTINSRQVQGKDLKKAIQTFVK
EKGLPQTCWKIFECSGTVPGQDTAFGLLTFGATLSVVGFTMDKIELRLSNLMAFHARALGNWGCLTELYPAALDLVLEKK
IALAPFIEKHPLEKINEIFEAAHAHKLTRRAILVPGK

Sequences:

>Translated_357_residues
MSTAPHRWTMTAVGEPMVKADFDAAPPSDNEVVVEVAGCGVCHTDLGFYYDGVRVNHGLPLTLGHEISGRVVATGKGAEA
WQGKAVLIPAVIPCGVCDLCLSGHGTICRTQQMPGNDIQGGFATHIKVPARGLCPVDEKKLAAAGFELADISVVADAVTT
PYQAVVQAEVQKGDLAIVIGIGGVGSYAVQIANAMGATVVAIDVDQAKLDNMAKYGAGLTINSRQVQGKDLKKAIQTFVK
EKGLPQTCWKIFECSGTVPGQDTAFGLLTFGATLSVVGFTMDKIELRLSNLMAFHARALGNWGCLTELYPAALDLVLEKK
IALAPFIEKHPLEKINEIFEAAHAHKLTRRAILVPGK
>Mature_356_residues
STAPHRWTMTAVGEPMVKADFDAAPPSDNEVVVEVAGCGVCHTDLGFYYDGVRVNHGLPLTLGHEISGRVVATGKGAEAW
QGKAVLIPAVIPCGVCDLCLSGHGTICRTQQMPGNDIQGGFATHIKVPARGLCPVDEKKLAAAGFELADISVVADAVTTP
YQAVVQAEVQKGDLAIVIGIGGVGSYAVQIANAMGATVVAIDVDQAKLDNMAKYGAGLTINSRQVQGKDLKKAIQTFVKE
KGLPQTCWKIFECSGTVPGQDTAFGLLTFGATLSVVGFTMDKIELRLSNLMAFHARALGNWGCLTELYPAALDLVLEKKI
ALAPFIEKHPLEKINEIFEAAHAHKLTRRAILVPGK

Specific function: Thermophilic NAD(+)-dependent alcohol dehydrogenase. Bears mainly an ethanol-dehydrogenase activity [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=383, Percent_Identity=24.8041775456919, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI4501929, Length=367, Percent_Identity=27.7929155313352, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI34577061, Length=370, Percent_Identity=27.8378378378378, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI156523966, Length=369, Percent_Identity=25.7452574525745, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI4501939, Length=361, Percent_Identity=25.7617728531856, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI262073058, Length=367, Percent_Identity=23.9782016348774, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI71743840, Length=367, Percent_Identity=23.9782016348774, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1788407, Length=346, Percent_Identity=26.3005780346821, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1786552, Length=376, Percent_Identity=28.4574468085106, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI226510992, Length=323, Percent_Identity=26.625386996904, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI87082125, Length=350, Percent_Identity=23.7142857142857, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87082401, Length=343, Percent_Identity=25.9475218658892, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87081918, Length=330, Percent_Identity=27.5757575757576, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1788073, Length=262, Percent_Identity=26.7175572519084, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1786825, Length=239, Percent_Identity=27.1966527196653, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787863, Length=333, Percent_Identity=24.6246246246246, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1786518, Length=225, Percent_Identity=31.1111111111111, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790718, Length=210, Percent_Identity=25.7142857142857, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788075, Length=330, Percent_Identity=24.2424242424242, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1790045, Length=315, Percent_Identity=21.9047619047619, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=328, Percent_Identity=26.5243902439024, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71988145, Length=196, Percent_Identity=30.1020408163265, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17562582, Length=180, Percent_Identity=33.8888888888889, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17562878, Length=326, Percent_Identity=25.7668711656442, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323729, Length=221, Percent_Identity=30.7692307692308, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323099, Length=366, Percent_Identity=24.8633879781421, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323961, Length=218, Percent_Identity=29.8165137614679, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6319258, Length=274, Percent_Identity=25.9124087591241, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6324486, Length=205, Percent_Identity=30.2439024390244, Blast_Score=73, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6319621, Length=221, Percent_Identity=30.7692307692308, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322619, Length=339, Percent_Identity=24.7787610619469, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319955, Length=339, Percent_Identity=24.7787610619469, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6323980, Length=355, Percent_Identity=26.4788732394366, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI17737895, Length=369, Percent_Identity=26.0162601626016, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 37768; Mature: 37637

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTAPHRWTMTAVGEPMVKADFDAAPPSDNEVVVEVAGCGVCHTDLGFYYDGVRVNHGLP
CCCCCCCEEEEECCCCCEECCCCCCCCCCCEEEEEEECCCEEECCCCEEECCEEECCCCC
LTLGHEISGRVVATGKGAEAWQGKAVLIPAVIPCGVCDLCLSGHGTICRTQQMPGNDIQG
EEECCCCCCEEEEECCCCCHHCCCEEEECCCCCCCHHHHHHCCCCCEEEECCCCCCCCCC
GFATHIKVPARGLCPVDEKKLAAAGFELADISVVADAVTTPYQAVVQAEVQKGDLAIVIG
CEEEEEECCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEE
IGGVGSYAVQIANAMGATVVAIDVDQAKLDNMAKYGAGLTINSRQVQGKDLKKAIQTFVK
ECCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHH
EKGLPQTCWKIFECSGTVPGQDTAFGLLTFGATLSVVGFTMDKIELRLSNLMAFHARALG
HCCCCHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NWGCLTELYPAALDLVLEKKIALAPFIEKHPLEKINEIFEAAHAHKLTRRAILVPGK
CCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHCEEEECCC
>Mature Secondary Structure 
STAPHRWTMTAVGEPMVKADFDAAPPSDNEVVVEVAGCGVCHTDLGFYYDGVRVNHGLP
CCCCCCEEEEECCCCCEECCCCCCCCCCCEEEEEEECCCEEECCCCEEECCEEECCCCC
LTLGHEISGRVVATGKGAEAWQGKAVLIPAVIPCGVCDLCLSGHGTICRTQQMPGNDIQG
EEECCCCCCEEEEECCCCCHHCCCEEEECCCCCCCHHHHHHCCCCCEEEECCCCCCCCCC
GFATHIKVPARGLCPVDEKKLAAAGFELADISVVADAVTTPYQAVVQAEVQKGDLAIVIG
CEEEEEECCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEE
IGGVGSYAVQIANAMGATVVAIDVDQAKLDNMAKYGAGLTINSRQVQGKDLKKAIQTFVK
ECCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHH
EKGLPQTCWKIFECSGTVPGQDTAFGLLTFGATLSVVGFTMDKIELRLSNLMAFHARALG
HCCCCHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NWGCLTELYPAALDLVLEKKIALAPFIEKHPLEKINEIFEAAHAHKLTRRAILVPGK
CCCCHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8020473 [H]