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The map label for this gene is dch [H]

Identifier: 78223357

GI number: 78223357

Start: 2420426

End: 2421196

Strand: Reverse

Name: dch [H]

Synonym: Gmet_2150

Alternate gene names: 78223357

Gene position: 2421196-2420426 (Counterclockwise)

Preceding gene: 78223358

Following gene: 78223356

Centisome position: 60.57

GC content: 64.33

Gene sequence:

>771_bases
ATGAGCGAGAGCCCTCTCAAGGTATGGCTTGAAAAAGACGGCGCGCTGCTCCGTCTGCGTCTGGCACGTCCCAAGGCGAA
CATCGTGGACGCCGCCATGATCGCGGCGCTGCAGGCAGCGTTAACGGAGCATCTCCCCAGTGCAAAGCTTCGGGCCGTGC
TGCTCGATGCGGAAGGCCCCCATTTCAGCTTTGGCGCCAGCGTTGAGGAACACATGCCCGAATCCTGCGCCGCCATGCTG
CAATCCCTGCATGCCCTGGTGATTCAGATGCTGGAATCTCCGGTGCCGGTCCTGGTTGCGGTGCGGGGCCAGTGCCTCGG
CGGTGGCCTTGAAGTGGTCGCCGCAGGTAACCTGATTTTCGCCGCACCGGGAGCAATGCTCGGGCAGCCGGAGATCAAGA
TCGGCGTCTTCGCCCCGGCGGCCTCCTGCCTGCTGCCGGAGAGGATCGGCAAGACCGCTTCCGAGGATCTCCTCTTCTCG
GGGCGCAGTATCACGGCGGAAGAAGGCTTCCGGATCGGCCTGGTCACTGCGGTGGCCGAAGATCCCGAGCAGGCCGCGGT
TGCCTACTTCGATGAGCACCTTGCAGGGCTCAGCGCCAGTTCGCTTCGGTTTGCCGTGCGCGCGGCGCGCATCGGCGTCC
TCGAGCGGACCAAGACGAAAATAGCCGCAGTAGAAAAGCTGTACCTGGAAGAGCTGATGGCAACCCATGACGCCGTGGAA
GGGCTGAACGCTTTCCTCGGCAAGCGGCCCGCCGCCTGGCAAGACCGCTGA

Upstream 100 bases:

>100_bases
ATTCTGGTTCCCGGCAAGTAATTTGTTGCCGAAAATGACCGGCGGGGCAGCAATGCCCCGCTGAACAATAATCAGCCTGA
TTTTAGGAGGAAAGAGAATC

Downstream 100 bases:

>100_bases
GTTCTTGTATAGAGTCGCAACAGGACGTACCACGTAGTAACTCCTTTTACTGGTGATTCAAGGGGCAGGACGCCATGCCT
GCCCCGGTTTTTTCATATCC

Product: enoyl-CoA hydratase/isomerase

Products: NA

Alternate protein names: Cyclohexa-1,5-diene-1-carboxyl-CoA hydratase; Dienoyl-CoA hydratase [H]

Number of amino acids: Translated: 256; Mature: 255

Protein sequence:

>256_residues
MSESPLKVWLEKDGALLRLRLARPKANIVDAAMIAALQAALTEHLPSAKLRAVLLDAEGPHFSFGASVEEHMPESCAAML
QSLHALVIQMLESPVPVLVAVRGQCLGGGLEVVAAGNLIFAAPGAMLGQPEIKIGVFAPAASCLLPERIGKTASEDLLFS
GRSITAEEGFRIGLVTAVAEDPEQAAVAYFDEHLAGLSASSLRFAVRAARIGVLERTKTKIAAVEKLYLEELMATHDAVE
GLNAFLGKRPAAWQDR

Sequences:

>Translated_256_residues
MSESPLKVWLEKDGALLRLRLARPKANIVDAAMIAALQAALTEHLPSAKLRAVLLDAEGPHFSFGASVEEHMPESCAAML
QSLHALVIQMLESPVPVLVAVRGQCLGGGLEVVAAGNLIFAAPGAMLGQPEIKIGVFAPAASCLLPERIGKTASEDLLFS
GRSITAEEGFRIGLVTAVAEDPEQAAVAYFDEHLAGLSASSLRFAVRAARIGVLERTKTKIAAVEKLYLEELMATHDAVE
GLNAFLGKRPAAWQDR
>Mature_255_residues
SESPLKVWLEKDGALLRLRLARPKANIVDAAMIAALQAALTEHLPSAKLRAVLLDAEGPHFSFGASVEEHMPESCAAMLQ
SLHALVIQMLESPVPVLVAVRGQCLGGGLEVVAAGNLIFAAPGAMLGQPEIKIGVFAPAASCLLPERIGKTASEDLLFSG
RSITAEEGFRIGLVTAVAEDPEQAAVAYFDEHLAGLSASSLRFAVRAARIGVLERTKTKIAAVEKLYLEELMATHDAVEG
LNAFLGKRPAAWQDR

Specific function: Catalyzes the hydration of cyclohexa-1,5-diene-1- carboxyl-CoA [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI31542718, Length=242, Percent_Identity=25.6198347107438, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI194097323, Length=257, Percent_Identity=27.6264591439689, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI20127408, Length=208, Percent_Identity=25.4807692307692, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI68989263, Length=178, Percent_Identity=26.9662921348315, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI221142681, Length=278, Percent_Identity=26.6187050359712, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1790281, Length=179, Percent_Identity=28.4916201117318, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787659, Length=247, Percent_Identity=27.9352226720648, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788682, Length=173, Percent_Identity=25.4335260115607, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17540306, Length=266, Percent_Identity=25.187969924812, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17554946, Length=262, Percent_Identity=27.0992366412214, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25145438, Length=241, Percent_Identity=25.3112033195021, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24653139, Length=244, Percent_Identity=27.4590163934426, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI20129971, Length=241, Percent_Identity=25.7261410788382, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24653477, Length=241, Percent_Identity=25.7261410788382, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI19922422, Length=258, Percent_Identity=24.8062015503876, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR017602 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.100 [H]

Molecular weight: Translated: 27138; Mature: 27007

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESPLKVWLEKDGALLRLRLARPKANIVDAAMIAALQAALTEHLPSAKLRAVLLDAEGP
CCCCCEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCC
HFSFGASVEEHMPESCAAMLQSLHALVIQMLESPVPVLVAVRGQCLGGGLEVVAAGNLIF
CCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEECCEEE
AAPGAMLGQPEIKIGVFAPAASCLLPERIGKTASEDLLFSGRSITAEEGFRIGLVTAVAE
ECCCCCCCCCCEEEEEECCHHHHHCHHHHCCCCCHHHEECCCCCCCCCCCEEEEEEEECC
DPEQAAVAYFDEHLAGLSASSLRFAVRAARIGVLERTKTKIAAVEKLYLEELMATHDAVE
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLNAFLGKRPAAWQDR
HHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SESPLKVWLEKDGALLRLRLARPKANIVDAAMIAALQAALTEHLPSAKLRAVLLDAEGP
CCCCEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCC
HFSFGASVEEHMPESCAAMLQSLHALVIQMLESPVPVLVAVRGQCLGGGLEVVAAGNLIF
CCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEEECCEEE
AAPGAMLGQPEIKIGVFAPAASCLLPERIGKTASEDLLFSGRSITAEEGFRIGLVTAVAE
ECCCCCCCCCCEEEEEECCHHHHHCHHHHCCCCCHHHEECCCCCCCCCCCEEEEEEEECC
DPEQAAVAYFDEHLAGLSASSLRFAVRAARIGVLERTKTKIAAVEKLYLEELMATHDAVE
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLNAFLGKRPAAWQDR
HHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9746358; 9738901 [H]