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The map label for this gene is ndhS [H]

Identifier: 78223342

GI number: 78223342

Start: 2401589

End: 2402104

Strand: Direct

Name: ndhS [H]

Synonym: Gmet_2135

Alternate gene names: 78223342

Gene position: 2401589-2402104 (Clockwise)

Preceding gene: 78223341

Following gene: 78223343

Centisome position: 60.08

GC content: 62.21

Gene sequence:

>516_bases
ATGTTGCAGTCAATAACCGACAAAGACGGAGTGAAGCGTTACCTGATCACCCTGAAGGTGAATGGGGATGCGAAGACCGT
GCTGGTAAAGGGAAACGCCATCCTGACCAATGTGCTGCGCGACCACCTGGACCTGACCGGCACCAAGAAGGGGTGCGAGC
TGGGGGACTGCGGTTCGTGCACCGTTCTGCTGGACGGCAAACCGGTGGATTCGTGCCTGATGCTGGCCGTTGAGGCAGAC
GGCCGGGAGATCACCACCATCGAAGGGGTTGCCGCCAACGGGGCACTGGACGCCATTCAGGAGTCCATGATCAACCACGC
CGCCGTGCAGTGCGGCTACTGCACCCCTGGCATGGTCCTCTCCGCCAAGGCACTTCTGACCCGCAACCCGCATCCCACGG
AACCGGAGGTTCGGGAGGCCATTGCCGGCAATCTCTGCCGCTGCACCGGCTACGTTCATATCGTCGAGGCCGTTCTGGCC
GCATCCCAAGGGCGAACTGCGCCGGCCGAGCATTAA

Upstream 100 bases:

>100_bases
CCGGGGTTCCGCCGAATATCGCCGGAACTTGGTCGGAGTGCTCACCAAACGGGCGCTGCGCAAAGCAATCGACGAAGGCC
ACTCGTAAGGAGGTAAATAT

Downstream 100 bases:

>100_bases
GGAGAACAACAGATGAGCGACAATCATAAAGTCATCGGCCGCAGCGTTCCCCGCATCGACGGGCCCGAGAAGGTAACCGG
CGCGGCAAAGTATACCGGGG

Product: ferredoxin:(2Fe-2S)-binding protein

Products: NA

Alternate protein names: NDH; Nicotinic acid hydroxylase small FeS subunit; NAH [H]

Number of amino acids: Translated: 171; Mature: 171

Protein sequence:

>171_residues
MLQSITDKDGVKRYLITLKVNGDAKTVLVKGNAILTNVLRDHLDLTGTKKGCELGDCGSCTVLLDGKPVDSCLMLAVEAD
GREITTIEGVAANGALDAIQESMINHAAVQCGYCTPGMVLSAKALLTRNPHPTEPEVREAIAGNLCRCTGYVHIVEAVLA
ASQGRTAPAEH

Sequences:

>Translated_171_residues
MLQSITDKDGVKRYLITLKVNGDAKTVLVKGNAILTNVLRDHLDLTGTKKGCELGDCGSCTVLLDGKPVDSCLMLAVEAD
GREITTIEGVAANGALDAIQESMINHAAVQCGYCTPGMVLSAKALLTRNPHPTEPEVREAIAGNLCRCTGYVHIVEAVLA
ASQGRTAPAEH
>Mature_171_residues
MLQSITDKDGVKRYLITLKVNGDAKTVLVKGNAILTNVLRDHLDLTGTKKGCELGDCGSCTVLLDGKPVDSCLMLAVEAD
GREITTIEGVAANGALDAIQESMINHAAVQCGYCTPGMVLSAKALLTRNPHPTEPEVREAIAGNLCRCTGYVHIVEAVLA
ASQGRTAPAEH

Specific function: Catalyzes the hydroxylation of nicotinate to 6- hydroxynicotinate. Also active against 2-pyrazinecarboxylic acid, but inactive against other nicotinate analogs [H]

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI71773480, Length=91, Percent_Identity=40.6593406593407, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI91823271, Length=148, Percent_Identity=37.1621621621622, Blast_Score=77, Evalue=5e-15,
Organism=Escherichia coli, GI1786480, Length=158, Percent_Identity=41.7721518987342, Blast_Score=126, Evalue=7e-31,
Organism=Escherichia coli, GI1789232, Length=146, Percent_Identity=44.5205479452055, Blast_Score=124, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17539860, Length=156, Percent_Identity=42.3076923076923, Blast_Score=115, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17540638, Length=133, Percent_Identity=43.609022556391, Blast_Score=114, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI32566215, Length=158, Percent_Identity=40.5063291139241, Blast_Score=112, Evalue=6e-26,
Organism=Drosophila melanogaster, GI17737937, Length=134, Percent_Identity=40.2985074626866, Blast_Score=98, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24647197, Length=153, Percent_Identity=35.2941176470588, Blast_Score=90, Evalue=9e-19,
Organism=Drosophila melanogaster, GI24647199, Length=144, Percent_Identity=37.5, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24647195, Length=153, Percent_Identity=35.2941176470588, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24647193, Length=150, Percent_Identity=36.6666666666667, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24647201, Length=151, Percent_Identity=34.4370860927152, Blast_Score=81, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.17.1.5 [H]

Molecular weight: Translated: 17983; Mature: 17983

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
4.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQSITDKDGVKRYLITLKVNGDAKTVLVKGNAILTNVLRDHLDLTGTKKGCELGDCGSC
CCCCCCCCCCCEEEEEEEEECCCEEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCE
TVLLDGKPVDSCLMLAVEADGREITTIEGVAANGALDAIQESMINHAAVQCGYCTPGMVL
EEEECCCCCCCEEEEEEECCCCEEEEECCEECCCHHHHHHHHHHHHHHEECCCCCCCHHH
SAKALLTRNPHPTEPEVREAIAGNLCRCTGYVHIVEAVLAASQGRTAPAEH
HHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MLQSITDKDGVKRYLITLKVNGDAKTVLVKGNAILTNVLRDHLDLTGTKKGCELGDCGSC
CCCCCCCCCCCEEEEEEEEECCCEEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCCE
TVLLDGKPVDSCLMLAVEADGREITTIEGVAANGALDAIQESMINHAAVQCGYCTPGMVL
EEEECCCCCCCEEEEEEECCCCEEEEECCEECCCHHHHHHHHHHHHHHEECCCCCCCHHH
SAKALLTRNPHPTEPEVREAIAGNLCRCTGYVHIVEAVLAASQGRTAPAEH
HHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA