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The map label for this gene is xylR [H]

Identifier: 78223321

GI number: 78223321

Start: 2379375

End: 2381096

Strand: Reverse

Name: xylR [H]

Synonym: Gmet_2114

Alternate gene names: 78223321

Gene position: 2381096-2379375 (Counterclockwise)

Preceding gene: 78223322

Following gene: 78223320

Centisome position: 59.57

GC content: 61.21

Gene sequence:

>1722_bases
ATGACCAAACCCCGCGGTAACCGAAATATCGCCTGCGACGCAACCAACAGCGACCTGCGCTCACTGGTGCATTTCTGTGC
CGAAACCGGTCAGATATGGCTCCACGAGCACCGTATGCTCTTGGTTCATGCCAATGCACAGGGGGGGATGCGCAAGGAGT
TGATCGACACCCTCGGCATGGAACGCGCACGGGGGCTCCTCATTCGCATGGGCTTTGCATCGGGCATGCACGATGCCGAA
GTCTTCAGCAGGCGGGATCAGGGGGCAACCGACTACGAAGCTTTCATGACCGGCACCCAGCTCCATACCCTTGAAGGCAT
CGTCAAGGTGACCACCCTCAAGCTGGAGGCCGACCGCGCCGCCGGCAGGTACTACGGCGAGTTCCTGTGGGAAAACTCCT
GGGAAGGGCAGTGGCACCGGCACCAGTACGGCACCCATTCCGAACCGGTCTGCTGGAGCCAGATCGGCTATGCCTGCGGC
TATACCACGGCCTTGATGGGGCGGCCGATTCTGTACAAGGAAATCGAGTGTGTCGGCAAGGGGGACAACAGCTGTCGCAT
CGTCGGCAAGCCCATCGAGGAATGGGAGGACTCGGCCGACTACCTGCGCATCTTCAACCAGGAGTCCATTGCCGATCAGC
TCATCGACCTGCAGACCCAGGTGGTGCAGTTGCGTTCGGCCATAAACGAGAAGGAAAAGCTCCCTGCGGACATCGTGGGG
AATTCTCCGGCCTTTCGCGTTGCCTACGGACTGCTCAAGCAGGCGGCAAACAGCCAGATTACGGTGCTTCTGTTGGGCGA
GACCGGCGTCGGCAAGGAGGTCTTCGCCCGTTCACTGCACGAAATGGGCGCCCGCCGCAACGAGTCGTTCATCGCCATCA
ACTGCGCCGCCATCCCCCACGACCTGGTGGAATCGGAGCTGTTCGGGGTGGAAAAGGGGGCCTTCACCGGCGCGCTCAAC
ACCCGGCCGGGACGCTTCGAACGCGCCCACGGTGGGACTCTGTTTCTCGATGAGATTGGTGATCTCCCCCTCTCGGCCCA
GGTGAAACTGCTGCGGGTCCTCCAGGAGGGGGAAATCGAGCGCCTTGGGGGACAGAAGGTCCGCAAGGTGGATGTGAGGC
TGGTTGCGGCGACCAATGTCGACTTGAAACAGCTGGTCAAAGAGGGGAAATTTCGATCGGATCTCTATTACCGGCTCAAT
GCTTTCCAGATCAACATCCCGCCTCTCAGGGAGCGCGAAGAGGATATCCCCCTCCTTGCCCACGGTTTTGTCGAAAAGTA
TTCCGCGATTCACGGCAAAAAGCTCACCGGTTTTACCGACAAGGCCATGCGGGCCATTCTGGCCTACCCCTGGCCGGGCA
ACATCCGCGAGTTGATGAACATGGTGGAGCGGGGGGTCATACTGGCTCCCAGCGGCTCGCGCATAGAGCTGGAACAGATG
TTCTCGGGGAGTGCCGATGGGCTGGGACTGGAATTCGGGCTGGACAGCAGCGGCAGTCTCGGTATCGACCGCCCCGCAAG
CGGGAACGACCTCCGGGATGAGGTCCTGAACGGCACCATGACCCTGGATCAGGCCGAAGCCGCACTGATAGAAGCAGCGG
TGAAAAAGGCCAATGGCAATCTCTCCGCTGCTGCCCGGCTGCTCGGACTGACCCGGCCGCAACTGGCCTATCGCCTGGGC
CGTCTGCACGATGACGGGTCCGACGCAGGTGGCGAGAAGTGA

Upstream 100 bases:

>100_bases
TTTTCCGGAAATTGACCGAATTTACCGGCGACGGGCCTCTTGCTGACGATGTGGCGATGATTATTGTCAAAATTGCACCA
TCGGATGAGGCACAGTAACG

Downstream 100 bases:

>100_bases
AAGACGCGCTGGGCATGCGGGTGCAGAGGTACCTGCTGGACCACAATGTTGCCACCGTGGCAACCAGCGGCAGCGGTGGC
CCGTGGGCGGCGGCGGTGTT

Product: Fis family transcriptional regulator

Products: NA

Alternate protein names: 67 kDa protein [H]

Number of amino acids: Translated: 573; Mature: 572

Protein sequence:

>573_residues
MTKPRGNRNIACDATNSDLRSLVHFCAETGQIWLHEHRMLLVHANAQGGMRKELIDTLGMERARGLLIRMGFASGMHDAE
VFSRRDQGATDYEAFMTGTQLHTLEGIVKVTTLKLEADRAAGRYYGEFLWENSWEGQWHRHQYGTHSEPVCWSQIGYACG
YTTALMGRPILYKEIECVGKGDNSCRIVGKPIEEWEDSADYLRIFNQESIADQLIDLQTQVVQLRSAINEKEKLPADIVG
NSPAFRVAYGLLKQAANSQITVLLLGETGVGKEVFARSLHEMGARRNESFIAINCAAIPHDLVESELFGVEKGAFTGALN
TRPGRFERAHGGTLFLDEIGDLPLSAQVKLLRVLQEGEIERLGGQKVRKVDVRLVAATNVDLKQLVKEGKFRSDLYYRLN
AFQINIPPLREREEDIPLLAHGFVEKYSAIHGKKLTGFTDKAMRAILAYPWPGNIRELMNMVERGVILAPSGSRIELEQM
FSGSADGLGLEFGLDSSGSLGIDRPASGNDLRDEVLNGTMTLDQAEAALIEAAVKKANGNLSAAARLLGLTRPQLAYRLG
RLHDDGSDAGGEK

Sequences:

>Translated_573_residues
MTKPRGNRNIACDATNSDLRSLVHFCAETGQIWLHEHRMLLVHANAQGGMRKELIDTLGMERARGLLIRMGFASGMHDAE
VFSRRDQGATDYEAFMTGTQLHTLEGIVKVTTLKLEADRAAGRYYGEFLWENSWEGQWHRHQYGTHSEPVCWSQIGYACG
YTTALMGRPILYKEIECVGKGDNSCRIVGKPIEEWEDSADYLRIFNQESIADQLIDLQTQVVQLRSAINEKEKLPADIVG
NSPAFRVAYGLLKQAANSQITVLLLGETGVGKEVFARSLHEMGARRNESFIAINCAAIPHDLVESELFGVEKGAFTGALN
TRPGRFERAHGGTLFLDEIGDLPLSAQVKLLRVLQEGEIERLGGQKVRKVDVRLVAATNVDLKQLVKEGKFRSDLYYRLN
AFQINIPPLREREEDIPLLAHGFVEKYSAIHGKKLTGFTDKAMRAILAYPWPGNIRELMNMVERGVILAPSGSRIELEQM
FSGSADGLGLEFGLDSSGSLGIDRPASGNDLRDEVLNGTMTLDQAEAALIEAAVKKANGNLSAAARLLGLTRPQLAYRLG
RLHDDGSDAGGEK
>Mature_572_residues
TKPRGNRNIACDATNSDLRSLVHFCAETGQIWLHEHRMLLVHANAQGGMRKELIDTLGMERARGLLIRMGFASGMHDAEV
FSRRDQGATDYEAFMTGTQLHTLEGIVKVTTLKLEADRAAGRYYGEFLWENSWEGQWHRHQYGTHSEPVCWSQIGYACGY
TTALMGRPILYKEIECVGKGDNSCRIVGKPIEEWEDSADYLRIFNQESIADQLIDLQTQVVQLRSAINEKEKLPADIVGN
SPAFRVAYGLLKQAANSQITVLLLGETGVGKEVFARSLHEMGARRNESFIAINCAAIPHDLVESELFGVEKGAFTGALNT
RPGRFERAHGGTLFLDEIGDLPLSAQVKLLRVLQEGEIERLGGQKVRKVDVRLVAATNVDLKQLVKEGKFRSDLYYRLNA
FQINIPPLREREEDIPLLAHGFVEKYSAIHGKKLTGFTDKAMRAILAYPWPGNIRELMNMVERGVILAPSGSRIELEQMF
SGSADGLGLEFGLDSSGSLGIDRPASGNDLRDEVLNGTMTLDQAEAALIEAAVKKANGNLSAAARLLGLTRPQLAYRLGR
LHDDGSDAGGEK

Specific function: Regulatory protein of the TOL plasmid xyl operons. In the presence of m-xylene or m-methylbenzyl alcohol xylR activates both the xylCMABN operon and the regulatory gene xylS; xylS itself activates the xylXYZLTEGFJQKIH operon. XylR interacts with sigma- 54

COG id: COG1221

COG function: function code KT; Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI87082117, Length=330, Percent_Identity=45.7575757575758, Blast_Score=268, Evalue=9e-73,
Organism=Escherichia coli, GI1788550, Length=370, Percent_Identity=40.5405405405405, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI1789087, Length=367, Percent_Identity=42.7792915531335, Blast_Score=256, Evalue=3e-69,
Organism=Escherichia coli, GI1790437, Length=327, Percent_Identity=44.3425076452599, Blast_Score=253, Evalue=3e-68,
Organism=Escherichia coli, GI1790299, Length=335, Percent_Identity=41.4925373134328, Blast_Score=237, Evalue=2e-63,
Organism=Escherichia coli, GI1789233, Length=240, Percent_Identity=48.3333333333333, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI1788905, Length=269, Percent_Identity=44.9814126394052, Blast_Score=228, Evalue=1e-60,
Organism=Escherichia coli, GI87081872, Length=320, Percent_Identity=41.5625, Blast_Score=218, Evalue=1e-57,
Organism=Escherichia coli, GI87082152, Length=244, Percent_Identity=45.9016393442623, Blast_Score=213, Evalue=3e-56,
Organism=Escherichia coli, GI1786524, Length=336, Percent_Identity=37.797619047619, Blast_Score=201, Evalue=7e-53,
Organism=Escherichia coli, GI1787583, Length=256, Percent_Identity=37.5, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI1789828, Length=255, Percent_Identity=40, Blast_Score=158, Evalue=9e-40,
Organism=Escherichia coli, GI87081858, Length=391, Percent_Identity=30.1790281329923, Blast_Score=146, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR004096
- InterPro:   IPR010523
- ProDom:   PD485437 [H]

Pfam domain/function: PF02954 HTH_8; PF00158 Sigma54_activat; PF02830 V4R; PF06505 XylR_N [H]

EC number: NA

Molecular weight: Translated: 63306; Mature: 63175

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKPRGNRNIACDATNSDLRSLVHFCAETGQIWLHEHRMLLVHANAQGGMRKELIDTLGM
CCCCCCCCEEEECCCCHHHHHHHHHHHHCCCEEEEECEEEEEEECCCCCHHHHHHHHHCH
ERARGLLIRMGFASGMHDAEVFSRRDQGATDYEAFMTGTQLHTLEGIVKVTTLKLEADRA
HHHCCEEEEECCCCCCCHHHHHHHCCCCCCCHHHHHCCCHHHHHHHEEEEEEEEEECCHH
AGRYYGEFLWENSWEGQWHRHQYGTHSEPVCWSQIGYACGYTTALMGRPILYKEIECVGK
HHHHHHHHHCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHEECC
GDNSCRIVGKPIEEWEDSADYLRIFNQESIADQLIDLQTQVVQLRSAINEKEKLPADIVG
CCCCEEEECCCHHHHCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCHHHCCCHHHCC
NSPAFRVAYGLLKQAANSQITVLLLGETGVGKEVFARSLHEMGARRNESFIAINCAAIPH
CCCHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCH
DLVESELFGVEKGAFTGALNTRPGRFERAHGGTLFLDEIGDLPLSAQVKLLRVLQEGEIE
HHHHHHHHCCCCCCEECCCCCCCCCCEECCCCEEEEHHHCCCCCHHHHHHHHHHHCCCHH
RLGGQKVRKVDVRLVAATNVDLKQLVKEGKFRSDLYYRLNAFQINIPPLREREEDIPLLA
HHCCCCEEEEEEEEEEECCCCHHHHHHCCCCCCCEEEEEEEEEEECCCCCCCCCCCCHHH
HGFVEKYSAIHGKKLTGFTDKAMRAILAYPWPGNIRELMNMVERGVILAPSGSRIELEQM
HHHHHHHHHHCCCCCCCCHHHHHHHHEECCCCCCHHHHHHHHHCCEEECCCCCEEEHHHH
FSGSADGLGLEFGLDSSGSLGIDRPASGNDLRDEVLNGTMTLDQAEAALIEAAVKKANGN
HCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCC
LSAAARLLGLTRPQLAYRLGRLHDDGSDAGGEK
HHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TKPRGNRNIACDATNSDLRSLVHFCAETGQIWLHEHRMLLVHANAQGGMRKELIDTLGM
CCCCCCCEEEECCCCHHHHHHHHHHHHCCCEEEEECEEEEEEECCCCCHHHHHHHHHCH
ERARGLLIRMGFASGMHDAEVFSRRDQGATDYEAFMTGTQLHTLEGIVKVTTLKLEADRA
HHHCCEEEEECCCCCCCHHHHHHHCCCCCCCHHHHHCCCHHHHHHHEEEEEEEEEECCHH
AGRYYGEFLWENSWEGQWHRHQYGTHSEPVCWSQIGYACGYTTALMGRPILYKEIECVGK
HHHHHHHHHCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHEECC
GDNSCRIVGKPIEEWEDSADYLRIFNQESIADQLIDLQTQVVQLRSAINEKEKLPADIVG
CCCCEEEECCCHHHHCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCHHHCCCHHHCC
NSPAFRVAYGLLKQAANSQITVLLLGETGVGKEVFARSLHEMGARRNESFIAINCAAIPH
CCCHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCH
DLVESELFGVEKGAFTGALNTRPGRFERAHGGTLFLDEIGDLPLSAQVKLLRVLQEGEIE
HHHHHHHHCCCCCCEECCCCCCCCCCEECCCCEEEEHHHCCCCCHHHHHHHHHHHCCCHH
RLGGQKVRKVDVRLVAATNVDLKQLVKEGKFRSDLYYRLNAFQINIPPLREREEDIPLLA
HHCCCCEEEEEEEEEEECCCCHHHHHHCCCCCCCEEEEEEEEEEECCCCCCCCCCCCHHH
HGFVEKYSAIHGKKLTGFTDKAMRAILAYPWPGNIRELMNMVERGVILAPSGSRIELEQM
HHHHHHHHHHCCCCCCCCHHHHHHHHEECCCCCCHHHHHHHHHCCEEECCCCCEEEHHHH
FSGSADGLGLEFGLDSSGSLGIDRPASGNDLRDEVLNGTMTLDQAEAALIEAAVKKANGN
HCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCC
LSAAARLLGLTRPQLAYRLGRLHDDGSDAGGEK
HHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3169574; 2993247; 2430049 [H]