Click here to switch to the map view.

The map label for this gene is ppaX [H]

Identifier: 78223319

GI number: 78223319

Start: 2378160

End: 2378879

Strand: Reverse

Name: ppaX [H]

Synonym: Gmet_2112

Alternate gene names: 78223319

Gene position: 2378879-2378160 (Counterclockwise)

Preceding gene: 78223320

Following gene: 78223306

Centisome position: 59.51

GC content: 64.03

Gene sequence:

>720_bases
ATGGCATTTGAAGGGCATTCTACGTTTGGGACCGAGGCAGGGCCCGGGGCGGAGTTGTGTTGCTCGCTCGCCGTCAGGGC
GGTACTGTTCGATCTTGACGGTACGCTGGTCGATTCGGTCGGCGCCTACATCGAGGTGGCGCGGGTCGCTGCCGAGCCGT
TCGGCTTTGAGGTGACAGAGGAACAGGTGCGGCTGGCGCTCTCCTCTGGGGGCAGCTTCTGGAAAGGCATTGTGCCGGAG
GATCGGAGTGATGGCGCTGCCATCTTGAAGGCTATTTCCGCCAATGCCGCCCGGGAGTGGCCGCGGATACTGCGGGAGCA
CGGCAAGCTGTTCGACGGGGTGCTGGAAACGCTCGATGCGCTGAAAGGTCTCGGGATACTGCTCGGCATCGTGAGCGGCG
CCCGCCCCGAAGTTCTGGAACTGCTTCGGCCAAACGGTGTCCTGGAGCGCTTTGACGCGGTCGTGCTCGGCAAGGATGTC
TCCAAGAGCAAGCCCGACCCCGAGGGGATCCTTAAATGCCTGGATCACCTCAGCGTCGCACCCGCCGACGCCCTCTACGT
GGGTGATGCCCCGATAGATATTTTCGCCAGCCGCGCCGCCGGCGTGCGAGTGGTGAGCGTGCTCACCGGGGCCGGCGACA
GCGCCTCCCTGTCGATGCATGCTCCTGACCGGCTGATTCCCTCCCACACCGTACTCCCTGCTATCGTCACATCGTTCTGA

Upstream 100 bases:

>100_bases
CGTCTCTATTTTATCGACAATTCACTCGGCTTGGGCAATCGCGACGAGGTTGATCTGAGCATGGCAGATAAGACTTGAAC
CGGTAGTTCCGGGAGTCATC

Downstream 100 bases:

>100_bases
ACCGGCGGATTCAACGGCTGGTGCTCATTACTTCAACTTGGTCACGCATGGTGTCGGAAGGGGCGGATCTCTCGCTCCGA
AGCGATCCAGCGTCACCAGC

Product: HAD family hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 239; Mature: 238

Protein sequence:

>239_residues
MAFEGHSTFGTEAGPGAELCCSLAVRAVLFDLDGTLVDSVGAYIEVARVAAEPFGFEVTEEQVRLALSSGGSFWKGIVPE
DRSDGAAILKAISANAAREWPRILREHGKLFDGVLETLDALKGLGILLGIVSGARPEVLELLRPNGVLERFDAVVLGKDV
SKSKPDPEGILKCLDHLSVAPADALYVGDAPIDIFASRAAGVRVVSVLTGAGDSASLSMHAPDRLIPSHTVLPAIVTSF

Sequences:

>Translated_239_residues
MAFEGHSTFGTEAGPGAELCCSLAVRAVLFDLDGTLVDSVGAYIEVARVAAEPFGFEVTEEQVRLALSSGGSFWKGIVPE
DRSDGAAILKAISANAAREWPRILREHGKLFDGVLETLDALKGLGILLGIVSGARPEVLELLRPNGVLERFDAVVLGKDV
SKSKPDPEGILKCLDHLSVAPADALYVGDAPIDIFASRAAGVRVVSVLTGAGDSASLSMHAPDRLIPSHTVLPAIVTSF
>Mature_238_residues
AFEGHSTFGTEAGPGAELCCSLAVRAVLFDLDGTLVDSVGAYIEVARVAAEPFGFEVTEEQVRLALSSGGSFWKGIVPED
RSDGAAILKAISANAAREWPRILREHGKLFDGVLETLDALKGLGILLGIVSGARPEVLELLRPNGVLERFDAVVLGKDVS
KSKPDPEGILKCLDHLSVAPADALYVGDAPIDIFASRAAGVRVVSVLTGAGDSASLSMHAPDRLIPSHTVLPAIVTSF

Specific function: Hydrolyzes pyrophosphate formed during P-Ser-HPr dephosphorylation by HPrK/P. Might play a role in controlling the intracellular pyrophosphate pool [H]

COG id: COG0546

COG function: function code R; Predicted phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HAD-like hydrolase superfamily. PpaX family [H]

Homologues:

Organism=Homo sapiens, GI23308749, Length=237, Percent_Identity=27.0042194092827, Blast_Score=75, Evalue=6e-14,
Organism=Escherichia coli, GI1789787, Length=236, Percent_Identity=32.2033898305085, Blast_Score=77, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006439
- InterPro:   IPR006402
- InterPro:   IPR005833 [H]

Pfam domain/function: PF00702 Hydrolase [H]

EC number: =3.6.1.1 [H]

Molecular weight: Translated: 25012; Mature: 24881

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFEGHSTFGTEAGPGAELCCSLAVRAVLFDLDGTLVDSVGAYIEVARVAAEPFGFEVTE
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCH
EQVRLALSSGGSFWKGIVPEDRSDGAAILKAISANAAREWPRILREHGKLFDGVLETLDA
HHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKGLGILLGIVSGARPEVLELLRPNGVLERFDAVVLGKDVSKSKPDPEGILKCLDHLSVA
HHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCC
PADALYVGDAPIDIFASRAAGVRVVSVLTGAGDSASLSMHAPDRLIPSHTVLPAIVTSF
CCCEEEECCCCHHHHHHHCCCCEEEHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
AFEGHSTFGTEAGPGAELCCSLAVRAVLFDLDGTLVDSVGAYIEVARVAAEPFGFEVTE
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCH
EQVRLALSSGGSFWKGIVPEDRSDGAAILKAISANAAREWPRILREHGKLFDGVLETLDA
HHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKGLGILLGIVSGARPEVLELLRPNGVLERFDAVVLGKDVSKSKPDPEGILKCLDHLSVA
HHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCC
PADALYVGDAPIDIFASRAAGVRVVSVLTGAGDSASLSMHAPDRLIPSHTVLPAIVTSF
CCCEEEECCCCHHHHHHHCCCCEEEHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 9465101; 12359880 [H]