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The map label for this gene is etfA [H]

Identifier: 78223273

GI number: 78223273

Start: 2323563

End: 2324909

Strand: Reverse

Name: etfA [H]

Synonym: Gmet_2066

Alternate gene names: 78223273

Gene position: 2324909-2323563 (Counterclockwise)

Preceding gene: 78223274

Following gene: 78223272

Centisome position: 58.16

GC content: 63.4

Gene sequence:

>1347_bases
ATGACTGAAACGAAAAAAACAATCAAGAAGCCCCGCGGCAAGGCCCGCGTTCTCGACGGGAAATGCATTGCCTGCGGTGC
CCGGTGCGAGAGTTCCTGTCCGGTGGACGGCATCGAGATGAATGCCGCCGGTGAGCCGACGGTACTTGGGGAGAAGTGCA
TCGGCTGCGCCAAGTGCGTCAAGGTCTGCGCTGCCGGTGCCCTGGAGATGTTTTACACCCCCGAGGAACTGGAATTGCTG
AAGCAGTGGGACCAGCAGCACCATACCGTCGAGGAAGAGGTTGACGAAGGGGAAAAGCAGCTTCGGGAGATGCTCGCCCG
CTATCGGGGTGTCTGGGTCTTCATTGAGCAGTACGACGGCGAGGCCGCCAAGGTCTCCTGGGAACTTCTGGGAACCGGCG
CGGAACTGGCCAAAAGCCTCGGGGTGGAACTCTCCGCGGTGATCATCGGCCACAAGGTTGAACACCTCTGTGACGAAGCG
TTCGGCTACGGCGCCCACAAGGCCATCACCCTCGATGCCCCCGTGTTCGCCAACTACCGGACCAAGCCGTACACCGACGC
CATCTGCCACCTGATCAGCAAGCACCGGCCCGAGATCATCCTCATGGGGGCCACTGGCCAGGGGCGCGACCTGGCAGGCG
CCGTGGCGACGATCGTAAAGACCGGCCTCACCGCCGACTGCACGGGTCTCGGCATTGACGACAAGCGCAACCTCATGCAG
ACCCGCCCCGCTTTCGGCGGCAACATCATGGCCACCATCATGTGCGACCGGTTCCGGCCCCAGATGTCCACGGTCCGTCC
CCACGTCATGCCCATGCCTGAATTCCAGGTGGGGCGAACCGGGGAAGTGGTGCGCGAGCAGTACGACCTCCGCGAGGAGG
ATGTGCTGGTCAAGGTGATCGAGGTCTTGAGCGACAAGGGTGGCAAGGACATCGACATCGCCGGCGCCGAGATCATCGTC
TCCGGGGGGCGGGGTCTCATGAACAAAGAGAACTTCGCCATGCTCCAGGAACTGGCCGACGAGCTGGGCGGGGTGGTCGG
CGCTTCGCGTAGTGCCGTTGACGCCGGCTGGATGCCCCACAGCCGCCAGGTGGGCCAGACCGGCAAGACCGTCCGTCCCA
AGATCTACGTCGCCTGCGGCATCTCCGGGGCGATCCAGCACCTGGTGGGGATGCAGGACTCCGACGTCGTCATCGCCATC
AACCGCGATCCCGAGGCCCCTATCTTCCAGGTGGCCACCTACGGCATTGTCGGCGATCTCTTCCAGATCGTTCCTTCAAT
CATCCGCAAGGTGAGAAGTCTGAAAGGCCAGCGCGGCGGTGTCATTCCCGACCGGGTCGCGGTCTGA

Upstream 100 bases:

>100_bases
GCGACGGTGTCGGTGATCCGGAGGGGACGGCCAACCTCCTGATCGACAAGCTGCTCAGCAAGGATCTCTTGGCAGTGTGA
GATGTGAAGGGGGAATGACG

Downstream 100 bases:

>100_bases
TCCTTCGCCGTCATCGCAATATCGTTTGTGAGGTGTATCATGGCAATCAACCACTCGCTCTTCATTCCGCTCTTCGTCGT
GGCCGTCGCGACTTTCTGCT

Product: electron transfer flavoprotein subunit alpha

Products: NA

Alternate protein names: Alpha-ETF; Electron transfer flavoprotein large subunit; ETFLS [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MTETKKTIKKPRGKARVLDGKCIACGARCESSCPVDGIEMNAAGEPTVLGEKCIGCAKCVKVCAAGALEMFYTPEELELL
KQWDQQHHTVEEEVDEGEKQLREMLARYRGVWVFIEQYDGEAAKVSWELLGTGAELAKSLGVELSAVIIGHKVEHLCDEA
FGYGAHKAITLDAPVFANYRTKPYTDAICHLISKHRPEIILMGATGQGRDLAGAVATIVKTGLTADCTGLGIDDKRNLMQ
TRPAFGGNIMATIMCDRFRPQMSTVRPHVMPMPEFQVGRTGEVVREQYDLREEDVLVKVIEVLSDKGGKDIDIAGAEIIV
SGGRGLMNKENFAMLQELADELGGVVGASRSAVDAGWMPHSRQVGQTGKTVRPKIYVACGISGAIQHLVGMQDSDVVIAI
NRDPEAPIFQVATYGIVGDLFQIVPSIIRKVRSLKGQRGGVIPDRVAV

Sequences:

>Translated_448_residues
MTETKKTIKKPRGKARVLDGKCIACGARCESSCPVDGIEMNAAGEPTVLGEKCIGCAKCVKVCAAGALEMFYTPEELELL
KQWDQQHHTVEEEVDEGEKQLREMLARYRGVWVFIEQYDGEAAKVSWELLGTGAELAKSLGVELSAVIIGHKVEHLCDEA
FGYGAHKAITLDAPVFANYRTKPYTDAICHLISKHRPEIILMGATGQGRDLAGAVATIVKTGLTADCTGLGIDDKRNLMQ
TRPAFGGNIMATIMCDRFRPQMSTVRPHVMPMPEFQVGRTGEVVREQYDLREEDVLVKVIEVLSDKGGKDIDIAGAEIIV
SGGRGLMNKENFAMLQELADELGGVVGASRSAVDAGWMPHSRQVGQTGKTVRPKIYVACGISGAIQHLVGMQDSDVVIAI
NRDPEAPIFQVATYGIVGDLFQIVPSIIRKVRSLKGQRGGVIPDRVAV
>Mature_447_residues
TETKKTIKKPRGKARVLDGKCIACGARCESSCPVDGIEMNAAGEPTVLGEKCIGCAKCVKVCAAGALEMFYTPEELELLK
QWDQQHHTVEEEVDEGEKQLREMLARYRGVWVFIEQYDGEAAKVSWELLGTGAELAKSLGVELSAVIIGHKVEHLCDEAF
GYGAHKAITLDAPVFANYRTKPYTDAICHLISKHRPEIILMGATGQGRDLAGAVATIVKTGLTADCTGLGIDDKRNLMQT
RPAFGGNIMATIMCDRFRPQMSTVRPHVMPMPEFQVGRTGEVVREQYDLREEDVLVKVIEVLSDKGGKDIDIAGAEIIVS
GGRGLMNKENFAMLQELADELGGVVGASRSAVDAGWMPHSRQVGQTGKTVRPKIYVACGISGAIQHLVGMQDSDVVIAIN
RDPEAPIFQVATYGIVGDLFQIVPSIIRKVRSLKGQRGGVIPDRVAV

Specific function: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) [H]

COG id: COG2025

COG function: function code C; Electron transfer flavoprotein, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ETF alpha-subunit/fixB family [H]

Homologues:

Organism=Homo sapiens, GI4503607, Length=338, Percent_Identity=36.3905325443787, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI189181759, Length=232, Percent_Identity=43.1034482758621, Blast_Score=170, Evalue=2e-42,
Organism=Escherichia coli, GI1787990, Length=330, Percent_Identity=27.8787878787879, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1786226, Length=248, Percent_Identity=29.4354838709677, Blast_Score=112, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17506929, Length=116, Percent_Identity=61.2068965517241, Blast_Score=159, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6325261, Length=206, Percent_Identity=39.3203883495146, Blast_Score=152, Evalue=1e-37,
Organism=Drosophila melanogaster, GI17136898, Length=299, Percent_Identity=38.1270903010033, Blast_Score=171, Evalue=7e-43,
Organism=Drosophila melanogaster, GI24652801, Length=299, Percent_Identity=38.1270903010033, Blast_Score=171, Evalue=7e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001308
- InterPro:   IPR014730
- InterPro:   IPR014731
- InterPro:   IPR018206
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01012 ETF; PF00766 ETF_alpha [H]

EC number: NA

Molecular weight: Translated: 48589; Mature: 48458

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00696 ETF_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTETKKTIKKPRGKARVLDGKCIACGARCESSCPVDGIEMNAAGEPTVLGEKCIGCAKCV
CCCCHHHHHCCCCCEEEECCCEEEECCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHH
KVCAAGALEMFYTPEELELLKQWDQQHHTVEEEVDEGEKQLREMLARYRGVWVFIEQYDG
HHHHCCHHHHHCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCC
EAAKVSWELLGTGAELAKSLGVELSAVIIGHKVEHLCDEAFGYGAHKAITLDAPVFANYR
CCCEEEEEEECCHHHHHHHHCCEEEEHHHHHHHHHHHHHHHCCCCCEEEEECCCEEECCC
TKPYTDAICHLISKHRPEIILMGATGQGRDLAGAVATIVKTGLTADCTGLGIDDKRNLMQ
CCCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
TRPAFGGNIMATIMCDRFRPQMSTVRPHVMPMPEFQVGRTGEVVREQYDLREEDVLVKVI
CCCCCCCCEEEEEEHHHCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHH
EVLSDKGGKDIDIAGAEIIVSGGRGLMNKENFAMLQELADELGGVVGASRSAVDAGWMPH
HHHHCCCCCEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
SRQVGQTGKTVRPKIYVACGISGAIQHLVGMQDSDVVIAINRDPEAPIFQVATYGIVGDL
CCCCCCCCCCCCCEEEEEECCHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHH
FQIVPSIIRKVRSLKGQRGGVIPDRVAV
HHHHHHHHHHHHHHCCCCCCCCCHHCCC
>Mature Secondary Structure 
TETKKTIKKPRGKARVLDGKCIACGARCESSCPVDGIEMNAAGEPTVLGEKCIGCAKCV
CCCHHHHHCCCCCEEEECCCEEEECCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHH
KVCAAGALEMFYTPEELELLKQWDQQHHTVEEEVDEGEKQLREMLARYRGVWVFIEQYDG
HHHHCCHHHHHCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCC
EAAKVSWELLGTGAELAKSLGVELSAVIIGHKVEHLCDEAFGYGAHKAITLDAPVFANYR
CCCEEEEEEECCHHHHHHHHCCEEEEHHHHHHHHHHHHHHHCCCCCEEEEECCCEEECCC
TKPYTDAICHLISKHRPEIILMGATGQGRDLAGAVATIVKTGLTADCTGLGIDDKRNLMQ
CCCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHH
TRPAFGGNIMATIMCDRFRPQMSTVRPHVMPMPEFQVGRTGEVVREQYDLREEDVLVKVI
CCCCCCCCEEEEEEHHHCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHH
EVLSDKGGKDIDIAGAEIIVSGGRGLMNKENFAMLQELADELGGVVGASRSAVDAGWMPH
HHHHCCCCCEEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
SRQVGQTGKTVRPKIYVACGISGAIQHLVGMQDSDVVIAINRDPEAPIFQVATYGIVGDL
CCCCCCCCCCCCCEEEEEECCHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHH
FQIVPSIIRKVRSLKGQRGGVIPDRVAV
HHHHHHHHHHHHHHCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA