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The map label for this gene is mutL

Identifier: 78223260

GI number: 78223260

Start: 2304458

End: 2306326

Strand: Reverse

Name: mutL

Synonym: Gmet_2053

Alternate gene names: 78223260

Gene position: 2306326-2304458 (Counterclockwise)

Preceding gene: 78223261

Following gene: 78223259

Centisome position: 57.7

GC content: 64.85

Gene sequence:

>1869_bases
ATGCTCCGGGTTTTTCATTTTTATGGTATGCTGCGTCTCCCGCGCAGCGGAATTGAACAATCGCTCAAGGGGGAGAGGTG
CACCGTGTCGACCCAGATCCGAATCCTGCCTGAAAACCTGACCAACAAGATCGCCGCCGGCGAGGTGGTGGAACGCCCTG
CTTCGGTGGTTAAGGAACTGGTGGAAAATTCCCTGGACGCCGGGTGTCGCGACATCATTGTCGAGATCGAGGCAGGGGGG
CGGCGCCTCATCCGGGTCACCGACGACGGGAGCGGCATGTCCCGGGAGGATGCCCTCCTTTCCCTTGAACGCCACGCCAC
CAGCAAGATCGCCTCCGATGACGACCTCTTCTCCCTCTGCACCCTCGGTTTCCGGGGAGAGGCGCTCCCGTCCATTGCCT
CCGTCTCCCGGTTCTCCCTTGCCACCCGCCAGCGGGGAGCCATCGAGGGGACGGAAATCTATGCCGAGGGGGGACGGATC
AAAGAGGTGAAGGCGTGCGGCATGGCCGAGGGGACGGTCATCACCGTGCGGAACCTCTTCTTCAATACCCCGGCACGGCT
CAAGTTCATGAAGAGCGCCGAGACCGAGGCCGGCCATGTGGGGGATCTTCTCACCCGCCTCGCCATCTCCCGCCCCGAGG
TGCGCTTCACCTATGTGAACGACGGCAAGACTGTCTTCCGGGCCCTGAACGGCACCATGGAGGAGCGGGTGGCGGCGCTG
CTGGGGCGCACCATTGCCGGAGCCCTGTACCCCCTGGACTCCACCGTGGAAGGGGTGACGGTGCGGGGGCTCGTGGCCCG
GCCCGACGTGAGCCGCTCCGCCGCAGGGCACCTCTACACCTTCATCAATGGCCGCTTCATCCGTGATCGGGTGGTGCAAC
ACGCCGTACTCCAAGCCTACCGCAACTTCCTGGAGCGGGGGCGCTACCCTGTGGTGGTCCTCTTTATCCAGGTACCGGCA
GGGGATGTGGACGTGAACGTCCATCCCACCAAGCATGAGGTCCGGTTCCGGCAACAGGGGGTCGTTCACGACGTGATCCA
GGGGGTGATCGAGGAGGCGCTTCGCCCGACCCCCTGGCTGCGCAAGGAATCGCAGTCGACAGTTTCCTCACCCCCCCCTG
AACGCCGCGAGCCAGCCACGAGTTCGGAACGGGTCGCCGAGGTGCGGGAGCTTCTCGTCAACTACCGTCCCTCGCCAGCC
CCAAGCCGTCCCTTCTTTCAGCCTCTGCCTGCGGTTGTTCCGGCACCAGACCAGTCCGCGGAGGAACCGGACCGGCCCAT
GGATCGCGGCTACTTCTCACGGCTTGCGATCATCGGGCAGTTTCATGCCTCCTACATTCTCTGCCAGGACGGAAGCGACC
TGGTTATCATCGACCAGCACGCGGCCCACGAACGGGTGGCCTTCGAGCGCCTCAAGGCCCAGTTCGCGGCCGGCGGGGTG
GAAGGGCAGGGGCTCCTTTTCCCCGACACCCTTGAGCTCTCCCATCGTGAGGTGGCGGAACTGCGCGAACATGGCGAGGA
GCTGCGCCGCATCGGGTTTGATCTGGATGAGTTCGGCGGCACCACCTGGGTGGTGAAAGGTGTGCCGCGGCTTCTGGCCG
GGAAGGACTACCTCCGCATCCTGAGGGATACCCTGGAGGAGTTTCAGGCGGTCGGTGCGAACCGTTCCGTTGCCGACGCC
GTAGAGGAGATCCTTACCCGCATCGCCTGCCACAGCGTGGTGCGGGGAGAACACCCCCTCACCACCGCCCAGATCGAGGC
CCTGTTTGCCCAGATGGACGCCACCGACTACTCCACCAACTGCCCCCACGGCCGCCCCGTCCTGCAGCGGCTCACCCTTG
CCGAGGTGGAGCGGATGTTCAAACGGTAA

Upstream 100 bases:

>100_bases
TCCCGGACTGGGACCGGCACCGTACGCCCGGAAGCAACTTTTCCTCGGCGTACGGTGCATTTTTTTTTCAGAAGAACAGG
CACGTGTGGCTCGGAGAGAA

Downstream 100 bases:

>100_bases
GGAGTCATGGCGTGAAGGAAGAAGAAAAGACCAGGCTCGTCATCGTCCAGGGACCCACGGCATCGGGAAAGTCGGCGCTG
GCCCTGGAGCTTGCCGAGCG

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 622; Mature: 622

Protein sequence:

>622_residues
MLRVFHFYGMLRLPRSGIEQSLKGERCTVSTQIRILPENLTNKIAAGEVVERPASVVKELVENSLDAGCRDIIVEIEAGG
RRLIRVTDDGSGMSREDALLSLERHATSKIASDDDLFSLCTLGFRGEALPSIASVSRFSLATRQRGAIEGTEIYAEGGRI
KEVKACGMAEGTVITVRNLFFNTPARLKFMKSAETEAGHVGDLLTRLAISRPEVRFTYVNDGKTVFRALNGTMEERVAAL
LGRTIAGALYPLDSTVEGVTVRGLVARPDVSRSAAGHLYTFINGRFIRDRVVQHAVLQAYRNFLERGRYPVVVLFIQVPA
GDVDVNVHPTKHEVRFRQQGVVHDVIQGVIEEALRPTPWLRKESQSTVSSPPPERREPATSSERVAEVRELLVNYRPSPA
PSRPFFQPLPAVVPAPDQSAEEPDRPMDRGYFSRLAIIGQFHASYILCQDGSDLVIIDQHAAHERVAFERLKAQFAAGGV
EGQGLLFPDTLELSHREVAELREHGEELRRIGFDLDEFGGTTWVVKGVPRLLAGKDYLRILRDTLEEFQAVGANRSVADA
VEEILTRIACHSVVRGEHPLTTAQIEALFAQMDATDYSTNCPHGRPVLQRLTLAEVERMFKR

Sequences:

>Translated_622_residues
MLRVFHFYGMLRLPRSGIEQSLKGERCTVSTQIRILPENLTNKIAAGEVVERPASVVKELVENSLDAGCRDIIVEIEAGG
RRLIRVTDDGSGMSREDALLSLERHATSKIASDDDLFSLCTLGFRGEALPSIASVSRFSLATRQRGAIEGTEIYAEGGRI
KEVKACGMAEGTVITVRNLFFNTPARLKFMKSAETEAGHVGDLLTRLAISRPEVRFTYVNDGKTVFRALNGTMEERVAAL
LGRTIAGALYPLDSTVEGVTVRGLVARPDVSRSAAGHLYTFINGRFIRDRVVQHAVLQAYRNFLERGRYPVVVLFIQVPA
GDVDVNVHPTKHEVRFRQQGVVHDVIQGVIEEALRPTPWLRKESQSTVSSPPPERREPATSSERVAEVRELLVNYRPSPA
PSRPFFQPLPAVVPAPDQSAEEPDRPMDRGYFSRLAIIGQFHASYILCQDGSDLVIIDQHAAHERVAFERLKAQFAAGGV
EGQGLLFPDTLELSHREVAELREHGEELRRIGFDLDEFGGTTWVVKGVPRLLAGKDYLRILRDTLEEFQAVGANRSVADA
VEEILTRIACHSVVRGEHPLTTAQIEALFAQMDATDYSTNCPHGRPVLQRLTLAEVERMFKR
>Mature_622_residues
MLRVFHFYGMLRLPRSGIEQSLKGERCTVSTQIRILPENLTNKIAAGEVVERPASVVKELVENSLDAGCRDIIVEIEAGG
RRLIRVTDDGSGMSREDALLSLERHATSKIASDDDLFSLCTLGFRGEALPSIASVSRFSLATRQRGAIEGTEIYAEGGRI
KEVKACGMAEGTVITVRNLFFNTPARLKFMKSAETEAGHVGDLLTRLAISRPEVRFTYVNDGKTVFRALNGTMEERVAAL
LGRTIAGALYPLDSTVEGVTVRGLVARPDVSRSAAGHLYTFINGRFIRDRVVQHAVLQAYRNFLERGRYPVVVLFIQVPA
GDVDVNVHPTKHEVRFRQQGVVHDVIQGVIEEALRPTPWLRKESQSTVSSPPPERREPATSSERVAEVRELLVNYRPSPA
PSRPFFQPLPAVVPAPDQSAEEPDRPMDRGYFSRLAIIGQFHASYILCQDGSDLVIIDQHAAHERVAFERLKAQFAAGGV
EGQGLLFPDTLELSHREVAELREHGEELRRIGFDLDEFGGTTWVVKGVPRLLAGKDYLRILRDTLEEFQAVGANRSVADA
VEEILTRIACHSVVRGEHPLTTAQIEALFAQMDATDYSTNCPHGRPVLQRLTLAEVERMFKR

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=329, Percent_Identity=34.0425531914894, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI4505911, Length=342, Percent_Identity=30.1169590643275, Blast_Score=143, Evalue=5e-34,
Organism=Homo sapiens, GI189458898, Length=342, Percent_Identity=30.1169590643275, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI189458896, Length=338, Percent_Identity=28.698224852071, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI4505913, Length=343, Percent_Identity=29.1545189504373, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI310128478, Length=343, Percent_Identity=29.1545189504373, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI263191589, Length=235, Percent_Identity=28.0851063829787, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI310128480, Length=296, Percent_Identity=27.7027027027027, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI91992160, Length=361, Percent_Identity=23.8227146814404, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI91992162, Length=361, Percent_Identity=23.8227146814404, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1790612, Length=519, Percent_Identity=37.7649325626204, Blast_Score=285, Evalue=6e-78,
Organism=Caenorhabditis elegans, GI71991825, Length=317, Percent_Identity=36.5930599369085, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17562796, Length=382, Percent_Identity=27.4869109947644, Blast_Score=116, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6323819, Length=359, Percent_Identity=32.3119777158774, Blast_Score=187, Evalue=6e-48,
Organism=Saccharomyces cerevisiae, GI6325093, Length=720, Percent_Identity=21.8055555555556, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324247, Length=354, Percent_Identity=24.0112994350282, Blast_Score=104, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6323063, Length=89, Percent_Identity=39.3258426966292, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17136968, Length=327, Percent_Identity=35.474006116208, Blast_Score=199, Evalue=3e-51,
Organism=Drosophila melanogaster, GI17136970, Length=402, Percent_Identity=25.3731343283582, Blast_Score=108, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 69000; Mature: 69000

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRVFHFYGMLRLPRSGIEQSLKGERCTVSTQIRILPENLTNKIAAGEVVERPASVVKEL
CEEEEEEHHHHHCCHHHHHHHCCCCCEEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHH
VENSLDAGCRDIIVEIEAGGRRLIRVTDDGSGMSREDALLSLERHATSKIASDDDLFSLC
HHHHHCCCCEEEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHH
TLGFRGEALPSIASVSRFSLATRQRGAIEGTEIYAEGGRIKEVKACGMAEGTVITVRNLF
HCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEHHHHCCCCCCCEEEEEHHH
FNTPARLKFMKSAETEAGHVGDLLTRLAISRPEVRFTYVNDGKTVFRALNGTMEERVAAL
HCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHCCCHHHHHHHH
LGRTIAGALYPLDSTVEGVTVRGLVARPDVSRSAAGHLYTFINGRFIRDRVVQHAVLQAY
HHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEHHCCCHHHHHHHHHHHHHHH
RNFLERGRYPVVVLFIQVPAGDVDVNVHPTKHEVRFRQQGVVHDVIQGVIEEALRPTPWL
HHHHHCCCCCEEEEEEEECCCCEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCCC
RKESQSTVSSPPPERREPATSSERVAEVRELLVNYRPSPAPSRPFFQPLPAVVPAPDQSA
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
EEPDRPMDRGYFSRLAIIGQFHASYILCQDGSDLVIIDQHAAHERVAFERLKAQFAAGGV
CCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHCCCC
EGQGLLFPDTLELSHREVAELREHGEELRRIGFDLDEFGGTTWVVKGVPRLLAGKDYLRI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCEEEECCCHHHHCCHHHHHH
LRDTLEEFQAVGANRSVADAVEEILTRIACHSVVRGEHPLTTAQIEALFAQMDATDYSTN
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCC
CPHGRPVLQRLTLAEVERMFKR
CCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLRVFHFYGMLRLPRSGIEQSLKGERCTVSTQIRILPENLTNKIAAGEVVERPASVVKEL
CEEEEEEHHHHHCCHHHHHHHCCCCCEEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHH
VENSLDAGCRDIIVEIEAGGRRLIRVTDDGSGMSREDALLSLERHATSKIASDDDLFSLC
HHHHHCCCCEEEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHH
TLGFRGEALPSIASVSRFSLATRQRGAIEGTEIYAEGGRIKEVKACGMAEGTVITVRNLF
HCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEHHHHCCCCCCCEEEEEHHH
FNTPARLKFMKSAETEAGHVGDLLTRLAISRPEVRFTYVNDGKTVFRALNGTMEERVAAL
HCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHCCCHHHHHHHH
LGRTIAGALYPLDSTVEGVTVRGLVARPDVSRSAAGHLYTFINGRFIRDRVVQHAVLQAY
HHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEHHCCCHHHHHHHHHHHHHHH
RNFLERGRYPVVVLFIQVPAGDVDVNVHPTKHEVRFRQQGVVHDVIQGVIEEALRPTPWL
HHHHHCCCCCEEEEEEEECCCCEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCCC
RKESQSTVSSPPPERREPATSSERVAEVRELLVNYRPSPAPSRPFFQPLPAVVPAPDQSA
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
EEPDRPMDRGYFSRLAIIGQFHASYILCQDGSDLVIIDQHAAHERVAFERLKAQFAAGGV
CCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHCCCC
EGQGLLFPDTLELSHREVAELREHGEELRRIGFDLDEFGGTTWVVKGVPRLLAGKDYLRI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCEEEECCCHHHHCCHHHHHH
LRDTLEEFQAVGANRSVADAVEEILTRIACHSVVRGEHPLTTAQIEALFAQMDATDYSTN
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCC
CPHGRPVLQRLTLAEVERMFKR
CCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA