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The map label for this gene is zraR [H]

Identifier: 78223241

GI number: 78223241

Start: 2277374

End: 2278723

Strand: Reverse

Name: zraR [H]

Synonym: Gmet_2034

Alternate gene names: 78223241

Gene position: 2278723-2277374 (Counterclockwise)

Preceding gene: 78223242

Following gene: 78223240

Centisome position: 57.0

GC content: 53.93

Gene sequence:

>1350_bases
ATGCAGGGTAAAGCGCACGGGAAGGTGCTCATTGTCGATGATGAGCCGAATGCCCTGAAGGTGCTCGCTGCAATCCTGCG
GGAGGAAGGTTATTCTGTATTCAAGGCCGGCGATGCCGCCGAGGCGGAGCAAGCCTTGAGTAAAGAGGATATAGACACTG
TCATTACCGACATGAAGATGCCTGGCAAGGACGGCATACAGTTGATGGATTTTATGGCGGAGCACTATCCCGATATACCG
ATTATTTTCCTGACGGCGTATGGTTCCGTGGATTCAGCCGTGCATGCCATCACCCGCGGAGCATTCTATTATTTCATCAA
ACCCCCTGATTACGTTAAGCTCAAGGGAATCCTGGCTCGGGCAGTGGAACAACGCAGCCTTAAGCGCGAACTGGAAACTC
TGCGCAAGAGGGTCTCTGGCGGAACGCCGGCACGCATTGTTGGCGCCACTCCGGAAATGCTCCGTATCTTTGAAACTGTC
GAGGCCGTCAAGGATTCCATGAGCAGCGTGCTCATCTGTGGCGAGACCGGAACCGGCAAGGAACTCATTGCCCGCTCCCT
TCACTACGGAAGCGTGCGAAGGGATAAACCGTTCGTTGCGGTAAATTGCGCGGCCATGCCTCGCGAGCTGATTGAGTCGG
AACTCTTCGGGTACGAGAAGGGGGCTTTCAGCGGGGCTTTCTCCCGTCGCATCGGCCGATTTGAAGAAGCGGCGGAAGGA
ACGATCTTTCTCGATGAGATCGGTGAACTGGAAATGCCGCTTCAGGCAAAATTGCTCAGAGTCCTTCAGGAAAAGGAAAT
AGAACGACTTGGCAGCAACAAGAAGATCAAGGTCAATTTCCGGCTAATCTCATCTACAAACAGGAATATACCCTCGGAGA
TAACCGCCGGGAACTTTCGGGAGGACCTCTTCTATCGGCTCAACGTGGTTCAGGTGCAGGTGCCTCCCCTTCGCGACCGC
CGGGAAGACATTCCTCTCCTTGCCGCCGAACTTGTCAGGGAGTACGGCGCACGAGAAGGAAAGGTGCTCCGTTTCGACGA
CGAAGTAATGCAGGTCTTTCTGAACTATGACTGGCCCGGAAATATACGCCAGTTGGGCAACATTATTGAACGCGCCGTAG
TTCTTGCGAAGAAGGACCGAATCACAACCAAGGAGCTTCCCGAAGAGCTGAAGCCCTATGTGGTGCGGGTTGAAAGCCGT
CAGCAGGTGCGTACCCTTCGTGAACTCGAAGAGGCGGCAATACTGGCGGCATTGGAAGAGAGCGGTGGGAATAAGTCGCA
TGCGGCCAAAATGCTGGGAATTTCTCGAAAGGCTCTCTACAAGCGACTTGGTGAAATGGAGGTTTTTTGA

Upstream 100 bases:

>100_bases
ATTCAGTATCACGGTGGAAGTCTTGAAATAATAAACTCCAAGGGAAACGGTGCGACCGTGCGTCTCAGCCTTCCTGTAGA
GAGTTCTCATGGAGAAACTC

Downstream 100 bases:

>100_bases
GGGTGAGTTAGAAGAGTGTTTCCGATGGATACAATAACTAACGATGATAACTAACGGTTAATTACGGTTTTGTATTTAAG
GTGTATCTTTTGGATACACC

Product: two component, sigma54 specific, Fis family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MQGKAHGKVLIVDDEPNALKVLAAILREEGYSVFKAGDAAEAEQALSKEDIDTVITDMKMPGKDGIQLMDFMAEHYPDIP
IIFLTAYGSVDSAVHAITRGAFYYFIKPPDYVKLKGILARAVEQRSLKRELETLRKRVSGGTPARIVGATPEMLRIFETV
EAVKDSMSSVLICGETGTGKELIARSLHYGSVRRDKPFVAVNCAAMPRELIESELFGYEKGAFSGAFSRRIGRFEEAAEG
TIFLDEIGELEMPLQAKLLRVLQEKEIERLGSNKKIKVNFRLISSTNRNIPSEITAGNFREDLFYRLNVVQVQVPPLRDR
REDIPLLAAELVREYGAREGKVLRFDDEVMQVFLNYDWPGNIRQLGNIIERAVVLAKKDRITTKELPEELKPYVVRVESR
QQVRTLRELEEAAILAALEESGGNKSHAAKMLGISRKALYKRLGEMEVF

Sequences:

>Translated_449_residues
MQGKAHGKVLIVDDEPNALKVLAAILREEGYSVFKAGDAAEAEQALSKEDIDTVITDMKMPGKDGIQLMDFMAEHYPDIP
IIFLTAYGSVDSAVHAITRGAFYYFIKPPDYVKLKGILARAVEQRSLKRELETLRKRVSGGTPARIVGATPEMLRIFETV
EAVKDSMSSVLICGETGTGKELIARSLHYGSVRRDKPFVAVNCAAMPRELIESELFGYEKGAFSGAFSRRIGRFEEAAEG
TIFLDEIGELEMPLQAKLLRVLQEKEIERLGSNKKIKVNFRLISSTNRNIPSEITAGNFREDLFYRLNVVQVQVPPLRDR
REDIPLLAAELVREYGAREGKVLRFDDEVMQVFLNYDWPGNIRQLGNIIERAVVLAKKDRITTKELPEELKPYVVRVESR
QQVRTLRELEEAAILAALEESGGNKSHAAKMLGISRKALYKRLGEMEVF
>Mature_449_residues
MQGKAHGKVLIVDDEPNALKVLAAILREEGYSVFKAGDAAEAEQALSKEDIDTVITDMKMPGKDGIQLMDFMAEHYPDIP
IIFLTAYGSVDSAVHAITRGAFYYFIKPPDYVKLKGILARAVEQRSLKRELETLRKRVSGGTPARIVGATPEMLRIFETV
EAVKDSMSSVLICGETGTGKELIARSLHYGSVRRDKPFVAVNCAAMPRELIESELFGYEKGAFSGAFSRRIGRFEEAAEG
TIFLDEIGELEMPLQAKLLRVLQEKEIERLGSNKKIKVNFRLISSTNRNIPSEITAGNFREDLFYRLNVVQVQVPPLRDR
REDIPLLAAELVREYGAREGKVLRFDDEVMQVFLNYDWPGNIRQLGNIIERAVVLAKKDRITTKELPEELKPYVVRVESR
QQVRTLRELEEAAILAALEESGGNKSHAAKMLGISRKALYKRLGEMEVF

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=437, Percent_Identity=43.9359267734554, Blast_Score=377, Evalue=1e-106,
Organism=Escherichia coli, GI1788550, Length=451, Percent_Identity=43.0155210643016, Blast_Score=371, Evalue=1e-104,
Organism=Escherichia coli, GI1788905, Length=449, Percent_Identity=42.0935412026726, Blast_Score=340, Evalue=1e-94,
Organism=Escherichia coli, GI1790299, Length=470, Percent_Identity=38.936170212766, Blast_Score=313, Evalue=2e-86,
Organism=Escherichia coli, GI87082117, Length=341, Percent_Identity=42.8152492668622, Blast_Score=258, Evalue=5e-70,
Organism=Escherichia coli, GI1789087, Length=302, Percent_Identity=45.364238410596, Blast_Score=249, Evalue=3e-67,
Organism=Escherichia coli, GI87082152, Length=318, Percent_Identity=42.1383647798742, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1789233, Length=326, Percent_Identity=38.3435582822086, Blast_Score=223, Evalue=1e-59,
Organism=Escherichia coli, GI1786524, Length=316, Percent_Identity=41.1392405063291, Blast_Score=222, Evalue=3e-59,
Organism=Escherichia coli, GI87081872, Length=311, Percent_Identity=39.5498392282958, Blast_Score=202, Evalue=3e-53,
Organism=Escherichia coli, GI1787583, Length=307, Percent_Identity=34.8534201954397, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI87081858, Length=336, Percent_Identity=29.7619047619048, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1789828, Length=293, Percent_Identity=34.4709897610922, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1790863, Length=120, Percent_Identity=35.8333333333333, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87082052, Length=185, Percent_Identity=31.8918918918919, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50450; Mature: 50450

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQGKAHGKVLIVDDEPNALKVLAAILREEGYSVFKAGDAAEAEQALSKEDIDTVITDMKM
CCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCC
PGKDGIQLMDFMAEHYPDIPIIFLTAYGSVDSAVHAITRGAFYYFIKPPDYVKLKGILAR
CCCCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCEEEEEECCCCCHHHHHHHHH
AVEQRSLKRELETLRKRVSGGTPARIVGATPEMLRIFETVEAVKDSMSSVLICGETGTGK
HHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCH
ELIARSLHYGSVRRDKPFVAVNCAAMPRELIESELFGYEKGAFSGAFSRRIGRFEEAAEG
HHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCC
TIFLDEIGELEMPLQAKLLRVLQEKEIERLGSNKKIKVNFRLISSTNRNIPSEITAGNFR
CEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCCCCCHH
EDLFYRLNVVQVQVPPLRDRREDIPLLAAELVREYGAREGKVLRFDDEVMQVFLNYDWPG
HHHHEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEECHHHHHHHHCCCCCC
NIRQLGNIIERAVVLAKKDRITTKELPEELKPYVVRVESRQQVRTLRELEEAAILAALEE
CHHHHHHHHHHHHHHHHCCCCCHHHCHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHH
SGGNKSHAAKMLGISRKALYKRLGEMEVF
CCCCHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQGKAHGKVLIVDDEPNALKVLAAILREEGYSVFKAGDAAEAEQALSKEDIDTVITDMKM
CCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCC
PGKDGIQLMDFMAEHYPDIPIIFLTAYGSVDSAVHAITRGAFYYFIKPPDYVKLKGILAR
CCCCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCEEEEEECCCCCHHHHHHHHH
AVEQRSLKRELETLRKRVSGGTPARIVGATPEMLRIFETVEAVKDSMSSVLICGETGTGK
HHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCH
ELIARSLHYGSVRRDKPFVAVNCAAMPRELIESELFGYEKGAFSGAFSRRIGRFEEAAEG
HHHHHHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCC
TIFLDEIGELEMPLQAKLLRVLQEKEIERLGSNKKIKVNFRLISSTNRNIPSEITAGNFR
CEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCCCCCHH
EDLFYRLNVVQVQVPPLRDRREDIPLLAAELVREYGAREGKVLRFDDEVMQVFLNYDWPG
HHHHEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEECHHHHHHHHCCCCCC
NIRQLGNIIERAVVLAKKDRITTKELPEELKPYVVRVESRQQVRTLRELEEAAILAALEE
CHHHHHHHHHHHHHHHHCCCCCHHHCHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHH
SGGNKSHAAKMLGISRKALYKRLGEMEVF
CCCCHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]