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The map label for this gene is atoC [H]

Identifier: 78223199

GI number: 78223199

Start: 2223204

End: 2224571

Strand: Reverse

Name: atoC [H]

Synonym: Gmet_1992

Alternate gene names: 78223199

Gene position: 2224571-2223204 (Counterclockwise)

Preceding gene: 78223200

Following gene: 78223195

Centisome position: 55.65

GC content: 55.99

Gene sequence:

>1368_bases
ATGGAAAAGCTGCTCATAGTTGATGACAACGAGGATATCCGCCGTCAGCTTCGATGGGGGATTGGGAAGGAGTATTCCCT
TCATCTGGCCGCCGATGGCACAGAGGCGCTGGAACTCTTCCGCAAGCACCGCCCCCAGGTCGTTACTCTCGACCTGGGGC
TCCCTCCCCATGAGGACAGTTCAGAAGAGGGGTTTCGCTGCCTCGGTGAGATGCTTCGCATTGCCCCCGACGCAAAGGTG
ATCGTCATTACCGGTAACGAGGGGAAGGAGAACGCCGTGAAGGCGGTGCAGATGGGGGCCTATGACTTTTACCAGAAGCC
CATCGATCTGAATGAGCTCAAGGTTATAATCAAGCGGGCTTTTCACCTGCAGACCCTTGAGGATGAGAACCGTCGCCTGC
AGAGCGCCCTTGGGGGGAGCGGCCCGGATGTCAAAGGGATAATCGGCCAGTGTGCCGAGATGCAGCAGGTATTTTCGACG
ATCAGGAAGGTTGCCACCTCTGACATCTCTGTTCTTATCCACGGCGAGAGTGGCACCGGCAAGGAGCTTGTGGCTCGCGC
CATCCACGCTCAGAGTCTGCGCAAGGACGGCCCGTTCATCCCCATCAACTGCGGTGCTATCCCTGAAAATCTTCTTGAAT
CAGAGCTGTTCGGGCATGAGAAGGGCGCGTTCACTGGAGCAATGGCCCGGGTTCAGGGGAAGGTGGAATATGCCCACAAG
GGGACACTCTTCCTGGACGAAATCGGTGAGCTTCCCCTCAACCTCCAGGTCAAGCTCCTTCGTTTCCTGCAGGAAAAAGC
CATTCAACGGGTTGGGGGGAGGGAGGATATCTCCATTGACTCCCGGATCATAGCGGCCACCAATGTCGATATCGTTCGCG
CCATGGAAGAGGGGAGGTTTCGGGAAGACCTCTATTACCGGATCGGGGTGGTAACCGTCACGCTTCCTCCCCTCAGGAAC
CGCGGCGATGATGTTATGCTGTTAGCCAATTTCTTCCTGAAGCGGTGCGTCAATGAGTTCAAGAAGAAGATAAAAGGTTT
TAGTGAAACATCCCGTGAATACATCGAAAATTATGGTTGGCCGGGGAACGTGCGCGAATTGGAAAACAAGGTTCAGCGGG
CAGTGCTCATGGCATCGGGGGCAGTAATCGAGCCCGACGATCTGGGCTTCACCGAGCGACCCTCGGCACGAAAAGCAGGC
ATCGGTGAGGTGACGACCCTGCGTGAAGCCAGGGAACAGGTTGAGCGGGAGATGATCAGGGGGGCTATTACCAATAGCAA
GGGGAATATCGCCAAGGCTGCGGAAGAGTTGGGAATCAGCAGGCCAACACTCTATGATCTCATGAGGAAGCACGGCATTA
ACGCATGA

Upstream 100 bases:

>100_bases
AGTACCGTTGGGGTTGGTACGGTTTTCACCGTATGGTTTAACTGCGGTGATCAGGGTCGGATCGGGATAACCGAACCGGA
ATTCATCTGAGGTGCAATTG

Downstream 100 bases:

>100_bases
TTGGTGACTGGCACGGCGGAACAGCCGTCCGCTGGTCTTGCTACTCCACCCCCTCGCCAACGACGAAATCCAACGCCTTC
ACCACCTTCGGGTCGTAGAG

Product: two component, sigma54 specific, Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MEKLLIVDDNEDIRRQLRWGIGKEYSLHLAADGTEALELFRKHRPQVVTLDLGLPPHEDSSEEGFRCLGEMLRIAPDAKV
IVITGNEGKENAVKAVQMGAYDFYQKPIDLNELKVIIKRAFHLQTLEDENRRLQSALGGSGPDVKGIIGQCAEMQQVFST
IRKVATSDISVLIHGESGTGKELVARAIHAQSLRKDGPFIPINCGAIPENLLESELFGHEKGAFTGAMARVQGKVEYAHK
GTLFLDEIGELPLNLQVKLLRFLQEKAIQRVGGREDISIDSRIIAATNVDIVRAMEEGRFREDLYYRIGVVTVTLPPLRN
RGDDVMLLANFFLKRCVNEFKKKIKGFSETSREYIENYGWPGNVRELENKVQRAVLMASGAVIEPDDLGFTERPSARKAG
IGEVTTLREAREQVEREMIRGAITNSKGNIAKAAEELGISRPTLYDLMRKHGINA

Sequences:

>Translated_455_residues
MEKLLIVDDNEDIRRQLRWGIGKEYSLHLAADGTEALELFRKHRPQVVTLDLGLPPHEDSSEEGFRCLGEMLRIAPDAKV
IVITGNEGKENAVKAVQMGAYDFYQKPIDLNELKVIIKRAFHLQTLEDENRRLQSALGGSGPDVKGIIGQCAEMQQVFST
IRKVATSDISVLIHGESGTGKELVARAIHAQSLRKDGPFIPINCGAIPENLLESELFGHEKGAFTGAMARVQGKVEYAHK
GTLFLDEIGELPLNLQVKLLRFLQEKAIQRVGGREDISIDSRIIAATNVDIVRAMEEGRFREDLYYRIGVVTVTLPPLRN
RGDDVMLLANFFLKRCVNEFKKKIKGFSETSREYIENYGWPGNVRELENKVQRAVLMASGAVIEPDDLGFTERPSARKAG
IGEVTTLREAREQVEREMIRGAITNSKGNIAKAAEELGISRPTLYDLMRKHGINA
>Mature_455_residues
MEKLLIVDDNEDIRRQLRWGIGKEYSLHLAADGTEALELFRKHRPQVVTLDLGLPPHEDSSEEGFRCLGEMLRIAPDAKV
IVITGNEGKENAVKAVQMGAYDFYQKPIDLNELKVIIKRAFHLQTLEDENRRLQSALGGSGPDVKGIIGQCAEMQQVFST
IRKVATSDISVLIHGESGTGKELVARAIHAQSLRKDGPFIPINCGAIPENLLESELFGHEKGAFTGAMARVQGKVEYAHK
GTLFLDEIGELPLNLQVKLLRFLQEKAIQRVGGREDISIDSRIIAATNVDIVRAMEEGRFREDLYYRIGVVTVTLPPLRN
RGDDVMLLANFFLKRCVNEFKKKIKGFSETSREYIENYGWPGNVRELENKVQRAVLMASGAVIEPDDLGFTERPSARKAG
IGEVTTLREAREQVEREMIRGAITNSKGNIAKAAEELGISRPTLYDLMRKHGINA

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=464, Percent_Identity=43.75, Blast_Score=364, Evalue=1e-102,
Organism=Escherichia coli, GI1790437, Length=451, Percent_Identity=40.5764966740577, Blast_Score=321, Evalue=7e-89,
Organism=Escherichia coli, GI1788905, Length=456, Percent_Identity=39.2543859649123, Blast_Score=299, Evalue=2e-82,
Organism=Escherichia coli, GI1790299, Length=473, Percent_Identity=37.2093023255814, Blast_Score=293, Evalue=1e-80,
Organism=Escherichia coli, GI87082117, Length=374, Percent_Identity=41.1764705882353, Blast_Score=266, Evalue=3e-72,
Organism=Escherichia coli, GI87082152, Length=316, Percent_Identity=45.253164556962, Blast_Score=254, Evalue=7e-69,
Organism=Escherichia coli, GI1789233, Length=356, Percent_Identity=40.7303370786517, Blast_Score=250, Evalue=1e-67,
Organism=Escherichia coli, GI1789087, Length=336, Percent_Identity=42.5595238095238, Blast_Score=245, Evalue=4e-66,
Organism=Escherichia coli, GI87081872, Length=319, Percent_Identity=41.3793103448276, Blast_Score=242, Evalue=3e-65,
Organism=Escherichia coli, GI1786524, Length=315, Percent_Identity=42.2222222222222, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI1787583, Length=349, Percent_Identity=33.5243553008596, Blast_Score=197, Evalue=8e-52,
Organism=Escherichia coli, GI87081858, Length=298, Percent_Identity=33.8926174496644, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1789828, Length=250, Percent_Identity=34.8, Blast_Score=135, Evalue=7e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 50770; Mature: 50770

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKLLIVDDNEDIRRQLRWGIGKEYSLHLAADGTEALELFRKHRPQVVTLDLGLPPHEDS
CCCEEEEECCHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCEEEEEECCCCCCCCC
SEEGFRCLGEMLRIAPDAKVIVITGNEGKENAVKAVQMGAYDFYQKPIDLNELKVIIKRA
CHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHH
FHLQTLEDENRRLQSALGGSGPDVKGIIGQCAEMQQVFSTIRKVATSDISVLIHGESGTG
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCC
KELVARAIHAQSLRKDGPFIPINCGAIPENLLESELFGHEKGAFTGAMARVQGKVEYAHK
HHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCEEECCC
GTLFLDEIGELPLNLQVKLLRFLQEKAIQRVGGREDISIDSRIIAATNVDIVRAMEEGRF
CCEEHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCHHHHHHHHHCCH
REDLYYRIGVVTVTLPPLRNRGDDVMLLANFFLKRCVNEFKKKIKGFSETSREYIENYGW
HHHHHEEEEEEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
PGNVRELENKVQRAVLMASGAVIEPDDLGFTERPSARKAGIGEVTTLREAREQVEREMIR
CCCHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHH
GAITNSKGNIAKAAEELGISRPTLYDLMRKHGINA
HHHCCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure
MEKLLIVDDNEDIRRQLRWGIGKEYSLHLAADGTEALELFRKHRPQVVTLDLGLPPHEDS
CCCEEEEECCHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCEEEEEECCCCCCCCC
SEEGFRCLGEMLRIAPDAKVIVITGNEGKENAVKAVQMGAYDFYQKPIDLNELKVIIKRA
CHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHH
FHLQTLEDENRRLQSALGGSGPDVKGIIGQCAEMQQVFSTIRKVATSDISVLIHGESGTG
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCC
KELVARAIHAQSLRKDGPFIPINCGAIPENLLESELFGHEKGAFTGAMARVQGKVEYAHK
HHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCEEECCC
GTLFLDEIGELPLNLQVKLLRFLQEKAIQRVGGREDISIDSRIIAATNVDIVRAMEEGRF
CCEEHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCHHHHHHHHHCCH
REDLYYRIGVVTVTLPPLRNRGDDVMLLANFFLKRCVNEFKKKIKGFSETSREYIENYGW
HHHHHEEEEEEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCC
PGNVRELENKVQRAVLMASGAVIEPDDLGFTERPSARKAGIGEVTTLREAREQVEREMIR
CCCHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHHHHHHH
GAITNSKGNIAKAAEELGISRPTLYDLMRKHGINA
HHHCCCCCCHHHHHHHHCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]