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The map label for this gene is dxs1

Identifier: 78223141

GI number: 78223141

Start: 2158962

End: 2160839

Strand: Reverse

Name: dxs1

Synonym: Gmet_1934

Alternate gene names: 78223141

Gene position: 2160839-2158962 (Counterclockwise)

Preceding gene: 78223142

Following gene: 78223140

Centisome position: 54.06

GC content: 62.67

Gene sequence:

>1878_bases
ATGACAGCAATTCTCGACACCATCGAATCCCCCTGCGACCTGAAGGGGGTCACCCAGCGGGAGCTTGCACAGCTTGCCGC
GGAGTTGCGGGAGAAAATCATTACCGTCTGCGCCAGGAACGGCGGACACCTGGCTCCAAGCCTCGGGGTGGTCGAGTTGA
CCCTGGCGCTCCATAGAGTCTTCGATTCTCCGGCCGACAAGATCATCTGGGACGTGGGGCACCAGGCCTATGCCCACAAG
CTGCTCACGGGCCGGCGCGACCGGTTCGCCACGCTCCGCACCCTTGGCGGAATCAGCGGGTTTCCCAAACGGTGCGAGTC
CTCCCATGATGCCTTCGACACAGGGCACACCTCTACCTCCATCTCTGCTGCCCTGGGTTTTGCCGTTGCCCGGGACCTGC
GGGGGGAGCGGAACAAGGTGGTGGCCGTCATCGGCGACGGCTCCATGACCGGCGGCCTCGCCTACGAAGGGCTCAATAAC
GCCGGGCACCTGAACAAGGATCTGGTCGTGGTCCTGAACGACAACGAGATGTCCATTGCCGAGAACGTGGGAGCCCTGTC
GAATTTCTTGAACCGGACCGTCACCAGCGAATTCGTCCATACCATGAAGAAGGACCTGGAAGGGTTCCTCGGCGGACTCG
ACCGCATCGGCCACGGGGTTCTGAAGGTGGCCAAGCGGGCAGAGGAGTCCCTCAAGGGGCTCTTCACCCCCGGCATGCTC
TTCGAGGCCTTCGGGTTCGAGTACATCGGCCCCATCGACGGCCACGACACGGCCCGACTCATGGAGACCTTCGAGAAGGT
GAAGCGCTTTGACGACGCGGTCCTGATCCATGTCCTGACCAAGAAAGGGAGGGGGTATCCTCCCGCCGAAGAAAAACCGG
CGCTCTTCCACGGCGTTGGCCCCTTTGAGCTGGAAACCGGCAAGGTCATCAAGGGGAAGGGGGGCGCAGCCTCTTACACC
GGCGTCTTTGGCGAGGCCATCAGAAAAATCGCCGCCGAGGACGAGCGGGTCATCGCCCTGACTGCGGCCATGCCCGACGG
CACCGGGCTTACCCCCTTTGCCGCCGACTATCCCACGCGGTTCTTCGACGTGGGTATAGCCGAACAGCATGGGGTCACCT
TTGCCGCAGGGCTCGCCGCCGAAGGATACCGGCCGGTCTTTGCCGTCTATTCGTCGTTCCTGCAGCGGGCCTACGACCAG
GTCTTCCACGACGTCTGCCTCCAGAATCTTCCGGTTACCTTCGCCATTGACCGTGCCGGGGTGGTGGGGAGCGACGGTCC
GACCCACCATGGACTTTTCGATCTTGCGTACCTGCGCCATCTCCCCAATATGGTGGTCATGGCACCCAAGGACGAAAACG
AGCTTCAGCACCTGCTCTTGACCGCCATCGAGCACGACGGACCGGCGGCCGTCCGCTATCCCCGGGGTAACGGTTACGGG
GTTTCCCTGGACCAGACCTGCAGCGTCCTTCCCATTGGGAAGGGAGAGATCCTGAGGGAAGGTCTGGACGGTGCCCTCCT
TGCCATCGGTTCCACCGTCTACCCGGCCCGTGAGGCAGCTGAAGCCTTGGCCGCCGAAGGAATCGACCTCGCCGTCGTGA
ATGCCCGCTTCGTGAAACCCCTCGACCGGGACCTGATCCTCAGCTTGGCCCGAACCACCGGCAGGCTCATCATCGTTGAG
GAGAACGTCATCCAGGGAGGCTTCGGCACGGCGGTGCTGGAACTTCTCGAAGAGGAAGGAATCAATGGGGTCAAGGTTCT
CCGCCTGGGATACCCGGACCGGTACGTGGAGCAGGGGGAGCAGCATGAACTGAGGGCCCAGTATGGCCTCGACGCCCCGG
GAATAACGGCTCGGGTCAGAACATTCATGAAGGGATAA

Upstream 100 bases:

>100_bases
AGGAGTTGGTGGATCTGGCCCTCGAAGCCCTTTCCCCCTTCGGCGAGAAAGCGGAACCCCTGCGGGAGATCGCCCGTTAC
ATCGTATCCCGGAAATCGTA

Downstream 100 bases:

>100_bases
ACGAAGCCGGGGATTCCCCGGCTTTTTTCTTACTTGCGAGTCACGAGCGAATTCAGCGATCATGGAGTATCCGCGATGCG
ATATGCCAATCTCGTCAGAG

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase 1; DXP synthase 1; DXPS 1

Number of amino acids: Translated: 625; Mature: 624

Protein sequence:

>625_residues
MTAILDTIESPCDLKGVTQRELAQLAAELREKIITVCARNGGHLAPSLGVVELTLALHRVFDSPADKIIWDVGHQAYAHK
LLTGRRDRFATLRTLGGISGFPKRCESSHDAFDTGHTSTSISAALGFAVARDLRGERNKVVAVIGDGSMTGGLAYEGLNN
AGHLNKDLVVVLNDNEMSIAENVGALSNFLNRTVTSEFVHTMKKDLEGFLGGLDRIGHGVLKVAKRAEESLKGLFTPGML
FEAFGFEYIGPIDGHDTARLMETFEKVKRFDDAVLIHVLTKKGRGYPPAEEKPALFHGVGPFELETGKVIKGKGGAASYT
GVFGEAIRKIAAEDERVIALTAAMPDGTGLTPFAADYPTRFFDVGIAEQHGVTFAAGLAAEGYRPVFAVYSSFLQRAYDQ
VFHDVCLQNLPVTFAIDRAGVVGSDGPTHHGLFDLAYLRHLPNMVVMAPKDENELQHLLLTAIEHDGPAAVRYPRGNGYG
VSLDQTCSVLPIGKGEILREGLDGALLAIGSTVYPAREAAEALAAEGIDLAVVNARFVKPLDRDLILSLARTTGRLIIVE
ENVIQGGFGTAVLELLEEEGINGVKVLRLGYPDRYVEQGEQHELRAQYGLDAPGITARVRTFMKG

Sequences:

>Translated_625_residues
MTAILDTIESPCDLKGVTQRELAQLAAELREKIITVCARNGGHLAPSLGVVELTLALHRVFDSPADKIIWDVGHQAYAHK
LLTGRRDRFATLRTLGGISGFPKRCESSHDAFDTGHTSTSISAALGFAVARDLRGERNKVVAVIGDGSMTGGLAYEGLNN
AGHLNKDLVVVLNDNEMSIAENVGALSNFLNRTVTSEFVHTMKKDLEGFLGGLDRIGHGVLKVAKRAEESLKGLFTPGML
FEAFGFEYIGPIDGHDTARLMETFEKVKRFDDAVLIHVLTKKGRGYPPAEEKPALFHGVGPFELETGKVIKGKGGAASYT
GVFGEAIRKIAAEDERVIALTAAMPDGTGLTPFAADYPTRFFDVGIAEQHGVTFAAGLAAEGYRPVFAVYSSFLQRAYDQ
VFHDVCLQNLPVTFAIDRAGVVGSDGPTHHGLFDLAYLRHLPNMVVMAPKDENELQHLLLTAIEHDGPAAVRYPRGNGYG
VSLDQTCSVLPIGKGEILREGLDGALLAIGSTVYPAREAAEALAAEGIDLAVVNARFVKPLDRDLILSLARTTGRLIIVE
ENVIQGGFGTAVLELLEEEGINGVKVLRLGYPDRYVEQGEQHELRAQYGLDAPGITARVRTFMKG
>Mature_624_residues
TAILDTIESPCDLKGVTQRELAQLAAELREKIITVCARNGGHLAPSLGVVELTLALHRVFDSPADKIIWDVGHQAYAHKL
LTGRRDRFATLRTLGGISGFPKRCESSHDAFDTGHTSTSISAALGFAVARDLRGERNKVVAVIGDGSMTGGLAYEGLNNA
GHLNKDLVVVLNDNEMSIAENVGALSNFLNRTVTSEFVHTMKKDLEGFLGGLDRIGHGVLKVAKRAEESLKGLFTPGMLF
EAFGFEYIGPIDGHDTARLMETFEKVKRFDDAVLIHVLTKKGRGYPPAEEKPALFHGVGPFELETGKVIKGKGGAASYTG
VFGEAIRKIAAEDERVIALTAAMPDGTGLTPFAADYPTRFFDVGIAEQHGVTFAAGLAAEGYRPVFAVYSSFLQRAYDQV
FHDVCLQNLPVTFAIDRAGVVGSDGPTHHGLFDLAYLRHLPNMVVMAPKDENELQHLLLTAIEHDGPAAVRYPRGNGYGV
SLDQTCSVLPIGKGEILREGLDGALLAIGSTVYPAREAAEALAAEGIDLAVVNARFVKPLDRDLILSLARTTGRLIIVEE
NVIQGGFGTAVLELLEEEGINGVKVLRLGYPDRYVEQGEQHELRAQYGLDAPGITARVRTFMKG

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=427, Percent_Identity=27.6346604215457, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI4507521, Length=427, Percent_Identity=27.6346604215457, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI225637463, Length=429, Percent_Identity=27.5058275058275, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI225637461, Length=429, Percent_Identity=27.5058275058275, Blast_Score=114, Evalue=4e-25,
Organism=Homo sapiens, GI225637459, Length=429, Percent_Identity=27.5058275058275, Blast_Score=114, Evalue=4e-25,
Organism=Homo sapiens, GI133778974, Length=429, Percent_Identity=27.7389277389277, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI4557353, Length=235, Percent_Identity=27.6595744680851, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI34101272, Length=235, Percent_Identity=27.6595744680851, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI156564403, Length=234, Percent_Identity=27.3504273504274, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI291084858, Length=226, Percent_Identity=27.4336283185841, Blast_Score=70, Evalue=9e-12,
Organism=Escherichia coli, GI1786622, Length=620, Percent_Identity=47.9032258064516, Blast_Score=596, Evalue=1e-171,
Organism=Caenorhabditis elegans, GI17539652, Length=431, Percent_Identity=27.1461716937355, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17506935, Length=163, Percent_Identity=30.0613496932515, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24666278, Length=591, Percent_Identity=27.2419627749577, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI45551847, Length=676, Percent_Identity=25.1479289940828, Blast_Score=119, Evalue=9e-27,
Organism=Drosophila melanogaster, GI45550715, Length=676, Percent_Identity=25.1479289940828, Blast_Score=119, Evalue=9e-27,
Organism=Drosophila melanogaster, GI24645119, Length=632, Percent_Identity=25.1582278481013, Blast_Score=115, Evalue=9e-26,
Organism=Drosophila melanogaster, GI21358145, Length=235, Percent_Identity=28.0851063829787, Blast_Score=77, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24650940, Length=235, Percent_Identity=28.0851063829787, Blast_Score=77, Evalue=5e-14,
Organism=Drosophila melanogaster, GI160714832, Length=234, Percent_Identity=26.4957264957265, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI160714828, Length=234, Percent_Identity=26.4957264957265, Blast_Score=74, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS1_GEOMG (Q39UB1)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_384888.1
- STRING:   Q39UB1
- GeneID:   3738118
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_1934
- NMPDR:   fig|269799.3.peg.2197
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   VESICSA
- PhylomeDB:   Q39UB1
- ProtClustDB:   PRK05444
- BioCyc:   GMET269799:GMET_1934-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 67364; Mature: 67233

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAILDTIESPCDLKGVTQRELAQLAAELREKIITVCARNGGHLAPSLGVVELTLALHRV
CCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
FDSPADKIIWDVGHQAYAHKLLTGRRDRFATLRTLGGISGFPKRCESSHDAFDTGHTSTS
HCCCHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCHH
ISAALGFAVARDLRGERNKVVAVIGDGSMTGGLAYEGLNNAGHLNKDLVVVLNDNEMSIA
HHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEECCCCCCCCCCCCEEEEECCCCHHHH
ENVGALSNFLNRTVTSEFVHTMKKDLEGFLGGLDRIGHGVLKVAKRAEESLKGLFTPGML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
FEAFGFEYIGPIDGHDTARLMETFEKVKRFDDAVLIHVLTKKGRGYPPAEEKPALFHGVG
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHEEEEHHHCCCCCCCCCCCCCEEECCC
PFELETGKVIKGKGGAASYTGVFGEAIRKIAAEDERVIALTAAMPDGTGLTPFAADYPTR
CCEECCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCH
FFDVGIAEQHGVTFAAGLAAEGYRPVFAVYSSFLQRAYDQVFHDVCLQNLPVTFAIDRAG
HEECCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
VVGSDGPTHHGLFDLAYLRHLPNMVVMAPKDENELQHLLLTAIEHDGPAAVRYPRGNGYG
CCCCCCCCCCHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCCCCCEEECCCCCCCC
VSLDQTCSVLPIGKGEILREGLDGALLAIGSTVYPAREAAEALAAEGIDLAVVNARFVKP
CCCCCCCCEEECCCHHHHHHCCCCEEHHHCCCCCCHHHHHHHHHHCCCCEEEECHHHHCC
LDRDLILSLARTTGRLIIVEENVIQGGFGTAVLELLEEEGINGVKVLRLGYPDRYVEQGE
CCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHCCC
QHELRAQYGLDAPGITARVRTFMKG
HHHHHHHCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
TAILDTIESPCDLKGVTQRELAQLAAELREKIITVCARNGGHLAPSLGVVELTLALHRV
CCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
FDSPADKIIWDVGHQAYAHKLLTGRRDRFATLRTLGGISGFPKRCESSHDAFDTGHTSTS
HCCCHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCHH
ISAALGFAVARDLRGERNKVVAVIGDGSMTGGLAYEGLNNAGHLNKDLVVVLNDNEMSIA
HHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCEEECCCCCCCCCCCCEEEEECCCCHHHH
ENVGALSNFLNRTVTSEFVHTMKKDLEGFLGGLDRIGHGVLKVAKRAEESLKGLFTPGML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
FEAFGFEYIGPIDGHDTARLMETFEKVKRFDDAVLIHVLTKKGRGYPPAEEKPALFHGVG
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCHHHEEEEHHHCCCCCCCCCCCCCEEECCC
PFELETGKVIKGKGGAASYTGVFGEAIRKIAAEDERVIALTAAMPDGTGLTPFAADYPTR
CCEECCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCH
FFDVGIAEQHGVTFAAGLAAEGYRPVFAVYSSFLQRAYDQVFHDVCLQNLPVTFAIDRAG
HEECCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
VVGSDGPTHHGLFDLAYLRHLPNMVVMAPKDENELQHLLLTAIEHDGPAAVRYPRGNGYG
CCCCCCCCCCHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHCCCCCCEEECCCCCCCC
VSLDQTCSVLPIGKGEILREGLDGALLAIGSTVYPAREAAEALAAEGIDLAVVNARFVKP
CCCCCCCCEEECCCHHHHHHCCCCEEHHHCCCCCCHHHHHHHHHHCCCCEEEECHHHHCC
LDRDLILSLARTTGRLIIVEENVIQGGFGTAVLELLEEEGINGVKVLRLGYPDRYVEQGE
CCHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHCCC
QHELRAQYGLDAPGITARVRTFMKG
HHHHHHHCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA