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The map label for this gene is ispA [C]

Identifier: 78223142

GI number: 78223142

Start: 2160839

End: 2161732

Strand: Reverse

Name: ispA [C]

Synonym: Gmet_1935

Alternate gene names: 78223142

Gene position: 2161732-2160839 (Counterclockwise)

Preceding gene: 78223143

Following gene: 78223141

Centisome position: 54.08

GC content: 60.63

Gene sequence:

>894_bases
ATGGACCTTAAAAACTATCTCAAAGAACGCTGTGCCATTGTTGATGAAGCTCTTGAACGCTCCCTGCCCGGTGAGGGGGA
CCTTCCCGTTTCCGTTCATCGCGCCATGCGCTATTCGGTTTTCGCAGGGGGGAAACGGATTCGGCCGGTTCTGATGCTCG
CCGCCTGTGAGGCGGTGGGAGGAACTCCGGACTTGGCGCTTCCCGCTGCGTGCGCCATGGAGATGATCCACACCTATTCC
CTCATCCACGACGATCTCCCCGCAATGGACGACGACGATTTCCGCCGCGGACGTCCCACAAACCACAAGGTTTTCGGCGA
GGCAATCGCCATCCTTGCCGGTGATGCGCTCCTTACGGAAGCGTTCATCCTCATGAGCTCTCCCGAATACGCCGCAAAGG
CCGGACATGCCCGTATTCTTCCGGTTATCCACGAGATTGGCATCTGTGCCGGTTCCCGGGGGATGGTCGGCGGCCAAGTA
GTCGACATGGAGAGCGAGGGGAAAAAGGATATCGATCTGGCCACGGTCCAGTACATACACACCCACAAGACCGGCGCCCT
CATGAAGGCTTCGGTCAAGGCGGGCGCAATACTCGGCGGAGCGGAAGGGGACGCCCTTGCGGCCATGACCCGTTACGGCG
AGGCCATCGGCCTTGCGTTCCAGATTGCCGATGACATCCTTGACATCGAGGGTACCACCGAGCAGATCGGCAAGGATGCG
GGGAGCGACGAAGCCCGGGGGAAAGCCACCTATCCGGCGGTCATGGGGCTTGCCGATTCCAAACGCCGCGCCCAGGAGTT
GGTGGATCTGGCCCTCGAAGCCCTTTCCCCCTTCGGCGAGAAAGCGGAACCCCTGCGGGAGATCGCCCGTTACATCGTAT
CCCGGAAATCGTAA

Upstream 100 bases:

>100_bases
TCAAAAAGAAGGACGGCAGTTTTGCCAAGGAGCCGTTCCGGCTCGAGGATGACTGAAACAAGCGATTACTGATTTACAAT
ATCACGCAAAGCGAGTTCCC

Downstream 100 bases:

>100_bases
TGACAGCAATTCTCGACACCATCGAATCCCCCTGCGACCTGAAGGGGGTCACCCAGCGGGAGCTTGCACAGCTTGCCGCG
GAGTTGCGGGAGAAAATCAT

Product: farnesyl-diphosphate synthase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MDLKNYLKERCAIVDEALERSLPGEGDLPVSVHRAMRYSVFAGGKRIRPVLMLAACEAVGGTPDLALPAACAMEMIHTYS
LIHDDLPAMDDDDFRRGRPTNHKVFGEAIAILAGDALLTEAFILMSSPEYAAKAGHARILPVIHEIGICAGSRGMVGGQV
VDMESEGKKDIDLATVQYIHTHKTGALMKASVKAGAILGGAEGDALAAMTRYGEAIGLAFQIADDILDIEGTTEQIGKDA
GSDEARGKATYPAVMGLADSKRRAQELVDLALEALSPFGEKAEPLREIARYIVSRKS

Sequences:

>Translated_297_residues
MDLKNYLKERCAIVDEALERSLPGEGDLPVSVHRAMRYSVFAGGKRIRPVLMLAACEAVGGTPDLALPAACAMEMIHTYS
LIHDDLPAMDDDDFRRGRPTNHKVFGEAIAILAGDALLTEAFILMSSPEYAAKAGHARILPVIHEIGICAGSRGMVGGQV
VDMESEGKKDIDLATVQYIHTHKTGALMKASVKAGAILGGAEGDALAAMTRYGEAIGLAFQIADDILDIEGTTEQIGKDA
GSDEARGKATYPAVMGLADSKRRAQELVDLALEALSPFGEKAEPLREIARYIVSRKS
>Mature_297_residues
MDLKNYLKERCAIVDEALERSLPGEGDLPVSVHRAMRYSVFAGGKRIRPVLMLAACEAVGGTPDLALPAACAMEMIHTYS
LIHDDLPAMDDDDFRRGRPTNHKVFGEAIAILAGDALLTEAFILMSSPEYAAKAGHARILPVIHEIGICAGSRGMVGGQV
VDMESEGKKDIDLATVQYIHTHKTGALMKASVKAGAILGGAEGDALAAMTRYGEAIGLAFQIADDILDIEGTTEQIGKDA
GSDEARGKATYPAVMGLADSKRRAQELVDLALEALSPFGEKAEPLREIARYIVSRKS

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=225, Percent_Identity=30.6666666666667, Blast_Score=99, Evalue=6e-21,
Organism=Escherichia coli, GI1786623, Length=301, Percent_Identity=44.1860465116279, Blast_Score=198, Evalue=3e-52,
Organism=Escherichia coli, GI1789578, Length=237, Percent_Identity=32.4894514767932, Blast_Score=122, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17505681, Length=295, Percent_Identity=28.4745762711864, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24651612, Length=186, Percent_Identity=31.7204301075269, Blast_Score=93, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 31676; Mature: 31676

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLKNYLKERCAIVDEALERSLPGEGDLPVSVHRAMRYSVFAGGKRIRPVLMLAACEAVG
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
GTPDLALPAACAMEMIHTYSLIHDDLPAMDDDDFRRGRPTNHKVFGEAIAILAGDALLTE
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCHHHHHHHHHHHHCHHHHHH
AFILMSSPEYAAKAGHARILPVIHEIGICAGSRGMVGGQVVDMESEGKKDIDLATVQYIH
HHHHCCCCHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHH
THKTGALMKASVKAGAILGGAEGDALAAMTRYGEAIGLAFQIADDILDIEGTTEQIGKDA
HCCCCHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCC
GSDEARGKATYPAVMGLADSKRRAQELVDLALEALSPFGEKAEPLREIARYIVSRKS
CCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDLKNYLKERCAIVDEALERSLPGEGDLPVSVHRAMRYSVFAGGKRIRPVLMLAACEAVG
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
GTPDLALPAACAMEMIHTYSLIHDDLPAMDDDDFRRGRPTNHKVFGEAIAILAGDALLTE
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCHHHHHHHHHHHHCHHHHHH
AFILMSSPEYAAKAGHARILPVIHEIGICAGSRGMVGGQVVDMESEGKKDIDLATVQYIH
HHHHCCCCHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHH
THKTGALMKASVKAGAILGGAEGDALAAMTRYGEAIGLAFQIADDILDIEGTTEQIGKDA
HCCCCHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCC
GSDEARGKATYPAVMGLADSKRRAQELVDLALEALSPFGEKAEPLREIARYIVSRKS
CCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]