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The map label for this gene is nrdZ [H]

Identifier: 78223118

GI number: 78223118

Start: 2131606

End: 2132304

Strand: Reverse

Name: nrdZ [H]

Synonym: Gmet_1911

Alternate gene names: 78223118

Gene position: 2132304-2131606 (Counterclockwise)

Preceding gene: 78223119

Following gene: 78223117

Centisome position: 53.34

GC content: 55.65

Gene sequence:

>699_bases
ATGGAACTCTCGGAAAATGCGCTAAAGGTTTTGAAGGCCCGCTACCTGCTGAAGGATGAAAACGGGCAGATTATAGAAAC
GCCAGAGGAGATGTTCGAGCGGATCGCCCGAACCGTCGCCAACACTGAAAAGCTCTATGACGGTGATACCGCCCAGTGGG
AAGAGCGTTTTTTCACTCTTCTCTCGTCCCTGAGATTCCTCCCCAACTCCTCTGCACTCATGAACGCCGGCAAGCCGATG
GGGCAGCTAGCCGCCTGCTTCGTTCTTCCTTTGGAAGATTCCATGCAGAGCATCTTCGATACCCTGAAGAACGCTGCGTT
GATCCTCCAGAGCGGTGGCGGCACCGGCTTTTCCTTTTCCCGGCTTCGCCCCAGGGCTGATATTGTCCGCTCAACCGGCG
GCATTGCCAGCGGCCCGGTTTCCTTCATGAAGATATTCAATACGGCCACCGACATCATCAAGCAGGGAGGAGCGCGGCGG
GGCGCGAACATGGGGATACTCCACATCGATCACCCCGACATCCTGGAGTTCATCCGGGTGAAACGGAATGTTCAGGAGCT
GGCCAACTTCAACATTTCCGTGGCGGTTACCGATGCCTTCATGGAGGCGCTCCACGCAAAAGGGGAATACCAGATCGTCA
ACCCACGTTCAGGCAAGATAGTTGGCACCTCAAGGCCGACGAGGTTTTCGATGAAATAG

Upstream 100 bases:

>100_bases
GGGGGTCTTGAATTTTGCGGAAGCGTGCCTGAACTTTCGTGAACTGTACTGGAACAGAGGGCAAGGTTGAGCTTCCCACG
TAACGCCGTATACTCCTTTC

Downstream 100 bases:

>100_bases
TCGAAAGCGCGTGGGGAACGGGAGACCCGGGTCTGGTATTCATCGACCGGATCAACCGCGCAAATCCTACCCCTCATATC
GGCTCATTCGAGAGCACAAA

Product: ribonucleotide reductase large subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MELSENALKVLKARYLLKDENGQIIETPEEMFERIARTVANTEKLYDGDTAQWEERFFTLLSSLRFLPNSSALMNAGKPM
GQLAACFVLPLEDSMQSIFDTLKNAALILQSGGGTGFSFSRLRPRADIVRSTGGIASGPVSFMKIFNTATDIIKQGGARR
GANMGILHIDHPDILEFIRVKRNVQELANFNISVAVTDAFMEALHAKGEYQIVNPRSGKIVGTSRPTRFSMK

Sequences:

>Translated_232_residues
MELSENALKVLKARYLLKDENGQIIETPEEMFERIARTVANTEKLYDGDTAQWEERFFTLLSSLRFLPNSSALMNAGKPM
GQLAACFVLPLEDSMQSIFDTLKNAALILQSGGGTGFSFSRLRPRADIVRSTGGIASGPVSFMKIFNTATDIIKQGGARR
GANMGILHIDHPDILEFIRVKRNVQELANFNISVAVTDAFMEALHAKGEYQIVNPRSGKIVGTSRPTRFSMK
>Mature_232_residues
MELSENALKVLKARYLLKDENGQIIETPEEMFERIARTVANTEKLYDGDTAQWEERFFTLLSSLRFLPNSSALMNAGKPM
GQLAACFVLPLEDSMQSIFDTLKNAALILQSGGGTGFSFSRLRPRADIVRSTGGIASGPVSFMKIFNTATDIIKQGGARR
GANMGILHIDHPDILEFIRVKRNVQELANFNISVAVTDAFMEALHAKGEYQIVNPRSGKIVGTSRPTRFSMK

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=214, Percent_Identity=32.2429906542056, Blast_Score=105, Evalue=3e-23,
Organism=Escherichia coli, GI1789030, Length=119, Percent_Identity=37.8151260504202, Blast_Score=84, Evalue=7e-18,
Organism=Escherichia coli, GI2367133, Length=185, Percent_Identity=24.3243243243243, Blast_Score=61, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17555242, Length=214, Percent_Identity=28.9719626168224, Blast_Score=104, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6320914, Length=217, Percent_Identity=29.9539170506912, Blast_Score=105, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6322123, Length=217, Percent_Identity=27.1889400921659, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI17352481, Length=215, Percent_Identity=30.6976744186047, Blast_Score=100, Evalue=7e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013344
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 25661; Mature: 25661

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELSENALKVLKARYLLKDENGQIIETPEEMFERIARTVANTEKLYDGDTAQWEERFFTL
CCCCHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LSSLRFLPNSSALMNAGKPMGQLAACFVLPLEDSMQSIFDTLKNAALILQSGGGTGFSFS
HHHHHHCCCCHHHHHCCCCHHHHHHHHEECCHHHHHHHHHHHHHHEEEEECCCCCCCCHH
RLRPRADIVRSTGGIASGPVSFMKIFNTATDIIKQGGARRGANMGILHIDHPDILEFIRV
HCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCHHHHHHHHH
KRNVQELANFNISVAVTDAFMEALHAKGEYQIVNPRSGKIVGTSRPTRFSMK
HHHHHHHHCCCEEEEEHHHHHHHHHCCCCEEEECCCCCEEEECCCCCCCCCC
>Mature Secondary Structure
MELSENALKVLKARYLLKDENGQIIETPEEMFERIARTVANTEKLYDGDTAQWEERFFTL
CCCCHHHHHHHHHHHHHCCCCCCEEECHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LSSLRFLPNSSALMNAGKPMGQLAACFVLPLEDSMQSIFDTLKNAALILQSGGGTGFSFS
HHHHHHCCCCHHHHHCCCCHHHHHHHHEECCHHHHHHHHHHHHHHEEEEECCCCCCCCHH
RLRPRADIVRSTGGIASGPVSFMKIFNTATDIIKQGGARRGANMGILHIDHPDILEFIRV
HCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCHHHHHHHHH
KRNVQELANFNISVAVTDAFMEALHAKGEYQIVNPRSGKIVGTSRPTRFSMK
HHHHHHHHCCCEEEEEHHHHHHHHHCCCCEEEECCCCCEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]