Click here to switch to the map view.

The map label for this gene is purM

Identifier: 78223051

GI number: 78223051

Start: 2056726

End: 2057772

Strand: Direct

Name: purM

Synonym: Gmet_1844

Alternate gene names: 78223051

Gene position: 2056726-2057772 (Clockwise)

Preceding gene: 78223046

Following gene: 78223052

Centisome position: 51.45

GC content: 57.69

Gene sequence:

>1047_bases
TTGGGCGCTAAGGGAATTACCTATAAAGATGCCGGCGTTGACATCGATGCCGGCAATACTTTTGTCAAAATGATCAAACC
GTTCGTGCGGGCCACGTCGAGACCGGAGGTAATCTCCGACATCGGGGGCTTCGGGGGCCTCTTCTCGCTTAACACCAACA
AATACAAGAATCCCGTGCTGGTTTCCGGCACCGACGGCGTTGGCACGAAACTCAAGATAGCCATGATGGCGGACCGCCAC
GACACGGTCGGGATCGATCTCGTGGCAATGTGCGTCAACGATATCGTTGTCCAGGGTGCCGAACCGCTCTTCTTCCTCGA
CTACTTTGCCACCGGCAGCCTCTCGCCGGAGCGCGGCGCCGCTGTCGTCAAGGGGATTTCCGAAGGATGCATCCAGGCAG
GATGCGCTCTCATTGGCGGCGAGACGGCCGAGATGCCCGGATTCTATCAGGACGGCGAGTACGACCTGGCAGGCTTCACC
GTCGGTGTTGTGGATCGGGACAAGATCATTGACGGATCTTCCATCACCGTCGGTAATACCCTCATCGGCCTCGCCTCAAG
CGGCCTCCACAGCAACGGCTACTCCCTGGCCCGCAAAATCATTTTCGATACCCTTGGGTTTGGCATCAACGACATGCTTC
CCGGACACGATCGGAGCGTTGCCGATGAACTGCTCACCCCGACCCGGATTTATGTAAAGTCAGTTCTCAATCTTCTCCGG
GACTTCCGGGTAAACGGCATCGCCCACATCACGGGAGGCGGGCTCCTGGAAAACGTTCCCCGCATTCTCCCCAAGGGATG
CAAGGCGATCATACGACGCGACAGCTGGACCATGCCCGAGATATTCCGCATCCTGCAGAACGGCGGGAATATGGAGTGGA
CCGAGATGTATCGCACCTTCAACTGCGGCATCGGTATGGTTCTGGCTGTTCCCGAGAACGATGTGGACGAAGTCCTCATA
CGCCTCTCGGGACTCCAAGAGAAGGCTTTCGTCATCGGCGAAGTGGCCAAGTGTGAGGCCGGCACCGAGTCGGTGGAAAT
GATCTAA

Upstream 100 bases:

>100_bases
TTGTAAACTGATTTTTTGGGCCTTGACGACCACCAGATAGGGTTTGACTTTTAACGGTTCATGGGGTAAATTTTTTCGTC
ATTTCACGGGAGGAAACATT

Downstream 100 bases:

>100_bases
ACGGTTAATTCCCATGACTGATCTTCTTACTATCGGCGTTCTTGTCTCAGGAAACGGCTCTAACCTCCAGGCCATCATTG
ACCGGATCGAGGACGGTAGC

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 348; Mature: 347

Protein sequence:

>348_residues
MGAKGITYKDAGVDIDAGNTFVKMIKPFVRATSRPEVISDIGGFGGLFSLNTNKYKNPVLVSGTDGVGTKLKIAMMADRH
DTVGIDLVAMCVNDIVVQGAEPLFFLDYFATGSLSPERGAAVVKGISEGCIQAGCALIGGETAEMPGFYQDGEYDLAGFT
VGVVDRDKIIDGSSITVGNTLIGLASSGLHSNGYSLARKIIFDTLGFGINDMLPGHDRSVADELLTPTRIYVKSVLNLLR
DFRVNGIAHITGGGLLENVPRILPKGCKAIIRRDSWTMPEIFRILQNGGNMEWTEMYRTFNCGIGMVLAVPENDVDEVLI
RLSGLQEKAFVIGEVAKCEAGTESVEMI

Sequences:

>Translated_348_residues
MGAKGITYKDAGVDIDAGNTFVKMIKPFVRATSRPEVISDIGGFGGLFSLNTNKYKNPVLVSGTDGVGTKLKIAMMADRH
DTVGIDLVAMCVNDIVVQGAEPLFFLDYFATGSLSPERGAAVVKGISEGCIQAGCALIGGETAEMPGFYQDGEYDLAGFT
VGVVDRDKIIDGSSITVGNTLIGLASSGLHSNGYSLARKIIFDTLGFGINDMLPGHDRSVADELLTPTRIYVKSVLNLLR
DFRVNGIAHITGGGLLENVPRILPKGCKAIIRRDSWTMPEIFRILQNGGNMEWTEMYRTFNCGIGMVLAVPENDVDEVLI
RLSGLQEKAFVIGEVAKCEAGTESVEMI
>Mature_347_residues
GAKGITYKDAGVDIDAGNTFVKMIKPFVRATSRPEVISDIGGFGGLFSLNTNKYKNPVLVSGTDGVGTKLKIAMMADRHD
TVGIDLVAMCVNDIVVQGAEPLFFLDYFATGSLSPERGAAVVKGISEGCIQAGCALIGGETAEMPGFYQDGEYDLAGFTV
GVVDRDKIIDGSSITVGNTLIGLASSGLHSNGYSLARKIIFDTLGFGINDMLPGHDRSVADELLTPTRIYVKSVLNLLRD
FRVNGIAHITGGGLLENVPRILPKGCKAIIRRDSWTMPEIFRILQNGGNMEWTEMYRTFNCGIGMVLAVPENDVDEVLIR
LSGLQEKAFVIGEVAKCEAGTESVEMI

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=346, Percent_Identity=51.7341040462428, Blast_Score=355, Evalue=3e-98,
Organism=Homo sapiens, GI209869995, Length=346, Percent_Identity=51.7341040462428, Blast_Score=355, Evalue=3e-98,
Organism=Homo sapiens, GI209869993, Length=346, Percent_Identity=51.7341040462428, Blast_Score=355, Evalue=3e-98,
Organism=Escherichia coli, GI1788845, Length=328, Percent_Identity=58.8414634146341, Blast_Score=390, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17567511, Length=354, Percent_Identity=44.0677966101695, Blast_Score=264, Evalue=6e-71,
Organism=Saccharomyces cerevisiae, GI6321203, Length=339, Percent_Identity=48.0825958702065, Blast_Score=304, Evalue=2e-83,
Organism=Drosophila melanogaster, GI24582400, Length=286, Percent_Identity=44.4055944055944, Blast_Score=245, Evalue=3e-65,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_GEOMG (Q39UK1)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_384798.1
- ProteinModelPortal:   Q39UK1
- SMR:   Q39UK1
- STRING:   Q39UK1
- GeneID:   3741521
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_1844
- NMPDR:   fig|269799.3.peg.1899
- eggNOG:   COG0150
- HOGENOM:   HBG531222
- OMA:   HYDLAGF
- PhylomeDB:   Q39UK1
- ProtClustDB:   PRK05385
- BioCyc:   GMET269799:GMET_1844-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 37269; Mature: 37138

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGAKGITYKDAGVDIDAGNTFVKMIKPFVRATSRPEVISDIGGFGGLFSLNTNKYKNPVL
CCCCCCEEECCCEEECCCCHHHHHHHHHHHCCCCCHHHHHCCCCCCEEEECCCCCCCCEE
VSGTDGVGTKLKIAMMADRHDTVGIDLVAMCVNDIVVQGAEPLFFLDYFATGSLSPERGA
EECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCCCHHCH
AVVKGISEGCIQAGCALIGGETAEMPGFYQDGEYDLAGFTVGVVDRDKIIDGSSITVGNT
HHHHHHHHHHHHHCHHHCCCCCCCCCCCCCCCCEEECEEEEEEECCCCEECCCCEEECHH
LIGLASSGLHSNGYSLARKIIFDTLGFGINDMLPGHDRSVADELLTPTRIYVKSVLNLLR
HHHHHCCCCCCCHHHHHHHHHHHHHCCCHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHH
DFRVNGIAHITGGGLLENVPRILPKGCKAIIRRDSWTMPEIFRILQNGGNMEWTEMYRTF
HHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHH
NCGIGMVLAVPENDVDEVLIRLSGLQEKAFVIGEVAKCEAGTESVEMI
CCCCEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
GAKGITYKDAGVDIDAGNTFVKMIKPFVRATSRPEVISDIGGFGGLFSLNTNKYKNPVL
CCCCCEEECCCEEECCCCHHHHHHHHHHHCCCCCHHHHHCCCCCCEEEECCCCCCCCEE
VSGTDGVGTKLKIAMMADRHDTVGIDLVAMCVNDIVVQGAEPLFFLDYFATGSLSPERGA
EECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEHHCCCCCCHHCH
AVVKGISEGCIQAGCALIGGETAEMPGFYQDGEYDLAGFTVGVVDRDKIIDGSSITVGNT
HHHHHHHHHHHHHCHHHCCCCCCCCCCCCCCCCEEECEEEEEEECCCCEECCCCEEECHH
LIGLASSGLHSNGYSLARKIIFDTLGFGINDMLPGHDRSVADELLTPTRIYVKSVLNLLR
HHHHHCCCCCCCHHHHHHHHHHHHHCCCHHCCCCCCCHHHHHHHCCCHHHHHHHHHHHHH
DFRVNGIAHITGGGLLENVPRILPKGCKAIIRRDSWTMPEIFRILQNGGNMEWTEMYRTF
HHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHH
NCGIGMVLAVPENDVDEVLIRLSGLQEKAFVIGEVAKCEAGTESVEMI
CCCCEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA