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The map label for this gene is moeA [H]

Identifier: 78223011

GI number: 78223011

Start: 2019654

End: 2020958

Strand: Direct

Name: moeA [H]

Synonym: Gmet_1804

Alternate gene names: 78223011

Gene position: 2019654-2020958 (Clockwise)

Preceding gene: 78223010

Following gene: 78223012

Centisome position: 50.52

GC content: 63.3

Gene sequence:

>1305_bases
ATGCCAGGCTCAGAGGAAACCCTCCGGATTATTCTTGATAACATAACTCCGCTCGGAGTGGAGCGTGTCGACCTGCAGTC
CGCCCTGGGGAGGGTCCTGGCCAGGGATGTGGTGGCACCATGGGATTTGCCGCTTTTCGACAATTCGGCGAGGGACGGAT
TCGCCCTGAGAAGTGCGGACTGCACGGGCGAGGGGACCACCCTACGGATTACCGGCTTTATTCCGGCCGGATGCAATGTG
TCGGAGCCGGTTCTGGGGGGGTGCGCCGTCCGGATCATGACCGGTGCACCTATCCCCCACAACTGCGATGCGGTGGTGCC
GGGGGAGGATACCCTGGAGACAGATGGCCAGGTGACGGTCATGGCGCCGGTCCGTCGCCGGCAGTATATCCGCTTCCGGG
GTGAGGACCTGACAGGCGGTGACCTGGTGCTGACGGAGGGGACGGTCATTCAGGCACAGGAAATAGGCTTGCTGGCCTCA
TTTGGCCAAGCGGTGGTGCCGGTCTACCGGAAGGCGCGGGTGGCGGTGCTCTCCACCGGCGATGAGTTGATCGAACTGGG
AGAGCAGCCGTCAAACGGACGCATCATCAACAGCAATGCCCAGTATCTGGCTGCGGCTCTCAGGGAGATCGGCGCCGAGC
CGATTCTCCTCTGCATCGGTCGTGACAACCGGGAAAGCCTGAAAGAGCAGCTTCAGACGGGACTGAAGGCCGATGCGCTG
ATCACTACGGCCGGCGTCTCGGCAGGAGCCCGGGACCTCGTGCGGGATGTGCTGGTTGAGGTGGGGGTCAGGCAGATGCT
CGGAAAGATTGAGATGAAGTCGGGCGGACCCAAGGCCTTCGGCATGAAGGACGGGATCCCGGTCTTCTCCCTTCCCGGCA
ATCCGCTGTCGACCATGGTCACGTTCGAGGAATTCGTCAGACCGGGGCTGCTCAGGCTGATGGGGCATCGCCGGACGGTC
AGGCCGAACCTCAAGGCACGGCTGCGGGAAGATATCCGCAAGGAGCCCGGCCGGGTCCATTGCCAGTCGGTCCGGGTAGA
GGCGGAGAACGGCCGCTACATGGCCACCACGGTCGGAAACCACAAGGCGTGCCGGCTGAGTACCATCCAACGGGCCAATG
CCATTGTCATCCTCCCCGAAGGACCGTCGGTGGTGGCGGCAGGGGAAGAGGTGGAGGTACATCTGCTGCGCGGTGACCTG
GTCCTGCTGGAAGAACCGAACCTCACTGCCGGTTGCGTACCTGATGACCGTGTGTCGGAAGAGGGGGAGACCTTCGAGAG
AAGGGTGCGGGTGGCAACCCGTTAG

Upstream 100 bases:

>100_bases
CGGGCGCAAGAACGGGTAGCATGATACTCCCCCCGGCAGGGCCGGGGGGACCACAACATGCGTCCAACATGGAAGCTGAA
CGGATTTTGGAGAAGGTGAG

Downstream 100 bases:

>100_bases
GGAAGGGGTAGATATCATGCGACAGGATGGGGGACCGTCAGATGAACGCGTATGAGCAGATCAGTTTGCAGATACCCGGG
GAGGTCGAGCGTCTCATGGA

Product: molybdopterin biosynthesis protein MoeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MPGSEETLRIILDNITPLGVERVDLQSALGRVLARDVVAPWDLPLFDNSARDGFALRSADCTGEGTTLRITGFIPAGCNV
SEPVLGGCAVRIMTGAPIPHNCDAVVPGEDTLETDGQVTVMAPVRRRQYIRFRGEDLTGGDLVLTEGTVIQAQEIGLLAS
FGQAVVPVYRKARVAVLSTGDELIELGEQPSNGRIINSNAQYLAAALREIGAEPILLCIGRDNRESLKEQLQTGLKADAL
ITTAGVSAGARDLVRDVLVEVGVRQMLGKIEMKSGGPKAFGMKDGIPVFSLPGNPLSTMVTFEEFVRPGLLRLMGHRRTV
RPNLKARLREDIRKEPGRVHCQSVRVEAENGRYMATTVGNHKACRLSTIQRANAIVILPEGPSVVAAGEEVEVHLLRGDL
VLLEEPNLTAGCVPDDRVSEEGETFERRVRVATR

Sequences:

>Translated_434_residues
MPGSEETLRIILDNITPLGVERVDLQSALGRVLARDVVAPWDLPLFDNSARDGFALRSADCTGEGTTLRITGFIPAGCNV
SEPVLGGCAVRIMTGAPIPHNCDAVVPGEDTLETDGQVTVMAPVRRRQYIRFRGEDLTGGDLVLTEGTVIQAQEIGLLAS
FGQAVVPVYRKARVAVLSTGDELIELGEQPSNGRIINSNAQYLAAALREIGAEPILLCIGRDNRESLKEQLQTGLKADAL
ITTAGVSAGARDLVRDVLVEVGVRQMLGKIEMKSGGPKAFGMKDGIPVFSLPGNPLSTMVTFEEFVRPGLLRLMGHRRTV
RPNLKARLREDIRKEPGRVHCQSVRVEAENGRYMATTVGNHKACRLSTIQRANAIVILPEGPSVVAAGEEVEVHLLRGDL
VLLEEPNLTAGCVPDDRVSEEGETFERRVRVATR
>Mature_433_residues
PGSEETLRIILDNITPLGVERVDLQSALGRVLARDVVAPWDLPLFDNSARDGFALRSADCTGEGTTLRITGFIPAGCNVS
EPVLGGCAVRIMTGAPIPHNCDAVVPGEDTLETDGQVTVMAPVRRRQYIRFRGEDLTGGDLVLTEGTVIQAQEIGLLASF
GQAVVPVYRKARVAVLSTGDELIELGEQPSNGRIINSNAQYLAAALREIGAEPILLCIGRDNRESLKEQLQTGLKADALI
TTAGVSAGARDLVRDVLVEVGVRQMLGKIEMKSGGPKAFGMKDGIPVFSLPGNPLSTMVTFEEFVRPGLLRLMGHRRTVR
PNLKARLREDIRKEPGRVHCQSVRVEAENGRYMATTVGNHKACRLSTIQRANAIVILPEGPSVVAAGEEVEVHLLRGDLV
LLEEPNLTAGCVPDDRVSEEGETFERRVRVATR

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=381, Percent_Identity=36.745406824147, Blast_Score=188, Evalue=7e-48,
Organism=Homo sapiens, GI10880983, Length=381, Percent_Identity=36.745406824147, Blast_Score=188, Evalue=8e-48,
Organism=Escherichia coli, GI1787049, Length=378, Percent_Identity=37.5661375661376, Blast_Score=214, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI25147659, Length=322, Percent_Identity=31.3664596273292, Blast_Score=136, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17562606, Length=335, Percent_Identity=25.3731343283582, Blast_Score=81, Evalue=8e-16,
Organism=Drosophila melanogaster, GI17136978, Length=411, Percent_Identity=30.4136253041363, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24638841, Length=411, Percent_Identity=30.4136253041363, Blast_Score=141, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 46858; Mature: 46726

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGSEETLRIILDNITPLGVERVDLQSALGRVLARDVVAPWDLPLFDNSARDGFALRSAD
CCCCHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCC
CTGEGTTLRITGFIPAGCNVSEPVLGGCAVRIMTGAPIPHNCDAVVPGEDTLETDGQVTV
CCCCCCEEEEEEEECCCCCCCCCCCCCEEEEEEECCCCCCCCCEECCCCCCCCCCCCEEE
MAPVRRRQYIRFRGEDLTGGDLVLTEGTVIQAQEIGLLASFGQAVVPVYRKARVAVLSTG
ECCCCCCEEEEECCCCCCCCCEEEECCCEEEHHHCCHHHHCCHHHHHHHHCCEEEEEECC
DELIELGEQPSNGRIINSNAQYLAAALREIGAEPILLCIGRDNRESLKEQLQTGLKADAL
HHHHHCCCCCCCCEEECCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCEE
ITTAGVSAGARDLVRDVLVEVGVRQMLGKIEMKSGGPKAFGMKDGIPVFSLPGNPLSTMV
EEECCCCCCHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCCCCCCEEEECCCCCHHHHH
TFEEFVRPGLLRLMGHRRTVRPNLKARLREDIRKEPGRVHCQSVRVEAENGRYMATTVGN
HHHHHHCHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEEEECCCEEEEEECCC
HKACRLSTIQRANAIVILPEGPSVVAAGEEVEVHLLRGDLVLLEEPNLTAGCVPDDRVSE
CCEEEEHHHHHCCEEEEEECCCCEEECCCCEEEEEEECCEEEEECCCCCCCCCCCCCCCC
EGETFERRVRVATR
CCHHHHHHHHCCCC
>Mature Secondary Structure 
PGSEETLRIILDNITPLGVERVDLQSALGRVLARDVVAPWDLPLFDNSARDGFALRSAD
CCCHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCC
CTGEGTTLRITGFIPAGCNVSEPVLGGCAVRIMTGAPIPHNCDAVVPGEDTLETDGQVTV
CCCCCCEEEEEEEECCCCCCCCCCCCCEEEEEEECCCCCCCCCEECCCCCCCCCCCCEEE
MAPVRRRQYIRFRGEDLTGGDLVLTEGTVIQAQEIGLLASFGQAVVPVYRKARVAVLSTG
ECCCCCCEEEEECCCCCCCCCEEEECCCEEEHHHCCHHHHCCHHHHHHHHCCEEEEEECC
DELIELGEQPSNGRIINSNAQYLAAALREIGAEPILLCIGRDNRESLKEQLQTGLKADAL
HHHHHCCCCCCCCEEECCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCEE
ITTAGVSAGARDLVRDVLVEVGVRQMLGKIEMKSGGPKAFGMKDGIPVFSLPGNPLSTMV
EEECCCCCCHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCCCCCCEEEECCCCCHHHHH
TFEEFVRPGLLRLMGHRRTVRPNLKARLREDIRKEPGRVHCQSVRVEAENGRYMATTVGN
HHHHHHCHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEEEECCCEEEEEECCC
HKACRLSTIQRANAIVILPEGPSVVAAGEEVEVHLLRGDLVLLEEPNLTAGCVPDDRVSE
CCEEEEHHHHHCCEEEEEECCCCEEECCCCEEEEEEECCEEEEECCCCCCCCCCCCCCCC
EGETFERRVRVATR
CCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]