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The map label for this gene is hbdA [H]

Identifier: 78222926

GI number: 78222926

Start: 1930132

End: 1930977

Strand: Reverse

Name: hbdA [H]

Synonym: Gmet_1717

Alternate gene names: 78222926

Gene position: 1930977-1930132 (Counterclockwise)

Preceding gene: 78222928

Following gene: 78222925

Centisome position: 48.31

GC content: 58.75

Gene sequence:

>846_bases
ATGATCAACAAAGTAGGTGTGCTCGGCGCAGGTCAGATGGGAAACGGCATTGCCCACGTGTTCGCCCAGTTCGGCTATGA
CGTGGTGCTCTACGACATCGCGGAGCTTCAGCTCGAAAAGGCGGTGTCAACCATCAGGAAGAACCTGGAGCGGCAGGCAA
AGAAGGGGGGCATTCCCGAATCGCTGGTCGGTGAAACTGTCGGCAGGATTCTGACCACGAAGAACATGACCGATCTCGCC
GGCTGTGATTTCTGCGTGGAGGCGGTCACGGAGCACGAGCCCCTCAAGCTGGACATCTTCCGCAAACTGGACGATATCGT
TCAGCCGAGCGCTATTCTGGCATCAAACACCTCGTCCATCCCCATCACCAAGATCGCTTCGGTAACGAAGCGTCCCGACA
AGGTCATCGGCATGCACTTCATGAATCCGGTGCCGGTCATGAAGCTGGTGGAGGTCATCCGCGGCCACGCCAGCAGCGAC
GTCACCTTCCGCCTCACCGCCGAACTGGTGGCCAGGCTGGAAAAGGAAATGGCGGTTTCCCAGGACTACCCCGGCTTCAT
CGTGAACCGCATTCTTATGCCCATGATCAACGAGGCGGTCTTCGCCCTCTACGAAGGGATCGCCACCGCCGAGGACATCG
ACAAAGGGATGAAGCTCGGCACCAACCAGCCCATGGGCCCCCTGACGCTCGCCGACTTCATTGGCCTCGACACCTGCCTG
GCAATCATGGATGTCCTCTACGACGGCTTCAAGGACCCGAAGTACCGTCCCTGCCCGCTCCTGGTGAAGATGGTGAACGC
GGGGTATTTGGGGCGCAAGTCGGGAAGAGGGTTTTATTCCTACTAA

Upstream 100 bases:

>100_bases
GATCAACAGAGAAAGGCAAAAGACTTCCATCCCTGGCTTCCTGGTTTATCTCTGTTGCTCTGTTGCTCAGTGTTATTCGT
TTCTGAAATGGAGGCATCTG

Downstream 100 bases:

>100_bases
TATTTGCCACAGAGGTCACAGAGAAAACCAGTAAACCTTTAAGGCCCGGCTCGCATAACACCGCAGTACGTATAGGGATT
TTGGTTATTAGACTTGAAAG

Product: 3-hydroxyacyl-CoA dehydrogenase-like

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MINKVGVLGAGQMGNGIAHVFAQFGYDVVLYDIAELQLEKAVSTIRKNLERQAKKGGIPESLVGETVGRILTTKNMTDLA
GCDFCVEAVTEHEPLKLDIFRKLDDIVQPSAILASNTSSIPITKIASVTKRPDKVIGMHFMNPVPVMKLVEVIRGHASSD
VTFRLTAELVARLEKEMAVSQDYPGFIVNRILMPMINEAVFALYEGIATAEDIDKGMKLGTNQPMGPLTLADFIGLDTCL
AIMDVLYDGFKDPKYRPCPLLVKMVNAGYLGRKSGRGFYSY

Sequences:

>Translated_281_residues
MINKVGVLGAGQMGNGIAHVFAQFGYDVVLYDIAELQLEKAVSTIRKNLERQAKKGGIPESLVGETVGRILTTKNMTDLA
GCDFCVEAVTEHEPLKLDIFRKLDDIVQPSAILASNTSSIPITKIASVTKRPDKVIGMHFMNPVPVMKLVEVIRGHASSD
VTFRLTAELVARLEKEMAVSQDYPGFIVNRILMPMINEAVFALYEGIATAEDIDKGMKLGTNQPMGPLTLADFIGLDTCL
AIMDVLYDGFKDPKYRPCPLLVKMVNAGYLGRKSGRGFYSY
>Mature_281_residues
MINKVGVLGAGQMGNGIAHVFAQFGYDVVLYDIAELQLEKAVSTIRKNLERQAKKGGIPESLVGETVGRILTTKNMTDLA
GCDFCVEAVTEHEPLKLDIFRKLDDIVQPSAILASNTSSIPITKIASVTKRPDKVIGMHFMNPVPVMKLVEVIRGHASSD
VTFRLTAELVARLEKEMAVSQDYPGFIVNRILMPMINEAVFALYEGIATAEDIDKGMKLGTNQPMGPLTLADFIGLDTCL
AIMDVLYDGFKDPKYRPCPLLVKMVNAGYLGRKSGRGFYSY

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=288, Percent_Identity=42.3611111111111, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI296179427, Length=306, Percent_Identity=40.8496732026144, Blast_Score=199, Evalue=2e-51,
Organism=Homo sapiens, GI20127408, Length=287, Percent_Identity=34.1463414634146, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI68989263, Length=293, Percent_Identity=33.7883959044369, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI261878539, Length=293, Percent_Identity=33.7883959044369, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI115430219, Length=219, Percent_Identity=31.0502283105023, Blast_Score=92, Evalue=5e-19,
Organism=Escherichia coli, GI1787661, Length=284, Percent_Identity=38.0281690140845, Blast_Score=197, Evalue=8e-52,
Organism=Escherichia coli, GI1790281, Length=263, Percent_Identity=34.6007604562738, Blast_Score=138, Evalue=4e-34,
Organism=Escherichia coli, GI1788682, Length=258, Percent_Identity=35.2713178294574, Blast_Score=134, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI17549919, Length=287, Percent_Identity=39.3728222996516, Blast_Score=203, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI17553560, Length=286, Percent_Identity=40.2097902097902, Blast_Score=197, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI17563036, Length=287, Percent_Identity=39.0243902439024, Blast_Score=194, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17558304, Length=282, Percent_Identity=35.8156028368794, Blast_Score=164, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI25144276, Length=282, Percent_Identity=35.8156028368794, Blast_Score=160, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI17508953, Length=282, Percent_Identity=35.8156028368794, Blast_Score=160, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI17508951, Length=282, Percent_Identity=35.8156028368794, Blast_Score=160, Evalue=9e-40,
Organism=Caenorhabditis elegans, GI71985923, Length=282, Percent_Identity=31.9148936170213, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI71985930, Length=282, Percent_Identity=28.0141843971631, Blast_Score=120, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI193203623, Length=201, Percent_Identity=26.3681592039801, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI115533614, Length=201, Percent_Identity=26.3681592039801, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24583077, Length=283, Percent_Identity=36.3957597173145, Blast_Score=158, Evalue=5e-39,
Organism=Drosophila melanogaster, GI24583079, Length=283, Percent_Identity=36.3957597173145, Blast_Score=158, Evalue=5e-39,
Organism=Drosophila melanogaster, GI19921000, Length=283, Percent_Identity=36.3957597173145, Blast_Score=157, Evalue=5e-39,
Organism=Drosophila melanogaster, GI45549573, Length=227, Percent_Identity=30.3964757709251, Blast_Score=97, Evalue=9e-21,
Organism=Drosophila melanogaster, GI20129993, Length=227, Percent_Identity=27.7533039647577, Blast_Score=86, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 30777; Mature: 30777

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINKVGVLGAGQMGNGIAHVFAQFGYDVVLYDIAELQLEKAVSTIRKNLERQAKKGGIPE
CCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
SLVGETVGRILTTKNMTDLAGCDFCVEAVTEHEPLKLDIFRKLDDIVQPSAILASNTSSI
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHCCCCCC
PITKIASVTKRPDKVIGMHFMNPVPVMKLVEVIRGHASSDVTFRLTAELVARLEKEMAVS
CHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHC
QDYPGFIVNRILMPMINEAVFALYEGIATAEDIDKGMKLGTNQPMGPLTLADFIGLDTCL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
AIMDVLYDGFKDPKYRPCPLLVKMVNAGYLGRKSGRGFYSY
HHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MINKVGVLGAGQMGNGIAHVFAQFGYDVVLYDIAELQLEKAVSTIRKNLERQAKKGGIPE
CCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
SLVGETVGRILTTKNMTDLAGCDFCVEAVTEHEPLKLDIFRKLDDIVQPSAILASNTSSI
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHCCCCCC
PITKIASVTKRPDKVIGMHFMNPVPVMKLVEVIRGHASSDVTFRLTAELVARLEKEMAVS
CHHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHC
QDYPGFIVNRILMPMINEAVFALYEGIATAEDIDKGMKLGTNQPMGPLTLADFIGLDTCL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
AIMDVLYDGFKDPKYRPCPLLVKMVNAGYLGRKSGRGFYSY
HHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]