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The map label for this gene is bcd [H]

Identifier: 78222919

GI number: 78222919

Start: 1922128

End: 1923288

Strand: Reverse

Name: bcd [H]

Synonym: Gmet_1710

Alternate gene names: 78222919

Gene position: 1923288-1922128 (Counterclockwise)

Preceding gene: 78222920

Following gene: 78222918

Centisome position: 48.11

GC content: 62.53

Gene sequence:

>1161_bases
ATGTATCTCGAACTGACCGAAGAACAGAAACTGATTCAGGACACCGCCCGTGACTTTGCCAAGGCCGAACTGGAGCCGGT
GGCGGCGCAGCTTGACCAGGGAAGCGACCGCGGCCCCCTGCTGGCCAACCTGAAAAAGCTGGCCGAACTGGGTTTCATGG
GATTGAACGTGCGGGAGGAGTACGGCGGCGCCGAGGCCGGGGCCATCTCCTTCAGCGTGGCCATGACCGAGATCGCGCGG
GCCTGCGCCTCCACGGCGGTCACGGTCTCGGTCAACAACATGGCCGCCGAGGTTATCCAGGTCGTCGGTTCCGAGGAGCA
GAAACGGGCTTACATCCCGAAGATCTGTTCCGGCGAGTATTCCGCCGCCAGCTTCGCCCTCACCGAAACCTGCGCCGGCT
CCGATCCCGCCGGGATGGTGACCCAGGCCGTGGACGACGGCGACTCCTGGGTGCTGAACGGCTCCAAAATTTTCATTACC
AGCGCCTCCTATGCCGGGGTTTTCGTGGTCTGGGCGGTCACCGACAAGGCTGCCCCCAAGGGTAAAGGTATCAGTTGCTT
CCTGGTGGAGGCTGGAACGCCCGGCCTCATCATCGGCAAGGAAGAGCACAAGATGGGACAGCACGCCTCGGCCACCAACG
AGGTAATCTTCACCGACTGCCGCATCCCCAAGAGCGCCATGATGGGGAAGTTGAACGACGGTTTCCGGATCGCCGTGGCG
GAGCTGGCCGGCGGGCGGATCGGGATCGGTTCCCTGGGGCTCGGCGTCGGGCTGGCAGCCATGGACCATGCCACCCGCTA
TGCCTCCGAGCGGACCCAGTTCGGGCAAAAGATCAGCAACTTCCAGGCTATCCAGTGGATGGTGGCCGATGCCTACACCG
AACTGGAAGCGGCCCGGCTCCTCCTCATGAACGCCGCCTTTCGCAAGGACCAGGGTAAATCCTTTGCCAAGGAGGCCTCC
ATGGCGAAGCTGTATGCCACCGAGGCGGCCAACCGGGCCTGCTACGCGGCAATCCAGATGCTCGGCGGGTACGGCTACAC
CCAGGATTTCCCGGTTGAGCGTTATGCCCGCGATGCCCGAATCACCTCCATCTACGAAGGGACCAGCGAGATCCAGCGGG
TGGTTATCTCGCGGGAAATTCTCAAGAATTTTAACCAATAG

Upstream 100 bases:

>100_bases
AAGAGTACCGCGCCGCCTTTGCCGACCGGAGCGCCCGGGAGTGGCAGGAATGGGGACGGGAGCAGGATATTCCGATTATC
GTCGCAGAGGAGAAGAAACC

Downstream 100 bases:

>100_bases
AAATTATCACATATGGAGGTATGTATGGGGACAGGTAAACGCATTACCTTGCAGCAGGCCGCCGAGATCATCAAGGACGG
CTCCAGCCTCACCTTCTCCG

Product: Acyl-CoA dehydrogenase-like

Products: NA

Alternate protein names: Butyryl-CoA dehydrogenase; SCAD [H]

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MYLELTEEQKLIQDTARDFAKAELEPVAAQLDQGSDRGPLLANLKKLAELGFMGLNVREEYGGAEAGAISFSVAMTEIAR
ACASTAVTVSVNNMAAEVIQVVGSEEQKRAYIPKICSGEYSAASFALTETCAGSDPAGMVTQAVDDGDSWVLNGSKIFIT
SASYAGVFVVWAVTDKAAPKGKGISCFLVEAGTPGLIIGKEEHKMGQHASATNEVIFTDCRIPKSAMMGKLNDGFRIAVA
ELAGGRIGIGSLGLGVGLAAMDHATRYASERTQFGQKISNFQAIQWMVADAYTELEAARLLLMNAAFRKDQGKSFAKEAS
MAKLYATEAANRACYAAIQMLGGYGYTQDFPVERYARDARITSIYEGTSEIQRVVISREILKNFNQ

Sequences:

>Translated_386_residues
MYLELTEEQKLIQDTARDFAKAELEPVAAQLDQGSDRGPLLANLKKLAELGFMGLNVREEYGGAEAGAISFSVAMTEIAR
ACASTAVTVSVNNMAAEVIQVVGSEEQKRAYIPKICSGEYSAASFALTETCAGSDPAGMVTQAVDDGDSWVLNGSKIFIT
SASYAGVFVVWAVTDKAAPKGKGISCFLVEAGTPGLIIGKEEHKMGQHASATNEVIFTDCRIPKSAMMGKLNDGFRIAVA
ELAGGRIGIGSLGLGVGLAAMDHATRYASERTQFGQKISNFQAIQWMVADAYTELEAARLLLMNAAFRKDQGKSFAKEAS
MAKLYATEAANRACYAAIQMLGGYGYTQDFPVERYARDARITSIYEGTSEIQRVVISREILKNFNQ
>Mature_386_residues
MYLELTEEQKLIQDTARDFAKAELEPVAAQLDQGSDRGPLLANLKKLAELGFMGLNVREEYGGAEAGAISFSVAMTEIAR
ACASTAVTVSVNNMAAEVIQVVGSEEQKRAYIPKICSGEYSAASFALTETCAGSDPAGMVTQAVDDGDSWVLNGSKIFIT
SASYAGVFVVWAVTDKAAPKGKGISCFLVEAGTPGLIIGKEEHKMGQHASATNEVIFTDCRIPKSAMMGKLNDGFRIAVA
ELAGGRIGIGSLGLGVGLAAMDHATRYASERTQFGQKISNFQAIQWMVADAYTELEAARLLLMNAAFRKDQGKSFAKEAS
MAKLYATEAANRACYAAIQMLGGYGYTQDFPVERYARDARITSIYEGTSEIQRVVISREILKNFNQ

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=384, Percent_Identity=47.65625, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI4501859, Length=377, Percent_Identity=40.8488063660477, Blast_Score=286, Evalue=3e-77,
Organism=Homo sapiens, GI7656849, Length=379, Percent_Identity=41.1609498680739, Blast_Score=278, Evalue=5e-75,
Organism=Homo sapiens, GI226958412, Length=383, Percent_Identity=37.0757180156658, Blast_Score=251, Evalue=8e-67,
Organism=Homo sapiens, GI4557231, Length=385, Percent_Identity=35.8441558441558, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI187960098, Length=385, Percent_Identity=35.8441558441558, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI226958414, Length=343, Percent_Identity=38.1924198250729, Blast_Score=234, Evalue=9e-62,
Organism=Homo sapiens, GI4501857, Length=379, Percent_Identity=32.4538258575198, Blast_Score=210, Evalue=1e-54,
Organism=Homo sapiens, GI21361497, Length=345, Percent_Identity=37.6811594202899, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI76496475, Length=399, Percent_Identity=33.8345864661654, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI4557235, Length=399, Percent_Identity=33.8345864661654, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI4503943, Length=392, Percent_Identity=29.8469387755102, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI7669494, Length=378, Percent_Identity=29.6296296296296, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI48976061, Length=298, Percent_Identity=28.8590604026846, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI211971008, Length=298, Percent_Identity=28.8590604026846, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI38505218, Length=300, Percent_Identity=26.6666666666667, Blast_Score=99, Evalue=8e-21,
Organism=Escherichia coli, GI1786223, Length=385, Percent_Identity=29.8701298701299, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI87081958, Length=385, Percent_Identity=30.1298701298701, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI87081702, Length=325, Percent_Identity=27.6923076923077, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17506239, Length=377, Percent_Identity=40.053050397878, Blast_Score=281, Evalue=5e-76,
Organism=Caenorhabditis elegans, GI17508101, Length=385, Percent_Identity=39.7402597402597, Blast_Score=273, Evalue=9e-74,
Organism=Caenorhabditis elegans, GI17534899, Length=386, Percent_Identity=37.3056994818653, Blast_Score=255, Evalue=3e-68,
Organism=Caenorhabditis elegans, GI17538396, Length=383, Percent_Identity=38.1201044386423, Blast_Score=250, Evalue=8e-67,
Organism=Caenorhabditis elegans, GI17569725, Length=386, Percent_Identity=36.2694300518135, Blast_Score=249, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI17533517, Length=372, Percent_Identity=37.6344086021505, Blast_Score=248, Evalue=5e-66,
Organism=Caenorhabditis elegans, GI17570075, Length=389, Percent_Identity=34.7043701799486, Blast_Score=239, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI71990804, Length=299, Percent_Identity=41.4715719063545, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI32563615, Length=233, Percent_Identity=39.4849785407725, Blast_Score=168, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI71985184, Length=348, Percent_Identity=32.7586206896552, Blast_Score=161, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI71982178, Length=280, Percent_Identity=31.4285714285714, Blast_Score=158, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI17534353, Length=382, Percent_Identity=29.0575916230367, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17531909, Length=249, Percent_Identity=36.144578313253, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17551932, Length=374, Percent_Identity=28.3422459893048, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI71985192, Length=294, Percent_Identity=31.2925170068027, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17505929, Length=377, Percent_Identity=27.5862068965517, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17531913, Length=186, Percent_Identity=34.9462365591398, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17562446, Length=290, Percent_Identity=29.3103448275862, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI86563381, Length=345, Percent_Identity=28.695652173913, Blast_Score=71, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI86563383, Length=345, Percent_Identity=28.695652173913, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI21356377, Length=383, Percent_Identity=44.3864229765013, Blast_Score=298, Evalue=5e-81,
Organism=Drosophila melanogaster, GI24646207, Length=384, Percent_Identity=40.8854166666667, Blast_Score=290, Evalue=9e-79,
Organism=Drosophila melanogaster, GI24666513, Length=383, Percent_Identity=38.1201044386423, Blast_Score=265, Evalue=3e-71,
Organism=Drosophila melanogaster, GI24660351, Length=379, Percent_Identity=36.4116094986807, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI21355753, Length=382, Percent_Identity=33.7696335078534, Blast_Score=222, Evalue=4e-58,
Organism=Drosophila melanogaster, GI281363737, Length=350, Percent_Identity=36.8571428571429, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI19920834, Length=385, Percent_Identity=31.4285714285714, Blast_Score=154, Evalue=7e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: =1.3.99.2 [H]

Molecular weight: Translated: 41396; Mature: 41396

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYLELTEEQKLIQDTARDFAKAELEPVAAQLDQGSDRGPLLANLKKLAELGFMGLNVREE
CCEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCHHH
YGGAEAGAISFSVAMTEIARACASTAVTVSVNNMAAEVIQVVGSEEQKRAYIPKICSGEY
CCCCCCCCEEHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHCCCHHHHCCCCHHCCCCC
SAASFALTETCAGSDPAGMVTQAVDDGDSWVLNGSKIFITSASYAGVFVVWAVTDKAAPK
CHHHEEHHHHCCCCCCCCHHHHEECCCCCEEEECCEEEEEECCCCCEEEEEEEECCCCCC
GKGISCFLVEAGTPGLIIGKEEHKMGQHASATNEVIFTDCRIPKSAMMGKLNDGFRIAVA
CCCCEEEEEECCCCCEEECCHHHHCCCCCCCCCCEEEEECCCCHHHHHCCCCCCCEEEEE
ELAGGRIGIGSLGLGVGLAAMDHATRYASERTQFGQKISNFQAIQWMVADAYTELEAARL
ECCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLMNAAFRKDQGKSFAKEASMAKLYATEAANRACYAAIQMLGGYGYTQDFPVERYARDAR
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
ITSIYEGTSEIQRVVISREILKNFNQ
HHHHHCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MYLELTEEQKLIQDTARDFAKAELEPVAAQLDQGSDRGPLLANLKKLAELGFMGLNVREE
CCEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCHHH
YGGAEAGAISFSVAMTEIARACASTAVTVSVNNMAAEVIQVVGSEEQKRAYIPKICSGEY
CCCCCCCCEEHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHCCCHHHHCCCCHHCCCCC
SAASFALTETCAGSDPAGMVTQAVDDGDSWVLNGSKIFITSASYAGVFVVWAVTDKAAPK
CHHHEEHHHHCCCCCCCCHHHHEECCCCCEEEECCEEEEEECCCCCEEEEEEEECCCCCC
GKGISCFLVEAGTPGLIIGKEEHKMGQHASATNEVIFTDCRIPKSAMMGKLNDGFRIAVA
CCCCEEEEEECCCCCEEECCHHHHCCCCCCCCCCEEEEECCCCHHHHHCCCCCCCEEEEE
ELAGGRIGIGSLGLGVGLAAMDHATRYASERTQFGQKISNFQAIQWMVADAYTELEAARL
ECCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLMNAAFRKDQGKSFAKEASMAKLYATEAANRACYAAIQMLGGYGYTQDFPVERYARDAR
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
ITSIYEGTSEIQRVVISREILKNFNQ
HHHHHCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]