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The map label for this gene is nodT [H]

Identifier: 78222875

GI number: 78222875

Start: 1870554

End: 1872194

Strand: Reverse

Name: nodT [H]

Synonym: Gmet_1666

Alternate gene names: 78222875

Gene position: 1872194-1870554 (Counterclockwise)

Preceding gene: 78222876

Following gene: 78222874

Centisome position: 46.84

GC content: 60.76

Gene sequence:

>1641_bases
ATGTTTGTTCAAAGACGTACCACCTTCAACAAAAGCCGGCGTCAATGCGTAGTGCTGGCAGCCGTATTCATCCTCTCTGG
TTGCATCAAGGTGGGGCCGGATTTTCACCGGCCAGATGTCGCGGTTCCATCTGACTGGACGGAGGCAGGAGAAAACCAGG
GGGAAACCGGCCCCGCGGATTATCGCAGTTGGTGGCGGGTATTCAACGACCCGATCCTCGACCGCCTTATTGACCTCGCT
TACCGTGAGAACCTCACCCTCAGGATCGCCGGAGCGCGAGTGCTCGAAGCCAGGGCGCTGCTCGGCATAGTGGTCGGAGA
GTATTTCCCGCAGACCCAGCAGGGCTTTGGCTCGGTTCACTACAACAGGACAAGCCGGGGGTCTGTGCAGACCGGCACCC
AACAATCTTCCGCCAGCCAAAGCAGTGCGTCGCTCGGAGGTGGCTCCGGGTTATCGTTCTGGCAATCGCAGATCGGGTTG
ACGGCCAGTTGGGAACTCGATTTCTGGGGCAAGTACAGGCGGGCCATCGAATCGGCCGATGCAAGCTGGCTTGCCTCTGT
GGCCGACTACGACAATGCACTTGTGGCTCTTACGGCGGATGTCGCCAATTCCTACATAACCATCAGGACCCTGGAAACGC
GGCTCGACATTGCCCGCCGGAACACGCAAACCCAGAGAGAGAACCTGAACATCGCCGAAGCCCGGTTCAAGTACGGCACA
GCAACGCAGCTGGATCTGGATCAGGCAGAAACTTCGCTCAATACCACCCTTGCCACGACCCCCTCCCTGGAAGCGCAACT
CCGGCAGACAAAACACGGCCTCAGCGTCCTGTTGGGAATGGCGCCGGGCGATCTGTCCGGCTATCTGAATGGTCCTGCCA
CTATCCCCGTCTCTCCCCCCCAGGTTGTGTTCGGCATCCCGGCCGACCTGCTACGCCGCCGGCCCGATATCCGCGCCGCG
GAACACCGTGCAGCGGCCCAGAGCGCCCAGATCGGCGTGGCAAAGGCTGACCTCTATCCCGCTTTCTCCCTCTCCGGCAC
GTTTGGTTTCCTCTCAACCGATATCGGCGGTGCCAGCCTGAGCGACATGTTCAACTGGAGCAGCCGTTTCATACAGGCAG
GCCCTTCGTTCCAGTGGAACATCCTCAATTACGGCCGGATTTCGAACAATGTCCGGCTCCAGGATGCGCGGCTCCAGGAA
CTGCTCATCACCTACCAGAACATGGTGCTCACCGCGCAGCAGGAGGTTGAGGACAACCTGGTGGCCTTCCTGCGGGCCCG
CGACCGGGCCGAATTCCTGGCGCGGAGCACAGCCGCTGCGGCGAGATCTCTCAATCTCGCGGTCCTCCAGTATCAGCAGG
GGATCAAGGACTTCACCACGGTACTTATCGCGCAGCAGTCCCTCTTGAATGAGCAGGACAGCCTGGCCACAACCATGGGC
AGCATCGCGAGCAGTCTGGTTGGTGTGTACCGGGCACTGGGGGGCGGTTGGGAGATACGGGAAGGAAAAGAACTGGTTCC
CCCTGAGATCAGAAAAGAAATGGAACAGCGAACCGATTGGGGAAAGCTCCTTGCCCCGGCGTCATACAATCCGCCCGCCC
CCCCGGAGCACAAGCCAGGAGTCCGGGGGCCGGACTGGTGA

Upstream 100 bases:

>100_bases
ACAGCATTACTGCCGACTGTCACTGCCGAACGACCGCCGAAAGGTGCTACCGAAACCTCGATTCCAGCAGTGAACGGACC
AAGGATGGGCTCGTACGGCA

Downstream 100 bases:

>100_bases
CCGTTTTGCCGCGGCATCATGAATAGATCAGTACTGAACGGAGACATTCGATAGTCTGATGCGGACCAGGGAGGCAATGC
GGCTATGTTTCGCGGAATGA

Product: RND efflux system, outer membrane lipoprotein, NodT

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 546; Mature: 546

Protein sequence:

>546_residues
MFVQRRTTFNKSRRQCVVLAAVFILSGCIKVGPDFHRPDVAVPSDWTEAGENQGETGPADYRSWWRVFNDPILDRLIDLA
YRENLTLRIAGARVLEARALLGIVVGEYFPQTQQGFGSVHYNRTSRGSVQTGTQQSSASQSSASLGGGSGLSFWQSQIGL
TASWELDFWGKYRRAIESADASWLASVADYDNALVALTADVANSYITIRTLETRLDIARRNTQTQRENLNIAEARFKYGT
ATQLDLDQAETSLNTTLATTPSLEAQLRQTKHGLSVLLGMAPGDLSGYLNGPATIPVSPPQVVFGIPADLLRRRPDIRAA
EHRAAAQSAQIGVAKADLYPAFSLSGTFGFLSTDIGGASLSDMFNWSSRFIQAGPSFQWNILNYGRISNNVRLQDARLQE
LLITYQNMVLTAQQEVEDNLVAFLRARDRAEFLARSTAAAARSLNLAVLQYQQGIKDFTTVLIAQQSLLNEQDSLATTMG
SIASSLVGVYRALGGGWEIREGKELVPPEIRKEMEQRTDWGKLLAPASYNPPAPPEHKPGVRGPDW

Sequences:

>Translated_546_residues
MFVQRRTTFNKSRRQCVVLAAVFILSGCIKVGPDFHRPDVAVPSDWTEAGENQGETGPADYRSWWRVFNDPILDRLIDLA
YRENLTLRIAGARVLEARALLGIVVGEYFPQTQQGFGSVHYNRTSRGSVQTGTQQSSASQSSASLGGGSGLSFWQSQIGL
TASWELDFWGKYRRAIESADASWLASVADYDNALVALTADVANSYITIRTLETRLDIARRNTQTQRENLNIAEARFKYGT
ATQLDLDQAETSLNTTLATTPSLEAQLRQTKHGLSVLLGMAPGDLSGYLNGPATIPVSPPQVVFGIPADLLRRRPDIRAA
EHRAAAQSAQIGVAKADLYPAFSLSGTFGFLSTDIGGASLSDMFNWSSRFIQAGPSFQWNILNYGRISNNVRLQDARLQE
LLITYQNMVLTAQQEVEDNLVAFLRARDRAEFLARSTAAAARSLNLAVLQYQQGIKDFTTVLIAQQSLLNEQDSLATTMG
SIASSLVGVYRALGGGWEIREGKELVPPEIRKEMEQRTDWGKLLAPASYNPPAPPEHKPGVRGPDW
>Mature_546_residues
MFVQRRTTFNKSRRQCVVLAAVFILSGCIKVGPDFHRPDVAVPSDWTEAGENQGETGPADYRSWWRVFNDPILDRLIDLA
YRENLTLRIAGARVLEARALLGIVVGEYFPQTQQGFGSVHYNRTSRGSVQTGTQQSSASQSSASLGGGSGLSFWQSQIGL
TASWELDFWGKYRRAIESADASWLASVADYDNALVALTADVANSYITIRTLETRLDIARRNTQTQRENLNIAEARFKYGT
ATQLDLDQAETSLNTTLATTPSLEAQLRQTKHGLSVLLGMAPGDLSGYLNGPATIPVSPPQVVFGIPADLLRRRPDIRAA
EHRAAAQSAQIGVAKADLYPAFSLSGTFGFLSTDIGGASLSDMFNWSSRFIQAGPSFQWNILNYGRISNNVRLQDARLQE
LLITYQNMVLTAQQEVEDNLVAFLRARDRAEFLARSTAAAARSLNLAVLQYQQGIKDFTTVLIAQQSLLNEQDSLATTMG
SIASSLVGVYRALGGGWEIREGKELVPPEIRKEMEQRTDWGKLLAPASYNPPAPPEHKPGVRGPDW

Specific function: In Pathogenic Strains It Allows The Bacteria To Invade Brain Microvascular Endothelial Cells (Bmec) Thus Allowing It To Cross The Blood-Brain Barrier And Cause Neonatal Meningitis. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=486, Percent_Identity=28.1893004115226, Blast_Score=150, Evalue=3e-37,
Organism=Escherichia coli, GI2367348, Length=488, Percent_Identity=24.5901639344262, Blast_Score=114, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 59976; Mature: 59976

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVQRRTTFNKSRRQCVVLAAVFILSGCIKVGPDFHRPDVAVPSDWTEAGENQGETGPAD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCCCCCHH
YRSWWRVFNDPILDRLIDLAYRENLTLRIAGARVLEARALLGIVVGEYFPQTQQGFGSVH
HHHHHHHHCCHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHCCCHHHCCCCEE
YNRTSRGSVQTGTQQSSASQSSASLGGGSGLSFWQSQIGLTASWELDFWGKYRRAIESAD
ECCCCCCCCCCCCCHHCCCCCCCCCCCCCCHHHHHHHCCCEEEECCHHHHHHHHHHHHCC
ASWLASVADYDNALVALTADVANSYITIRTLETRLDIARRNTQTQRENLNIAEARFKYGT
HHHHHHHHCCCCEEEEEEEECCCCEEEEEEHHHHHHHHHHCCHHHHHCCCHHHHHHCCCC
ATQLDLDQAETSLNTTLATTPSLEAQLRQTKHGLSVLLGMAPGDLSGYLNGPATIPVSPP
CCEEEHHHHHHHHCCEEECCCCHHHHHHHHHHCHHEEEECCCCCCCCCCCCCEEECCCCC
QVVFGIPADLLRRRPDIRAAEHRAAAQSAQIGVAKADLYPAFSLSGTFGFLSTDIGGASL
CEEEECCHHHHHCCCCCHHHHHHHHHHHHHCCEEECCCCCCEECCCCCCCCCCCCCCCHH
SDMFNWSSRFIQAGPSFQWNILNYGRISNNVRLQDARLQELLITYQNMVLTAQQEVEDNL
HHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAFLRARDRAEFLARSTAAAARSLNLAVLQYQQGIKDFTTVLIAQQSLLNEQDSLATTMG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
SIASSLVGVYRALGGGWEIREGKELVPPEIRKEMEQRTDWGKLLAPASYNPPAPPEHKPG
HHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHCCCHHHEECCCCCCCCCCCCCCCC
VRGPDW
CCCCCC
>Mature Secondary Structure
MFVQRRTTFNKSRRQCVVLAAVFILSGCIKVGPDFHRPDVAVPSDWTEAGENQGETGPAD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCCCCCHH
YRSWWRVFNDPILDRLIDLAYRENLTLRIAGARVLEARALLGIVVGEYFPQTQQGFGSVH
HHHHHHHHCCHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHCCCHHHCCCCEE
YNRTSRGSVQTGTQQSSASQSSASLGGGSGLSFWQSQIGLTASWELDFWGKYRRAIESAD
ECCCCCCCCCCCCCHHCCCCCCCCCCCCCCHHHHHHHCCCEEEECCHHHHHHHHHHHHCC
ASWLASVADYDNALVALTADVANSYITIRTLETRLDIARRNTQTQRENLNIAEARFKYGT
HHHHHHHHCCCCEEEEEEEECCCCEEEEEEHHHHHHHHHHCCHHHHHCCCHHHHHHCCCC
ATQLDLDQAETSLNTTLATTPSLEAQLRQTKHGLSVLLGMAPGDLSGYLNGPATIPVSPP
CCEEEHHHHHHHHCCEEECCCCHHHHHHHHHHCHHEEEECCCCCCCCCCCCCEEECCCCC
QVVFGIPADLLRRRPDIRAAEHRAAAQSAQIGVAKADLYPAFSLSGTFGFLSTDIGGASL
CEEEECCHHHHHCCCCCHHHHHHHHHHHHHCCEEECCCCCCEECCCCCCCCCCCCCCCHH
SDMFNWSSRFIQAGPSFQWNILNYGRISNNVRLQDARLQELLITYQNMVLTAQQEVEDNL
HHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAFLRARDRAEFLARSTAAAARSLNLAVLQYQQGIKDFTTVLIAQQSLLNEQDSLATTMG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
SIASSLVGVYRALGGGWEIREGKELVPPEIRKEMEQRTDWGKLLAPASYNPPAPPEHKPG
HHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHCCCHHHEECCCCCCCCCCCCCCCC
VRGPDW
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2338917; 2622339 [H]