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The map label for this gene is tlpA [H]

Identifier: 78222850

GI number: 78222850

Start: 1841071

End: 1843062

Strand: Direct

Name: tlpA [H]

Synonym: Gmet_1641

Alternate gene names: 78222850

Gene position: 1841071-1843062 (Clockwise)

Preceding gene: 78222849

Following gene: 78222851

Centisome position: 46.06

GC content: 53.51

Gene sequence:

>1992_bases
ATGGATTCCGGGGCTGTCGTGAAGAATAGAAGTATTCGCTACGGGCTTTTCGGGTGTATTCTGGGTATCAGCGCCCCCAT
AGGGTGGACGCTCATCCGCCTGATTTTTTTCGCCAATCCCGACCAGTCTCTCCTGTCGCGAGTTTTTGGCGATATCGTTA
AATCCCCCTTTAATATCGCACTGTATACCTACATGGGAATCGGCACCGCAGGTGTGCTCGCCGTGCTCGGCTACTATATC
GGCAAGACGACTGATGAACTCCATAGCCGGGCTTCGGAACTGAATGTTCTTCATCAGGAGGTCGCTTCTCAAAAGGAAAT
TTTTGAACAGCGTTACCGTGCCCTCGACAGCAACATCAAAAACTTTCACCAAATCAGCAGTAAAATCCAGAAATCCATTG
ACATCGAAGAGGTTCTGCTCCTGTGCGCTGAAGGGCTCCACGATGTCCTCGGTTACGAGCGGGTCTCCATCCTGATGGCC
GACGAAGGGCGCTCCAATCTTTCTTTTGTGGCGTCCGTCGGCACACCGGACTTCAACCCCCAAGGAGTCAGCATCCCTCT
TGATATCCGTAGCGGAGTCATTTTCAAGTGCTTTGCGGATCGGCAGATCTACATGATCGACGACCTCAGCACGTATCCGG
CTGACTTCCGGCTCAAGCCTCCCTACGACGCCATCCGTGCGTTGCGCTCCAGGAGCTTTGTTCTCTGCCCCATCATCGTG
AAGGGTGAATCAGTGGGGGTATTCGGCATCGACAACCGGCAAAGCCGGCGTCCTCTCAATGACACCGATGTCGACACCAT
CAGGCTTTTCGCCGACCAGGCAGCCTCGGCCATCATCCGGATCAACCTCCTGAAGGCAATCGGAACGCTCACCTCTGAGC
TGGAAACCACTTTCTCCGACCTGCTTAAGAACCGCGACCACTATTCCCGCTACGTAGTAAATCTCAAGGATGCGGTCAAT
TCTGTTGCCGACGGTACCGCTCACATCGCATCCGCCGCCGAAAGCGTCCTTGCCTCCGTTGATGAGACAAGTTCGTCGGT
GAGCAATATTTACGTATCCATCGAGCAGGTTACGAAAAATCTCGATTATCTTTCCGAATCTATCGAAAAATCGGTGTCGG
CCATGGAAGAGCTCAACTCCACCATCAAGAATGTTGAGCAGAGTGCCGCGATCTCGCACCAGGTTTCAAGCAAGGTAAAA
GAGGAAGCTGACCGGGGGAGGCGTGTGGTGAAGGAGACCATCGCGTCGCTGGCCGAGATCCAGCGTTCGGTTGAGCTTTC
CTTTGATGCCATGAAGCGGCTCACGGAAAACAGCGGCCGTATCGAGAGCATCGTAGGGGTTATCAACGACATTACCAAGC
GGACCAATCTCCTTGCTCTCAACGCCTCAATCATCGCTGCCCAGGCCGGAGAATACGGCAAGAGCTTCGGTGTTGTTGCC
GATGAGATCCGTAACCTTTCGCTCCAGACCGGTCAGTCAACCGGTGAAATCACCGGCATCATCGAAGAGATCATGAATGA
GTCCCACAGTGCCGCCCAGAACATTTCCGCCTCCAAGGAACTCGTGCAGAAAGGGGTGGAACTGGGGGGGGTTATGGGGC
AATCGCTCCAGGTGATTCACGAGAGTTCGGCCCGATCACTGGACATGACCCAGGAAATTAAGATTGCAACCGAAGAGCAG
GTCCGCAGCGTGCAGCTTGTCACCCATTCCATCGAAAACGTGAGCAGCATGAGTTCTCAAATATTCAAGGCGTCCAAGGA
GCAGTCCGATGCCGCCATGAGCATTGTCCGTTCCGTTGATACGATTAAGGAAATGACCCAGGAAATGGTCAAGGCGACCG
TCAAACAGGTGGAAGACGGCAGCGAGATCAAGCAGTCGGTGGAAGCCGTGGGCGAGATGGTAACCAAAATATTTGAAGAC
ATGGAAGTTCGGCGCGGAGAAAGCTCCGCCGTAGTGAGAGAACTTGAAATGATGAAGAAAATCGCCGAATGA

Upstream 100 bases:

>100_bases
TAGAGTGTGACGATATTTCTCTGAAGAAACTCATGCAGCGACCGATGTTATTATGTATGAACCTCTTTCGGGGTACGATT
CACATGGAGGGAAACCGTTT

Downstream 100 bases:

>100_bases
ATTTAATGGACAGTCTCATCTGATTTATGGTAAACAATAACCGTGTTCTATAAATGACCCGCAACGCTGGCGGAGTCGAA
AATCTGTTCACGACAAATTG

Product: methyl-accepting chemotaxis sensory transducer with GAF sensor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 663; Mature: 663

Protein sequence:

>663_residues
MDSGAVVKNRSIRYGLFGCILGISAPIGWTLIRLIFFANPDQSLLSRVFGDIVKSPFNIALYTYMGIGTAGVLAVLGYYI
GKTTDELHSRASELNVLHQEVASQKEIFEQRYRALDSNIKNFHQISSKIQKSIDIEEVLLLCAEGLHDVLGYERVSILMA
DEGRSNLSFVASVGTPDFNPQGVSIPLDIRSGVIFKCFADRQIYMIDDLSTYPADFRLKPPYDAIRALRSRSFVLCPIIV
KGESVGVFGIDNRQSRRPLNDTDVDTIRLFADQAASAIIRINLLKAIGTLTSELETTFSDLLKNRDHYSRYVVNLKDAVN
SVADGTAHIASAAESVLASVDETSSSVSNIYVSIEQVTKNLDYLSESIEKSVSAMEELNSTIKNVEQSAAISHQVSSKVK
EEADRGRRVVKETIASLAEIQRSVELSFDAMKRLTENSGRIESIVGVINDITKRTNLLALNASIIAAQAGEYGKSFGVVA
DEIRNLSLQTGQSTGEITGIIEEIMNESHSAAQNISASKELVQKGVELGGVMGQSLQVIHESSARSLDMTQEIKIATEEQ
VRSVQLVTHSIENVSSMSSQIFKASKEQSDAAMSIVRSVDTIKEMTQEMVKATVKQVEDGSEIKQSVEAVGEMVTKIFED
MEVRRGESSAVVRELEMMKKIAE

Sequences:

>Translated_663_residues
MDSGAVVKNRSIRYGLFGCILGISAPIGWTLIRLIFFANPDQSLLSRVFGDIVKSPFNIALYTYMGIGTAGVLAVLGYYI
GKTTDELHSRASELNVLHQEVASQKEIFEQRYRALDSNIKNFHQISSKIQKSIDIEEVLLLCAEGLHDVLGYERVSILMA
DEGRSNLSFVASVGTPDFNPQGVSIPLDIRSGVIFKCFADRQIYMIDDLSTYPADFRLKPPYDAIRALRSRSFVLCPIIV
KGESVGVFGIDNRQSRRPLNDTDVDTIRLFADQAASAIIRINLLKAIGTLTSELETTFSDLLKNRDHYSRYVVNLKDAVN
SVADGTAHIASAAESVLASVDETSSSVSNIYVSIEQVTKNLDYLSESIEKSVSAMEELNSTIKNVEQSAAISHQVSSKVK
EEADRGRRVVKETIASLAEIQRSVELSFDAMKRLTENSGRIESIVGVINDITKRTNLLALNASIIAAQAGEYGKSFGVVA
DEIRNLSLQTGQSTGEITGIIEEIMNESHSAAQNISASKELVQKGVELGGVMGQSLQVIHESSARSLDMTQEIKIATEEQ
VRSVQLVTHSIENVSSMSSQIFKASKEQSDAAMSIVRSVDTIKEMTQEMVKATVKQVEDGSEIKQSVEAVGEMVTKIFED
MEVRRGESSAVVRELEMMKKIAE
>Mature_663_residues
MDSGAVVKNRSIRYGLFGCILGISAPIGWTLIRLIFFANPDQSLLSRVFGDIVKSPFNIALYTYMGIGTAGVLAVLGYYI
GKTTDELHSRASELNVLHQEVASQKEIFEQRYRALDSNIKNFHQISSKIQKSIDIEEVLLLCAEGLHDVLGYERVSILMA
DEGRSNLSFVASVGTPDFNPQGVSIPLDIRSGVIFKCFADRQIYMIDDLSTYPADFRLKPPYDAIRALRSRSFVLCPIIV
KGESVGVFGIDNRQSRRPLNDTDVDTIRLFADQAASAIIRINLLKAIGTLTSELETTFSDLLKNRDHYSRYVVNLKDAVN
SVADGTAHIASAAESVLASVDETSSSVSNIYVSIEQVTKNLDYLSESIEKSVSAMEELNSTIKNVEQSAAISHQVSSKVK
EEADRGRRVVKETIASLAEIQRSVELSFDAMKRLTENSGRIESIVGVINDITKRTNLLALNASIIAAQAGEYGKSFGVVA
DEIRNLSLQTGQSTGEITGIIEEIMNESHSAAQNISASKELVQKGVELGGVMGQSLQVIHESSARSLDMTQEIKIATEEQ
VRSVQLVTHSIENVSSMSSQIFKASKEQSDAAMSIVRSVDTIKEMTQEMVKATVKQVEDGSEIKQSVEAVGEMVTKIFED
MEVRRGESSAVVRELEMMKKIAE

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1788195, Length=292, Percent_Identity=26.027397260274, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1787690, Length=302, Percent_Identity=27.1523178807947, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1789453, Length=272, Percent_Identity=27.5735294117647, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI2367378, Length=324, Percent_Identity=25, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788194, Length=199, Percent_Identity=32.6633165829146, Blast_Score=86, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004010
- InterPro:   IPR003122
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR022094 [H]

Pfam domain/function: PF02743 Cache_1; PF00672 HAMP; PF12332 McpA_N; PF00015 MCPsignal; PF02203 TarH [H]

EC number: NA

Molecular weight: Translated: 72753; Mature: 72753

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSGAVVKNRSIRYGLFGCILGISAPIGWTLIRLIFFANPDQSLLSRVFGDIVKSPFNIA
CCCCCEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEE
LYTYMGIGTAGVLAVLGYYIGKTTDELHSRASELNVLHQEVASQKEIFEQRYRALDSNIK
EHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NFHQISSKIQKSIDIEEVLLLCAEGLHDVLGYERVSILMADEGRSNLSFVASVGTPDFNP
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHEEEEEECCCCCCCEEEEECCCCCCCC
QGVSIPLDIRSGVIFKCFADRQIYMIDDLSTYPADFRLKPPYDAIRALRSRSFVLCPIIV
CCCEEEEECCCCEEEEEECCCEEEEEECCCCCCCCCEECCCHHHHHHHHCCCEEEEEEEE
KGESVGVFGIDNRQSRRPLNDTDVDTIRLFADQAASAIIRINLLKAIGTLTSELETTFSD
ECCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLKNRDHYSRYVVNLKDAVNSVADGTAHIASAAESVLASVDETSSSVSNIYVSIEQVTKN
HHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDYLSESIEKSVSAMEELNSTIKNVEQSAAISHQVSSKVKEEADRGRRVVKETIASLAEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRSVELSFDAMKRLTENSGRIESIVGVINDITKRTNLLALNASIIAAQAGEYGKSFGVVA
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCEEEECHHHHHHCCCCCCCCCCHHH
DEIRNLSLQTGQSTGEITGIIEEIMNESHSAAQNISASKELVQKGVELGGVMGQSLQVIH
HHHHCCHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ESSARSLDMTQEIKIATEEQVRSVQLVTHSIENVSSMSSQIFKASKEQSDAAMSIVRSVD
HCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TIKEMTQEMVKATVKQVEDGSEIKQSVEAVGEMVTKIFEDMEVRRGESSAVVRELEMMKK
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
IAE
HCC
>Mature Secondary Structure
MDSGAVVKNRSIRYGLFGCILGISAPIGWTLIRLIFFANPDQSLLSRVFGDIVKSPFNIA
CCCCCEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEE
LYTYMGIGTAGVLAVLGYYIGKTTDELHSRASELNVLHQEVASQKEIFEQRYRALDSNIK
EHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NFHQISSKIQKSIDIEEVLLLCAEGLHDVLGYERVSILMADEGRSNLSFVASVGTPDFNP
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCHHHEEEEEECCCCCCCEEEEECCCCCCCC
QGVSIPLDIRSGVIFKCFADRQIYMIDDLSTYPADFRLKPPYDAIRALRSRSFVLCPIIV
CCCEEEEECCCCEEEEEECCCEEEEEECCCCCCCCCEECCCHHHHHHHHCCCEEEEEEEE
KGESVGVFGIDNRQSRRPLNDTDVDTIRLFADQAASAIIRINLLKAIGTLTSELETTFSD
ECCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLKNRDHYSRYVVNLKDAVNSVADGTAHIASAAESVLASVDETSSSVSNIYVSIEQVTKN
HHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDYLSESIEKSVSAMEELNSTIKNVEQSAAISHQVSSKVKEEADRGRRVVKETIASLAEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRSVELSFDAMKRLTENSGRIESIVGVINDITKRTNLLALNASIIAAQAGEYGKSFGVVA
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCEEEECHHHHHHCCCCCCCCCCHHH
DEIRNLSLQTGQSTGEITGIIEEIMNESHSAAQNISASKELVQKGVELGGVMGQSLQVIH
HHHHCCHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ESSARSLDMTQEIKIATEEQVRSVQLVTHSIENVSSMSSQIFKASKEQSDAAMSIVRSVD
HCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TIKEMTQEMVKATVKQVEDGSEIKQSVEAVGEMVTKIFEDMEVRRGESSAVVRELEMMKK
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
IAE
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8188684; 9384377 [H]