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The map label for this gene is glcK [H]

Identifier: 78222848

GI number: 78222848

Start: 1838882

End: 1839856

Strand: Direct

Name: glcK [H]

Synonym: Gmet_1639

Alternate gene names: 78222848

Gene position: 1838882-1839856 (Clockwise)

Preceding gene: 78222847

Following gene: 78222849

Centisome position: 46.0

GC content: 59.18

Gene sequence:

>975_bases
ATGAATGGCAACAAGCGCGCCTATATCGGCATAGACATAGGAGGTACCAATCTCCGCATGGCTCTCATTGATGAACGGGG
CGCCATTATCCACAAAACCAAGAGCAGGACCGATATCCACCATGGTCGATCCTCTTTCCTCTCGCGCCTTGGCAAGGGGA
TTGAGTCCCTGCTGCTCGCGGCCAGAGATAATAACATCGAACCTGCCGGGCTGGGGGCAGGGGTGCCGGGACTCATTGCC
AATGACGGCCATGTGTATGTTTCGGTGAACCTCAGGCCATTGGACGGGGTAAATCTGCGGGATGAGCTTCAGGCCATGAG
CGGGCTCCCCGCAGTGGTGGCGAACGATGTAAACGCGTTTGCCTTCGGAGAGAGCGTCTACGGGGCGGGCAGGGACTATC
GGTCATTTCTTATGGTTACCCTCGGCACTGGCGTTGGGGGAGGTCTGATCCTCGACGGCAAGGTCTGGAGCGGAATCGAC
GGGGTGGCAGGCGAGTTTGGCCACATGACCGTGGAATCCGAGGGGAGGCCCTGTCCCTGCGGCAACCGCGGTTGTCTCGA
GCAGTACGCATCCGCAAGCGCCCTGGTTTCCGCGGCAAGAGAGATGATCTGCCAACAGAAGGATGTATTCGGGGCGCAAT
GCGACATGGACGCCATTTCAACCAAAATACTTGCCGCTGCGGCACTGGACGGTAACCAGGCGGCGTTGGGCCTCTTCGCC
GATGCCGGACGGTATCTGGGGATCGCTGCCGCGTCGGTTGCCAATCTCCTTAATCTCGAAGCGATAATTCTCGGGGGAGG
AGTCTCCTCGAGTTTCAACCTCCTGTGCGAGAGCATGAGACGGGAAGTTCTTGCCAGGGCCTTTCCCATTCCGGGCAAGC
GCCTCGTTATCCGCCAGGCTTCCCTGGGAGACGACGGTGGGATTCTCGGCAGTGCCGCACTGGCAAGGAGTTTTCTTCAG
GAGGGGAAACCATGA

Upstream 100 bases:

>100_bases
CGACGTACGCGTTGTCCCTGAAGGGTTGCTGACTACCTACGACCGGCTTTATCCCCGTTTTGCGGCCCGCACGCAATAGA
GCACGAGGAGTTCTGCTCCC

Downstream 100 bases:

>100_bases
AACGGAAGATCGGCATCCTTACGGGAGGGGGAGACTGTCCCGGCCTCAACGCGGTGATACGGGGCGTGGTGAAGAGCGCC
ATCATCGGGAGGGGATGGGA

Product: glucokinase

Products: NA

Alternate protein names: Glucose kinase [H]

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MNGNKRAYIGIDIGGTNLRMALIDERGAIIHKTKSRTDIHHGRSSFLSRLGKGIESLLLAARDNNIEPAGLGAGVPGLIA
NDGHVYVSVNLRPLDGVNLRDELQAMSGLPAVVANDVNAFAFGESVYGAGRDYRSFLMVTLGTGVGGGLILDGKVWSGID
GVAGEFGHMTVESEGRPCPCGNRGCLEQYASASALVSAAREMICQQKDVFGAQCDMDAISTKILAAAALDGNQAALGLFA
DAGRYLGIAAASVANLLNLEAIILGGGVSSSFNLLCESMRREVLARAFPIPGKRLVIRQASLGDDGGILGSAALARSFLQ
EGKP

Sequences:

>Translated_324_residues
MNGNKRAYIGIDIGGTNLRMALIDERGAIIHKTKSRTDIHHGRSSFLSRLGKGIESLLLAARDNNIEPAGLGAGVPGLIA
NDGHVYVSVNLRPLDGVNLRDELQAMSGLPAVVANDVNAFAFGESVYGAGRDYRSFLMVTLGTGVGGGLILDGKVWSGID
GVAGEFGHMTVESEGRPCPCGNRGCLEQYASASALVSAAREMICQQKDVFGAQCDMDAISTKILAAAALDGNQAALGLFA
DAGRYLGIAAASVANLLNLEAIILGGGVSSSFNLLCESMRREVLARAFPIPGKRLVIRQASLGDDGGILGSAALARSFLQ
EGKP
>Mature_324_residues
MNGNKRAYIGIDIGGTNLRMALIDERGAIIHKTKSRTDIHHGRSSFLSRLGKGIESLLLAARDNNIEPAGLGAGVPGLIA
NDGHVYVSVNLRPLDGVNLRDELQAMSGLPAVVANDVNAFAFGESVYGAGRDYRSFLMVTLGTGVGGGLILDGKVWSGID
GVAGEFGHMTVESEGRPCPCGNRGCLEQYASASALVSAAREMICQQKDVFGAQCDMDAISTKILAAAALDGNQAALGLFA
DAGRYLGIAAASVANLLNLEAIILGGGVSSSFNLLCESMRREVLARAFPIPGKRLVIRQASLGDDGGILGSAALARSFLQ
EGKP

Specific function: May Be A Regulator In Specific Sugar Metabolism. May Influence The Rate Of Glucose Uptake Or Glycolysis In Cells In The Rich Medium. [C]

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family [H]

Homologues:

Organism=Homo sapiens, GI298566315, Length=284, Percent_Identity=30.2816901408451, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI298566325, Length=284, Percent_Identity=30.2816901408451, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI190014632, Length=284, Percent_Identity=30.2816901408451, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI4885285, Length=284, Percent_Identity=30.2816901408451, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1787878, Length=268, Percent_Identity=23.8805970149254, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1790522, Length=336, Percent_Identity=29.7619047619048, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI1786891, Length=318, Percent_Identity=23.5849056603774, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI1787363, Length=321, Percent_Identity=27.7258566978193, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI87081733, Length=330, Percent_Identity=27.5757575757576, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI87082127, Length=170, Percent_Identity=27.6470588235294, Blast_Score=72, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000600
- InterPro:   IPR004654 [H]

Pfam domain/function: PF00480 ROK [H]

EC number: =2.7.1.2 [H]

Molecular weight: Translated: 33671; Mature: 33671

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS01125 ROK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGNKRAYIGIDIGGTNLRMALIDERGAIIHKTKSRTDIHHGRSSFLSRLGKGIESLLLA
CCCCCEEEEEEEECCCEEEEEEEECCCCEEEECCCCCHHHCCHHHHHHHHHHHHHHHHHH
ARDNNIEPAGLGAGVPGLIANDGHVYVSVNLRPLDGVNLRDELQAMSGLPAVVANDVNAF
HCCCCCCCCCCCCCCCCEEECCCEEEEEEEEECCCCCCHHHHHHHHCCCCEEECCCCCCE
AFGESVYGAGRDYRSFLMVTLGTGVGGGLILDGKVWSGIDGVAGEFGHMTVESEGRPCPC
EECCHHHCCCCCHHEEEEEEECCCCCCCEEECCCCCCCCCCCCCCCCCEEECCCCCCCCC
GNRGCLEQYASASALVSAAREMICQQKDVFGAQCDMDAISTKILAAAALDGNQAALGLFA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHEECCCCCEEEEEEC
DAGRYLGIAAASVANLLNLEAIILGGGVSSSFNLLCESMRREVLARAFPIPGKRLVIRQA
CCCCHHHHHHHHHHHHHCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEC
SLGDDGGILGSAALARSFLQEGKP
CCCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNGNKRAYIGIDIGGTNLRMALIDERGAIIHKTKSRTDIHHGRSSFLSRLGKGIESLLLA
CCCCCEEEEEEEECCCEEEEEEEECCCCEEEECCCCCHHHCCHHHHHHHHHHHHHHHHHH
ARDNNIEPAGLGAGVPGLIANDGHVYVSVNLRPLDGVNLRDELQAMSGLPAVVANDVNAF
HCCCCCCCCCCCCCCCCEEECCCEEEEEEEEECCCCCCHHHHHHHHCCCCEEECCCCCCE
AFGESVYGAGRDYRSFLMVTLGTGVGGGLILDGKVWSGIDGVAGEFGHMTVESEGRPCPC
EECCHHHCCCCCHHEEEEEEECCCCCCCEEECCCCCCCCCCCCCCCCCEEECCCCCCCCC
GNRGCLEQYASASALVSAAREMICQQKDVFGAQCDMDAISTKILAAAALDGNQAALGLFA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHEECCCCCEEEEEEC
DAGRYLGIAAASVANLLNLEAIILGGGVSSSFNLLCESMRREVLARAFPIPGKRLVIRQA
CCCCHHHHHHHHHHHHHCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEC
SLGDDGGILGSAALARSFLQEGKP
CCCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]