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The map label for this gene is 78222847

Identifier: 78222847

GI number: 78222847

Start: 1838372

End: 1838860

Strand: Direct

Name: 78222847

Synonym: Gmet_1638

Alternate gene names: NA

Gene position: 1838372-1838860 (Clockwise)

Preceding gene: 78222844

Following gene: 78222848

Centisome position: 45.99

GC content: 54.4

Gene sequence:

>489_bases
ATGGAAAGAATCTGGGCGCCGTGGCGCATGGATTATATTCTCGATGAAAAGCCGCATGGCTGCATTTTTTGCCTGGATGC
ACGGACGGACGAGGATCGACAGAATCTTGTTCTCTACAAAACGCCGTTATCGTTGGTGATGCTTAATCGTTATCCCTATA
CAAATGGTCACCTGATGGTGGCGCCACGACACCACACTGCGGAACTGGACTCCCTGACGGACGTCGAGATGCTTGACCTT
TTCCGAACCGTTCGGCTCTGCAGAAGCGTTCTTGAGGAGGAAGCCTCACCCCAGGGATTCAATATCGGGCTCAATCTCGG
CCGGGCAGCCGGGGCAGGGATAGAAGACCACCTCCATATCCATATCGTTCCGCGCTGGAATGGCGATACAAATTTCATGA
CGGTTGTCGCCGACGTACGCGTTGTCCCTGAAGGGTTGCTGACTACCTACGACCGGCTTTATCCCCGTTTTGCGGCCCGC
ACGCAATAG

Upstream 100 bases:

>100_bases
TTGCGGGGTGAAATGTCTCGTGAATACTTGTATTTGAAGCAAAGTTCGTTGATAATTCCCGTGATGTGGACAGATAAATA
ACCGCGGAGAAGGGGGAGTG

Downstream 100 bases:

>100_bases
AGCACGAGGAGTTCTGCTCCCATGAATGGCAACAAGCGCGCCTATATCGGCATAGACATAGGAGGTACCAATCTCCGCAT
GGCTCTCATTGATGAACGGG

Product: histidine triad (HIT) protein

Products: NA

Alternate protein names: ATP adenylyltransferase; Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase; AP,A phosphorylase [H]

Number of amino acids: Translated: 162; Mature: 162

Protein sequence:

>162_residues
MERIWAPWRMDYILDEKPHGCIFCLDARTDEDRQNLVLYKTPLSLVMLNRYPYTNGHLMVAPRHHTAELDSLTDVEMLDL
FRTVRLCRSVLEEEASPQGFNIGLNLGRAAGAGIEDHLHIHIVPRWNGDTNFMTVVADVRVVPEGLLTTYDRLYPRFAAR
TQ

Sequences:

>Translated_162_residues
MERIWAPWRMDYILDEKPHGCIFCLDARTDEDRQNLVLYKTPLSLVMLNRYPYTNGHLMVAPRHHTAELDSLTDVEMLDL
FRTVRLCRSVLEEEASPQGFNIGLNLGRAAGAGIEDHLHIHIVPRWNGDTNFMTVVADVRVVPEGLLTTYDRLYPRFAAR
TQ
>Mature_162_residues
MERIWAPWRMDYILDEKPHGCIFCLDARTDEDRQNLVLYKTPLSLVMLNRYPYTNGHLMVAPRHHTAELDSLTDVEMLDL
FRTVRLCRSVLEEEASPQGFNIGLNLGRAAGAGIEDHLHIHIVPRWNGDTNFMTVVADVRVVPEGLLTTYDRLYPRFAAR
TQ

Specific function: Catabolizes diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) into ADP and ATP. It does not catalyze the reverse phosphorolysis reaction. The optimum substrates are dinucleoside polyphosphates containing four or five phosphate residues [H]

COG id: COG0537

COG function: function code FGR; Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HIT domain [H]

Homologues:

Organism=Caenorhabditis elegans, GI17556280, Length=93, Percent_Identity=37.6344086021505, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011146
- InterPro:   IPR011151
- InterPro:   IPR001310 [H]

Pfam domain/function: PF01230 HIT [H]

EC number: =2.7.7.53 [H]

Molecular weight: Translated: 18678; Mature: 18678

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS51084 HIT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERIWAPWRMDYILDEKPHGCIFCLDARTDEDRQNLVLYKTPLSLVMLNRYPYTNGHLMV
CCCCCCCEEECEEECCCCCCEEEEEECCCCCCCCCEEEEECCCEEEEEECCCCCCCEEEE
APRHHTAELDSLTDVEMLDLFRTVRLCRSVLEEEASPQGFNIGLNLGRAAGAGIEDHLHI
ECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCEEE
HIVPRWNGDTNFMTVVADVRVVPEGLLTTYDRLYPRFAARTQ
EEEECCCCCCCEEEEEEEEEECCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MERIWAPWRMDYILDEKPHGCIFCLDARTDEDRQNLVLYKTPLSLVMLNRYPYTNGHLMV
CCCCCCCEEECEEECCCCCCEEEEEECCCCCCCCCEEEEECCCEEEEEECCCCCCCEEEE
APRHHTAELDSLTDVEMLDLFRTVRLCRSVLEEEASPQGFNIGLNLGRAAGAGIEDHLHI
ECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCEEE
HIVPRWNGDTNFMTVVADVRVVPEGLLTTYDRLYPRFAARTQ
EEEECCCCCCCEEEEEEEEEECCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12368430; 12218036 [H]