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The map label for this gene is moaC

Identifier: 78222255

GI number: 78222255

Start: 1152312

End: 1152794

Strand: Reverse

Name: moaC

Synonym: Gmet_1037

Alternate gene names: 78222255

Gene position: 1152794-1152312 (Counterclockwise)

Preceding gene: 78222256

Following gene: 78222254

Centisome position: 28.84

GC content: 66.46

Gene sequence:

>483_bases
ATGTCCTTCAATCACTTCGACGACCAGGGCCGGGCCATCATGGTGGACGTGAGCGGAAAACAGCCTACCCTGCGCACCGC
AACCGCCGCCGCCACGGTGGCCATGAAACCCGAGACGCTGGCAGACCTCCTGGCCGGACGGACCACCAAGGGGGATGTCC
TGGGCGTGGCGCGACTGGCGGGCATCGCCGCCGCCAAGAAGACCCCGGAACTGATCCCCCTCTCCCACCCGCTGGCCATC
CACCATGCCGCGGTTGACTTCGAGACCGAGCCGGAGACCGGGACCATCACGGTGAAGGCAACGGTACGGGCCTTCGAGCG
GACCGGCGTGGAGATGGAGGCCATGACCTCGGCGGCGGTGGCGGCCCTCACCATCTACGACATGTGCAAGGGAGCCGACA
AGGGGATCACCATCGGCGATATCTGCCTCCTCTTCAAGGAGGGAGGGAAAAGCGGCACCTGGCAGCGGGAGGAACCGGCA
TGA

Upstream 100 bases:

>100_bases
TCCCCCTGGAAGCGTCCATCGTCCACGCCGGGAGCGAGGTGGACCTGATGCTCCTGAGGGACGATGTGACCATGCTGGAA
CGCTAAGGGAGATTACCGAT

Downstream 100 bases:

>100_bases
GAGCGGCAATTCTCACCTTGAGCGACAAGGGTTCCCGGGGAGAGCGGGCAGACGCCAGCGGCCCGGCCCTCTCTGCCTGG
TTGGCGGAACGTGGCGTCGA

Product: GTP cyclohydrolase subunit MoaC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 160; Mature: 159

Protein sequence:

>160_residues
MSFNHFDDQGRAIMVDVSGKQPTLRTATAAATVAMKPETLADLLAGRTTKGDVLGVARLAGIAAAKKTPELIPLSHPLAI
HHAAVDFETEPETGTITVKATVRAFERTGVEMEAMTSAAVAALTIYDMCKGADKGITIGDICLLFKEGGKSGTWQREEPA

Sequences:

>Translated_160_residues
MSFNHFDDQGRAIMVDVSGKQPTLRTATAAATVAMKPETLADLLAGRTTKGDVLGVARLAGIAAAKKTPELIPLSHPLAI
HHAAVDFETEPETGTITVKATVRAFERTGVEMEAMTSAAVAALTIYDMCKGADKGITIGDICLLFKEGGKSGTWQREEPA
>Mature_159_residues
SFNHFDDQGRAIMVDVSGKQPTLRTATAAATVAMKPETLADLLAGRTTKGDVLGVARLAGIAAAKKTPELIPLSHPLAIH
HAAVDFETEPETGTITVKATVRAFERTGVEMEAMTSAAVAALTIYDMCKGADKGITIGDICLLFKEGGKSGTWQREEPA

Specific function: Together with moaA, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z

COG id: COG0315

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaC family

Homologues:

Organism=Escherichia coli, GI1787001, Length=156, Percent_Identity=50.6410256410256, Blast_Score=151, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI32566331, Length=149, Percent_Identity=38.9261744966443, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI28574490, Length=159, Percent_Identity=47.7987421383648, Blast_Score=128, Evalue=2e-30,
Organism=Drosophila melanogaster, GI28574492, Length=147, Percent_Identity=48.2993197278912, Blast_Score=119, Evalue=6e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MOAC_GEOMG (Q39WU7)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_384002.1
- ProteinModelPortal:   Q39WU7
- SMR:   Q39WU7
- STRING:   Q39WU7
- GeneID:   3741322
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_1037
- NMPDR:   fig|269799.3.peg.1127
- eggNOG:   COG0315
- HOGENOM:   HBG605231
- OMA:   PMCHPLM
- PhylomeDB:   Q39WU7
- ProtClustDB:   CLSK828946
- BioCyc:   GMET269799:GMET_1037-MONOMER
- HAMAP:   MF_01224_B
- InterPro:   IPR023045
- InterPro:   IPR023046
- InterPro:   IPR002820
- Gene3D:   G3DSA:3.30.70.640
- TIGRFAMs:   TIGR00581

Pfam domain/function: PF01967 MoaC; SSF55040 MoaC

EC number: NA

Molecular weight: Translated: 16854; Mature: 16722

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: ACT_SITE 127-127

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFNHFDDQGRAIMVDVSGKQPTLRTATAAATVAMKPETLADLLAGRTTKGDVLGVARLA
CCCCCCCCCCCEEEEEECCCCCCEEEHHHEEEEEECHHHHHHHHHCCCCCCCHHHHHHHH
GIAAAKKTPELIPLSHPLAIHHAAVDFETEPETGTITVKATVRAFERTGVEMEAMTSAAV
HHHHCCCCCCEEECCCCEEEEEEEECCCCCCCCCEEEEEEEEEHHHHCCCCHHHHHHHHH
AALTIYDMCKGADKGITIGDICLLFKEGGKSGTWQREEPA
HHHHHHHHHCCCCCCCCHHHEEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SFNHFDDQGRAIMVDVSGKQPTLRTATAAATVAMKPETLADLLAGRTTKGDVLGVARLA
CCCCCCCCCCEEEEEECCCCCCEEEHHHEEEEEECHHHHHHHHHCCCCCCCHHHHHHHH
GIAAAKKTPELIPLSHPLAIHHAAVDFETEPETGTITVKATVRAFERTGVEMEAMTSAAV
HHHHCCCCCCEEECCCCEEEEEEEECCCCCCCCCEEEEEEEEEHHHHCCCCHHHHHHHHH
AALTIYDMCKGADKGITIGDICLLFKEGGKSGTWQREEPA
HHHHHHHHHCCCCCCCCHHHEEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Involved in molybdopterin biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA