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The map label for this gene is moeA [H]

Identifier: 78222256

GI number: 78222256

Start: 1152809

End: 1154026

Strand: Reverse

Name: moeA [H]

Synonym: Gmet_1038

Alternate gene names: 78222256

Gene position: 1154026-1152809 (Counterclockwise)

Preceding gene: 78222257

Following gene: 78222255

Centisome position: 28.87

GC content: 67.16

Gene sequence:

>1218_bases
GTGCCGTCTTTCACCGAAGCCCGCAACATCATTCTCGATCGCGTAACCCCCCTCGGCATCGAGCGGGTGGGAATTCTGGA
GGCCGCAGGCCGCGTCCTGGCCGAGGACGTGGTGGCCCCCTGGGAGATGCCCCTCTGCGACAACTCCGCCATGGACGGCT
TTGCCGTGCGAGCCGCCGACTGCGCAACCATCCCGGCAGCACTGAAGGTGACCGGCTATATCCCGGCCGGCGGCGAGGTG
ACCGGAGCAGTGGAGTCTGGCTGCGCCATCAGGATCATGACCGGCGCTCCCCTCCCCCCCGGCTGCGACGCCGTGGTCCC
CGTAGAGGAGACTGAGGACGACGGCGCCGCCATCCGGGTCGTGGCCCCCGTGAAGGAACGCCAGCACATCCGTTTCAAGG
GCGAGGACGTAGCCACCGGTGAGACCGTCATCCCGGCGGGCACCCTTATCCAGCCCCCCGAGGTCAGCATGCTCGCCTCC
TTCGGCAAGGCCCTGGTGCCGGTCTTCCGCAAGGCCCGCGTCGCCATCCTCTCCACCGGCGACGAACTGGTCGAGCTGGG
CGAGCCCCCGGTTCCGGGCAAGATCATCAACTCCAACACCCTGTCGCTGGCGGCGGCGGTGCGCCAGTGCGGCGCAGAAC
CGATCGTCATCGGCATTGCCCGGGACAACCGGGAAAGTCACCGGGAAAAGCTCGCCGAAGGGCTGAAGGCCGACGCCCTC
ATCACCTCCGCCGGAGTTTCCGCCGGCGACCGGGACCTGGTCCGGGACGTCCTGGCCGAGATGGGTGTGGAGCAGATATT
CTGGAAGGTGGACATGAAACCCGGCGGCCCCACGGCTTTCGGGATGCACGGGGCGAAGCCGGTTTTCTCGCTTCCCGGCA
ACCCCGTCTCCACCATGGTCACCTTCGAGCTCTTTGCCCGTCCGGCCCTGCTGCGGATGATGGGGCACCGGCGCGTGGTG
CGCCCTTTTGTCAAGGCCATCCTCCGGGAAGACGCGAAAAAGAAACCGGGCAAGGTCAACTTCCTCCGGGTCCAGGTGAC
GGTGCAGGAAGGGCGCTTCGTGGCCTCTACCGCAGGCGACCAGCACACTGGAATCCTCAGGACCATGGTCAGGGCCAACG
GCCTGGCGCTGCTCCCCCTGGAAGCGTCCATCGTCCACGCCGGGAGCGAGGTGGACCTGATGCTCCTGAGGGACGATGTG
ACCATGCTGGAACGCTAA

Upstream 100 bases:

>100_bases
TGGAACGCCTGAAGGGCGAACGCATCCACCTGGCAGCGGGCCGTCTCGCCGCGCCGCAATCGTTCAGCACCACATCTGTC
GAGGAAGGAGAAATCCAACC

Downstream 100 bases:

>100_bases
GGGAGATTACCGATATGTCCTTCAATCACTTCGACGACCAGGGCCGGGCCATCATGGTGGACGTGAGCGGAAAACAGCCT
ACCCTGCGCACCGCAACCGC

Product: molybdopterin molybdochelatase

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MPSFTEARNIILDRVTPLGIERVGILEAAGRVLAEDVVAPWEMPLCDNSAMDGFAVRAADCATIPAALKVTGYIPAGGEV
TGAVESGCAIRIMTGAPLPPGCDAVVPVEETEDDGAAIRVVAPVKERQHIRFKGEDVATGETVIPAGTLIQPPEVSMLAS
FGKALVPVFRKARVAILSTGDELVELGEPPVPGKIINSNTLSLAAAVRQCGAEPIVIGIARDNRESHREKLAEGLKADAL
ITSAGVSAGDRDLVRDVLAEMGVEQIFWKVDMKPGGPTAFGMHGAKPVFSLPGNPVSTMVTFELFARPALLRMMGHRRVV
RPFVKAILREDAKKKPGKVNFLRVQVTVQEGRFVASTAGDQHTGILRTMVRANGLALLPLEASIVHAGSEVDLMLLRDDV
TMLER

Sequences:

>Translated_405_residues
MPSFTEARNIILDRVTPLGIERVGILEAAGRVLAEDVVAPWEMPLCDNSAMDGFAVRAADCATIPAALKVTGYIPAGGEV
TGAVESGCAIRIMTGAPLPPGCDAVVPVEETEDDGAAIRVVAPVKERQHIRFKGEDVATGETVIPAGTLIQPPEVSMLAS
FGKALVPVFRKARVAILSTGDELVELGEPPVPGKIINSNTLSLAAAVRQCGAEPIVIGIARDNRESHREKLAEGLKADAL
ITSAGVSAGDRDLVRDVLAEMGVEQIFWKVDMKPGGPTAFGMHGAKPVFSLPGNPVSTMVTFELFARPALLRMMGHRRVV
RPFVKAILREDAKKKPGKVNFLRVQVTVQEGRFVASTAGDQHTGILRTMVRANGLALLPLEASIVHAGSEVDLMLLRDDV
TMLER
>Mature_404_residues
PSFTEARNIILDRVTPLGIERVGILEAAGRVLAEDVVAPWEMPLCDNSAMDGFAVRAADCATIPAALKVTGYIPAGGEVT
GAVESGCAIRIMTGAPLPPGCDAVVPVEETEDDGAAIRVVAPVKERQHIRFKGEDVATGETVIPAGTLIQPPEVSMLASF
GKALVPVFRKARVAILSTGDELVELGEPPVPGKIINSNTLSLAAAVRQCGAEPIVIGIARDNRESHREKLAEGLKADALI
TSAGVSAGDRDLVRDVLAEMGVEQIFWKVDMKPGGPTAFGMHGAKPVFSLPGNPVSTMVTFELFARPALLRMMGHRRVVR
PFVKAILREDAKKKPGKVNFLRVQVTVQEGRFVASTAGDQHTGILRTMVRANGLALLPLEASIVHAGSEVDLMLLRDDVT
MLER

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=415, Percent_Identity=37.8313253012048, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI66932975, Length=415, Percent_Identity=37.8313253012048, Blast_Score=210, Evalue=2e-54,
Organism=Escherichia coli, GI1787049, Length=380, Percent_Identity=41.0526315789474, Blast_Score=247, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI25147659, Length=321, Percent_Identity=34.2679127725857, Blast_Score=151, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI17562606, Length=337, Percent_Identity=26.4094955489614, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI17136978, Length=362, Percent_Identity=33.7016574585635, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24638841, Length=362, Percent_Identity=33.7016574585635, Blast_Score=144, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43048; Mature: 42916

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSFTEARNIILDRVTPLGIERVGILEAAGRVLAEDVVAPWEMPLCDNSAMDGFAVRAAD
CCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECC
CATIPAALKVTGYIPAGGEVTGAVESGCAIRIMTGAPLPPGCDAVVPVEETEDDGAAIRV
HHCCCCEEEEEEECCCCCCEEEEECCCCEEEEEECCCCCCCCCEEEECCCCCCCCCEEEE
VAPVKERQHIRFKGEDVATGETVIPAGTLIQPPEVSMLASFGKALVPVFRKARVAILSTG
EECCCCCCCEEECCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCEEEEEECC
DELVELGEPPVPGKIINSNTLSLAAAVRQCGAEPIVIGIARDNRESHREKLAEGLKADAL
HHHHHCCCCCCCCEEECCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCCCCE
ITSAGVSAGDRDLVRDVLAEMGVEQIFWKVDMKPGGPTAFGMHGAKPVFSLPGNPVSTMV
EEECCCCCCCHHHHHHHHHHCCHHHEEEEEECCCCCCCEECCCCCCCEEECCCCCHHHHH
TFELFARPALLRMMGHRRVVRPFVKAILREDAKKKPGKVNFLRVQVTVQEGRFVASTAGD
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCEEEEECCCC
QHTGILRTMVRANGLALLPLEASIVHAGSEVDLMLLRDDVTMLER
CHHHHHHHHHHHCCEEEEEECCEEEECCCCEEEEEEECCHHHHCC
>Mature Secondary Structure 
PSFTEARNIILDRVTPLGIERVGILEAAGRVLAEDVVAPWEMPLCDNSAMDGFAVRAAD
CCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECC
CATIPAALKVTGYIPAGGEVTGAVESGCAIRIMTGAPLPPGCDAVVPVEETEDDGAAIRV
HHCCCCEEEEEEECCCCCCEEEEECCCCEEEEEECCCCCCCCCEEEECCCCCCCCCEEEE
VAPVKERQHIRFKGEDVATGETVIPAGTLIQPPEVSMLASFGKALVPVFRKARVAILSTG
EECCCCCCCEEECCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCEEEEEECC
DELVELGEPPVPGKIINSNTLSLAAAVRQCGAEPIVIGIARDNRESHREKLAEGLKADAL
HHHHHCCCCCCCCEEECCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHCCCCCCCE
ITSAGVSAGDRDLVRDVLAEMGVEQIFWKVDMKPGGPTAFGMHGAKPVFSLPGNPVSTMV
EEECCCCCCCHHHHHHHHHHCCHHHEEEEEECCCCCCCEECCCCCCCEEECCCCCHHHHH
TFELFARPALLRMMGHRRVVRPFVKAILREDAKKKPGKVNFLRVQVTVQEGRFVASTAGD
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEECCEEEEECCCC
QHTGILRTMVRANGLALLPLEASIVHAGSEVDLMLLRDDVTMLER
CHHHHHHHHHHHCCEEEEEECCEEEECCCCEEEEEEECCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]