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The map label for this gene is vvpD [H]

Identifier: 78222179

GI number: 78222179

Start: 1068551

End: 1069330

Strand: Direct

Name: vvpD [H]

Synonym: Gmet_0959

Alternate gene names: 78222179

Gene position: 1068551-1069330 (Clockwise)

Preceding gene: 78222177

Following gene: 78222180

Centisome position: 26.73

GC content: 62.69

Gene sequence:

>780_bases
ATGTCCCCAGTGGTTATTTTTGCACTATTTTCTTTTCTCCTCGGCGCCGCGGTCGGCTCCTTCCTCAACGTCTGCATTTA
CCGGCTGCCGGCGGGGGAATCGGTGGTTTCTCCCCCATCCCGCTGCCCTGCCTGTGGTGCCAGAATCCGCCCGTGGCACA
ACATCCCGATTCTCGGCTGGCTGATCCTGCGAGGGAAGTGCCGCGACTGCGGCGCCCCCATTTCGCCCCGCTACCCCTTT
GTGGAGTTGCTGAACGGCCTCCTCACCCTCGCCCTTTTCCTGAAGTTCGGGCCGTCTCCCACCTTCCTGGTCCTCTTCGT
CTTCTGCTCGGCCCTGGTGGCCGTCACCTTCATCGACCTGGACCACCAGCTCATCCCCGACGTCATCAGCCTGCCGGGGA
TCGTGGTGGGCTTTGCTTGCTCCTTCGCGCTCCCGTGGCTTGGCTGGAAAAGTTCCCTCATCGGCATCGTGGCCGGCGGG
GGAAGCCTTCTGTCCGTGGCGCGGCTCTACGAGCTCCTGACGAAGAAGGAAGGGATGGGGGGAGGCGACATCAAGCTCCT
GGCCATGATGGGGGCGTTCCTTGGCTGGCGCTCCGTGCCGTTCATCATCTTCGCCTCGTCCCTCATCGGATCGGTGATCG
GCGTCACCCTCATGCTCGTCCAGAAAAAAGACTCCAAGCTCGCCATTCCCTTCGGGCCGTTCCTGGCGACGGGGGCCGTG
CTCTACATCTTCTTCGGCAAGACGATCATCACCTGGTACCTGACTTTGGGCGCCCGCTAG

Upstream 100 bases:

>100_bases
AGATCTGGCAAATTATTGGGTTAAGCATTGACATCTCCGTTGCTCCGTTGCTCCGTGTTATTATGACTGCCGTTTTCATG
ATTGCTTACAGGATCATTTC

Downstream 100 bases:

>100_bases
GGAGGCCTTCGTGAAGCAGTTTCGCTTCAGCTTCAGCTTCCTGATCCTCTCGTCCCTCTCCTTCATCCTGGTCCTCACCT
GGGTGCTCCTCAGCCTCATC

Product: type 4 prepilin peptidase 1. Aspartic peptidase. MEROPS family A24A

Products: NA

Alternate protein names: Leader peptidase; Prepilin peptidase; N-methyltransferase [H]

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MSPVVIFALFSFLLGAAVGSFLNVCIYRLPAGESVVSPPSRCPACGARIRPWHNIPILGWLILRGKCRDCGAPISPRYPF
VELLNGLLTLALFLKFGPSPTFLVLFVFCSALVAVTFIDLDHQLIPDVISLPGIVVGFACSFALPWLGWKSSLIGIVAGG
GSLLSVARLYELLTKKEGMGGGDIKLLAMMGAFLGWRSVPFIIFASSLIGSVIGVTLMLVQKKDSKLAIPFGPFLATGAV
LYIFFGKTIITWYLTLGAR

Sequences:

>Translated_259_residues
MSPVVIFALFSFLLGAAVGSFLNVCIYRLPAGESVVSPPSRCPACGARIRPWHNIPILGWLILRGKCRDCGAPISPRYPF
VELLNGLLTLALFLKFGPSPTFLVLFVFCSALVAVTFIDLDHQLIPDVISLPGIVVGFACSFALPWLGWKSSLIGIVAGG
GSLLSVARLYELLTKKEGMGGGDIKLLAMMGAFLGWRSVPFIIFASSLIGSVIGVTLMLVQKKDSKLAIPFGPFLATGAV
LYIFFGKTIITWYLTLGAR
>Mature_258_residues
SPVVIFALFSFLLGAAVGSFLNVCIYRLPAGESVVSPPSRCPACGARIRPWHNIPILGWLILRGKCRDCGAPISPRYPFV
ELLNGLLTLALFLKFGPSPTFLVLFVFCSALVAVTFIDLDHQLIPDVISLPGIVVGFACSFALPWLGWKSSLIGIVAGGG
SLLSVARLYELLTKKEGMGGGDIKLLAMMGAFLGWRSVPFIIFASSLIGSVIGVTLMLVQKKDSKLAIPFGPFLATGAVL
YIFFGKTIITWYLTLGAR

Specific function: Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue [H]

COG id: COG1989

COG function: function code NOU; Type II secretory pathway, prepilin signal peptidase PulO and related peptidases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A24 family [H]

Homologues:

Organism=Escherichia coli, GI87082194, Length=250, Percent_Identity=34, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1789732, Length=146, Percent_Identity=34.9315068493151, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010627
- InterPro:   IPR014032
- InterPro:   IPR000045 [H]

Pfam domain/function: PF06750 DiS_P_DiS; PF01478 Peptidase_A24 [H]

EC number: =3.4.23.43 [H]

Molecular weight: Translated: 27784; Mature: 27653

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPVVIFALFSFLLGAAVGSFLNVCIYRLPAGESVVSPPSRCPACGARIRPWHNIPILGW
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
LILRGKCRDCGAPISPRYPFVELLNGLLTLALFLKFGPSPTFLVLFVFCSALVAVTFIDL
HHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
DHQLIPDVISLPGIVVGFACSFALPWLGWKSSLIGIVAGGGSLLSVARLYELLTKKEGMG
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCEEEEEECCHHHHHHHHHHHHHHHHCCCC
GGDIKLLAMMGAFLGWRSVPFIIFASSLIGSVIGVTLMLVQKKDSKLAIPFGPFLATGAV
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEECCCCEEECCCCHHHHHHHH
LYIFFGKTIITWYLTLGAR
HHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SPVVIFALFSFLLGAAVGSFLNVCIYRLPAGESVVSPPSRCPACGARIRPWHNIPILGW
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
LILRGKCRDCGAPISPRYPFVELLNGLLTLALFLKFGPSPTFLVLFVFCSALVAVTFIDL
HHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
DHQLIPDVISLPGIVVGFACSFALPWLGWKSSLIGIVAGGGSLLSVARLYELLTKKEGMG
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCEEEEEECCHHHHHHHHHHHHHHHHCCCC
GGDIKLLAMMGAFLGWRSVPFIIFASSLIGSVIGVTLMLVQKKDSKLAIPFGPFLATGAV
CCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEECCCCEEECCCCHHHHHHHH
LYIFFGKTIITWYLTLGAR
HHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9826339 [H]