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The map label for this gene is zraS [H]

Identifier: 78222180

GI number: 78222180

Start: 1069341

End: 1070936

Strand: Direct

Name: zraS [H]

Synonym: Gmet_0960

Alternate gene names: 78222180

Gene position: 1069341-1070936 (Clockwise)

Preceding gene: 78222179

Following gene: 78222181

Centisome position: 26.75

GC content: 63.91

Gene sequence:

>1596_bases
GTGAAGCAGTTTCGCTTCAGCTTCAGCTTCCTGATCCTCTCGTCCCTCTCCTTCATCCTGGTCCTCACCTGGGTGCTCCT
CAGCCTCATCTCCTTCAAGACTGCCGAGAACGACCTCCTGCAGCAGAAAAGCGACAAGGCGCGGCTTCTCCTCGCGTCCT
TCACGGCCCTGGTCCCCCGGGACCCGGCGGCCGTGGCGTCGTCTCCGGCCAGCACCCTGGCACAGCGGTTCGCCCGGGAA
GGGGAGTTCGTGGGGCTCACGGTGTCAGGACGCGACGGCACGGTGTTGTACAGTCTGGGATCGGAAGTCCTCGGCGACGG
GATGCTCGCCGAAACCATCGCGTCCGGCGCTGAGTTAGCCCGGTTTTCCGGGGGACGCGGGACACTGCGCCGTTATGCGC
CCCTTGTGCGCGACGGGAGATCCGTGGGGGCAGTCCGACTTGAGCTGTCATTAAAGGGAGAGCAGAAGCTCTTGGCCCAG
TCGCGGCATCTCTTCTTGGCGTACTGTGTCCTTGATTTTCTCCTGCTTCTGGCGGTTGGCTCGTTCCTCCTCTCTCGCTT
CATCGTGGCTCCCGTGCGCAGGCTTCTGGCAACCACCGAGCGCATCGGTCAGGGTGACTACAGCCATCGGGCCGCGGTGG
GGGGCGGACGGGAGATCGCCGAATTGGCTGAATCATTCAACGGCATGGTCGATGCCCTGCGAGCCAAGCAGGAGGAGGCC
GACCGGTATGTCCGGTCCCTGGAGCAGGCCAACCGGGAGCTCCAGAAAGCCCGGGAAGAGGCGCTTCGTTCCGAAAAACT
GGCATCGGTGGGGCTTCTGGCTGCTGGTACAGCCCACGAGATCGGCACTCCCCTCACGTCAATTATGGGGTATGCGGGGC
TTCTCATGGACGAGGTGGCCGATGACCCCCGAAAAGCCGACTACCTGCGCCGCATCGAACGGGATGCGGAGCGGATCGAC
CGGATCGTACGCGACCTCCTCAATTTTGCCCGCCCCGCCGAGGGGACCACGGAGACCGTCGATGTGGTCGCTCTCGTGGC
CTCGACCCTGGAGATGCTCGAACTGCAGGGGGCCTTCAAGGGGATTGCAGTGACCGTGGACGCCGCCGGGGAGCTTCCCC
CGATCGTGGTTGACCCATTCCAGCTCCAGCAGGTGCTCATCAACCTGTTCATAAACGCCCGCGACGCCATGTCCGATGGC
GGCAAACTTGACGTCAGAACCAGTGCCGACTGGTTCACTCCCCCCGTTCAGACCACCGGTTCGTCTCTCCATGTCAGCGG
GCGCCGCAGGGAAGATTTCGACGGCGTGTTCCGCGCATCCTTCGCCGCCGAGAGTGAACCGGTCCCCTGTGTCCGTATCG
AGGTGGCCGACACCGGCTGCGGCATTGCACCGGAAAGACTCGGGCGGATCTTCGACCCGTTCTTTACCACCAAGGAACCC
GGCAAGGGGACCGGCCTCGGGCTTGCCATCTCGGCCCGCATCGTCGATTCCTTCGACGGGCGGATCACCGTGGAGAGCTC
TGTGGGGAAGGGGACCACGTTTGTCATCTGGCTCCCGGTCGCCGGGAGCGTGACGGACAAAGGAATGGAGCAATGA

Upstream 100 bases:

>100_bases
TTCGGGCCGTTCCTGGCGACGGGGGCCGTGCTCTACATCTTCTTCGGCAAGACGATCATCACCTGGTACCTGACTTTGGG
CGCCCGCTAGGGAGGCCTTC

Downstream 100 bases:

>100_bases
AACAACGGGTGCTGGTCATCGACGACGAGGAGAACCTGCGGCACATGCTTGGGGCCATGCTTCGCAAGAACGGCTACCAT
GCCGACGAGGCGGCGGACGG

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 531; Mature: 531

Protein sequence:

>531_residues
MKQFRFSFSFLILSSLSFILVLTWVLLSLISFKTAENDLLQQKSDKARLLLASFTALVPRDPAAVASSPASTLAQRFARE
GEFVGLTVSGRDGTVLYSLGSEVLGDGMLAETIASGAELARFSGGRGTLRRYAPLVRDGRSVGAVRLELSLKGEQKLLAQ
SRHLFLAYCVLDFLLLLAVGSFLLSRFIVAPVRRLLATTERIGQGDYSHRAAVGGGREIAELAESFNGMVDALRAKQEEA
DRYVRSLEQANRELQKAREEALRSEKLASVGLLAAGTAHEIGTPLTSIMGYAGLLMDEVADDPRKADYLRRIERDAERID
RIVRDLLNFARPAEGTTETVDVVALVASTLEMLELQGAFKGIAVTVDAAGELPPIVVDPFQLQQVLINLFINARDAMSDG
GKLDVRTSADWFTPPVQTTGSSLHVSGRRREDFDGVFRASFAAESEPVPCVRIEVADTGCGIAPERLGRIFDPFFTTKEP
GKGTGLGLAISARIVDSFDGRITVESSVGKGTTFVIWLPVAGSVTDKGMEQ

Sequences:

>Translated_531_residues
MKQFRFSFSFLILSSLSFILVLTWVLLSLISFKTAENDLLQQKSDKARLLLASFTALVPRDPAAVASSPASTLAQRFARE
GEFVGLTVSGRDGTVLYSLGSEVLGDGMLAETIASGAELARFSGGRGTLRRYAPLVRDGRSVGAVRLELSLKGEQKLLAQ
SRHLFLAYCVLDFLLLLAVGSFLLSRFIVAPVRRLLATTERIGQGDYSHRAAVGGGREIAELAESFNGMVDALRAKQEEA
DRYVRSLEQANRELQKAREEALRSEKLASVGLLAAGTAHEIGTPLTSIMGYAGLLMDEVADDPRKADYLRRIERDAERID
RIVRDLLNFARPAEGTTETVDVVALVASTLEMLELQGAFKGIAVTVDAAGELPPIVVDPFQLQQVLINLFINARDAMSDG
GKLDVRTSADWFTPPVQTTGSSLHVSGRRREDFDGVFRASFAAESEPVPCVRIEVADTGCGIAPERLGRIFDPFFTTKEP
GKGTGLGLAISARIVDSFDGRITVESSVGKGTTFVIWLPVAGSVTDKGMEQ
>Mature_531_residues
MKQFRFSFSFLILSSLSFILVLTWVLLSLISFKTAENDLLQQKSDKARLLLASFTALVPRDPAAVASSPASTLAQRFARE
GEFVGLTVSGRDGTVLYSLGSEVLGDGMLAETIASGAELARFSGGRGTLRRYAPLVRDGRSVGAVRLELSLKGEQKLLAQ
SRHLFLAYCVLDFLLLLAVGSFLLSRFIVAPVRRLLATTERIGQGDYSHRAAVGGGREIAELAESFNGMVDALRAKQEEA
DRYVRSLEQANRELQKAREEALRSEKLASVGLLAAGTAHEIGTPLTSIMGYAGLLMDEVADDPRKADYLRRIERDAERID
RIVRDLLNFARPAEGTTETVDVVALVASTLEMLELQGAFKGIAVTVDAAGELPPIVVDPFQLQQVLINLFINARDAMSDG
GKLDVRTSADWFTPPVQTTGSSLHVSGRRREDFDGVFRASFAAESEPVPCVRIEVADTGCGIAPERLGRIFDPFFTTKEP
GKGTGLGLAISARIVDSFDGRITVESSVGKGTTFVIWLPVAGSVTDKGMEQ

Specific function: Member of the two-component regulatory system zraS/zraR. May function as a membrane-associated protein kinase that phosphorylates zraR in response to high concentrations of zinc or lead in the medium [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=279, Percent_Identity=34.0501792114695, Blast_Score=145, Evalue=6e-36,
Organism=Escherichia coli, GI1788549, Length=268, Percent_Identity=35.0746268656716, Blast_Score=143, Evalue=3e-35,
Organism=Escherichia coli, GI1789149, Length=400, Percent_Identity=25.75, Blast_Score=108, Evalue=8e-25,
Organism=Escherichia coli, GI87081816, Length=376, Percent_Identity=27.6595744680851, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790300, Length=272, Percent_Identity=31.25, Blast_Score=96, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 57478; Mature: 57478

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQFRFSFSFLILSSLSFILVLTWVLLSLISFKTAENDLLQQKSDKARLLLASFTALVPR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHCCC
DPAAVASSPASTLAQRFAREGEFVGLTVSGRDGTVLYSLGSEVLGDGMLAETIASGAELA
CCHHHHCCCHHHHHHHHHCCCCEEEEEEECCCCEEEEECCHHHHCCCHHHHHHHCCHHHH
RFSGGRGTLRRYAPLVRDGRSVGAVRLELSLKGEQKLLAQSRHLFLAYCVLDFLLLLAVG
HCCCCCCHHHHHHHHHHCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SFLLSRFIVAPVRRLLATTERIGQGDYSHRAAVGGGREIAELAESFNGMVDALRAKQEEA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
DRYVRSLEQANRELQKAREEALRSEKLASVGLLAAGTAHEIGTPLTSIMGYAGLLMDEVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHC
DDPRKADYLRRIERDAERIDRIVRDLLNFARPAEGTTETVDVVALVASTLEMLELQGAFK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
GIAVTVDAAGELPPIVVDPFQLQQVLINLFINARDAMSDGGKLDVRTSADWFTPPVQTTG
CEEEEEECCCCCCCEEECHHHHHHHHHHHHHCCHHHCCCCCEEEEECCCCCCCCCCCCCC
SSLHVSGRRREDFDGVFRASFAAESEPVPCVRIEVADTGCGIAPERLGRIFDPFFTTKEP
CEEEECCCCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCHHHHHHHHCCCCCCCCC
GKGTGLGLAISARIVDSFDGRITVESSVGKGTTFVIWLPVAGSVTDKGMEQ
CCCCCCEEEEEEHHHHCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MKQFRFSFSFLILSSLSFILVLTWVLLSLISFKTAENDLLQQKSDKARLLLASFTALVPR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHCCC
DPAAVASSPASTLAQRFAREGEFVGLTVSGRDGTVLYSLGSEVLGDGMLAETIASGAELA
CCHHHHCCCHHHHHHHHHCCCCEEEEEEECCCCEEEEECCHHHHCCCHHHHHHHCCHHHH
RFSGGRGTLRRYAPLVRDGRSVGAVRLELSLKGEQKLLAQSRHLFLAYCVLDFLLLLAVG
HCCCCCCHHHHHHHHHHCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SFLLSRFIVAPVRRLLATTERIGQGDYSHRAAVGGGREIAELAESFNGMVDALRAKQEEA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
DRYVRSLEQANRELQKAREEALRSEKLASVGLLAAGTAHEIGTPLTSIMGYAGLLMDEVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHC
DDPRKADYLRRIERDAERIDRIVRDLLNFARPAEGTTETVDVVALVASTLEMLELQGAFK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHC
GIAVTVDAAGELPPIVVDPFQLQQVLINLFINARDAMSDGGKLDVRTSADWFTPPVQTTG
CEEEEEECCCCCCCEEECHHHHHHHHHHHHHCCHHHCCCCCEEEEECCCCCCCCCCCCCC
SSLHVSGRRREDFDGVFRASFAAESEPVPCVRIEVADTGCGIAPERLGRIFDPFFTTKEP
CEEEECCCCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCHHHHHHHHCCCCCCCCC
GKGTGLGLAISARIVDSFDGRITVESSVGKGTTFVIWLPVAGSVTDKGMEQ
CCCCCCEEEEEEHHHHCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11243806 [H]