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The map label for this gene is 78221971

Identifier: 78221971

GI number: 78221971

Start: 825369

End: 827132

Strand: Reverse

Name: 78221971

Synonym: Gmet_0751

Alternate gene names: NA

Gene position: 827132-825369 (Counterclockwise)

Preceding gene: 78221981

Following gene: 78221970

Centisome position: 20.69

GC content: 60.49

Gene sequence:

>1764_bases
ATGCGCTGCACGAAACGAGTTTGTGGGAAGATCACCCTTCACCTTGGCACCCTCGGTATCCTCTGCCTGGCAGCGGGAAT
GGCCGGTGCCGCCCCCCCTCCCCAGAAGTTCGTAACCGATGAGCTCCTCGTCCAGTTCAAGGCTGGCGTCCACAAGGACA
ATTCAGACACCGTCCTCAAGGGAGCCGGCGCCCAGGAAGCCGAGGAAATCGCTCCGATCCGGGTAAAGAGGATCAAGGTC
CCTGCTGCTGCCCGGGCAAAGGTCAAGGCTGCTCTGGCCAAGAATCCCCACGTAACGTTCGTCGAAGAGAATTACCTGGC
TGAGCAGACAATGGTTCCCAACGATCCCTCCTACGCCTCCCAGTGGCATCTCCCCAAGATTGCCGCTCCGGCGGGATGGG
ACATCTCCACCGGCTCCAGTTCCGTTGACATCGCCATCCTGGACTCGGGCGTCGATCCATCTCACCCGGACCTGGCCGGC
AAGCTTCTCCCCGGTTTCAACTTTGTCTTCAACAACACCGATACCCACGATGTGACCGGGCACGGGACAAAGGTCGCAGG
CTCGGCCGGGGCCATGGGTAATAACGGCGCCGGGGTTGCCGGCGTGGCGTGGCAGAACCAGATCATGCCCCTGGTGATCG
CGGATTCCACCGGCTACGCTACCTACTCGCGCATGGCCAGTGCCATCACCTACGCCGCCGATCATGGGGTCCGCATCATC
AATCTCAGCTACGGCGGCTCCACCAGTTCCTCGACTCTCCAGAATGCCGTGAACTACGCCTGGAACAAAGGGGCCATTGT
CTTTGCCTCGGCAGCCAACTACAACACGAGCACCCCCTACTATCCGGCCGCCTGCACCAACGCCGTGTCGGTGGCGGCCA
CCGACGCCAACGACGCCAAGGCGAGCTTCTCCAACTACGGTTCCACCATCGATATCACCGCCCCTGGCGTCTCCATCCTC
ACCACCGCCAACGGCGGCGGCTATGCGAGCGTGAGCGGCACCTCCTTCTCCTCTCCCATCGCAGCGGGGCTCGGCGCGCT
GATCCTCTCCGTTAACCCGACCCTGACCAATGCCCAGGTGGTGGACATCATCACCAAAAATGCCGACGACATCGGCACCC
CCGGCTTCGATCAGTACTTCGGCTACGGCCGGATCAACGTCCTCAAGAGCCTCACGGCTGCCCAGAATGCGGTGCCGGTC
GGCGACACAACTGCCCCGACAGTCTCAATCCCATCGCTCAACGCCGGCTCGACGGTCAAGGGAACGGTAACAGTCAACGT
TGCGGCAGCCGACAACATCGGTGTCACCCGGATAGAGCTTTACATAAACGGCGCACTGTACGCCTCCAGTAACACATCCC
CCTTCAGCTTCTCATGGGACACAACCACCCTGCCCGACAGCATCTACACTATCGCGGTCAAAGCCTATGACGCCGCCGGG
AACGTGGGAGAATTGAGCCTAGCGGGAATCGTCGTGTACAACTCACTGGACACCATTGCGCCCACGGTCTCCATCACAGC
GCCGGCAACGGGCATCACGCTCGGCACAAAAACGACGGTCAGCATTTCAGCAAAAGACAATCTGGCGGTCAGAAAGATTG
AACTTTACTTTGACGGACTCCTCCTCACCACGGCAAGCGGCACCAACACCCTCACCTATGCATGGAACACCCGCAAGGTA
GCCACGGGCACTCACACAATTCTCGCCAAGGCCTTCGACTGGTTCGGAAACGTCGGTACGACCACCATTACCGTCTACAA
GTAA

Upstream 100 bases:

>100_bases
GGTCAGGATAGCCGGGTTGTCGAAGAGCAACGCCCGCCTTCCATAGGTACGGGGGTCTGTTTCTGAGGTAGGAAGCAAAC
TCAACCCATGGAGGTGGCGC

Downstream 100 bases:

>100_bases
TCAACTCCATTGCGGGTTAACGAAAAGGGGAGAGGGCAGAGTCAGCCCCTCCCCTCTTTTTTTGTCTGTTACCCTGTTAC
GTGTATTCATCTTCAAGGCT

Product: peptidase S8/S53 subtilisin kexin sedolisin

Products: NA

Alternate protein names: Ak.1 protease [H]

Number of amino acids: Translated: 587; Mature: 587

Protein sequence:

>587_residues
MRCTKRVCGKITLHLGTLGILCLAAGMAGAAPPPQKFVTDELLVQFKAGVHKDNSDTVLKGAGAQEAEEIAPIRVKRIKV
PAAARAKVKAALAKNPHVTFVEENYLAEQTMVPNDPSYASQWHLPKIAAPAGWDISTGSSSVDIAILDSGVDPSHPDLAG
KLLPGFNFVFNNTDTHDVTGHGTKVAGSAGAMGNNGAGVAGVAWQNQIMPLVIADSTGYATYSRMASAITYAADHGVRII
NLSYGGSTSSSTLQNAVNYAWNKGAIVFASAANYNTSTPYYPAACTNAVSVAATDANDAKASFSNYGSTIDITAPGVSIL
TTANGGGYASVSGTSFSSPIAAGLGALILSVNPTLTNAQVVDIITKNADDIGTPGFDQYFGYGRINVLKSLTAAQNAVPV
GDTTAPTVSIPSLNAGSTVKGTVTVNVAAADNIGVTRIELYINGALYASSNTSPFSFSWDTTTLPDSIYTIAVKAYDAAG
NVGELSLAGIVVYNSLDTIAPTVSITAPATGITLGTKTTVSISAKDNLAVRKIELYFDGLLLTTASGTNTLTYAWNTRKV
ATGTHTILAKAFDWFGNVGTTTITVYK

Sequences:

>Translated_587_residues
MRCTKRVCGKITLHLGTLGILCLAAGMAGAAPPPQKFVTDELLVQFKAGVHKDNSDTVLKGAGAQEAEEIAPIRVKRIKV
PAAARAKVKAALAKNPHVTFVEENYLAEQTMVPNDPSYASQWHLPKIAAPAGWDISTGSSSVDIAILDSGVDPSHPDLAG
KLLPGFNFVFNNTDTHDVTGHGTKVAGSAGAMGNNGAGVAGVAWQNQIMPLVIADSTGYATYSRMASAITYAADHGVRII
NLSYGGSTSSSTLQNAVNYAWNKGAIVFASAANYNTSTPYYPAACTNAVSVAATDANDAKASFSNYGSTIDITAPGVSIL
TTANGGGYASVSGTSFSSPIAAGLGALILSVNPTLTNAQVVDIITKNADDIGTPGFDQYFGYGRINVLKSLTAAQNAVPV
GDTTAPTVSIPSLNAGSTVKGTVTVNVAAADNIGVTRIELYINGALYASSNTSPFSFSWDTTTLPDSIYTIAVKAYDAAG
NVGELSLAGIVVYNSLDTIAPTVSITAPATGITLGTKTTVSISAKDNLAVRKIELYFDGLLLTTASGTNTLTYAWNTRKV
ATGTHTILAKAFDWFGNVGTTTITVYK
>Mature_587_residues
MRCTKRVCGKITLHLGTLGILCLAAGMAGAAPPPQKFVTDELLVQFKAGVHKDNSDTVLKGAGAQEAEEIAPIRVKRIKV
PAAARAKVKAALAKNPHVTFVEENYLAEQTMVPNDPSYASQWHLPKIAAPAGWDISTGSSSVDIAILDSGVDPSHPDLAG
KLLPGFNFVFNNTDTHDVTGHGTKVAGSAGAMGNNGAGVAGVAWQNQIMPLVIADSTGYATYSRMASAITYAADHGVRII
NLSYGGSTSSSTLQNAVNYAWNKGAIVFASAANYNTSTPYYPAACTNAVSVAATDANDAKASFSNYGSTIDITAPGVSIL
TTANGGGYASVSGTSFSSPIAAGLGALILSVNPTLTNAQVVDIITKNADDIGTPGFDQYFGYGRINVLKSLTAAQNAVPV
GDTTAPTVSIPSLNAGSTVKGTVTVNVAAADNIGVTRIELYINGALYASSNTSPFSFSWDTTTLPDSIYTIAVKAYDAAG
NVGELSLAGIVVYNSLDTIAPTVSITAPATGITLGTKTTVSISAKDNLAVRKIELYFDGLLLTTASGTNTLTYAWNTRKV
ATGTHTILAKAFDWFGNVGTTTITVYK

Specific function: Unknown

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI4505579, Length=436, Percent_Identity=22.9357798165138, Blast_Score=87, Evalue=6e-17,
Organism=Homo sapiens, GI76443679, Length=378, Percent_Identity=24.3386243386243, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI31317307, Length=301, Percent_Identity=25.2491694352159, Blast_Score=67, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71988308, Length=337, Percent_Identity=25.8160237388724, Blast_Score=69, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI71988315, Length=337, Percent_Identity=25.8160237388724, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71988312, Length=337, Percent_Identity=25.8160237388724, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71988301, Length=337, Percent_Identity=25.8160237388724, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71988297, Length=337, Percent_Identity=25.8160237388724, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71988321, Length=337, Percent_Identity=25.8160237388724, Blast_Score=68, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320775, Length=286, Percent_Identity=29.3706293706294, Blast_Score=91, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6324576, Length=288, Percent_Identity=28.4722222222222, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319893, Length=244, Percent_Identity=29.0983606557377, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500
- InterPro:   IPR009020 [H]

Pfam domain/function: PF00082 Peptidase_S8 [H]

EC number: NA

Molecular weight: Translated: 60591; Mature: 60591

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS00136 SUBTILASE_ASP ; PS00137 SUBTILASE_HIS ; PS00138 SUBTILASE_SER ; PS00678 WD_REPEATS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRCTKRVCGKITLHLGTLGILCLAAGMAGAAPPPQKFVTDELLVQFKAGVHKDNSDTVLK
CCCCHHHHCEEEEEHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEE
GAGAQEAEEIAPIRVKRIKVPAAARAKVKAALAKNPHVTFVEENYLAEQTMVPNDPSYAS
CCCCCHHHHCCCEEEEEEECCCHHHHHHHHHHCCCCCEEEEECCCCHHCCCCCCCCCCCC
QWHLPKIAAPAGWDISTGSSSVDIAILDSGVDPSHPDLAGKLLPGFNFVFNNTDTHDVTG
CCCCCEECCCCCCEECCCCCEEEEEEEECCCCCCCCCCHHHHCCCEEEEECCCCCCCCCC
HGTKVAGSAGAMGNNGAGVAGVAWQNQIMPLVIADSTGYATYSRMASAITYAADHGVRII
CCCEECCCCCCCCCCCCCEEEEEECCCEEEEEEECCCCCHHHHHHHHHHEEECCCCEEEE
NLSYGGSTSSSTLQNAVNYAWNKGAIVFASAANYNTSTPYYPAACTNAVSVAATDANDAK
EEECCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHCCCEEEEEECCCCCH
ASFSNYGSTIDITAPGVSILTTANGGGYASVSGTSFSSPIAAGLGALILSVNPTLTNAQV
HHHHHCCCEEEEECCCEEEEEECCCCCEEEECCCCCCCHHHHCCEEEEEEECCCCCCCEE
VDIITKNADDIGTPGFDQYFGYGRINVLKSLTAAQNAVPVGDTTAPTVSIPSLNAGSTVK
EEEEECCCCCCCCCCHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCEEE
GTVTVNVAAADNIGVTRIELYINGALYASSNTSPFSFSWDTTTLPDSIYTIAVKAYDAAG
EEEEEEEEECCCCCEEEEEEEEEEEEEECCCCCCEEEECCCCCCCCCEEEEEEEEECCCC
NVGELSLAGIVVYNSLDTIAPTVSITAPATGITLGTKTTVSISAKDNLAVRKIELYFDGL
CCCCEEEEEEEEECCCCHHCCEEEEECCCCEEEECCCEEEEEECCCCEEEEEEEEEECEE
LLTTASGTNTLTYAWNTRKVATGTHTILAKAFDWFGNVGTTTITVYK
EEEECCCCCEEEEEECCEEEECCHHHHHHHHHHHHCCCCCEEEEEEC
>Mature Secondary Structure
MRCTKRVCGKITLHLGTLGILCLAAGMAGAAPPPQKFVTDELLVQFKAGVHKDNSDTVLK
CCCCHHHHCEEEEEHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEE
GAGAQEAEEIAPIRVKRIKVPAAARAKVKAALAKNPHVTFVEENYLAEQTMVPNDPSYAS
CCCCCHHHHCCCEEEEEEECCCHHHHHHHHHHCCCCCEEEEECCCCHHCCCCCCCCCCCC
QWHLPKIAAPAGWDISTGSSSVDIAILDSGVDPSHPDLAGKLLPGFNFVFNNTDTHDVTG
CCCCCEECCCCCCEECCCCCEEEEEEEECCCCCCCCCCHHHHCCCEEEEECCCCCCCCCC
HGTKVAGSAGAMGNNGAGVAGVAWQNQIMPLVIADSTGYATYSRMASAITYAADHGVRII
CCCEECCCCCCCCCCCCCEEEEEECCCEEEEEEECCCCCHHHHHHHHHHEEECCCCEEEE
NLSYGGSTSSSTLQNAVNYAWNKGAIVFASAANYNTSTPYYPAACTNAVSVAATDANDAK
EEECCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHCCCEEEEEECCCCCH
ASFSNYGSTIDITAPGVSILTTANGGGYASVSGTSFSSPIAAGLGALILSVNPTLTNAQV
HHHHHCCCEEEEECCCEEEEEECCCCCEEEECCCCCCCHHHHCCEEEEEEECCCCCCCEE
VDIITKNADDIGTPGFDQYFGYGRINVLKSLTAAQNAVPVGDTTAPTVSIPSLNAGSTVK
EEEEECCCCCCCCCCHHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCEEE
GTVTVNVAAADNIGVTRIELYINGALYASSNTSPFSFSWDTTTLPDSIYTIAVKAYDAAG
EEEEEEEEECCCCCEEEEEEEEEEEEEECCCCCCEEEECCCCCCCCCEEEEEEEEECCCC
NVGELSLAGIVVYNSLDTIAPTVSITAPATGITLGTKTTVSISAKDNLAVRKIELYFDGL
CCCCEEEEEEEEECCCCHHCCEEEEECCCCEEEECCCEEEEEECCCCEEEEEEEEEECEE
LLTTASGTNTLTYAWNTRKVATGTHTILAKAFDWFGNVGTTTITVYK
EEEECCCCCEEEEEECCEEEECCHHHHHHHHHHHHCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7993087; 10588904 [H]