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The map label for this gene is rnz [H]

Identifier: 78221944

GI number: 78221944

Start: 797717

End: 798787

Strand: Reverse

Name: rnz [H]

Synonym: Gmet_0724

Alternate gene names: 78221944

Gene position: 798787-797717 (Counterclockwise)

Preceding gene: 78221946

Following gene: 78221933

Centisome position: 19.98

GC content: 63.87

Gene sequence:

>1071_bases
ATGCCCCCCCTGTTCCACCCGACCCCCGTGAACGGCCCCTTCGATGACCCCGGCGTTTACGTGGATTTCCTCTTCGAGCG
CCGGGCCATCCTCTTCGACCTGGGAGACATCACTCCCCTCCCCCCCCGGAAGGTTCTCCGCATCTCGGACATCTTCGTTT
CCCACACCCACGTGGACCACTTCATCGGTTTCGACCGGGTGGTGCGCCTCTGCCTGGGGCGGGAGAAGCGGCTCCGCCTC
TACGGCCCCCCCGGCTTCACGGACCAGGTGGCCCACCGACTGGCCGGCTACACCTGGAACCTGGTGGAGAGCTATCCCAC
CGACTTCACGGTGGAGGCCACGGAACTGGCTCCGGGCGGCGGGGTAAGGACGGTGGAATTCCACTGCCGGCGCGAGTTCG
TGCCGGAAAACGAGAGCTGGGAGCAAATCTCCAACGGTGTCATCCTCGACGAAGAAACCTTCCGGGTGCGGGCCGCTTTT
CTGGATCACGGCACCCCCTGCCTCGCCTTTGCCCTGGAGGAAAAGCTCCACGTGAACGTCCGCAAGAACCGCCTGGAGGA
GATGGGACTCCCCACGGGGGAGTGGCTTCGGGAACTGAAGAACGCGATCCTTCGGGGAGAGCGGGACGATCTTCCCTTCA
GGGTCTGGTGGCGTGAGGGGGGCCAGGTGCGGGAGAAGATCCATCCCCTGGGAGAACTGCGGGAGCGCTTGGTGGGGATA
GTGCCGGGACAACGGGTTGTCTACGTGACCGACGCAGGGCTCACCCCGGAGAACGGTTCGCGGATCGTGGAACTGGCCCG
GGAAGCCGACTACCTCTTCATCGAGACGACGTTTCTCCATGCGGAGGAGGAGCGGGCCCGCGAGCGGAGCCACCTGACCG
CCCGGCAGGCGGGTGAGCTGGCCCGAGAGGCGGGAGTGGCACGGGTGGTGCCGTTTCACTTTTCACCCAAATATAGGGGG
ATGGAGGAGATGCTCCGGACGGAGTTGGAGGAGGCGTTTTTTAGCGAAAAAACACCTGGAACACGGAGCAACCGTGTTCT
CAGTCAACAAATTAGTGCAGAAGTGGAGTGA

Upstream 100 bases:

>100_bases
CGGATAGTAGCACACCTTACCCCCCGAAATGCAAGGAAAAGTGCCACCGTGACGGCCCATTTCACCTTTCGCAGCCACGC
CGTTCCTACTGGAGGACCAC

Downstream 100 bases:

>100_bases
ATTTCGAGTGATCCCACTTCTGGTTGTTTTTCACCATGGCATTGAGGATGGTGAGTAGTTTTCGCATGCAAGCGGTGATC
GCGACTTTGTGAAGTTTTCC

Product: ribonuclease Z

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z [H]

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MPPLFHPTPVNGPFDDPGVYVDFLFERRAILFDLGDITPLPPRKVLRISDIFVSHTHVDHFIGFDRVVRLCLGREKRLRL
YGPPGFTDQVAHRLAGYTWNLVESYPTDFTVEATELAPGGGVRTVEFHCRREFVPENESWEQISNGVILDEETFRVRAAF
LDHGTPCLAFALEEKLHVNVRKNRLEEMGLPTGEWLRELKNAILRGERDDLPFRVWWREGGQVREKIHPLGELRERLVGI
VPGQRVVYVTDAGLTPENGSRIVELAREADYLFIETTFLHAEEERARERSHLTARQAGELAREAGVARVVPFHFSPKYRG
MEEMLRTELEEAFFSEKTPGTRSNRVLSQQISAEVE

Sequences:

>Translated_356_residues
MPPLFHPTPVNGPFDDPGVYVDFLFERRAILFDLGDITPLPPRKVLRISDIFVSHTHVDHFIGFDRVVRLCLGREKRLRL
YGPPGFTDQVAHRLAGYTWNLVESYPTDFTVEATELAPGGGVRTVEFHCRREFVPENESWEQISNGVILDEETFRVRAAF
LDHGTPCLAFALEEKLHVNVRKNRLEEMGLPTGEWLRELKNAILRGERDDLPFRVWWREGGQVREKIHPLGELRERLVGI
VPGQRVVYVTDAGLTPENGSRIVELAREADYLFIETTFLHAEEERARERSHLTARQAGELAREAGVARVVPFHFSPKYRG
MEEMLRTELEEAFFSEKTPGTRSNRVLSQQISAEVE
>Mature_355_residues
PPLFHPTPVNGPFDDPGVYVDFLFERRAILFDLGDITPLPPRKVLRISDIFVSHTHVDHFIGFDRVVRLCLGREKRLRLY
GPPGFTDQVAHRLAGYTWNLVESYPTDFTVEATELAPGGGVRTVEFHCRREFVPENESWEQISNGVILDEETFRVRAAFL
DHGTPCLAFALEEKLHVNVRKNRLEEMGLPTGEWLRELKNAILRGERDDLPFRVWWREGGQVREKIHPLGELRERLVGIV
PGQRVVYVTDAGLTPENGSRIVELAREADYLFIETTFLHAEEERARERSHLTARQAGELAREAGVARVVPFHFSPKYRGM
EEMLRTELEEAFFSEKTPGTRSNRVLSQQISAEVE

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA [H]

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family [H]

Homologues:

Organism=Homo sapiens, GI8922122, Length=334, Percent_Identity=26.0479041916168, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: =3.1.26.11 [H]

Molecular weight: Translated: 40852; Mature: 40721

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPLFHPTPVNGPFDDPGVYVDFLFERRAILFDLGDITPLPPRKVLRISDIFVSHTHVDH
CCCCCCCCCCCCCCCCCCCEEEHHHHCCEEEEECCCCCCCCCHHHEEHHHHHHHHHHHHH
FIGFDRVVRLCLGREKRLRLYGPPGFTDQVAHRLAGYTWNLVESYPTDFTVEATELAPGG
HHCHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHCCCEEEHHHHCCCCEEEEEHEECCCC
GVRTVEFHCRREFVPENESWEQISNGVILDEETFRVRAAFLDHGTPCLAFALEEKLHVNV
CEEEEEEEEHHCCCCCCCCHHHHHCCEEECCHHHEEEEHHHCCCCHHHHHHHHHHHEEHH
RKNRLEEMGLPTGEWLRELKNAILRGERDDLPFRVWWREGGQVREKIHPLGELRERLVGI
HHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHCCHHHHHHHHHCC
VPGQRVVYVTDAGLTPENGSRIVELAREADYLFIETTFLHAEEERARERSHLTARQAGEL
CCCCEEEEEEECCCCCCCCHHHHHHHHHCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHH
AREAGVARVVPFHFSPKYRGMEEMLRTELEEAFFSEKTPGTRSNRVLSQQISAEVE
HHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
PPLFHPTPVNGPFDDPGVYVDFLFERRAILFDLGDITPLPPRKVLRISDIFVSHTHVDH
CCCCCCCCCCCCCCCCCCEEEHHHHCCEEEEECCCCCCCCCHHHEEHHHHHHHHHHHHH
FIGFDRVVRLCLGREKRLRLYGPPGFTDQVAHRLAGYTWNLVESYPTDFTVEATELAPGG
HHCHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHCCCEEEHHHHCCCCEEEEEHEECCCC
GVRTVEFHCRREFVPENESWEQISNGVILDEETFRVRAAFLDHGTPCLAFALEEKLHVNV
CEEEEEEEEHHCCCCCCCCHHHHHCCEEECCHHHEEEEHHHCCCCHHHHHHHHHHHEEHH
RKNRLEEMGLPTGEWLRELKNAILRGERDDLPFRVWWREGGQVREKIHPLGELRERLVGI
HHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHCCHHHHHHHHHCC
VPGQRVVYVTDAGLTPENGSRIVELAREADYLFIETTFLHAEEERARERSHLTARQAGEL
CCCCEEEEEEECCCCCCCCHHHHHHHHHCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHH
AREAGVARVVPFHFSPKYRGMEEMLRTELEEAFFSEKTPGTRSNRVLSQQISAEVE
HHHCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]