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The map label for this gene is etfA [H]

Identifier: 78221904

GI number: 78221904

Start: 750516

End: 751847

Strand: Direct

Name: etfA [H]

Synonym: Gmet_0684

Alternate gene names: 78221904

Gene position: 750516-751847 (Clockwise)

Preceding gene: 78221903

Following gene: 78221905

Centisome position: 18.78

GC content: 65.17

Gene sequence:

>1332_bases
ATGACTGAACCAAAGAAGATAAAGAAGCCCCGGGGCACAGCCCGGCCCATCCCGGGAAAGTGCATCGCCTGCGGCGCCCG
GTGCCAGAGCGCCTGCCCCGTGGATGCCATAGAGATGAGCGATGCGGGGGAACCGATCATCCTCTCCGAGAAGTGCATCG
GCTGCCTTAAATGCGTGAAGGTCTGCCCCGCCGATGCCCTGGAGATGTTCTTCACCCCCGAGGAACTGAAGATTCTGGAG
GAACTGGCCAGGCAGCAGGCCGCCGGAGCGGCCCCCGCTGTCGAGGAAGAGGACGCCGAGGAGGCCGCCCTGGCGCAGAT
GCTCGCCGCTTACCGGGGGGTCTGGGTCTTTGTGGAGCAGACCGAAGGGGAGCCCGCCAAGGTCTCCTGGGAGCTGATGG
GGGTCGGTGCCCAACTGGCCCGGGACATCGGCACCGAACTCTGCGCCATCGTCATCGGCCACGGCGTGGAGCACCTTTGC
CGCGAGGCCTTCAGCTACGGCGCCACCAAGGCGTACCTCATGGACCAGGACGTCTTCCGCTTCTACCGCACCGAGCCCTA
CCTCGACGCCTGCTGCCACCTGATCGACAAATACAAGCCCGAGATTATCCTCATGGGGGCCACCGGCATGGGGCGCGACC
TTGCCGGGGCCGTTGCCACGCGGGTCAAGACCGGCCTCACCGCCGACTGCACCGGCCTCGACGTGGACGACAAGCGGAAC
CTCCGCCAGACCCGCCCCGCCTTCGGTGGCAACATCATGGCCACCATCATGTGCGACAAGTTCCGTCCGCAGATGGCCAC
GGTCCGCCCCCACGTGATGCCGATGCCCGAACGGATGGAAGGCGCCACCGGCGCGATCGTCCGGGAGCAGATTACCCTCA
ACGAGGCCGACATCCTCACCAAGGTCATTGAAATCATCAGGGACACGAAGGTAGGGGTCGACATCGCCGGGGCCGAGTTC
ATCGTTTCCGGCGGGCGCGGCCTGATGGGACCGGAGAACTTCGCCATGCTCCAGGAGTTGGCCGATGAGCTGGGGGGGGT
GGTCGGCGCGTCGCGCAGCGCCGTGGACGCCGGCTGGATGCCCCACGACCGCCAGGTCGGGCAGACCGGCAAGACCGTGC
GCCCAAAGATCTACATAGCCTGCGGCATCTCCGGCGCCATCCAGCATCTCGTCGGAATGCAGGATTCCGACGTGGTCATC
GCCATAAACCGCGACAAGGAGGCCCCCATCTTCCAGGTGGCCACCTATGGCATCGTGGGAGACCTGTTCAAAATCGTCCC
GGCCATCACCAGCCAACTGCGGGAACTGAAAGCATCGAAAAGAAAGGGCTGA

Upstream 100 bases:

>100_bases
GCGGCGAGCGCCGCGTTCGAAACGTTCGAGACGAAGTAAACGAACGAGCGAAGTGATCAAACGCGCGAAGCGCCCGAACA
AGAATACGGAGTATTCACCC

Downstream 100 bases:

>100_bases
TGGATAAAGGTCAAGGGAGTTCGCTCCATTCTCTTTAACCCCAGGCCCAAAAACTAGCCCTTAGATTGGCACCGAAAGGT
TCGCTATGACCATTTTCACT

Product: electron transfer flavoprotein subunit alpha

Products: NA

Alternate protein names: Alpha-ETF; Electron transfer flavoprotein large subunit; ETFLS [H]

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MTEPKKIKKPRGTARPIPGKCIACGARCQSACPVDAIEMSDAGEPIILSEKCIGCLKCVKVCPADALEMFFTPEELKILE
ELARQQAAGAAPAVEEEDAEEAALAQMLAAYRGVWVFVEQTEGEPAKVSWELMGVGAQLARDIGTELCAIVIGHGVEHLC
REAFSYGATKAYLMDQDVFRFYRTEPYLDACCHLIDKYKPEIILMGATGMGRDLAGAVATRVKTGLTADCTGLDVDDKRN
LRQTRPAFGGNIMATIMCDKFRPQMATVRPHVMPMPERMEGATGAIVREQITLNEADILTKVIEIIRDTKVGVDIAGAEF
IVSGGRGLMGPENFAMLQELADELGGVVGASRSAVDAGWMPHDRQVGQTGKTVRPKIYIACGISGAIQHLVGMQDSDVVI
AINRDKEAPIFQVATYGIVGDLFKIVPAITSQLRELKASKRKG

Sequences:

>Translated_443_residues
MTEPKKIKKPRGTARPIPGKCIACGARCQSACPVDAIEMSDAGEPIILSEKCIGCLKCVKVCPADALEMFFTPEELKILE
ELARQQAAGAAPAVEEEDAEEAALAQMLAAYRGVWVFVEQTEGEPAKVSWELMGVGAQLARDIGTELCAIVIGHGVEHLC
REAFSYGATKAYLMDQDVFRFYRTEPYLDACCHLIDKYKPEIILMGATGMGRDLAGAVATRVKTGLTADCTGLDVDDKRN
LRQTRPAFGGNIMATIMCDKFRPQMATVRPHVMPMPERMEGATGAIVREQITLNEADILTKVIEIIRDTKVGVDIAGAEF
IVSGGRGLMGPENFAMLQELADELGGVVGASRSAVDAGWMPHDRQVGQTGKTVRPKIYIACGISGAIQHLVGMQDSDVVI
AINRDKEAPIFQVATYGIVGDLFKIVPAITSQLRELKASKRKG
>Mature_442_residues
TEPKKIKKPRGTARPIPGKCIACGARCQSACPVDAIEMSDAGEPIILSEKCIGCLKCVKVCPADALEMFFTPEELKILEE
LARQQAAGAAPAVEEEDAEEAALAQMLAAYRGVWVFVEQTEGEPAKVSWELMGVGAQLARDIGTELCAIVIGHGVEHLCR
EAFSYGATKAYLMDQDVFRFYRTEPYLDACCHLIDKYKPEIILMGATGMGRDLAGAVATRVKTGLTADCTGLDVDDKRNL
RQTRPAFGGNIMATIMCDKFRPQMATVRPHVMPMPERMEGATGAIVREQITLNEADILTKVIEIIRDTKVGVDIAGAEFI
VSGGRGLMGPENFAMLQELADELGGVVGASRSAVDAGWMPHDRQVGQTGKTVRPKIYIACGISGAIQHLVGMQDSDVVIA
INRDKEAPIFQVATYGIVGDLFKIVPAITSQLRELKASKRKG

Specific function: The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) [H]

COG id: COG2025

COG function: function code C; Electron transfer flavoprotein, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ETF alpha-subunit/fixB family [H]

Homologues:

Organism=Homo sapiens, GI4503607, Length=337, Percent_Identity=34.4213649851632, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI189181759, Length=279, Percent_Identity=37.6344086021505, Blast_Score=178, Evalue=9e-45,
Organism=Escherichia coli, GI1787990, Length=331, Percent_Identity=30.8157099697885, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1786226, Length=122, Percent_Identity=47.5409836065574, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI87082157, Length=282, Percent_Identity=23.4042553191489, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17506929, Length=338, Percent_Identity=35.207100591716, Blast_Score=168, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6325261, Length=195, Percent_Identity=41.025641025641, Blast_Score=148, Evalue=2e-36,
Organism=Drosophila melanogaster, GI17136898, Length=299, Percent_Identity=39.4648829431438, Blast_Score=184, Evalue=8e-47,
Organism=Drosophila melanogaster, GI24652801, Length=299, Percent_Identity=39.4648829431438, Blast_Score=184, Evalue=8e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001308
- InterPro:   IPR014730
- InterPro:   IPR014731
- InterPro:   IPR018206
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01012 ETF; PF00766 ETF_alpha [H]

EC number: NA

Molecular weight: Translated: 47845; Mature: 47714

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00198 4FE4S_FERREDOXIN ; PS00696 ETF_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
7.4 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEPKKIKKPRGTARPIPGKCIACGARCQSACPVDAIEMSDAGEPIILSEKCIGCLKCVK
CCCCCCCCCCCCCCCCCCCHHHHCCHHCCCCCCCCCEECCCCCCCEEECHHHHHHHHHHH
VCPADALEMFFTPEELKILEELARQQAAGAAPAVEEEDAEEAALAQMLAAYRGVWVFVEQ
HCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEEC
TEGEPAKVSWELMGVGAQLARDIGTELCAIVIGHGVEHLCREAFSYGATKAYLMDQDVFR
CCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEHHHHHHH
FYRTEPYLDACCHLIDKYKPEIILMGATGMGRDLAGAVATRVKTGLTADCTGLDVDDKRN
HHCCCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHH
LRQTRPAFGGNIMATIMCDKFRPQMATVRPHVMPMPERMEGATGAIVREQITLNEADILT
HHHHCCCCCCCEEEEEEECCCCCCHHHCCCCCCCCCHHHCCCCCHHHHHHHCCCHHHHHH
KVIEIIRDTKVGVDIAGAEFIVSGGRGLMGPENFAMLQELADELGGVVGASRSAVDAGWM
HHHHHHHHCCCCEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
PHDRQVGQTGKTVRPKIYIACGISGAIQHLVGMQDSDVVIAINRDKEAPIFQVATYGIVG
CCCCCCCCCCCCCCCEEEEEECCHHHHHHHHCCCCCCEEEEEECCCCCCEEHHHHHHHHH
DLFKIVPAITSQLRELKASKRKG
HHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TEPKKIKKPRGTARPIPGKCIACGARCQSACPVDAIEMSDAGEPIILSEKCIGCLKCVK
CCCCCCCCCCCCCCCCCCHHHHCCHHCCCCCCCCCEECCCCCCCEEECHHHHHHHHHHH
VCPADALEMFFTPEELKILEELARQQAAGAAPAVEEEDAEEAALAQMLAAYRGVWVFVEQ
HCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEEC
TEGEPAKVSWELMGVGAQLARDIGTELCAIVIGHGVEHLCREAFSYGATKAYLMDQDVFR
CCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEEHHHHHHH
FYRTEPYLDACCHLIDKYKPEIILMGATGMGRDLAGAVATRVKTGLTADCTGLDVDDKRN
HHCCCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHH
LRQTRPAFGGNIMATIMCDKFRPQMATVRPHVMPMPERMEGATGAIVREQITLNEADILT
HHHHCCCCCCCEEEEEEECCCCCCHHHCCCCCCCCCHHHCCCCCHHHHHHHCCCHHHHHH
KVIEIIRDTKVGVDIAGAEFIVSGGRGLMGPENFAMLQELADELGGVVGASRSAVDAGWM
HHHHHHHHCCCCEEECCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
PHDRQVGQTGKTVRPKIYIACGISGAIQHLVGMQDSDVVIAINRDKEAPIFQVATYGIVG
CCCCCCCCCCCCCCCEEEEEECCHHHHHHHHCCCCCCEEEEEECCCCCCEEHHHHHHHHH
DLFKIVPAITSQLRELKASKRKG
HHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA