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The map label for this gene is cobD

Identifier: 78221707

GI number: 78221707

Start: 531658

End: 532614

Strand: Direct

Name: cobD

Synonym: Gmet_0486

Alternate gene names: 78221707

Gene position: 531658-532614 (Clockwise)

Preceding gene: 78221706

Following gene: 78221708

Centisome position: 13.3

GC content: 68.03

Gene sequence:

>957_bases
GTGACCGAGGCCGGCGCGGTCGTCCTGACCGCGGTCCTCCTCGATCTCCTCTTCGGCGACCCCCGCTGGCTCCCCCATCC
GGTGGTGGCCATCGGCAAGCTGATCACGGTGCTGGAGAAATTCCTGCGGCGGCTGGTGACGAACGAGCGTGTCGGCGGGG
TGCTGCTCCTTCTGCTGGCCGTCGGCATCACCGCCGGCGCCGCCTGGGGGGCGGTGCGGGGAGCTTCTCTCGTCCACCCG
CTCGCTGGAGTCGTTGTGTCGGCTCTCCTCGGGTGGACCTGTCTGGCGGCCCGGTCCCTCCATGGGGAATCGAAGCGGGT
GGCCGACGCCCTGGTACGGGGCGACCTGCCGGAGGCCCGGCGGTATCTCTCCTTTATCGTGGGACGGGACACTGCTGGAC
TTTCCGAGCCGGAGGTCTGGCGCGGCGCCGTGGAGACCGTGGCTGAGAACACTTCCGACGGCGTCATCGCCCCGCTCCTC
TTCTTCATGATCGGCGGGGCACCCCTGGCCCTGGCCTACAAGGCGGTCAACACCCTCGATTCCATGGTGGGGTACAAGAA
CGAGCGGTATCTTCATTTCGGCTGGGCCTCGGCCCGGAGCGACGACCTGGCCAACCTGATCCCGGCCAGGCTCACGGGGC
TCCTCATGACCCTTGCCGCTCCCCTGGCGGGTCTGTCGGGGCGCGGTGCCTGGCGGATAATGCTCCGGGATGGCCGCAAT
CACTCATCCCCCAACAGCGGCATCCCCGAGGCGGCCGCCGCCGGCGCCCTCGGCGTGCAACTGGGGGGGACCAACGTCTA
TTTCGGCAAGCCGGTGGCGAAGCCCACCATTGGCGATCCCTTGAAGCCCCTTGACGCCACGGCCTGGCGGGGTACCGTGC
GGCTCATGTACGGCGCCGAGTGTTTGCTGGTCCTTCTGGCGGCAGTAATGACCACCATCCTGACAATTACAGACTAA

Upstream 100 bases:

>100_bases
CCGCGGCGGAGGCGCAGGACGACCCCTTTGATCTCCTGGCGGCCCACCTGGAGAAGCACCTGGACATGGAGCGGCTCCTG
GCCGTCTGCGGGCTTGCCCG

Downstream 100 bases:

>100_bases
ACACAGAGGCGCAGAGACACAGAGATGGTAATTCCGGAGACCCTGGCTGAAATCTGTTTGCTTGCAGGGTAACACCTTAA
AACGGTTTTCCTCTGGGTCC

Product: adenosylcobinamide-phosphate synthase

Products: ADP; phosphate; Adenosyl cobinamide phosphate; Adenosyl cobinamide

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MTEAGAVVLTAVLLDLLFGDPRWLPHPVVAIGKLITVLEKFLRRLVTNERVGGVLLLLLAVGITAGAAWGAVRGASLVHP
LAGVVVSALLGWTCLAARSLHGESKRVADALVRGDLPEARRYLSFIVGRDTAGLSEPEVWRGAVETVAENTSDGVIAPLL
FFMIGGAPLALAYKAVNTLDSMVGYKNERYLHFGWASARSDDLANLIPARLTGLLMTLAAPLAGLSGRGAWRIMLRDGRN
HSSPNSGIPEAAAAGALGVQLGGTNVYFGKPVAKPTIGDPLKPLDATAWRGTVRLMYGAECLLVLLAAVMTTILTITD

Sequences:

>Translated_318_residues
MTEAGAVVLTAVLLDLLFGDPRWLPHPVVAIGKLITVLEKFLRRLVTNERVGGVLLLLLAVGITAGAAWGAVRGASLVHP
LAGVVVSALLGWTCLAARSLHGESKRVADALVRGDLPEARRYLSFIVGRDTAGLSEPEVWRGAVETVAENTSDGVIAPLL
FFMIGGAPLALAYKAVNTLDSMVGYKNERYLHFGWASARSDDLANLIPARLTGLLMTLAAPLAGLSGRGAWRIMLRDGRN
HSSPNSGIPEAAAAGALGVQLGGTNVYFGKPVAKPTIGDPLKPLDATAWRGTVRLMYGAECLLVLLAAVMTTILTITD
>Mature_317_residues
TEAGAVVLTAVLLDLLFGDPRWLPHPVVAIGKLITVLEKFLRRLVTNERVGGVLLLLLAVGITAGAAWGAVRGASLVHPL
AGVVVSALLGWTCLAARSLHGESKRVADALVRGDLPEARRYLSFIVGRDTAGLSEPEVWRGAVETVAENTSDGVIAPLLF
FMIGGAPLALAYKAVNTLDSMVGYKNERYLHFGWASARSDDLANLIPARLTGLLMTLAAPLAGLSGRGAWRIMLRDGRNH
SSPNSGIPEAAAAGALGVQLGGTNVYFGKPVAKPTIGDPLKPLDATAWRGTVRLMYGAECLLVLLAAVMTTILTITD

Specific function: Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group

COG id: COG1270

COG function: function code H; Cobalamin biosynthesis protein CobD/CbiB

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobD/CbiB family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBD_GEOMG (Q39YE5)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_383454.1
- STRING:   Q39YE5
- GeneID:   3738319
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_0486
- NMPDR:   fig|269799.3.peg.514
- eggNOG:   COG1270
- HOGENOM:   HBG647131
- OMA:   MINPIYL
- ProtClustDB:   CLSK829041
- BioCyc:   GMET269799:GMET_0486-MONOMER
- HAMAP:   MF_00024
- InterPro:   IPR004485
- TIGRFAMs:   TIGR00380

Pfam domain/function: PF03186 CobD_Cbib

EC number: 6.3.1.10

Molecular weight: Translated: 33443; Mature: 33311

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x10969c20)-; HASH(0xf7fec50)-; HASH(0xfb0ac1c)-; HASH(0x104e748c)-; HASH(0x1046fffc)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEAGAVVLTAVLLDLLFGDPRWLPHPVVAIGKLITVLEKFLRRLVTNERVGGVLLLLLA
CCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
VGITAGAAWGAVRGASLVHPLAGVVVSALLGWTCLAARSLHGESKRVADALVRGDLPEAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHH
RYLSFIVGRDTAGLSEPEVWRGAVETVAENTSDGVIAPLLFFMIGGAPLALAYKAVNTLD
HHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
SMVGYKNERYLHFGWASARSDDLANLIPARLTGLLMTLAAPLAGLSGRGAWRIMLRDGRN
HHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCC
HSSPNSGIPEAAAAGALGVQLGGTNVYFGKPVAKPTIGDPLKPLDATAWRGTVRLMYGAE
CCCCCCCCCHHHHCCCCEEEECCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
CLLVLLAAVMTTILTITD
HHHHHHHHHHHHHHHCCH
>Mature Secondary Structure 
TEAGAVVLTAVLLDLLFGDPRWLPHPVVAIGKLITVLEKFLRRLVTNERVGGVLLLLLA
CCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
VGITAGAAWGAVRGASLVHPLAGVVVSALLGWTCLAARSLHGESKRVADALVRGDLPEAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHH
RYLSFIVGRDTAGLSEPEVWRGAVETVAENTSDGVIAPLLFFMIGGAPLALAYKAVNTLD
HHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHH
SMVGYKNERYLHFGWASARSDDLANLIPARLTGLLMTLAAPLAGLSGRGAWRIMLRDGRN
HHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCC
HSSPNSGIPEAAAAGALGVQLGGTNVYFGKPVAKPTIGDPLKPLDATAWRGTVRLMYGAE
CCCCCCCCCHHHHCCCCEEEECCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
CLLVLLAAVMTTILTITD
HHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyric acid; (R)-1-aminopropan-2-yl phosphate; (R)-1-aminopropan-2-ol

Specific reaction: (1) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate; (2) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA