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The map label for this gene is cobQ [H]

Identifier: 78221706

GI number: 78221706

Start: 529268

End: 531661

Strand: Direct

Name: cobQ [H]

Synonym: Gmet_0485

Alternate gene names: 78221706

Gene position: 529268-531661 (Clockwise)

Preceding gene: 78221705

Following gene: 78221707

Centisome position: 13.24

GC content: 66.67

Gene sequence:

>2394_bases
ATGTCCAAGCTCTACGTCGTCGGCATCGGTCCCGGCGACCTCGACCATATGACCTTCCAGGCCAACGAGGCCCTTGACGC
CGCCGATGTGGTGGTGGGGTACAAGACCTACCTGGACCTGATCGCCCCTCTCATCGCCGGCAAGGAGATTATCTCCTCCG
GAATGATGAAGGAGGTGGAGCGCTGCCGCGAAGCCTTGGACCTGGCCGCCTCGGGGAAGACGGTGGCCCTGGTCTCCAGC
GGCGACGCCGGCATCTACGGCATGGCGGGGCTCGCCCTGGAGCTGGCGGCGGAGTTGGTCGCCCCCCCCGAGATCGTAGT
GGTTCCCGGCGTTTCGGCCGTGCAGGCGGCTGCAGCGGTCCTCGGCGCTCCCCTTATGCATGATTTCACCGTCATCTCCC
TCTCGGATCTCCTGACCCCGTGGGACCTCATCGAACGGCGGCTTGTGGCCGCCGCCACGGCCGATTTCGTCGTAGCCCTC
TACAACCCCCGGAGCAAGGGGCGGGTGCAGCAGATCGAGGAGGCCCGGCAGATCCTCCTGTCTGCCCGGCCGGCCGATAC
CCCGGTGGGGATCGTCCGCAACGCCTTGCGGGAGGGGGAGGAGCGGATCGTCACCACCCTCGGAAGGATGCTCGACCACC
CCATCGATATGTTCTCTCTGGTCATCGTGGGGAACTCTGCCACCTTCGTCGACCCGGCGGGGCGGATGGTGACCCCGCGC
GGCTACGCCGCCGGGATCCGGGACCGGGGACCAGGGGAAAAGGCCGGGACCGGGGACCAGGGACCAGGGACCAGGGAAAA
ACAAAAAAAACCAGTCACTGAGTACTCGGTGGATTCCCCGTCTCAGATTTTGAATTCCCGGTCCCCGGTCCCTGGTCCCC
GGTCCCGGTCTTTGATGGTGGTCGGTACGGCCTCCGATGTGGGCAAATCGGTCCTCACGGCCGGCATCTGCCGCATCCTC
AAGAACCGGGGGCTCCGGGTGGCCCCCTTCAAGTCCCAGAACATGGCCCTCAACTCGGCGGTCACCCCCGAGGGAGGGGA
GATCGGCCGGGCCCAGGCGGTACAGGCGGCGGCCTGCGGCATCCCCCCCCATGCCGACATGAACCCGATCCTCCTGAAAC
CCTCCTCCGATACGGGAAGTCAGGTCATCGTCGCGGGTGAGGTGGTGGGGAATATGTCGGTGCGGGAGTACCACGCCTAT
AAACCCATGGCTTTCGAGCAGGTACGGGAAAGTTTTGACCGCCTCTCCTCGGCCCACGATGTCGTGGTCATCGAGGGGGC
CGGAAGCATCGCCGAGATCAACCTGAAAGCCCACGACATCGCCAACCTGAAGGTGGCCGAGATGGCCGGATGCCGGGCCA
TCCTCGTGGCCGACATTGACCGGGGCGGGGTCTTCGCCCAGATCGTGGGGACCCTGGAGCTTCTGGAGCCGGCGGAGCGG
GAGCGGATCGCGGGCATCGTCATCAACAAGTTCCGGGGGGATGCCTCGCTTCTCACGCCGGGAATCAAGTTCGTGGAGAA
GCGGACCGGGGTGCCGGTTCTGGGGGTGGTCCCCTGCTTCAGCGGCTTCCGCATCCCCGAGGAGGACAGCGTCGCCCTGG
AAAAACGGGGATCGGGGACCGGGGACCGGGGACCGGGGGAAAAGCTCAAAATCGGGGTGGTGAAGCTGTCGCGGATCTCC
AACTACACCGACTTCGACGCCTTGGAAGCGGAACCCGACGTGCGTCTTACCTACGTGGAAGGGGCGGACCAGCTCCGGGG
GCTCGATCTCCTCATTATCCCCGGGAGCAAGGCGACCACCACCGACCTCTACTTCCTCATGGAGCGGGGGCTCTTCGAGG
CGATCCGGGCCTTTCAGGGGCTCATCGTGGGCATCTGCGGCGGCTACCAGATGCTGGGAAAGCGGGTCTCCGACCCCCAC
GCCGTGGAGTCGGGGATCCGGGAGGCCGAAGGGCTGGGTCTTCTGGACGTGGTGACGGTGATGCTGGAAAAGAAGACCAC
CCACCAGGCCCGGGCGGAACTCCTGCCGGCGGGGTACCAGGTGGCTCCCCGCTGCCGGGGCGAGCTGGAGGGGTACGAAA
TTCACATGGGGGAAACGATCCTCGGTCCGAGCGTCCGCCCCTTTGCCCGGGCCACGGAACGGTCGGGGCGGGCGGTGGAG
GTGCTGGACGGCGCCGTCTCCTGCGACGGCCGGGTCTTCGGCACTTACCTCCACGGCATCTTCGACAACGCCGGTTTCCG
CTCCGCCTTCCTCAACAAGCTCCGGCGGGCCAAGGGGCTTGTTGAGCGCCCCGCGGCGGAGGCGCAGGACGACCCCTTTG
ATCTCCTGGCGGCCCACCTGGAGAAGCACCTGGACATGGAGCGGCTCCTGGCCGTCTGCGGGCTTGCCCGGTGA

Upstream 100 bases:

>100_bases
AATCCAGAATTCAGAAGCCAGAATTCAGAAGAAAAGCACGGTCTTTTCATGATGTCTACTTCTGTATTCTGACTCCTGAC
TCCTTCATTTGAGGTTAACC

Downstream 100 bases:

>100_bases
CCGAGGCCGGCGCGGTCGTCCTGACCGCGGTCCTCCTCGATCTCCTCTTCGGCGACCCCCGCTGGCTCCCCCATCCGGTG
GTGGCCATCGGCAAGCTGAT

Product: cobyric acid synthase CobQ:precorrin-3B C17-methyltransferase region

Products: ADP; phosphate; adenosylcobyric acid; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 797; Mature: 796

Protein sequence:

>797_residues
MSKLYVVGIGPGDLDHMTFQANEALDAADVVVGYKTYLDLIAPLIAGKEIISSGMMKEVERCREALDLAASGKTVALVSS
GDAGIYGMAGLALELAAELVAPPEIVVVPGVSAVQAAAAVLGAPLMHDFTVISLSDLLTPWDLIERRLVAAATADFVVAL
YNPRSKGRVQQIEEARQILLSARPADTPVGIVRNALREGEERIVTTLGRMLDHPIDMFSLVIVGNSATFVDPAGRMVTPR
GYAAGIRDRGPGEKAGTGDQGPGTREKQKKPVTEYSVDSPSQILNSRSPVPGPRSRSLMVVGTASDVGKSVLTAGICRIL
KNRGLRVAPFKSQNMALNSAVTPEGGEIGRAQAVQAAACGIPPHADMNPILLKPSSDTGSQVIVAGEVVGNMSVREYHAY
KPMAFEQVRESFDRLSSAHDVVVIEGAGSIAEINLKAHDIANLKVAEMAGCRAILVADIDRGGVFAQIVGTLELLEPAER
ERIAGIVINKFRGDASLLTPGIKFVEKRTGVPVLGVVPCFSGFRIPEEDSVALEKRGSGTGDRGPGEKLKIGVVKLSRIS
NYTDFDALEAEPDVRLTYVEGADQLRGLDLLIIPGSKATTTDLYFLMERGLFEAIRAFQGLIVGICGGYQMLGKRVSDPH
AVESGIREAEGLGLLDVVTVMLEKKTTHQARAELLPAGYQVAPRCRGELEGYEIHMGETILGPSVRPFARATERSGRAVE
VLDGAVSCDGRVFGTYLHGIFDNAGFRSAFLNKLRRAKGLVERPAAEAQDDPFDLLAAHLEKHLDMERLLAVCGLAR

Sequences:

>Translated_797_residues
MSKLYVVGIGPGDLDHMTFQANEALDAADVVVGYKTYLDLIAPLIAGKEIISSGMMKEVERCREALDLAASGKTVALVSS
GDAGIYGMAGLALELAAELVAPPEIVVVPGVSAVQAAAAVLGAPLMHDFTVISLSDLLTPWDLIERRLVAAATADFVVAL
YNPRSKGRVQQIEEARQILLSARPADTPVGIVRNALREGEERIVTTLGRMLDHPIDMFSLVIVGNSATFVDPAGRMVTPR
GYAAGIRDRGPGEKAGTGDQGPGTREKQKKPVTEYSVDSPSQILNSRSPVPGPRSRSLMVVGTASDVGKSVLTAGICRIL
KNRGLRVAPFKSQNMALNSAVTPEGGEIGRAQAVQAAACGIPPHADMNPILLKPSSDTGSQVIVAGEVVGNMSVREYHAY
KPMAFEQVRESFDRLSSAHDVVVIEGAGSIAEINLKAHDIANLKVAEMAGCRAILVADIDRGGVFAQIVGTLELLEPAER
ERIAGIVINKFRGDASLLTPGIKFVEKRTGVPVLGVVPCFSGFRIPEEDSVALEKRGSGTGDRGPGEKLKIGVVKLSRIS
NYTDFDALEAEPDVRLTYVEGADQLRGLDLLIIPGSKATTTDLYFLMERGLFEAIRAFQGLIVGICGGYQMLGKRVSDPH
AVESGIREAEGLGLLDVVTVMLEKKTTHQARAELLPAGYQVAPRCRGELEGYEIHMGETILGPSVRPFARATERSGRAVE
VLDGAVSCDGRVFGTYLHGIFDNAGFRSAFLNKLRRAKGLVERPAAEAQDDPFDLLAAHLEKHLDMERLLAVCGLAR
>Mature_796_residues
SKLYVVGIGPGDLDHMTFQANEALDAADVVVGYKTYLDLIAPLIAGKEIISSGMMKEVERCREALDLAASGKTVALVSSG
DAGIYGMAGLALELAAELVAPPEIVVVPGVSAVQAAAAVLGAPLMHDFTVISLSDLLTPWDLIERRLVAAATADFVVALY
NPRSKGRVQQIEEARQILLSARPADTPVGIVRNALREGEERIVTTLGRMLDHPIDMFSLVIVGNSATFVDPAGRMVTPRG
YAAGIRDRGPGEKAGTGDQGPGTREKQKKPVTEYSVDSPSQILNSRSPVPGPRSRSLMVVGTASDVGKSVLTAGICRILK
NRGLRVAPFKSQNMALNSAVTPEGGEIGRAQAVQAAACGIPPHADMNPILLKPSSDTGSQVIVAGEVVGNMSVREYHAYK
PMAFEQVRESFDRLSSAHDVVVIEGAGSIAEINLKAHDIANLKVAEMAGCRAILVADIDRGGVFAQIVGTLELLEPAERE
RIAGIVINKFRGDASLLTPGIKFVEKRTGVPVLGVVPCFSGFRIPEEDSVALEKRGSGTGDRGPGEKLKIGVVKLSRISN
YTDFDALEAEPDVRLTYVEGADQLRGLDLLIIPGSKATTTDLYFLMERGLFEAIRAFQGLIVGICGGYQMLGKRVSDPHA
VESGIREAEGLGLLDVVTVMLEKKTTHQARAELLPAGYQVAPRCRGELEGYEIHMGETILGPSVRPFARATERSGRAVEV
LDGAVSCDGRVFGTYLHGIFDNAGFRSAFLNKLRRAKGLVERPAAEAQDDPFDLLAAHLEKHLDMERLLAVCGLAR

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation [H]

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698 [H]

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3 [H]

EC number: 6.3.5.10

Molecular weight: Translated: 84955; Mature: 84824

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLYVVGIGPGDLDHMTFQANEALDAADVVVGYKTYLDLIAPLIAGKEIISSGMMKEVE
CCEEEEEEECCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RCREALDLAASGKTVALVSSGDAGIYGMAGLALELAAELVAPPEIVVVPGVSAVQAAAAV
HHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHH
LGAPLMHDFTVISLSDLLTPWDLIERRLVAAATADFVVALYNPRSKGRVQQIEEARQILL
HCCHHHHCCCEEEHHHHCCCHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHH
SARPADTPVGIVRNALREGEERIVTTLGRMLDHPIDMFSLVIVGNSATFVDPAGRMVTPR
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEECCCCCEECCC
GYAAGIRDRGPGEKAGTGDQGPGTREKQKKPVTEYSVDSPSQILNSRSPVPGPRSRSLMV
CCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCHHHHHCCCCCCCCCCCCCEEE
VGTASDVGKSVLTAGICRILKNRGLRVAPFKSQNMALNSAVTPEGGEIGRAQAVQAAACG
EECCHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCEECCCCCCCCCCCCHHHHHHHHHCC
IPPHADMNPILLKPSSDTGSQVIVAGEVVGNMSVREYHAYKPMAFEQVRESFDRLSSAHD
CCCCCCCCCEEEECCCCCCCEEEEEEHHHCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCC
VVVIEGAGSIAEINLKAHDIANLKVAEMAGCRAILVADIDRGGVFAQIVGTLELLEPAER
EEEEECCCCEEEEEEEHHCCCCEEHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHCHHHH
ERIAGIVINKFRGDASLLTPGIKFVEKRTGVPVLGVVPCFSGFRIPEEDSVALEKRGSGT
HHHHHEEEECCCCCCHHHCCCHHHHHHHCCCCEEEHHHCCCCCCCCCCCCHHHHCCCCCC
GDRGPGEKLKIGVVKLSRISNYTDFDALEAEPDVRLTYVEGADQLRGLDLLIIPGSKATT
CCCCCCCEEEEEEEEEEHHCCCCCCCCCCCCCCEEEEEECCCHHHCCCEEEEECCCCCCH
TDLYFLMERGLFEAIRAFQGLIVGICGGYQMLGKRVSDPHAVESGIREAEGLGLLDVVTV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHH
MLEKKTTHQARAELLPAGYQVAPRCRGELEGYEIHMGETILGPSVRPFARATERSGRAVE
HHHCCHHHHHHHHHCCCCCEECCCCCCCCCCEEEEECCEECCCCCCHHHHHHHCCCCEEE
VLDGAVSCDGRVFGTYLHGIFDNAGFRSAFLNKLRRAKGLVERPAAEAQDDPFDLLAAHL
EECCCCCCCCEEHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHCCCCCCCCCHHHHHHHHH
EKHLDMERLLAVCGLAR
HHHCCHHHHHHHHCCCC
>Mature Secondary Structure 
SKLYVVGIGPGDLDHMTFQANEALDAADVVVGYKTYLDLIAPLIAGKEIISSGMMKEVE
CEEEEEEECCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RCREALDLAASGKTVALVSSGDAGIYGMAGLALELAAELVAPPEIVVVPGVSAVQAAAAV
HHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHH
LGAPLMHDFTVISLSDLLTPWDLIERRLVAAATADFVVALYNPRSKGRVQQIEEARQILL
HCCHHHHCCCEEEHHHHCCCHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHH
SARPADTPVGIVRNALREGEERIVTTLGRMLDHPIDMFSLVIVGNSATFVDPAGRMVTPR
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEECCCCCEECCC
GYAAGIRDRGPGEKAGTGDQGPGTREKQKKPVTEYSVDSPSQILNSRSPVPGPRSRSLMV
CCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCHHHHHCCCCCCCCCCCCCEEE
VGTASDVGKSVLTAGICRILKNRGLRVAPFKSQNMALNSAVTPEGGEIGRAQAVQAAACG
EECCHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCEECCCCCCCCCCCCHHHHHHHHHCC
IPPHADMNPILLKPSSDTGSQVIVAGEVVGNMSVREYHAYKPMAFEQVRESFDRLSSAHD
CCCCCCCCCEEEECCCCCCCEEEEEEHHHCCCCHHHHHCCCCHHHHHHHHHHHHHCCCCC
VVVIEGAGSIAEINLKAHDIANLKVAEMAGCRAILVADIDRGGVFAQIVGTLELLEPAER
EEEEECCCCEEEEEEEHHCCCCEEHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHCHHHH
ERIAGIVINKFRGDASLLTPGIKFVEKRTGVPVLGVVPCFSGFRIPEEDSVALEKRGSGT
HHHHHEEEECCCCCCHHHCCCHHHHHHHCCCCEEEHHHCCCCCCCCCCCCHHHHCCCCCC
GDRGPGEKLKIGVVKLSRISNYTDFDALEAEPDVRLTYVEGADQLRGLDLLIIPGSKATT
CCCCCCCEEEEEEEEEEHHCCCCCCCCCCCCCCEEEEEECCCHHHCCCEEEEECCCCCCH
TDLYFLMERGLFEAIRAFQGLIVGICGGYQMLGKRVSDPHAVESGIREAEGLGLLDVVTV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHH
MLEKKTTHQARAELLPAGYQVAPRCRGELEGYEIHMGETILGPSVRPFARATERSGRAVE
HHHCCHHHHHHHHHCCCCCEECCCCCCCCCCEEEEECCEECCCCCCHHHHHHHCCCCEEE
VLDGAVSCDGRVFGTYLHGIFDNAGFRSAFLNKLRRAKGLVERPAAEAQDDPFDLLAAHL
EECCCCCCCCEEHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHCCCCCCCCCHHHHHHHHH
EKHLDMERLLAVCGLAR
HHHCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyrinic acid a,c-diamide; L-glutamine; H2O

Specific reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA