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The map label for this gene is cobL [H]

Identifier: 78221702

GI number: 78221702

Start: 525353

End: 526570

Strand: Direct

Name: cobL [H]

Synonym: Gmet_0481

Alternate gene names: 78221702

Gene position: 525353-526570 (Clockwise)

Preceding gene: 78221701

Following gene: 78221703

Centisome position: 13.14

GC content: 63.63

Gene sequence:

>1218_bases
ATGCCTCACCAGAAAATCTACCTTGTCGGCGCAGGCATCGAAGGGTGGGAAGGGTTCGGCGCCAAGGCCCTGGAGGTCAT
CGGCAAGGCTGAGGTTCTCGTCGGCCACAAGCGGCACCTGGATATCTTCTCCGACTTCACCGGGAAGAAGCAGGAGCTGG
GTGACCTCTCCATCCTCCTGGAGCAGCTCAGGAGCACCGACAAGCGGACCGTGGTCCTCGGTTCCGGCGACCCGAACTTT
TTCGGCATCGCCCGGTTCCTGCTCCGCAACCTTCCCAAGGAGCGGATCGAGATCTTCCCCAACGTGACGAGCGTCCAGTA
CGCCTTTGCCCAGATCAAGGAGCCGTGGGACGACGCCATCTTCGTCTCGGTCCACGGCCGGGGGCTCAAGGGGGCCGTGG
ACCGGATCGTGGCCGCCGAGAAGGTGGCGGTCCTCACCGACAAGACCAACTCCCCGGCGGCCATCGCCCGGGAGCTCATC
GCCCGGGGTGCCGAGGGGTACGAGGCGTGGCTCTGCGAGAACCTGGGGCTCCCCGGCGAGAAGTTCACCAGGACCGACGT
GAAGGGGCTCCTGGAGCTGCCGGCGGCGGAACTGAACATCCTCATCCTCATCAAGGCCTGGGAACCCCAGCTGGCCCAGT
ACCCGGTCATCGGCATCGACGACGACGAGTTCGCCACCGCCAAGAAGCTCATCACCAAGCAGGAGGTACGGGCCGTGACC
CTGTCGAAGCTTCGGCTCCAGGATGACCTCGTTATGTGGGACATCGGCGCCGGGAGCGCTTCCGTCTCCATCGAAGCATC
GAATCTCATGCCCAACGGCCGCATCTTCGCCCTGGAGAGGAATCCCCAGTACCTCGGCTTCATCCGCGATAACCTGAAAA
AGTTCGTGGCCCGCAACGTGACCCTCGTGGAGGCCTTCGCCCCCGAGGGGCTCGACGATCTCCCGGACCCGGACCGGGTC
TTCATCGGCGGTTCCGGCGGCATGCTGGAAGAGATCATCGATGCCGTGGACCGGCGCCTCAAGTCCGAGGGGGTCATCGT
CCTCAACGCCGTGACCCTCGACACCCTCACCAAGGCGGTGGAGTTTCTGGAGGACCACGGCTACATGGTGGAGGTGGCCT
GCGTGAACGTGGCCAAGACCAAGGGGCTCACCGAGTACAAGATGTTCGAGTCCCACAATCCTGTCTATATCATCACCGCC
TGGAAGAGTGACGAATGA

Upstream 100 bases:

>100_bases
GTCTGGAATGTCGTGACGGGTGCCATGCCCGGGCTCCTCGAGCAGCTCGAACTGCTCCTGAAATCACAACGATTGGATGG
TTAATAAAGGAGGTTCCCCC

Downstream 100 bases:

>100_bases
CCGCTAAGATTTACGCCGTGGGCGTCGGCCCCGGCGACCCCGAGCTTCTGACGAGAAAGGCCGCGCGGATCATCCGTTCG
GCCGCCGTCATCTGCGCCCC

Product: precorrin-6Y C5,15-methyltransferase (decarboxylating)

Products: NA

Alternate protein names: Precorrin-6 methyltransferase; Precorrin-6Y methylase [H]

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MPHQKIYLVGAGIEGWEGFGAKALEVIGKAEVLVGHKRHLDIFSDFTGKKQELGDLSILLEQLRSTDKRTVVLGSGDPNF
FGIARFLLRNLPKERIEIFPNVTSVQYAFAQIKEPWDDAIFVSVHGRGLKGAVDRIVAAEKVAVLTDKTNSPAAIARELI
ARGAEGYEAWLCENLGLPGEKFTRTDVKGLLELPAAELNILILIKAWEPQLAQYPVIGIDDDEFATAKKLITKQEVRAVT
LSKLRLQDDLVMWDIGAGSASVSIEASNLMPNGRIFALERNPQYLGFIRDNLKKFVARNVTLVEAFAPEGLDDLPDPDRV
FIGGSGGMLEEIIDAVDRRLKSEGVIVLNAVTLDTLTKAVEFLEDHGYMVEVACVNVAKTKGLTEYKMFESHNPVYIITA
WKSDE

Sequences:

>Translated_405_residues
MPHQKIYLVGAGIEGWEGFGAKALEVIGKAEVLVGHKRHLDIFSDFTGKKQELGDLSILLEQLRSTDKRTVVLGSGDPNF
FGIARFLLRNLPKERIEIFPNVTSVQYAFAQIKEPWDDAIFVSVHGRGLKGAVDRIVAAEKVAVLTDKTNSPAAIARELI
ARGAEGYEAWLCENLGLPGEKFTRTDVKGLLELPAAELNILILIKAWEPQLAQYPVIGIDDDEFATAKKLITKQEVRAVT
LSKLRLQDDLVMWDIGAGSASVSIEASNLMPNGRIFALERNPQYLGFIRDNLKKFVARNVTLVEAFAPEGLDDLPDPDRV
FIGGSGGMLEEIIDAVDRRLKSEGVIVLNAVTLDTLTKAVEFLEDHGYMVEVACVNVAKTKGLTEYKMFESHNPVYIITA
WKSDE
>Mature_404_residues
PHQKIYLVGAGIEGWEGFGAKALEVIGKAEVLVGHKRHLDIFSDFTGKKQELGDLSILLEQLRSTDKRTVVLGSGDPNFF
GIARFLLRNLPKERIEIFPNVTSVQYAFAQIKEPWDDAIFVSVHGRGLKGAVDRIVAAEKVAVLTDKTNSPAAIARELIA
RGAEGYEAWLCENLGLPGEKFTRTDVKGLLELPAAELNILILIKAWEPQLAQYPVIGIDDDEFATAKKLITKQEVRAVTL
SKLRLQDDLVMWDIGAGSASVSIEASNLMPNGRIFALERNPQYLGFIRDNLKKFVARNVTLVEAFAPEGLDDLPDPDRVF
IGGSGGMLEEIIDAVDRRLKSEGVIVLNAVTLDTLTKAVEFLEDHGYMVEVACVNVAKTKGLTEYKMFESHNPVYIITAW
KSDE

Specific function: Catalyzes the methylation of both C-5 and C-15 in precorrin-6Y to form precorrin-8X [H]

COG id: COG2241

COG function: function code H; Precorrin-6B methylase 1

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR012818
- InterPro:   IPR014008
- InterPro:   IPR006365 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.132 [H]

Molecular weight: Translated: 44718; Mature: 44587

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHQKIYLVGAGIEGWEGFGAKALEVIGKAEVLVGHKRHLDIFSDFTGKKQELGDLSILL
CCCCEEEEEECCCCCCCCCCHHHHHHHCCHHEEECCCCCCHHHHCCCCCHHHHHHHHHHH
EQLRSTDKRTVVLGSGDPNFFGIARFLLRNLPKERIEIFPNVTSVQYAFAQIKEPWDDAI
HHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHCCCCCCEE
FVSVHGRGLKGAVDRIVAAEKVAVLTDKTNSPAAIARELIARGAEGYEAWLCENLGLPGE
EEEEECCCCHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCC
KFTRTDVKGLLELPAAELNILILIKAWEPQLAQYPVIGIDDDEFATAKKLITKQEVRAVT
CCHHHHHHHHHHCCCCCEEEEEEEEECCCCHHCCCEEECCCCHHHHHHHHHHHHHHHHHH
LSKLRLQDDLVMWDIGAGSASVSIEASNLMPNGRIFALERNPQYLGFIRDNLKKFVARNV
HHHHHCCCCEEEEEECCCCEEEEEEECCCCCCCEEEEEECCCCEEHHHHHHHHHHHHCCC
TLVEAFAPEGLDDLPDPDRVFIGGSGGMLEEIIDAVDRRLKSEGVIVLNAVTLDTLTKAV
EEEEECCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHH
EFLEDHGYMVEVACVNVAKTKGLTEYKMFESHNPVYIITAWKSDE
HHHHCCCCEEEEEEEEHHHHCCCCHHHHHCCCCCEEEEEEECCCC
>Mature Secondary Structure 
PHQKIYLVGAGIEGWEGFGAKALEVIGKAEVLVGHKRHLDIFSDFTGKKQELGDLSILL
CCCEEEEEECCCCCCCCCCHHHHHHHCCHHEEECCCCCCHHHHCCCCCHHHHHHHHHHH
EQLRSTDKRTVVLGSGDPNFFGIARFLLRNLPKERIEIFPNVTSVQYAFAQIKEPWDDAI
HHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHCCCCCCEE
FVSVHGRGLKGAVDRIVAAEKVAVLTDKTNSPAAIARELIARGAEGYEAWLCENLGLPGE
EEEEECCCCHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHCCCCCCC
KFTRTDVKGLLELPAAELNILILIKAWEPQLAQYPVIGIDDDEFATAKKLITKQEVRAVT
CCHHHHHHHHHHCCCCCEEEEEEEEECCCCHHCCCEEECCCCHHHHHHHHHHHHHHHHHH
LSKLRLQDDLVMWDIGAGSASVSIEASNLMPNGRIFALERNPQYLGFIRDNLKKFVARNV
HHHHHCCCCEEEEEECCCCEEEEEEECCCCCCCEEEEEECCCCEEHHHHHHHHHHHHCCC
TLVEAFAPEGLDDLPDPDRVFIGGSGGMLEEIIDAVDRRLKSEGVIVLNAVTLDTLTKAV
EEEEECCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHH
EFLEDHGYMVEVACVNVAKTKGLTEYKMFESHNPVYIITAWKSDE
HHHHCCCCEEEEEEEEHHHHCCCCHHHHHCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]