Click here to switch to the map view.

The map label for this gene is cobI [H]

Identifier: 78221703

GI number: 78221703

Start: 526567

End: 527271

Strand: Direct

Name: cobI [H]

Synonym: Gmet_0482

Alternate gene names: 78221703

Gene position: 526567-527271 (Clockwise)

Preceding gene: 78221702

Following gene: 78221704

Centisome position: 13.17

GC content: 64.11

Gene sequence:

>705_bases
ATGACCGCTAAGATTTACGCCGTGGGCGTCGGCCCCGGCGACCCCGAGCTTCTGACGAGAAAGGCCGCGCGGATCATCCG
TTCGGCCGCCGTCATCTGCGCCCCTACTGGTGCGGCCGATGCGGCCAGCTACGCCCTCTCCATCGTGGAGGACCTCATCG
ACCCCTCCCGCCAGGAGGTGCTGCCCCAAGTCTTTCCCATGCGCAAGGACCAGGAGGGGCTTGAAGCGTTCTGGGACGAG
GCGGCCGCCCAGGTGGCCGCGCGGGTGCGGGCGGGGAGGGACGTGGCCTTCATCACCATCGGCGACCCATTCCTCTACTC
CACCTTCCTCTACCTCTATCGTATCTTTCAAGAGCGCTACCCGGATATCCCTGTCGAGATCGTGCCGGGGATATCCAGCA
TCAACGCCGCCGCTGCCGCTGCCGGCGTCCCCCTGGGGATGGCCGCCGAGCGGATCGCCATCCTCCCCACCACCTACGAG
GACGACGAACTGCGCAGGACCTTCGCCGACTTCGATACCGTCATCCTCATGAAGGTGAACCGGGTCTTCGACCGGATTTA
CGCCCTGTTGAAGGAGTTGGGGCTGGAGCGGAAAGGGGTATTTGTCCGCCGGGTCGGTTCCGCCGACGAAGAGGTGATCT
TCGACTTGGAGCGGCTCGTGGGGGAGAAGCTCGATTACCTGTCGCTGCTGATTGTGAAAAAGTAG

Upstream 100 bases:

>100_bases
TGGCCTGCGTGAACGTGGCCAAGACCAAGGGGCTCACCGAGTACAAGATGTTCGAGTCCCACAATCCTGTCTATATCATC
ACCGCCTGGAAGAGTGACGA

Downstream 100 bases:

>100_bases
GAGCCCTTAGTGACCATCGTCCATTTCATCGGCGCCGGTCCCGGCGATGCCGAACTTATAACTGTAAAGGGTGCCCGGCT
TCTGCGGGAGGCGGATGTGG

Product: precorrin-2 C20-methyltransferase/cobalt-factor II C20-methyltransferase

Products: NA

Alternate protein names: S-adenosyl-L-methionine--precorrin-2 methyltransferase; SP2MT [H]

Number of amino acids: Translated: 234; Mature: 233

Protein sequence:

>234_residues
MTAKIYAVGVGPGDPELLTRKAARIIRSAAVICAPTGAADAASYALSIVEDLIDPSRQEVLPQVFPMRKDQEGLEAFWDE
AAAQVAARVRAGRDVAFITIGDPFLYSTFLYLYRIFQERYPDIPVEIVPGISSINAAAAAAGVPLGMAAERIAILPTTYE
DDELRRTFADFDTVILMKVNRVFDRIYALLKELGLERKGVFVRRVGSADEEVIFDLERLVGEKLDYLSLLIVKK

Sequences:

>Translated_234_residues
MTAKIYAVGVGPGDPELLTRKAARIIRSAAVICAPTGAADAASYALSIVEDLIDPSRQEVLPQVFPMRKDQEGLEAFWDE
AAAQVAARVRAGRDVAFITIGDPFLYSTFLYLYRIFQERYPDIPVEIVPGISSINAAAAAAGVPLGMAAERIAILPTTYE
DDELRRTFADFDTVILMKVNRVFDRIYALLKELGLERKGVFVRRVGSADEEVIFDLERLVGEKLDYLSLLIVKK
>Mature_233_residues
TAKIYAVGVGPGDPELLTRKAARIIRSAAVICAPTGAADAASYALSIVEDLIDPSRQEVLPQVFPMRKDQEGLEAFWDEA
AAQVAARVRAGRDVAFITIGDPFLYSTFLYLYRIFQERYPDIPVEIVPGISSINAAAAAAGVPLGMAAERIAILPTTYED
DELRRTFADFDTVILMKVNRVFDRIYALLKELGLERKGVFVRRVGSADEEVIFDLERLVGEKLDYLSLLIVKK

Specific function: Methylates precorrin-2 at the C-20 position to produce precorrin-3A [H]

COG id: COG2243

COG function: function code H; Precorrin-2 methylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR012382
- InterPro:   IPR006364 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.130 [H]

Molecular weight: Translated: 25828; Mature: 25697

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAKIYAVGVGPGDPELLTRKAARIIRSAAVICAPTGAADAASYALSIVEDLIDPSRQEV
CCEEEEEEECCCCCHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHCCCHHHH
LPQVFPMRKDQEGLEAFWDEAAAQVAARVRAGRDVAFITIGDPFLYSTFLYLYRIFQERY
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHC
PDIPVEIVPGISSINAAAAAAGVPLGMAAERIAILPTTYEDDELRRTFADFDTVILMKVN
CCCCEEEECCCHHHHHHHHHCCCCCCHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHH
RVFDRIYALLKELGLERKGVFVRRVGSADEEVIFDLERLVGEKLDYLSLLIVKK
HHHHHHHHHHHHHCCCCCCHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHEECC
>Mature Secondary Structure 
TAKIYAVGVGPGDPELLTRKAARIIRSAAVICAPTGAADAASYALSIVEDLIDPSRQEV
CEEEEEEECCCCCHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHCCCHHHH
LPQVFPMRKDQEGLEAFWDEAAAQVAARVRAGRDVAFITIGDPFLYSTFLYLYRIFQERY
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHC
PDIPVEIVPGISSINAAAAAAGVPLGMAAERIAILPTTYEDDELRRTFADFDTVILMKVN
CCCCEEEECCCHHHHHHHHHCCCCCCHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHH
RVFDRIYALLKELGLERKGVFVRRVGSADEEVIFDLERLVGEKLDYLSLLIVKK
HHHHHHHHHHHHHCCCCCCHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]