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The map label for this gene is shc [H]

Identifier: 78221640

GI number: 78221640

Start: 465281

End: 467473

Strand: Reverse

Name: shc [H]

Synonym: Gmet_0419

Alternate gene names: 78221640

Gene position: 467473-465281 (Counterclockwise)

Preceding gene: 78221641

Following gene: 78221596

Centisome position: 11.69

GC content: 61.38

Gene sequence:

>2193_bases
ATGGCAAAGGGAATTCTCAACAAGTTTGCCGTGATCGCCGGCAACAAGAACGCCGGACTGACGGCCGAGGAAGAATGCAC
CGTCGTCGCACCCATAAAAGAGGTCTCGGGAAAGGCCGTCCACTGTCGTCAGGCCGTCAAAATGGCGGAGGAGTATCTGC
TGGCGCTTCAGAATCCAGAGGGGTACTGGGTCTTTGAACTGGAGGCGGACGTCACAATACCGTCGGAGTACATCATGCTT
CAGCGGTTTCTCGGCAGGGAGATTTCTCCGGAACTGAGGATGCGGCTGGAGAATTACCTCCTGGACAGGCAATTGCCCGA
CGGCGGCTGGCCCCTCTACGCCGTGGACGGATTCGCCAATATCAGCGCCACGGTCAAGGCCTATCTCGCCCTCAAGGTGC
TGGGGCACTCACCCCAGGCACCCCACATGATACGCGCGCGCATCATGGTCCTCAGCCTCGGCGGCGCGGCCAGGTGCAAT
GTGTTCACGCGTATCCTTCTGGCCCTGTTCGGCCAGCTCCCCTGGCATACCCCACCGGCAATGCCCGTGGAGATCGTCCT
TCTGCCACAGCGGTTTTTCTTTCATTTGAGCAAAGTCTCCTACTGGTCGAGAACCGTCATCGTCCCCATGCTGCTGCTCT
ACGCCAAGCAACCCGTCTGCCGGTTGCGGCCCGAGGAGGGAATTCCCGAACTGTTCAACACACCGCCCGACAAGCTGCGC
AACCTTGATGGCTTTCAGTCGGGGCGCTGGCGGAAAAACGCCTTCATCATCATTGACCGCCTGCTCAAGCGTTTCAACCG
TTTCATCCCTTCCGCCATTCATCGGAAGGCCATGGCCGAAGCAGAGCACTGGACAAGATCCCGCATGCAGGGAAGCGGCG
GGATCGGCGCCATTTTCCCGGCCATGGCCTATGCGGTCATGGCCCTCCGCGTGCTCGGATGCAGGGAAGACGACCCCGAC
TATGTACGGGGGATGCAGGCCATCGACGACCTCCTCCAGCATCGCACTCCCCAGGAAGCTGATTCTCCCCGCACGGGCGG
ACCGTGCATCGACAGCGGCACGTCGGCGGCTTTTGCCTTCGATCCCTCTCCCCACGCGGCAGCGGACGGCAGAGGGAACA
GCAGCATCTGCCAGCCATGCAATTCCCCGATCTGGGACACCTGCCTAAGCCTTTCGGCGCTCATGGAAGCAGGCATGCCG
GCGAGCCACCCCGCAGCGAAACAGGCCGTTGAATGGCTGTTATCCCAGCAGATTTTCTCACCAGGAGACTGGTCGTTGAA
GGCTCCTGATCTGGAGGGGGGCGGATGGGCTTTCCAGTTCGAAAACACCCTCTATCCCGACCTGGACGACACCTCGAAAG
TCATCATGTCGCTTCTCCGTGCCGGAGCGCTGGAGAATGGGCTCTACCGCGACCGGGTGGCCCGCGGCGTGAATTGGGTA
CTCGGGATGCAGAGCAGTGACGGAGGGTGGGCAGCCTTCGACATCGACAACAACTACCACTACCTGAATGATATCCCGTT
CGCCGACCACGGGGCGCTCCTCGACCCGAGCACCTCGGACCTGACGGGACGCTGCATCGAGCTTCTCTCCATGGTCGGTT
TCGACAGGACGTTTCCCCCCATCGCGCAGGGGATCGGTTTCCTGCGCTCGAAGCAGGAAGGGAGCGGCGCCTGGTTCGGC
CGATGGGGGGTAAACTACATCTACGGTACGTGGTCGGTGCTGTCCGGCCTCAGACAGGCAGGGGAAGATATGCAGCAGCC
CTATATCCGCAGGGCAGTGGGATGGTTGACGTCATGCCAGAACCACGACGGGGGATGGGGAGAAACCTGCTATTCCTACG
ACGATCCTTCGCTGGCCGGCCAAGGGGAGAGCACCCCGTCTCAGACGGCCTGGAGTCTCCTGGGGCTCATGGCCGCCGGA
GATGTTCACAGCCTGGCCGTCCGGCGTGGCGTGCGCTACCTGCTCGACCACCAGAATCAATGGGGAACCTGGGAGGAGAA
ACATTTTACCGGTACCGGATTCCCGAGGGTCTTTTACCTGCGCTACCACGGGTACCGCCACTACTTTCCCCTGTGGGCGC
TCGGCGTCTATTCACGGCTCAGCTCGGGACAAAAGACCCGCCAGGAGGAACGCCGCCATTCATCGCCCGGCGATCTCCAT
CTCCCTTGGCTGGAGAGAATCGGAAGACGATAG

Upstream 100 bases:

>100_bases
GCCGGTTTCAGCGTGAAAAATTTTTTTGGCACAAATATTTACACTGTTAACTAAAAATACCACAGTTAACATTTCGCCAC
TCAAGGGAAAGGATGCACGA

Downstream 100 bases:

>100_bases
CGGTCTCACCGGGGAGGGGTCGCCTTCAGATACTCCCGCCTGAGCCGCTCGGCGTCGGCGCTGGCTATGACATCCCACGG
CAGCATCTCGTCGAGGGGGA

Product: Terpene synthase:squalene cyclase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 730; Mature: 729

Protein sequence:

>730_residues
MAKGILNKFAVIAGNKNAGLTAEEECTVVAPIKEVSGKAVHCRQAVKMAEEYLLALQNPEGYWVFELEADVTIPSEYIML
QRFLGREISPELRMRLENYLLDRQLPDGGWPLYAVDGFANISATVKAYLALKVLGHSPQAPHMIRARIMVLSLGGAARCN
VFTRILLALFGQLPWHTPPAMPVEIVLLPQRFFFHLSKVSYWSRTVIVPMLLLYAKQPVCRLRPEEGIPELFNTPPDKLR
NLDGFQSGRWRKNAFIIIDRLLKRFNRFIPSAIHRKAMAEAEHWTRSRMQGSGGIGAIFPAMAYAVMALRVLGCREDDPD
YVRGMQAIDDLLQHRTPQEADSPRTGGPCIDSGTSAAFAFDPSPHAAADGRGNSSICQPCNSPIWDTCLSLSALMEAGMP
ASHPAAKQAVEWLLSQQIFSPGDWSLKAPDLEGGGWAFQFENTLYPDLDDTSKVIMSLLRAGALENGLYRDRVARGVNWV
LGMQSSDGGWAAFDIDNNYHYLNDIPFADHGALLDPSTSDLTGRCIELLSMVGFDRTFPPIAQGIGFLRSKQEGSGAWFG
RWGVNYIYGTWSVLSGLRQAGEDMQQPYIRRAVGWLTSCQNHDGGWGETCYSYDDPSLAGQGESTPSQTAWSLLGLMAAG
DVHSLAVRRGVRYLLDHQNQWGTWEEKHFTGTGFPRVFYLRYHGYRHYFPLWALGVYSRLSSGQKTRQEERRHSSPGDLH
LPWLERIGRR

Sequences:

>Translated_730_residues
MAKGILNKFAVIAGNKNAGLTAEEECTVVAPIKEVSGKAVHCRQAVKMAEEYLLALQNPEGYWVFELEADVTIPSEYIML
QRFLGREISPELRMRLENYLLDRQLPDGGWPLYAVDGFANISATVKAYLALKVLGHSPQAPHMIRARIMVLSLGGAARCN
VFTRILLALFGQLPWHTPPAMPVEIVLLPQRFFFHLSKVSYWSRTVIVPMLLLYAKQPVCRLRPEEGIPELFNTPPDKLR
NLDGFQSGRWRKNAFIIIDRLLKRFNRFIPSAIHRKAMAEAEHWTRSRMQGSGGIGAIFPAMAYAVMALRVLGCREDDPD
YVRGMQAIDDLLQHRTPQEADSPRTGGPCIDSGTSAAFAFDPSPHAAADGRGNSSICQPCNSPIWDTCLSLSALMEAGMP
ASHPAAKQAVEWLLSQQIFSPGDWSLKAPDLEGGGWAFQFENTLYPDLDDTSKVIMSLLRAGALENGLYRDRVARGVNWV
LGMQSSDGGWAAFDIDNNYHYLNDIPFADHGALLDPSTSDLTGRCIELLSMVGFDRTFPPIAQGIGFLRSKQEGSGAWFG
RWGVNYIYGTWSVLSGLRQAGEDMQQPYIRRAVGWLTSCQNHDGGWGETCYSYDDPSLAGQGESTPSQTAWSLLGLMAAG
DVHSLAVRRGVRYLLDHQNQWGTWEEKHFTGTGFPRVFYLRYHGYRHYFPLWALGVYSRLSSGQKTRQEERRHSSPGDLH
LPWLERIGRR
>Mature_729_residues
AKGILNKFAVIAGNKNAGLTAEEECTVVAPIKEVSGKAVHCRQAVKMAEEYLLALQNPEGYWVFELEADVTIPSEYIMLQ
RFLGREISPELRMRLENYLLDRQLPDGGWPLYAVDGFANISATVKAYLALKVLGHSPQAPHMIRARIMVLSLGGAARCNV
FTRILLALFGQLPWHTPPAMPVEIVLLPQRFFFHLSKVSYWSRTVIVPMLLLYAKQPVCRLRPEEGIPELFNTPPDKLRN
LDGFQSGRWRKNAFIIIDRLLKRFNRFIPSAIHRKAMAEAEHWTRSRMQGSGGIGAIFPAMAYAVMALRVLGCREDDPDY
VRGMQAIDDLLQHRTPQEADSPRTGGPCIDSGTSAAFAFDPSPHAAADGRGNSSICQPCNSPIWDTCLSLSALMEAGMPA
SHPAAKQAVEWLLSQQIFSPGDWSLKAPDLEGGGWAFQFENTLYPDLDDTSKVIMSLLRAGALENGLYRDRVARGVNWVL
GMQSSDGGWAAFDIDNNYHYLNDIPFADHGALLDPSTSDLTGRCIELLSMVGFDRTFPPIAQGIGFLRSKQEGSGAWFGR
WGVNYIYGTWSVLSGLRQAGEDMQQPYIRRAVGWLTSCQNHDGGWGETCYSYDDPSLAGQGESTPSQTAWSLLGLMAAGD
VHSLAVRRGVRYLLDHQNQWGTWEEKHFTGTGFPRVFYLRYHGYRHYFPLWALGVYSRLSSGQKTRQEERRHSSPGDLHL
PWLERIGRR

Specific function: Catalyzes the cyclization of squalene into hopene [H]

COG id: COG1657

COG function: function code I; Squalene cyclase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 4 PFTB repeats [H]

Homologues:

Organism=Homo sapiens, GI224177556, Length=344, Percent_Identity=29.9418604651163, Blast_Score=138, Evalue=2e-32,
Organism=Homo sapiens, GI47933395, Length=344, Percent_Identity=29.9418604651163, Blast_Score=138, Evalue=2e-32,
Organism=Homo sapiens, GI47933397, Length=344, Percent_Identity=29.9418604651163, Blast_Score=138, Evalue=2e-32,
Organism=Homo sapiens, GI224177558, Length=344, Percent_Identity=29.9418604651163, Blast_Score=138, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6321863, Length=688, Percent_Identity=22.9651162790698, Blast_Score=132, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006400
- InterPro:   IPR001330
- InterPro:   IPR018333
- InterPro:   IPR002365
- InterPro:   IPR008930 [H]

Pfam domain/function: PF00432 Prenyltrans [H]

EC number: =5.4.99.17 [H]

Molecular weight: Translated: 81570; Mature: 81439

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKGILNKFAVIAGNKNAGLTAEEECTVVAPIKEVSGKAVHCRQAVKMAEEYLLALQNPE
CCCHHHHCEEEEECCCCCCCCCCCCCEEEECHHHHCCCHHHHHHHHHHHHHHHHHEECCC
GYWVFELEADVTIPSEYIMLQRFLGREISPELRMRLENYLLDRQLPDGGWPLYAVDGFAN
CEEEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCHH
ISATVKAYLALKVLGHSPQAPHMIRARIMVLSLGGAARCNVFTRILLALFGQLPWHTPPA
HHHHHHHHHHHHHHCCCCCCCHHHHHEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCC
MPVEIVLLPQRFFFHLSKVSYWSRTVIVPMLLLYAKQPVCRLRPEEGIPELFNTPPDKLR
CCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCHHHCCCHHHHH
NLDGFQSGRWRKNAFIIIDRLLKRFNRFIPSAIHRKAMAEAEHWTRSRMQGSGGIGAIFP
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
AMAYAVMALRVLGCREDDPDYVRGMQAIDDLLQHRTPQEADSPRTGGPCIDSGTSAAFAF
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEE
DPSPHAAADGRGNSSICQPCNSPIWDTCLSLSALMEAGMPASHPAAKQAVEWLLSQQIFS
CCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCC
PGDWSLKAPDLEGGGWAFQFENTLYPDLDDTSKVIMSLLRAGALENGLYRDRVARGVNWV
CCCCCEECCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCEEE
LGMQSSDGGWAAFDIDNNYHYLNDIPFADHGALLDPSTSDLTGRCIELLSMVGFDRTFPP
EEECCCCCCEEEEEECCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCH
IAQGIGFLRSKQEGSGAWFGRWGVNYIYGTWSVLSGLRQAGEDMQQPYIRRAVGWLTSCQ
HHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NHDGGWGETCYSYDDPSLAGQGESTPSQTAWSLLGLMAAGDVHSLAVRRGVRYLLDHQNQ
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCC
WGTWEEKHFTGTGFPRVFYLRYHGYRHYFPLWALGVYSRLSSGQKTRQEERRHSSPGDLH
CCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEE
LPWLERIGRR
CHHHHHCCCC
>Mature Secondary Structure 
AKGILNKFAVIAGNKNAGLTAEEECTVVAPIKEVSGKAVHCRQAVKMAEEYLLALQNPE
CCHHHHCEEEEECCCCCCCCCCCCCEEEECHHHHCCCHHHHHHHHHHHHHHHHHEECCC
GYWVFELEADVTIPSEYIMLQRFLGREISPELRMRLENYLLDRQLPDGGWPLYAVDGFAN
CEEEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCHH
ISATVKAYLALKVLGHSPQAPHMIRARIMVLSLGGAARCNVFTRILLALFGQLPWHTPPA
HHHHHHHHHHHHHHCCCCCCCHHHHHEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCC
MPVEIVLLPQRFFFHLSKVSYWSRTVIVPMLLLYAKQPVCRLRPEEGIPELFNTPPDKLR
CCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCHHHCCCHHHHH
NLDGFQSGRWRKNAFIIIDRLLKRFNRFIPSAIHRKAMAEAEHWTRSRMQGSGGIGAIFP
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
AMAYAVMALRVLGCREDDPDYVRGMQAIDDLLQHRTPQEADSPRTGGPCIDSGTSAAFAF
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEE
DPSPHAAADGRGNSSICQPCNSPIWDTCLSLSALMEAGMPASHPAAKQAVEWLLSQQIFS
CCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCC
PGDWSLKAPDLEGGGWAFQFENTLYPDLDDTSKVIMSLLRAGALENGLYRDRVARGVNWV
CCCCCEECCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHCCCEEE
LGMQSSDGGWAAFDIDNNYHYLNDIPFADHGALLDPSTSDLTGRCIELLSMVGFDRTFPP
EEECCCCCCEEEEEECCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCH
IAQGIGFLRSKQEGSGAWFGRWGVNYIYGTWSVLSGLRQAGEDMQQPYIRRAVGWLTSCQ
HHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NHDGGWGETCYSYDDPSLAGQGESTPSQTAWSLLGLMAAGDVHSLAVRRGVRYLLDHQNQ
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCC
WGTWEEKHFTGTGFPRVFYLRYHGYRHYFPLWALGVYSRLSSGQKTRQEERRHSSPGDLH
CCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEE
LPWLERIGRR
CHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7894707 [H]