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The map label for this gene is murB

Identifier: 78221635

GI number: 78221635

Start: 458106

End: 459008

Strand: Direct

Name: murB

Synonym: Gmet_0414

Alternate gene names: 78221635

Gene position: 458106-459008 (Clockwise)

Preceding gene: 78221634

Following gene: 78221636

Centisome position: 11.46

GC content: 63.46

Gene sequence:

>903_bases
TTGAACGACGAACTGTACGCCCGCCTCCGTGCAGAGTTGAGGGGGGAGATTCTGCGGGATGAGCCGATGGCTCGCCACAC
CTCGCTCAAGGTGGGGGGCGCCGCCGACTTCTTCGTCACCCCGGCTGACCGGGATGATCTTACGGCGCTCCTGGCGCTTC
TGGCTGAAACCGGTACCCCCTACCTGGTGGTCGGCGGGGGATACAACCTCCTGGTACGGGACGGCGGCATTCGTGGCGTG
GTCATTTCCCTCGCGCGCCTGGACGAGATGACCCTGCTCGCCGGGGAGAGGGTGATGGCCGGGGCTGGAGTAACCAACCG
GCAGTTCGTGCAGTTGCTGAGGGACAGGGGGCTTGGGGGGCTTGAGTTTCTCTGCGGCATTCCCGGCACGGTCGGCGGTG
CCCTGGCCATGAACGCCGGAGCTCACGGCGGAGCGGTGGTTGACCGAGTGGAGGAACTCCTCACCATCCGGGACGGGGAG
ATGCTGCAAACCGGCCGCGACGGCCTCGATTACGGCTACCGGTTCCTGAGGCTTGCGCCTGGTGAGATTATTGTTGGGGC
AACCTTTCGCCTGGATCCGGCCGATCCCGATCAGATCGGGGCACGGATCGCCGGTTACCTGGAACACCGGGCCGCGAGTC
AAAAAGTCGGCTTTCCCAATGCCGGGTCCTTCTTCAAGAATCCGGAGGGGACCGCTGCTTGGCGGCTGATTGACGAAACT
GGGCTTCGGGGAGAGCGGGTGGGGGGCGCCCAGGTGTCGGAGGCCCACGCTAACTTCCTGATAAATCGGGGGGGGGCGAC
GGCTGCCGATTTTCTTGCCCTGGCTACCCGAATTAATGAGGCAGTAAAACAACGTACCGGCATAACTCTTGAAGAAGAGG
TCAGGATTGTCGGTGAAGAGTGA

Upstream 100 bases:

>100_bases
GTGAGGCCCGGTGACATCGTCCTGACCCTCGGCGCCGGCAACATCTGGCAGACCGGAGAGGCCCTGCTCCGGAAGCTGGA
GACGGCAGAGGGATAGCTCT

Downstream 100 bases:

>100_bases
TTAAAGAACCGCTTCCAAGAAGCGCTCAGGCGAAAACGCGATGACCCGTGATGAACTGAAAACCAAGAAGATCGGCGTGC
TTATGGGGGGGCTCTCGGCG

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MNDELYARLRAELRGEILRDEPMARHTSLKVGGAADFFVTPADRDDLTALLALLAETGTPYLVVGGGYNLLVRDGGIRGV
VISLARLDEMTLLAGERVMAGAGVTNRQFVQLLRDRGLGGLEFLCGIPGTVGGALAMNAGAHGGAVVDRVEELLTIRDGE
MLQTGRDGLDYGYRFLRLAPGEIIVGATFRLDPADPDQIGARIAGYLEHRAASQKVGFPNAGSFFKNPEGTAAWRLIDET
GLRGERVGGAQVSEAHANFLINRGGATAADFLALATRINEAVKQRTGITLEEEVRIVGEE

Sequences:

>Translated_300_residues
MNDELYARLRAELRGEILRDEPMARHTSLKVGGAADFFVTPADRDDLTALLALLAETGTPYLVVGGGYNLLVRDGGIRGV
VISLARLDEMTLLAGERVMAGAGVTNRQFVQLLRDRGLGGLEFLCGIPGTVGGALAMNAGAHGGAVVDRVEELLTIRDGE
MLQTGRDGLDYGYRFLRLAPGEIIVGATFRLDPADPDQIGARIAGYLEHRAASQKVGFPNAGSFFKNPEGTAAWRLIDET
GLRGERVGGAQVSEAHANFLINRGGATAADFLALATRINEAVKQRTGITLEEEVRIVGEE
>Mature_300_residues
MNDELYARLRAELRGEILRDEPMARHTSLKVGGAADFFVTPADRDDLTALLALLAETGTPYLVVGGGYNLLVRDGGIRGV
VISLARLDEMTLLAGERVMAGAGVTNRQFVQLLRDRGLGGLEFLCGIPGTVGGALAMNAGAHGGAVVDRVEELLTIRDGE
MLQTGRDGLDYGYRFLRLAPGEIIVGATFRLDPADPDQIGARIAGYLEHRAASQKVGFPNAGSFFKNPEGTAAWRLIDET
GLRGERVGGAQVSEAHANFLINRGGATAADFLALATRINEAVKQRTGITLEEEVRIVGEE

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

Organism=Escherichia coli, GI1790407, Length=319, Percent_Identity=29.7805642633229, Blast_Score=85, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_GEOMG (Q39YL7)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_383382.1
- ProteinModelPortal:   Q39YL7
- SMR:   Q39YL7
- STRING:   Q39YL7
- GeneID:   3738169
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_0414
- NMPDR:   fig|269799.3.peg.442
- eggNOG:   COG0812
- HOGENOM:   HBG686573
- OMA:   ILIVPKH
- PhylomeDB:   Q39YL7
- ProtClustDB:   PRK13905
- BioCyc:   GMET269799:GMET_0414-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 32000; Mature: 32000

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 174-174 ACT_SITE 223-223 ACT_SITE 293-293

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDELYARLRAELRGEILRDEPMARHTSLKVGGAADFFVTPADRDDLTALLALLAETGTP
CCHHHHHHHHHHHHHHHHCCCCCHHHCEEEECCCCCEEECCCCCHHHHHHHHHHHCCCCC
YLVVGGGYNLLVRDGGIRGVVISLARLDEMTLLAGERVMAGAGVTNRQFVQLLRDRGLGG
EEEECCCEEEEEECCCCCEEHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHCCCCC
LEFLCGIPGTVGGALAMNAGAHGGAVVDRVEELLTIRDGEMLQTGRDGLDYGYRFLRLAP
CHHHHCCCCCCCCHHEECCCCCCCHHHHHHHHHHHCCCCCHHHCCCCCHHHCEEEEEECC
GEIIVGATFRLDPADPDQIGARIAGYLEHRAASQKVGFPNAGSFFKNPEGTAAWRLIDET
CCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEHHC
GLRGERVGGAQVSEAHANFLINRGGATAADFLALATRINEAVKQRTGITLEEEVRIVGEE
CCCCCCCCCCHHHHHHHCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEECCC
>Mature Secondary Structure
MNDELYARLRAELRGEILRDEPMARHTSLKVGGAADFFVTPADRDDLTALLALLAETGTP
CCHHHHHHHHHHHHHHHHCCCCCHHHCEEEECCCCCEEECCCCCHHHHHHHHHHHCCCCC
YLVVGGGYNLLVRDGGIRGVVISLARLDEMTLLAGERVMAGAGVTNRQFVQLLRDRGLGG
EEEECCCEEEEEECCCCCEEHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHCCCCC
LEFLCGIPGTVGGALAMNAGAHGGAVVDRVEELLTIRDGEMLQTGRDGLDYGYRFLRLAP
CHHHHCCCCCCCCHHEECCCCCCCHHHHHHHHHHHCCCCCHHHCCCCCHHHCEEEEEECC
GEIIVGATFRLDPADPDQIGARIAGYLEHRAASQKVGFPNAGSFFKNPEGTAAWRLIDET
CCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEHHC
GLRGERVGGAQVSEAHANFLINRGGATAADFLALATRINEAVKQRTGITLEEEVRIVGEE
CCCCCCCCCCHHHHHHHCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA