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The map label for this gene is hisE

Identifier: 78221611

GI number: 78221611

Start: 433621

End: 433950

Strand: Direct

Name: hisE

Synonym: Gmet_0390

Alternate gene names: 78221611

Gene position: 433621-433950 (Clockwise)

Preceding gene: 78221610

Following gene: 78221612

Centisome position: 10.85

GC content: 58.79

Gene sequence:

>330_bases
ATGAACGAACGTGACGATATTCTGCAGGCTGTTTATCGGGTGATCAAGGAGCGCAAGGGCGCTTCCGCTGATTCTTCCTA
CACCGCATCGCTCCTCCAGAAGGGGATCGACAAGATCCTCAAGAAGCTCGGCGAGGAGGCCACTGAAGTGGTCATCGCCG
GCAAGGGGGGGAAGCGGGAGGAGATTGTCTACGAGACCGCCGACCTCTTTTTTCACACTCTCGTGCTCCTGGGCTACTAC
GACATCGACCCCGAAGAGATCTACGCGGAACTGCGCCGTCGCTTCGGTACTTCCGGCATCGCCGAGAAGGCGTCGCGGCC
CAAGGAATGA

Upstream 100 bases:

>100_bases
GAGCCTCGGCATGTCTTGCCGCCTCCATTTTTCACTACAAGGAGTACACCATCGGCGAGGCGAAGGAGTATCTCCGTGGG
CGGGGGGTCCCGGTCCGGTT

Downstream 100 bases:

>100_bases
AAACCTCCTGAATATCTGTAAAAAATTGTTGACACAAATACGGTAGCCGCATATTATGTGTGGTCTGTGAAAAAATATCC
GGCCCATGAGTAATTTCTTC

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH

Number of amino acids: Translated: 109; Mature: 109

Protein sequence:

>109_residues
MNERDDILQAVYRVIKERKGASADSSYTASLLQKGIDKILKKLGEEATEVVIAGKGGKREEIVYETADLFFHTLVLLGYY
DIDPEEIYAELRRRFGTSGIAEKASRPKE

Sequences:

>Translated_109_residues
MNERDDILQAVYRVIKERKGASADSSYTASLLQKGIDKILKKLGEEATEVVIAGKGGKREEIVYETADLFFHTLVLLGYY
DIDPEEIYAELRRRFGTSGIAEKASRPKE
>Mature_109_residues
MNERDDILQAVYRVIKERKGASADSSYTASLLQKGIDKILKKLGEEATEVVIAGKGGKREEIVYETADLFFHTLVLLGYY
DIDPEEIYAELRRRFGTSGIAEKASRPKE

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=82, Percent_Identity=37.8048780487805, Blast_Score=60, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_GEOMG (Q39YP1)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_383358.1
- ProteinModelPortal:   Q39YP1
- SMR:   Q39YP1
- STRING:   Q39YP1
- GeneID:   3739368
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_0390
- NMPDR:   fig|269799.3.peg.402
- eggNOG:   COG0140
- HOGENOM:   HBG646527
- OMA:   ETVMAAK
- ProtClustDB:   PRK00400
- BioCyc:   GMET269799:GMET_0390-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01020
- InterPro:   IPR008179
- InterPro:   IPR021130
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01503 PRA-PH

EC number: =3.6.1.31

Molecular weight: Translated: 12284; Mature: 12284

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNERDDILQAVYRVIKERKGASADSSYTASLLQKGIDKILKKLGEEATEVVIAGKGGKRE
CCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHEEEECCCCCCH
EIVYETADLFFHTLVLLGYYDIDPEEIYAELRRRFGTSGIAEKASRPKE
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHCCCCCC
>Mature Secondary Structure
MNERDDILQAVYRVIKERKGASADSSYTASLLQKGIDKILKKLGEEATEVVIAGKGGKRE
CCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHEEEECCCCCCH
EIVYETADLFFHTLVLLGYYDIDPEEIYAELRRRFGTSGIAEKASRPKE
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA