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The map label for this gene is hisD

Identifier: 78221605

GI number: 78221605

Start: 428430

End: 429740

Strand: Direct

Name: hisD

Synonym: Gmet_0384

Alternate gene names: 78221605

Gene position: 428430-429740 (Clockwise)

Preceding gene: 78221604

Following gene: 78221606

Centisome position: 10.72

GC content: 66.06

Gene sequence:

>1311_bases
ATGAAATTCCTCGATATCAGGGATACGAACTTCGACATGGAATTCGCCGCCATCCTCGCCCGGGGCGAGGAGACCGGCCG
CGAGGTGGAACAGGTGGTCCTCGACATCATCGCCGATGTCCGTGCGCGGGGTGATGAGGCGCTCCTGGAGTACACCCGGC
GCTTCGACCGGCTTGAGGCCGATTCCGTCGCCTCGCTTCAGGTAACCGAGGACGAGGTCGACTACGCCTTTGCCCGGGTG
AAGGACGAGGAGATCGCGGCCCTCAAGCTGGCAGTGGAGCGGGTGGCCCGCTTCCACGAGAAGCAGAAGCAGGAGACCTG
GCTCTCCACCGGCGAGCCCGACATCCTTCTCGGCCAGATGGTGACTCCCCTGGAGCGGGTCGGGATCTATGTCCCCGGCG
GCAAAGCGAGCTATCCCTCCAGCGTCATCATGAACGCGGTACCGGCCCGGGTGGCGGGCGTCGGCGAGGTCGTCATGGTG
GCCCCGACTCCTGGCGGCGAGATCAATCCCCATGTCCTGGTGGCGGCGCGGTTCTCCGGCGTGGACCGGATCTTCCGACT
CGGCGGCGCCCAGGCCGTGGCGGCCCTGGCCTACGGAACCGCCACGGTGCCCAAGGTGGACAAAATCACCGGCCCGGGGA
ACATCTACGTGGCCACGGCCAAGAAGCTGGTCTTCGGCCAGGTGGGGATCGACATGATCGCCGGCCCCAGCGAGATCCTC
GTCATCAACGACGGAAGCGGCACCCCGGCCCACATCGCCGCAGACCTCCTCTCCCAGGCGGAGCACGACGAACTCGCTTC
GTCCATCCTCATCACCACCGACCGCGGCTTCGGCGAGCGGGTGGCGGCGGAGGTGGAGCGGCAACTGGCGGAGCTCTCCC
GGGAGACCATTGCCCGGAGATCGTGGGAAACGTACGGTGCCGTCATCGTGGCCGGAAGCCTCGACGAGGCCATCGCGTTC
AGCAACCGGATCGCCCCGGAGCACCTGGAGCTGGCCGTGACGAACCCCTTCGATGTCCTGCCGAAAATCAGGAACGCCGG
GGCCATCTTCCTCGGTCACTTTACTCCCGAGGCGGCGGGGGATTATCTGGCCGGTCCGAATCACACCCTTCCCACCGGCG
GCACGGCCCGGTTCTTCTCACCTCTGTCGGTGGACGATTTCGTGAAGAAGTCCTCCATCGTCTACTTCAGCGAGAGCGGG
TTGAATCGTCTGGGGGGGGGCATCGTCCGGATCGCCGAACTGGAGGGGCTGGAAGCCCACGGCAGGTCGGTGAGCGTGAG
ACTGAAGGGGGAAGGAGAGGCCCGGAAATGA

Upstream 100 bases:

>100_bases
CCATCGCCGAGATCACCACGCGCCTCATCGTCAACCGGGCGAGCCTCAAGACCAAGCACCCCCGGATCACCGAGATCATC
GAAGGGTTGGAGAAGCACGT

Downstream 100 bases:

>100_bases
TTCCACTTCGACAGAACATCGCCTCCATGAAGGGGTACATCCCCGGTTACCAGCCGCCCGATATCGCCTCGTGGATCAAG
CTGAACACGAACGAAAACCC

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MKFLDIRDTNFDMEFAAILARGEETGREVEQVVLDIIADVRARGDEALLEYTRRFDRLEADSVASLQVTEDEVDYAFARV
KDEEIAALKLAVERVARFHEKQKQETWLSTGEPDILLGQMVTPLERVGIYVPGGKASYPSSVIMNAVPARVAGVGEVVMV
APTPGGEINPHVLVAARFSGVDRIFRLGGAQAVAALAYGTATVPKVDKITGPGNIYVATAKKLVFGQVGIDMIAGPSEIL
VINDGSGTPAHIAADLLSQAEHDELASSILITTDRGFGERVAAEVERQLAELSRETIARRSWETYGAVIVAGSLDEAIAF
SNRIAPEHLELAVTNPFDVLPKIRNAGAIFLGHFTPEAAGDYLAGPNHTLPTGGTARFFSPLSVDDFVKKSSIVYFSESG
LNRLGGGIVRIAELEGLEAHGRSVSVRLKGEGEARK

Sequences:

>Translated_436_residues
MKFLDIRDTNFDMEFAAILARGEETGREVEQVVLDIIADVRARGDEALLEYTRRFDRLEADSVASLQVTEDEVDYAFARV
KDEEIAALKLAVERVARFHEKQKQETWLSTGEPDILLGQMVTPLERVGIYVPGGKASYPSSVIMNAVPARVAGVGEVVMV
APTPGGEINPHVLVAARFSGVDRIFRLGGAQAVAALAYGTATVPKVDKITGPGNIYVATAKKLVFGQVGIDMIAGPSEIL
VINDGSGTPAHIAADLLSQAEHDELASSILITTDRGFGERVAAEVERQLAELSRETIARRSWETYGAVIVAGSLDEAIAF
SNRIAPEHLELAVTNPFDVLPKIRNAGAIFLGHFTPEAAGDYLAGPNHTLPTGGTARFFSPLSVDDFVKKSSIVYFSESG
LNRLGGGIVRIAELEGLEAHGRSVSVRLKGEGEARK
>Mature_436_residues
MKFLDIRDTNFDMEFAAILARGEETGREVEQVVLDIIADVRARGDEALLEYTRRFDRLEADSVASLQVTEDEVDYAFARV
KDEEIAALKLAVERVARFHEKQKQETWLSTGEPDILLGQMVTPLERVGIYVPGGKASYPSSVIMNAVPARVAGVGEVVMV
APTPGGEINPHVLVAARFSGVDRIFRLGGAQAVAALAYGTATVPKVDKITGPGNIYVATAKKLVFGQVGIDMIAGPSEIL
VINDGSGTPAHIAADLLSQAEHDELASSILITTDRGFGERVAAEVERQLAELSRETIARRSWETYGAVIVAGSLDEAIAF
SNRIAPEHLELAVTNPFDVLPKIRNAGAIFLGHFTPEAAGDYLAGPNHTLPTGGTARFFSPLSVDDFVKKSSIVYFSESG
LNRLGGGIVRIAELEGLEAHGRSVSVRLKGEGEARK

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=408, Percent_Identity=41.9117647058824, Blast_Score=305, Evalue=5e-84,
Organism=Saccharomyces cerevisiae, GI6319819, Length=426, Percent_Identity=38.2629107981221, Blast_Score=270, Evalue=3e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_GEOMG (Q39YP7)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_383352.1
- ProteinModelPortal:   Q39YP7
- SMR:   Q39YP7
- STRING:   Q39YP7
- GeneID:   3739750
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_0384
- NMPDR:   fig|269799.3.peg.396
- eggNOG:   COG0141
- HOGENOM:   HBG329596
- OMA:   LDAHKNA
- PhylomeDB:   Q39YP7
- ProtClustDB:   PRK00877
- BioCyc:   GMET269799:GMET_0384-MONOMER
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 46820; Mature: 46820

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 327-327 ACT_SITE 328-328 BINDING 130-130 BINDING 191-191 BINDING 214-214 BINDING 237-237 BINDING 259-259 BINDING 262-262 BINDING 328-328 BINDING 361-361 BINDING 415-415 BINDING 420-420

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFLDIRDTNFDMEFAAILARGEETGREVEQVVLDIIADVRARGDEALLEYTRRFDRLEA
CCEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
DSVASLQVTEDEVDYAFARVKDEEIAALKLAVERVARFHEKQKQETWLSTGEPDILLGQM
CCCEEEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHH
VTPLERVGIYVPGGKASYPSSVIMNAVPARVAGVGEVVMVAPTPGGEINPHVLVAARFSG
HCCHHHCCEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEEECCC
VDRIFRLGGAQAVAALAYGTATVPKVDKITGPGNIYVATAKKLVFGQVGIDMIAGPSEIL
HHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCHHHHHCCHHEECCCCEEE
VINDGSGTPAHIAADLLSQAEHDELASSILITTDRGFGERVAAEVERQLAELSRETIARR
EEECCCCCHHHHHHHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
SWETYGAVIVAGSLDEAIAFSNRIAPEHLELAVTNPFDVLPKIRNAGAIFLGHFTPEAAG
CHHCCCEEEEECCCHHHHHHHCCCCCCCEEEEECCCHHHHHHHCCCCEEEEECCCCHHCC
DYLAGPNHTLPTGGTARFFSPLSVDDFVKKSSIVYFSESGLNRLGGGIVRIAELEGLEAH
CCCCCCCCCCCCCCCHHHCCCCCHHHHHHHCEEEEEECCCCHHHCCCEEEEEEECCCCCC
GRSVSVRLKGEGEARK
CCEEEEEEECCCCCCC
>Mature Secondary Structure
MKFLDIRDTNFDMEFAAILARGEETGREVEQVVLDIIADVRARGDEALLEYTRRFDRLEA
CCEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
DSVASLQVTEDEVDYAFARVKDEEIAALKLAVERVARFHEKQKQETWLSTGEPDILLGQM
CCCEEEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHH
VTPLERVGIYVPGGKASYPSSVIMNAVPARVAGVGEVVMVAPTPGGEINPHVLVAARFSG
HCCHHHCCEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEEECCC
VDRIFRLGGAQAVAALAYGTATVPKVDKITGPGNIYVATAKKLVFGQVGIDMIAGPSEIL
HHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCHHHHHCCHHEECCCCEEE
VINDGSGTPAHIAADLLSQAEHDELASSILITTDRGFGERVAAEVERQLAELSRETIARR
EEECCCCCHHHHHHHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
SWETYGAVIVAGSLDEAIAFSNRIAPEHLELAVTNPFDVLPKIRNAGAIFLGHFTPEAAG
CHHCCCEEEEECCCHHHHHHHCCCCCCCEEEEECCCHHHHHHHCCCCEEEEECCCCHHCC
DYLAGPNHTLPTGGTARFFSPLSVDDFVKKSSIVYFSESGLNRLGGGIVRIAELEGLEAH
CCCCCCCCCCCCCCCHHHCCCCCHHHHHHHCEEEEEECCCCHHHCCCEEEEEEECCCCCC
GRSVSVRLKGEGEARK
CCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA