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The map label for this gene is hisC

Identifier: 78221606

GI number: 78221606

Start: 429737

End: 430789

Strand: Direct

Name: hisC

Synonym: Gmet_0385

Alternate gene names: 78221606

Gene position: 429737-430789 (Clockwise)

Preceding gene: 78221605

Following gene: 78221607

Centisome position: 10.75

GC content: 60.97

Gene sequence:

>1053_bases
ATGATTCCACTTCGACAGAACATCGCCTCCATGAAGGGGTACATCCCCGGTTACCAGCCGCCCGATATCGCCTCGTGGAT
CAAGCTGAACACGAACGAAAACCCGTATCCGCCGTCGCCGGAGGTGGTAAAGGCCATTCTTGAGGAACTTGGACCGGACG
GGGCTGCCCTGCGCATCTACCCCAGTGCCTCCAGCCAGAAGCTGCGCGAAGTGGCCGGAGAACTGTACGGTTTCGACCCA
TCCTGGATCATCATGGCCAACGGCTCCGACGAGGTGCTGAACAACCTGATCCGTGCCTTTGCCGCCGAAGGGGAGGAGAT
CGGCTACGTTCACCCCTCATACTCCTACTACGGCACGCTTGCCGAGGTCCAGGGGGCCCGGGTACGCACGTTCGGCCTGA
CCGGCGACTTTCGGATCGCCGGTTTTCCGGAGCGCTACGAAGGGAAAGTATTCTTCCTCACCACCCCCAACGCACCGCTT
GGTCCCAGTTTCCCGCTCGAGTACATCGACGAGCTGGCCCGGCGTTGCGCCGGCATGCTGGTACTGGACGAAACCTATGC
CGAATTTGCCGAATCCAATGCTTTGGAGCTGGTGAGAAGACACGAGAATGTGGTGGTGACGCGCACCCTTTCCAAGAGCT
ATTCCCTGGCCGGCATGCGTATCGGCCTCGCCATTGCCCGTCCGGAGGTGATTGCGGCCTTGGACAAGATCCGTGACCAT
TACAATCTCGACCGCCTGGCCCAGGCGGCCTGCGTGGCCGCACTCCGCGATCAGGCATATCTGTCGGAATGCTGCCGGAG
AATCCGCGAGACGCGGGAATGGTTCACCACTGAACTGCGCTCCATTGGCTATGACGTTATCCCCTCCCAGGGGAACTACC
TGTTTGCCACTCCCCCTGATCGCGACGGCAAGCGGGTTTACGACGGGCTCTACGCCCGCAAGGTCCTGGTCCGTCACTTC
TCTGACCCGCTCCTGGCCCATGGGATGAGGATCTCCATTGGCACCCGGGAGGAGATGGAGCAGACCCTCGCCGCCCTGAA
AGAGATTGGCTAA

Upstream 100 bases:

>100_bases
GTCTGGGGGGGGGCATCGTCCGGATCGCCGAACTGGAGGGGCTGGAAGCCCACGGCAGGTCGGTGAGCGTGAGACTGAAG
GGGGAAGGAGAGGCCCGGAA

Downstream 100 bases:

>100_bases
CTTCGATCCCCACGAGGAGGGTTCCATGTCCCGGAAAGCCACCATCGAACGCGTCACCAAAGAAACCCAGATCAAACTCT
CCCTGGAGATCGACGGGGCG

Product: histidinol phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MIPLRQNIASMKGYIPGYQPPDIASWIKLNTNENPYPPSPEVVKAILEELGPDGAALRIYPSASSQKLREVAGELYGFDP
SWIIMANGSDEVLNNLIRAFAAEGEEIGYVHPSYSYYGTLAEVQGARVRTFGLTGDFRIAGFPERYEGKVFFLTTPNAPL
GPSFPLEYIDELARRCAGMLVLDETYAEFAESNALELVRRHENVVVTRTLSKSYSLAGMRIGLAIARPEVIAALDKIRDH
YNLDRLAQAACVAALRDQAYLSECCRRIRETREWFTTELRSIGYDVIPSQGNYLFATPPDRDGKRVYDGLYARKVLVRHF
SDPLLAHGMRISIGTREEMEQTLAALKEIG

Sequences:

>Translated_350_residues
MIPLRQNIASMKGYIPGYQPPDIASWIKLNTNENPYPPSPEVVKAILEELGPDGAALRIYPSASSQKLREVAGELYGFDP
SWIIMANGSDEVLNNLIRAFAAEGEEIGYVHPSYSYYGTLAEVQGARVRTFGLTGDFRIAGFPERYEGKVFFLTTPNAPL
GPSFPLEYIDELARRCAGMLVLDETYAEFAESNALELVRRHENVVVTRTLSKSYSLAGMRIGLAIARPEVIAALDKIRDH
YNLDRLAQAACVAALRDQAYLSECCRRIRETREWFTTELRSIGYDVIPSQGNYLFATPPDRDGKRVYDGLYARKVLVRHF
SDPLLAHGMRISIGTREEMEQTLAALKEIG
>Mature_350_residues
MIPLRQNIASMKGYIPGYQPPDIASWIKLNTNENPYPPSPEVVKAILEELGPDGAALRIYPSASSQKLREVAGELYGFDP
SWIIMANGSDEVLNNLIRAFAAEGEEIGYVHPSYSYYGTLAEVQGARVRTFGLTGDFRIAGFPERYEGKVFFLTTPNAPL
GPSFPLEYIDELARRCAGMLVLDETYAEFAESNALELVRRHENVVVTRTLSKSYSLAGMRIGLAIARPEVIAALDKIRDH
YNLDRLAQAACVAALRDQAYLSECCRRIRETREWFTTELRSIGYDVIPSQGNYLFATPPDRDGKRVYDGLYARKVLVRHF
SDPLLAHGMRISIGTREEMEQTLAALKEIG

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=334, Percent_Identity=28.7425149700599, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1788722, Length=242, Percent_Identity=26.8595041322314, Blast_Score=69, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6322075, Length=359, Percent_Identity=27.2980501392758, Blast_Score=103, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_GEOMG (Q39YP6)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_383353.1
- PDB:   3HDO
- PDBsum:   3HDO
- ProteinModelPortal:   Q39YP6
- SMR:   Q39YP6
- STRING:   Q39YP6
- GeneID:   3739751
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_0385
- NMPDR:   fig|269799.3.peg.397
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   DKIRDHY
- ProtClustDB:   CLSK829109
- BioCyc:   GMET269799:GMET_0385-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 39135; Mature: 39135

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPLRQNIASMKGYIPGYQPPDIASWIKLNTNENPYPPSPEVVKAILEELGPDGAALRIY
CCCCHHHHHHHHCCCCCCCCCCCHHEEEECCCCCCCCCCHHHHHHHHHHHCCCCCEEEEE
PSASSQKLREVAGELYGFDPSWIIMANGSDEVLNNLIRAFAAEGEEIGYVHPSYSYYGTL
CCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCEECCCHHHHHHH
AEVQGARVRTFGLTGDFRIAGFPERYEGKVFFLTTPNAPLGPSFPLEYIDELARRCAGML
HHHCCCEEEEEECCCCEEECCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCEE
VLDETYAEFAESNALELVRRHENVVVTRTLSKSYSLAGMRIGLAIARPEVIAALDKIRDH
EEHHHHHHHHHCHHHHHHHHCCCEEEEEECCCCCCHHHHEEEEEECCHHHHHHHHHHHHH
YNLDRLAQAACVAALRDQAYLSECCRRIRETREWFTTELRSIGYDVIPSQGNYLFATPPD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCEEEECCCC
RDGKRVYDGLYARKVLVRHFSDPLLAHGMRISIGTREEMEQTLAALKEIG
CCCHHHHHHHHHHHHHHHHCCCHHHHCCCEEECCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIPLRQNIASMKGYIPGYQPPDIASWIKLNTNENPYPPSPEVVKAILEELGPDGAALRIY
CCCCHHHHHHHHCCCCCCCCCCCHHEEEECCCCCCCCCCHHHHHHHHHHHCCCCCEEEEE
PSASSQKLREVAGELYGFDPSWIIMANGSDEVLNNLIRAFAAEGEEIGYVHPSYSYYGTL
CCCCHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCEECCCHHHHHHH
AEVQGARVRTFGLTGDFRIAGFPERYEGKVFFLTTPNAPLGPSFPLEYIDELARRCAGML
HHHCCCEEEEEECCCCEEECCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCEE
VLDETYAEFAESNALELVRRHENVVVTRTLSKSYSLAGMRIGLAIARPEVIAALDKIRDH
EEHHHHHHHHHCHHHHHHHHCCCEEEEEECCCCCCHHHHEEEEEECCHHHHHHHHHHHHH
YNLDRLAQAACVAALRDQAYLSECCRRIRETREWFTTELRSIGYDVIPSQGNYLFATPPD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCEEEECCCC
RDGKRVYDGLYARKVLVRHFSDPLLAHGMRISIGTREEMEQTLAALKEIG
CCCHHHHHHHHHHHHHHHHCCCHHHHCCCEEECCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA