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The map label for this gene is thyX

Identifier: 78221599

GI number: 78221599

Start: 422778

End: 423473

Strand: Direct

Name: thyX

Synonym: Gmet_0378

Alternate gene names: 78221599

Gene position: 422778-423473 (Clockwise)

Preceding gene: 78221598

Following gene: 78221600

Centisome position: 10.58

GC content: 62.93

Gene sequence:

>696_bases
ATGAAGGTTACCCTACTCCAGCACACCCCTGATCCCGAAATGGCCGTTGCCCTCGCCGCGCGGCTCTGCTACTCCCCCAT
CGGCATTGATGAGCTGAAGGAGCGTCTGTCGCGTTCCGACATTTCCGCGTTTCTCGACAAGATCATGTCGCTGGGGCACC
AGTCGGTGCTGGAGCATGCCTCCTTCACCTTCGGCATCGAGGGGATATCGCGGGCCACGAGCCATCAGCTCGTCCGGCAT
CGGATCGCCTCCTACTCCCAGCAGTCCCAGCGCTACGTGACCCATACGGAGCAATTCTCTGCCGTGATTCCCCCCTCCAT
CGCGGGGCGTCCCGATCTTGCTGCCCGCTTCAGATCGCAGCTGAAGGCGCTCCACGATACCTATGCCGAACTCTTCGAGG
CCGGCATCCCGGCCGAGGACGCCCGCTACATCCTCCCCAACGCCGCGGAGACGAAGATCATCATGACCATGAACGCCCGG
GAACTTCTCCACTTCTTCGGCCTGCGCTGCTGCGAGCGGGCCCAGTGGGAGATCCGGGCCATGGCCGTGGAGATGCTGCG
GCTTGTGAAGGGGGTTGCCCCCACCATCTTCCGGGATGCCGGACCCGGCTGCGTTGCCGGCCCCTGTCCGGAAGGGACCA
TGACCTGCGGTAAGATCGTCGAGGTCAGGAAGAGATTCAAGGAGATGTACGTATGA

Upstream 100 bases:

>100_bases
CGGCCTTGCGGATTTGAGCGGAAGGGGATTTTGTCCATGGCGAAATCCCCTTATCTGTTTCTTGAAGCGCTGTATCCAAA
TCGCCTCGTGAAGGGACTTC

Downstream 100 bases:

>100_bases
CGAGGTGGTTCCGGTTGCTGCTGGTGCAGTTGCTCATCCTTGCGGAGCGGATCAATGTAGGTGGGCAGGCTGTTCTCGAA
GGGGTCATGATGCGAGCGCC

Product: FAD-dependent thymidylate synthase

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MKVTLLQHTPDPEMAVALAARLCYSPIGIDELKERLSRSDISAFLDKIMSLGHQSVLEHASFTFGIEGISRATSHQLVRH
RIASYSQQSQRYVTHTEQFSAVIPPSIAGRPDLAARFRSQLKALHDTYAELFEAGIPAEDARYILPNAAETKIIMTMNAR
ELLHFFGLRCCERAQWEIRAMAVEMLRLVKGVAPTIFRDAGPGCVAGPCPEGTMTCGKIVEVRKRFKEMYV

Sequences:

>Translated_231_residues
MKVTLLQHTPDPEMAVALAARLCYSPIGIDELKERLSRSDISAFLDKIMSLGHQSVLEHASFTFGIEGISRATSHQLVRH
RIASYSQQSQRYVTHTEQFSAVIPPSIAGRPDLAARFRSQLKALHDTYAELFEAGIPAEDARYILPNAAETKIIMTMNAR
ELLHFFGLRCCERAQWEIRAMAVEMLRLVKGVAPTIFRDAGPGCVAGPCPEGTMTCGKIVEVRKRFKEMYV
>Mature_231_residues
MKVTLLQHTPDPEMAVALAARLCYSPIGIDELKERLSRSDISAFLDKIMSLGHQSVLEHASFTFGIEGISRATSHQLVRH
RIASYSQQSQRYVTHTEQFSAVIPPSIAGRPDLAARFRSQLKALHDTYAELFEAGIPAEDARYILPNAAETKIIMTMNAR
ELLHFFGLRCCERAQWEIRAMAVEMLRLVKGVAPTIFRDAGPGCVAGPCPEGTMTCGKIVEVRKRFKEMYV

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate [H]

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003669 [H]

Pfam domain/function: PF02511 Thy1 [H]

EC number: =2.1.1.148 [H]

Molecular weight: Translated: 25807; Mature: 25807

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVTLLQHTPDPEMAVALAARLCYSPIGIDELKERLSRSDISAFLDKIMSLGHQSVLEHA
CEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
SFTFGIEGISRATSHQLVRHRIASYSQQSQRYVTHTEQFSAVIPPSIAGRPDLAARFRSQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
LKALHDTYAELFEAGIPAEDARYILPNAAETKIIMTMNARELLHFFGLRCCERAQWEIRA
HHHHHHHHHHHHHCCCCCCCCEEECCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHH
MAVEMLRLVKGVAPTIFRDAGPGCVAGPCPEGTMTCGKIVEVRKRFKEMYV
HHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKVTLLQHTPDPEMAVALAARLCYSPIGIDELKERLSRSDISAFLDKIMSLGHQSVLEHA
CEEEEECCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
SFTFGIEGISRATSHQLVRHRIASYSQQSQRYVTHTEQFSAVIPPSIAGRPDLAARFRSQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
LKALHDTYAELFEAGIPAEDARYILPNAAETKIIMTMNARELLHFFGLRCCERAQWEIRA
HHHHHHHHHHHHHCCCCCCCCEEECCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHH
MAVEMLRLVKGVAPTIFRDAGPGCVAGPCPEGTMTCGKIVEVRKRFKEMYV
HHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA